Month: May 2026

Winner Medical Expands Global Manufacturing Footprint


Winner Medical Expands Global Manufacturing Footprint

Summary: Winner Medical, a leading manufacturer of advanced wound dressings and surgical products, has announced a major expansion of its global manufacturing facilities. The investment aims to increase production capacity, improve supply chain resilience, and meet growing international demand for high-quality wound care solutions.

Key Highlights:

  • Significant increase in global production capacity
  • Focus on advanced wound care and surgical consumables
  • Enhanced supply chain reliability for international markets
  • Strategic move to support growing clinical demand

Read full announcement

Keywords: Winner Medical, wound dressing manufacturing

Teaching Patients to Self-Care for Active Recurrent Periodontal or Peri-Implant Mucositis


Teaching Patients to Self-Care for Active Recurrent Periodontal or Peri-Implant Mucositis

Summary: This study assesses structured patient education and self-care training for individuals with recurrent periodontal disease or peri-implant mucositis. Results show that targeted teaching improves patient compliance, reduces inflammation, and helps maintain periodontal and peri-implant health through consistent daily self-care routines.

Key Highlights:

  • Structured education program for self-care
  • Improved patient adherence and clinical outcomes
  • Focus on recurrent mucositis and periodontitis
  • Emphasizes long-term maintenance and prevention

Read full open-access article

Keywords: patient self care periodontal, peri-implant mucositis

Application and Advances of Cell Membrane-Coated Nanoparticles in Diabetic Wound Healing


Application and Advances of Cell Membrane-Coated Nanoparticles in Diabetic Wound Healing

Summary: This review summarizes recent advances in cell membrane-coated nanoparticles (CMCNPs) for diabetic wound healing. These biomimetic nanocarriers inherit natural cell membrane properties, offering prolonged circulation, immune evasion, targeted delivery, and enhanced therapeutic effects including anti-inflammatory, pro-angiogenic, and antibacterial actions.

Key Highlights:

  • Biomimetic coating improves biocompatibility and targeting
  • Effective modulation of inflammation and oxidative stress
  • Enhanced angiogenesis and tissue regeneration
  • Promising platform for multifunctional diabetic wound therapy

Read full open-access review

Keywords: cell membrane nanoparticles, biomimetic diabetic wound, nanoparticle wound healing

Distribution and Antibiotic Resistance Characteristics of Pathogenic Bacteria in Diabetic Foot Ulcers


Distribution and Antibiotic Resistance Characteristics of Pathogenic Bacteria in Diabetic Foot Ulcers

Summary: This clinical microbiology study analyzed bacterial isolates from diabetic foot ulcers, identifying the most prevalent pathogens and their resistance profiles. Findings highlight the dominance of Gram-negative bacteria and rising multidrug resistance, underscoring the need for culture-guided therapy and updated local antibiograms in DFU management.

Key Highlights:

  • Comprehensive mapping of DFU microbial distribution
  • High rates of resistance to common antibiotics
  • Gram-negative organisms predominant in many cases
  • Important implications for empirical antibiotic selection

Read full open-access article

Keywords: DFU antibiotic resistance, diabetic foot ulcer bacteria, multidrug resistant DFU

A Photothermally Triggered Nanoplatform for Multidimensional Antibacterial Therapy in Diabetic Wound Healing


A Photothermally Triggered Nanoplatform for Multidimensional Antibacterial Therapy in Diabetic Wound Healing

Summary: Researchers developed a smart photothermally triggered nanoplatform that integrates near-infrared (NIR) responsive photothermal therapy, reactive oxygen species (ROS) scavenging, and broad-spectrum antibacterial effects. In diabetic wound models, the system demonstrated excellent infection control, reduced inflammation, and significantly accelerated healing through synergistic multidimensional mechanisms.

Key Highlights:

  • Photothermal + ROS scavenging + antibacterial triple action
  • Strong efficacy against multidrug-resistant bacteria
  • Promoted angiogenesis and collagen deposition in diabetic wounds
  • Potential for minimally invasive, on-demand therapy

Read full open-access article

Keywords: photothermal nanoplatform, diabetic wound antibacterial, ROS scavenging wound

Smart Technology Meets Wound Care to Combat Dangerous Diabetic Ulcers


Smart Technology Meets Wound Care to Combat Dangerous Diabetic Ulcers

Summary: Researchers at KAIST (Korea Advanced Institute of Science and Technology) have introduced a smart wireless sensor technology designed to improve monitoring and early intervention in diabetic foot ulcers. The system aims to detect changes in wound status and reduce the risk of severe complications through continuous, non-invasive data collection.

Key Highlights:

  • Wireless smart patch/sensor for DFU monitoring
  • Real-time detection of healing complications
  • Potential to enable earlier clinical intervention
  • Focus on preventing progression to amputation

Read full article

Keywords: smart sensor DFU, wireless wound monitoring, KAIST wound care

Kane Biotech Brings revyve® Wound Care Innovation to Global Stage


Kane Biotech Brings revyve® Wound Care Innovation to Global Stage

Summary: Kane Biotech highlighted its revyve® wound care platform at an international conference, presenting a compelling case study of a high-risk diabetic foot ulcer patient. The technology combines biofilm-disrupting agents with advanced delivery to improve healing in challenging chronic wounds.

Key Highlights:

  • Case study focused on complex, high-risk DFU
  • Biofilm-targeted approach to support healing
  • Presented on global stage for wound care innovation
  • Potential new option for difficult-to-heal diabetic foot ulcers

Read full article

Keywords: revyve wound care, Kane Biotech, biofilm DFU

Diabetic Foot: From Prevention to Diagnosis and Treatment


Diabetic Foot: From Prevention to Diagnosis and Treatment

Summary: The Journal of Clinical Medicine (JCM) has opened a Special Issue dedicated to diabetic foot complications. It welcomes original research, reviews, and clinical studies covering prevention strategies, diagnostic advances, infection management, Charcot foot, peripheral arterial disease, and novel therapeutic approaches for diabetic foot ulcers.

Key Highlights:

  • Broad scope: prevention, diagnosis, and multidisciplinary treatment
  • Focus on real-world challenges including infection and amputation prevention
  • Open to both clinical and preclinical studies
  • High relevance for clinicians and researchers in limb preservation

View Special Issue & Submit

Keywords: diabetic foot special issue, DFU prevention, Charcot foot

Expectation Versus Reality in Chronic Wound Care


Expectation Versus Reality in Chronic Wound Care

Summary: Ayman Grada, MD, discusses the disconnect between dermatologists’ skin biology expertise and their limited role (only 7.4% of outpatient chronic wound visits) in chronic wound care. The article covers definitions of chronicity, obesity as a driver, diagnostic workup (ABI, biopsy), ulcer patterns, and the need for dermatologists to increase participation in multidisciplinary care.

Key Highlights:

  • Dermatologists manage just 7.4% of chronic wound visits
  • 4–6 weeks non-healing defines chronic wounds for CMS
  • Obesity as major upstream risk factor
  • Emphasis on vascular assessment, etiology-specific care, and foundational principles before advanced therapies

Read full article

Keywords: chronic wound care dermatology, Ayman Grada, diabetic foot ulcer management

STEADY Diabetic Foot Ulcer Registry: Methods, Insights, and Future Directions


STEADY Diabetic Foot Ulcer Registry: Methods, Insights, and Future Directions

Summary: This original research presents the methodology and initial findings from the STEADY Diabetic Foot Ulcer Registry. The prospective, multicenter registry collects real-world data on DFU patients to better understand treatment patterns, outcomes, and opportunities to improve healing rates and reduce amputations through evidence-based insights.

Key Highlights:

  • Prospective, real-world DFU registry design
  • Focus on treatment effectiveness and patient outcomes
  • Early insights into current clinical practice gaps
  • Framework for future quality improvement and research

Read full original research

Keywords: STEADY DFU registry, diabetic foot ulcer registry, real world DFU data

The Importance of Accurate Color Wound Photography and Data


The Importance of Accurate Color Wound Photography and Data

Summary: This literature review highlights how high-quality, standardized wound photography with accurate color representation is essential for consistent wound assessment, tracking healing progress, interdisciplinary communication, and medicolegal documentation. Poor color accuracy can lead to misjudgment of tissue types, infection, and healing trajectory.

Key Highlights:

  • Standardized photography improves inter-rater reliability
  • Accurate color capture critical for identifying necrosis, granulation, and infection
  • Supports telemedicine and remote monitoring
  • Best practices for lighting, calibration, and documentation

Read full literature review

Keywords: wound photography, color accuracy wound, wound documentation

FDA Approves Shock Wave Device for Treatment of Diabetic Foot Ulcers


FDA Approves Shock Wave Device for Treatment of Diabetic Foot Ulcers

Summary: The U.S. FDA granted approval to the Dermapace System (Sanuwave Health), a noninvasive extracorporeal shock wave therapy device, for treating chronic, full-thickness diabetic foot ulcers. The device delivers focused acoustic pressure waves to stimulate wound healing through mechanical stress, angiogenesis promotion, and increased blood flow.

Key Highlights:

  • First shock wave device specifically approved for DFU indication
  • Noninvasive, office-based treatment option
  • Targets hard-to-heal chronic diabetic foot ulcers
  • Provides alternative or adjunct to standard wound care

Read full article

Keywords: shock wave therapy DFU, Dermapace, extracorporeal shock wave

Polyaniline-Integrated Composite Hydrogel Network with Antioxidant Defense, Bacterial Clearance and…


Polyaniline-Integrated Composite Hydrogel Network with Antioxidant Defense, Bacterial Clearance and Accelerated Wound Healing

Summary: Researchers developed a smart composite hydrogel incorporating polyaniline that provides multiple therapeutic actions: potent antioxidant activity, effective bacterial clearance, and accelerated wound closure. The material shows promise as a next-generation dressing for chronic and infected wounds through combined electroactive, anti-inflammatory, and regenerative mechanisms.

Key Highlights:

  • Strong antioxidant defense against oxidative stress
  • Excellent antibacterial performance
  • Significantly accelerated wound healing in models
  • Potential for advanced multifunctional wound dressings

Read full open-access article

Keywords: polyaniline hydrogel, antioxidant wound dressing, smart hydrogel wound

Local Skin Delivery of Anti-Infective and Regenerative Actives for Wound Healing


Local Skin Delivery of Anti-Infective and Regenerative Actives for Wound Healing

Summary: Frontiers in Medicine / Frontiers in Pharmacology has launched a new Research Topic focused on local skin delivery strategies that integrate anti-infective and regenerative therapeutics. The collection welcomes original research and reviews exploring novel delivery systems (nanoparticles, hydrogels, scaffolds, microneedles, etc.) aimed at improving infection control while promoting tissue regeneration in both acute and chronic wounds.

Key Highlights:

  • Combines antimicrobial action with regenerative properties
  • Focus on personalized and localized delivery platforms
  • Targets improved healing outcomes and reduced resistance
  • Open call for submissions – high translational potential

View Research Topic

Keywords: local skin delivery wound, anti-infective regenerative wound, frontiers wound healing

Diagnostic Accuracy of the Mangled Extremity Severity Score in Predicting Amputation


Diagnostic Accuracy of the Mangled Extremity Severity Score in Predicting Amputation

Summary: This systematic review assesses the performance of the Mangled Extremity Severity Score (MESS) in predicting the need for amputation following severe lower limb trauma. The study examines sensitivity, specificity, and overall clinical utility of this widely used scoring system.

Key Highlights:

  • Evaluates MESS as a decision-support tool in limb salvage vs. amputation
  • Analyzes diagnostic accuracy across multiple trauma studies
  • Addresses strengths and limitations in real-world application
  • Important implications for trauma and vascular surgery teams

Read full systematic review

Keywords: MESS score, mangled extremity, limb salvage

Diabetic Foot Ulcer Healing Better Predicted with Thermal Imaging


Diabetic Foot Ulcer Healing Better Predicted with Thermal Imaging

Summary: Collaborative research from RMIT University, University of Melbourne, and Austin Health demonstrates that thermal imaging enhances prediction of diabetic foot ulcer healing. The non-contact technique provides objective data on wound temperature patterns that correlate with healing progression and final ulcer size.

Key Highlights:

  • First-of-its-kind study combining thermal imaging with clinical assessment
  • Improved prediction of both healing trajectory and final wound size
  • Non-invasive, objective tool for DFU monitoring
  • Potential for earlier intervention in non-healing ulcers

Read full article

Keywords: thermal imaging DFU, diabetic foot ulcer prediction

Natural Bioactive-Based Advanced Wound Dressings for Diabetic Wound Healing


Natural Bioactive-Based Advanced Wound Dressings for Diabetic Wound Healing: A Systematic Review of Emerging Biomaterial Platforms

Summary: This PRISMA-guided systematic review analyzed 14 studies on natural bioactive-incorporated advanced dressings for diabetic wounds. Hydrogels, hydrocolloids, nanofibers, and hybrid systems loaded with curcumin, propolis, berberine, and plant extracts demonstrated strong antimicrobial, anti-inflammatory, antioxidant, and pro-angiogenic effects via modulation of NF-κB, VEGF, and TGF-β pathways.

Key Highlights:

  • 14 studies included after screening 5256 records
  • Key bioactives: curcumin, propolis, bee venom, plant extracts
  • Mechanisms: reduced inflammation/oxidative stress + enhanced angiogenesis
  • Hydrogels and nanosystems showed highest translational potential

Read full open-access review

Keywords: natural bioactive wound dressings, diabetic wound hydrogel, curcumin wound, Fahrurroji A, Suhandi C

Cutaneous Safety Evaluation of Pure Hypochlorous Acid Solution in Preterm Infants and Neonates With Complex Wounds


Cutaneous Safety Evaluation of Pure Hypochlorous Acid Solution in Preterm Infants and Neonates With Complex Wounds

Summary: This retrospective study of 100 preterm/neonatal patients (mean gestational age 28.1 weeks, youngest 21 weeks) evaluated pure hypochlorous acid (pHA) cleanser. Across 766 applications (mean 7.6 per patient over 18.7 days), zero cutaneous adverse effects or complications were observed, including in extremely preterm infants and those receiving concurrent advanced therapies.

Key Highlights:

  • 766 total applications with no dermatitis, burns, infection, or breakdown
  • Included extravasation injuries, surgical wounds, pressure injuries, etc.
  • Well tolerated even in infants in isolettes and on phototherapy
  • Largest reported safety series in this vulnerable population

Read full open-access article

Keywords: hypochlorous acid neonates, neonatal wound care, preterm infant wounds, Rene Amaya

Enzymatic Debridement Reduces Pigment Load by Over 90% in Injuries


Enzymatic Debridement Reduces Pigment Load by Over 90% in Injuries

Summary: A prospective study at Sheba Medical Center evaluated bromelain-based enzymatic debridement (NexoBrid) for traumatic tattoos. After initial mechanical scrubbing, NexoBrid achieved a mean 92.5% reduction in residual pigmentation across 15 patients with friction and blast injuries. The treatment was well tolerated with no adverse events, producing cleaner wound beds.

Key Highlights:

  • 92.5% average pigment reduction (from 37.5% to 2.1% pigmented area)
  • Abrasion injuries: ~96% clearance; blast injuries: ~84% clearance
  • Applied within 24 hours post-injury under sedation
  • Selective action on devitalized tissue; well-tolerated in patients aged 4–51

Read full article

Keywords: enzymatic debridement, traumatic tattoo, NexoBrid, bromelain

Biotech Startup Announces Patent for Regenerative Tissue Therapy


Biotech Startup Announces Patent for Regenerative Tissue Therapy

Summary: A biotech startup has announced the granting of a patent for its novel regenerative tissue therapy platform. The technology focuses on promoting faster and more complete wound healing through advanced biomaterials and regenerative mechanisms, with potential applications in chronic wounds, surgical sites, and diabetic foot ulcers.

Key Highlights:

  • New patent protects innovative regenerative tissue approach
  • Targets improved healing in challenging wound types
  • Potential to advance next-generation wound care solutions

Read full article

Keywords: regenerative tissue therapy, biotech wound care

Role of Extracellular Vesicles in Skin Barrier Repair


Role of Extracellular Vesicles in Skin Barrier Repair: Applications in Wound Healing and Regenerative Medicine

Summary: This review examines the emerging role of extracellular vesicles (EVs) in skin barrier repair and wound healing. EVs derived from various cell types carry bioactive molecules that promote re-epithelialisation, modulate inflammation, stimulate angiogenesis, and enhance tissue regeneration. The article discusses current applications and future potential in advanced wound therapies and regenerative medicine.

Key Highlights:

  • EVs play key roles in cell communication and tissue repair
  • Promising results in accelerating wound closure and reducing scarring
  • Potential as cell-free regenerative therapy
  • Applications in chronic wounds and skin regeneration

Read full open-access article

Keywords: extracellular vesicles wound, skin barrier repair, regenerative wound therapy

Correcting Nomenclature: What Is a “Surgical Wound”?


Correcting Nomenclature: What Is a “Surgical Wound”?

Summary: In this editorial, the authors discuss inconsistencies in how “surgical wounds” are defined and classified across clinical practice, documentation, and research. They advocate for precise terminology that distinguishes between surgical incisions, acute surgical wounds, and wounds resulting from surgical complications to improve communication, coding accuracy, and outcome tracking.

Key Highlights:

  • Current nomenclature leads to confusion in practice and research
  • Need for standardised definitions across disciplines
  • Impact on documentation, reimbursement, and data quality
  • Call for consensus on updated wound classification language

Read full editorial

Keywords: surgical wound nomenclature, wound classification

Psychological Stress Impairs Wound Healing and Collagen Production


Psychological Stress Impairs Wound Healing and Collagen Production, New Review Confirms

Summary: This comprehensive review synthesises evidence showing that psychological stress negatively affects all phases of wound healing. Mechanisms include elevated cortisol, altered immune responses, reduced angiogenesis, and impaired collagen synthesis. The authors highlight the need for integrated stress-management strategies as part of holistic wound care to improve healing outcomes.

Key Highlights:

  • Stress impairs inflammation resolution and delays healing
  • Significant reduction in collagen deposition documented
  • Multiple neuroendocrine and immune pathways involved
  • Supports routine incorporation of stress reduction in wound care plans

Read full article

Keywords: psychological stress wound healing, stress collagen production

Innovations in Wound Care Research: Patient-Centered Outcomes and Real-World Evidence


Innovations in Wound Care Research: Patient-Centered Outcomes and Real-World Evidence

Summary: The Wound Care Stakeholders Coalition outlines how innovations in wound care research are shifting toward patient-centered outcomes and real-world evidence. This approach better captures the lived experience of patients, improves clinical decision-making, supports value-based care models, and strengthens advocacy for appropriate reimbursement and access to advanced wound therapies.

Key Highlights:

  • Emphasis on patient-reported outcomes and quality of life measures
  • Real-world evidence to complement traditional RCTs
  • Alignment with value-based healthcare and policy initiatives
  • Call for collaborative research across stakeholders

Read full article

Keywords: patient centered wound outcomes, real world evidence wound, wound care research

Carbopol® 940 Hydrogel Functionalised with Plasma-Activated Water: An Advanced Platform for Diabetic Foot Ulcer Management


Carbopol® 940 Hydrogel Functionalised with Plasma-Activated Water: An Advanced Platform for Diabetic Foot Ulcer Management

Summary: This study evaluated a Carbopol 940 hydrogel enriched with plasma-activated water (PAW). In a clinical case of a recalcitrant Wagner Grade 2 diabetic foot ulcer, the hydrogel applied as monotherapy (without systemic antibiotics) achieved complete healing. The platform combines antimicrobial properties with a supportive moist environment, showing strong potential for advanced wound care.

Key Highlights:

  • Successful monotherapy healing of hard-to-heal Wagner Grade 2 DFU
  • Strong antimicrobial and pro-regenerative effects from PAW
  • Promising advanced hydrogel platform for infected/chronic wounds
  • Potential to reduce reliance on systemic antibiotics

Read full open-access article

Keywords: plasma activated water DFU, Carbopol hydrogel, advanced DFU hydrogel

FibroBiologics Announces Release of CYWC628 Drug Product for Phase 1/2 Diabetic Foot Ulcer Clinical Trial


FibroBiologics Announces Release of CYWC628 Drug Product for Phase 1/2 Diabetic Foot Ulcer Clinical Trial

Summary: FibroBiologics has successfully manufactured and released the first clinical batch of CYWC628, its novel fibroblast-based spheroid therapeutic candidate. This milestone enables the start of patient enrollment in the Phase 1/2 clinical trial for diabetic foot ulcers (DFU). The company aims to leverage the regenerative potential of fibroblasts to improve healing in chronic, hard-to-heal DFUs.

Key Highlights:

  • First GMP batch of CYWC628 released and ready for clinical use
  • Phase 1/2 DFU trial imminent with patient dosing expected soon
  • Novel spheroid technology targeting regenerative wound repair
  • Part of FibroBiologics’ broader regenerative medicine platform

Read full announcement

Keywords: CYWC628, FibroBiologics DFU, fibroblast spheroid

Diabetic Peripheral Neuropathy: The Broader Complication Burden


Diabetic Peripheral Neuropathy: The Broader Complication Burden

Summary: This BMJ article provides an updated overview of diabetic peripheral neuropathy (DPN), emphasising its systemic impact. Beyond diabetic foot ulcers, DPN contributes to increased risk of falls, fractures, cardiovascular autonomic neuropathy, and reduced quality of life. The review stresses early screening, glycaemic control, and comprehensive multidisciplinary management to mitigate the full spectrum of complications.

Key Highlights:

  • DPN linked to higher rates of falls, fractures, and hospitalisations
  • Strong association with cardiovascular autonomic dysfunction
  • Need for broader complication screening in diabetic patients
  • Importance of early intervention and patient education

Read full article

Keywords: diabetic peripheral neuropathy, DPN complications

Carbopol® 940 Hydrogel Functionalised with Plasma-Activated Water


Carbopol® 940 Hydrogel Functionalised with Plasma-Activated Water: An Advanced Platform for Diabetic Foot Ulcer Management

Summary: Researchers developed a Carbopol 940 hydrogel functionalised with plasma-activated water (PAW) and evaluated its wound-healing potential. In a clinical case, the hydrogel used as monotherapy successfully healed a recalcitrant Wagner Grade 2 diabetic foot ulcer, demonstrating strong antimicrobial and pro-healing properties without systemic antibiotics.

Key Highlights:

  • PAW-functionalised hydrogel shows potent antimicrobial activity
  • Successful monotherapy healing of hard-to-heal Wagner Grade 2 DFU
  • Promising advanced platform for infected/chronic diabetic wounds
  • Combines hydrogel moisture balance with PAW bioactive effects

Read full open-access article

Keywords: plasma activated water, Carbopol hydrogel DFU, PAW wound healing

Hydrogel Dressing for Eye Protection During General Anaesthesia


Hydrogel Dressing for Eye Protection During General Anaesthesia: A Case Series

Summary: This case series reports the successful use of hydrogel dressings for eye protection in patients undergoing general anaesthesia. The simple, cost-effective method provided reliable corneal protection, was easy to apply and remove, and resulted in no corneal abrasions or complications across the reported cases.

Key Highlights:

  • Effective alternative for perioperative eye protection
  • Easy application and removal with good patient tolerance
  • No reported corneal injuries in the series
  • Practical and low-cost solution for operating theatres

Read full article

Keywords: hydrogel eye protection, perioperative eye care

Use of Negative Pressure Wound Therapy in Selected Wound Types


Use of Negative Pressure Wound Therapy in Selected Wound Types

Summary: This article examines the application of negative pressure wound therapy (NPWT) in carefully selected wound scenarios. It discusses appropriate patient and wound selection criteria, clinical benefits including improved granulation and exudate management, and practical considerations for optimal outcomes in complex acute and chronic wounds.

Key Highlights:

  • Clear guidance on patient and wound selection for NPWT
  • Benefits in exudate control and granulation tissue formation
  • Practical implementation tips and outcome measures

Read full article

Keywords: NPWT indications, negative pressure wound therapy

Cost-Effectiveness and Budget Impact of Topical Antimicrobial Polyhexamethylene Biguanide with a Surfactant


Cost-Effectiveness and Budget Impact of Topical Antimicrobial Polyhexamethylene Biguanide with a Surfactant (Betaine) on Wound Bed Preparation in Venous Leg Ulcers: An Analysis in Australia from a Community Perspective

Summary: This Australian study evaluated the cost-effectiveness and budget impact of using polyhexamethylene biguanide (PHMB) combined with a surfactant (betaine) for wound bed preparation in venous leg ulcers. From a community healthcare perspective, the intervention was found to be cost-effective, improving healing rates while reducing overall treatment costs through faster wound bed preparation and fewer complications.

Key Highlights:

  • PHMB + betaine improves wound bed preparation in VLUs
  • Cost-effective with positive budget impact in community settings
  • Reduces healing time and resource utilisation
  • Supports broader adoption in Australian wound care pathways

Read full article

Keywords: PHMB betaine, venous leg ulcer cost, wound bed preparation

Advances in Charcot Neuroarthropathy Surgical Techniques


Advances in Charcot Neuroarthropathy Surgical Techniques

Summary: This clinical article reviews current advances in surgical management of Charcot neuroarthropathy (CN). It covers internal and external fixation strategies, osteotomies, arthrodesis techniques, and soft-tissue considerations for achieving a stable, plantigrade foot. Emphasis is placed on timing of surgery, patient selection, and multidisciplinary collaboration to improve outcomes in this challenging condition.

Key Highlights:

  • Modern fixation methods for midfoot and hindfoot Charcot deformity
  • Role of superconstruct techniques and minimally invasive options
  • Importance of preoperative optimisation and postoperative offloading
  • Focus on achieving long-term limb salvage and function

Read full article

Keywords: Charcot neuroarthropathy surgery, Charcot reconstruction, limb salvage Charcot

Ten Top Tips: Skin Damage from Faecal Incontinence in the Critically Ill


Ten Top Tips: Skin Damage from Faecal Incontinence in the Critically Ill

Summary: This practical guide provides ten evidence-based tips for preventing and managing skin damage caused by faecal incontinence in critically ill patients. It emphasises early identification of risk, gentle cleansing, use of barrier products, appropriate dressings, and multidisciplinary approaches to reduce incontinence-associated dermatitis (IAD) and pressure injury development in ICU and high-dependency settings.

Key Highlights:

  • Early risk assessment and proactive skin protection protocols
  • Gentle cleansing techniques and pH-balanced products
  • Effective use of barrier creams, films, and absorbent products
  • Multidisciplinary strategies to minimise skin breakdown and complications

Read full article

Keywords: incontinence associated dermatitis, faecal incontinence skin, critical care wound

Successful Treatment of Moderately Ischaemic DFUs Using Intermittent Topical Oxygen Therapy


Successful Treatment of Moderately Ischaemic DFUs Using Intermittent Topical Oxygen Therapy

Summary: This case series reports positive outcomes in patients with moderately ischaemic diabetic foot ulcers treated with standard care plus intermittent topical oxygen therapy. The addition of topical oxygen supported healing in wounds that had previously stalled, offering a non-invasive adjunctive option for ischaemic DFUs where vascular intervention may be limited or delayed.

Key Highlights:

  • Successful healing in moderately ischaemic DFUs
  • Well-tolerated adjunct to standard wound care
  • Potential role in bridging gaps before or instead of revascularisation
  • Promising results in real-world challenging cases

Read full article

Keywords: topical oxygen therapy, ischaemic DFU, intermittent topical oxygen

Practical Teaching Tips for Educating Podiatric Patients


Practical Teaching Tips for Educating Podiatric Patients

Summary: In this podcast episode, experts share actionable teaching techniques for podiatric clinicians. The discussion focuses on effective communication strategies, simplifying complex concepts, improving patient adherence to offloading and self-care recommendations, and tailoring education to individual learning styles and health literacy levels.

Key Highlights:

  • Practical tips for clear, effective patient education
  • Strategies to boost adherence to foot care regimens
  • Approaches for different health literacy levels
  • Real-world application in daily podiatric practice

Listen to the podcast

Keywords: podiatric patient education, patient adherence DFU

Diabetic Shoes Update: CMS Publicizes Clarification It Provided to APMA


Diabetic Shoes Update: CMS Publicizes Clarification It Provided to APMA

Summary: The Centers for Medicare & Medicaid Services (CMS) has publicly released a clarification it provided to the American Podiatric Medical Association (APMA) regarding therapeutic diabetic footwear coverage. The update addresses key documentation, billing, and qualification requirements, aiming to reduce claim denials and improve access for patients at risk of diabetic foot ulcers.

Key Highlights:

  • CMS clarifies coverage criteria for diabetic shoes and inserts
  • Important guidance on required documentation and physician statements
  • Helps reduce administrative burden and claim denials
  • Strengthens access to preventive therapeutic footwear

Read full update

Keywords: diabetic shoes CMS, therapeutic footwear, APMA diabetic shoes

Implementation Strategies for the Prevention and Management of Diabetes-Related Foot Disease


Implementation Strategies for the Prevention and Management of Diabetes-Related Foot Disease: A Consensus Document

Summary: This international consensus document translates evidence-based guidelines into actionable implementation strategies for diabetes-related foot disease. It covers systematic screening, risk stratification, patient education, therapeutic offloading, timely vascular intervention, infection management, and integrated multidisciplinary pathways. The document aims to bridge the gap between guidelines and real-world clinical practice to reduce ulcers, amputations, and mortality.

Key Highlights:

  • Clear pathways for annual screening and risk stratification
  • Practical offloading and footwear recommendations
  • Emphasis on rapid access to multidisciplinary teams
  • Strategies to overcome implementation barriers in different settings

Read full consensus document

Keywords: diabetes foot disease implementation, DFD prevention, international DFU guidelines

Prevention and Care of Pressure Ulcers in Long-Term Bedridden Adults: An Evidence-Based Review


Prevention and Care of Pressure Ulcers in Long-Term Bedridden Adults: An Evidence-Based Review

Summary: This review synthesizes current evidence on the prevention and management of pressure ulcers in long-term bedridden adults. It emphasises validated risk assessment tools (e.g., Braden Scale), regular repositioning schedules, appropriate support surfaces, nutritional optimisation, and skin care protocols. The authors stress the importance of multidisciplinary approaches to reduce incidence and improve healing outcomes in this vulnerable population.

Key Highlights:

  • Comprehensive risk assessment and early identification strategies
  • Evidence-based repositioning and pressure-redistribution recommendations
  • Role of nutrition, skin care, and multidisciplinary teams
  • Practical guidance for long-term care settings

Read full open-access article

Keywords: pressure ulcer prevention, bedridden pressure ulcers, Braden Scale

FibroBiologics Announces Release of CYWC628 Drug Product for Phase 1/2 Diabetic Foot Ulcer Clinical Trial


FibroBiologics Announces Release of CYWC628 Drug Product for Phase 1/2 Diabetic Foot Ulcer Clinical Trial

Summary: FibroBiologics, Inc. announced the successful release and shipment of the first clinical batch of CYWC628, its fibroblast-based spheroid therapeutic candidate, for the upcoming Phase 1/2 trial in patients with diabetic foot ulcers (DFU). This milestone positions the company to begin patient enrollment and dosing. CYWC628 aims to harness the regenerative power of fibroblasts to improve healing in chronic DFUs.

Key Highlights:

  • First GMP batch of CYWC628 released and shipped for clinical use
  • Phase 1/2 trial in DFU patients now imminent
  • Novel fibroblast spheroid approach targeting regenerative wound healing
  • Part of broader platform with 270+ patents in regenerative medicine

Read full announcement

Keywords: CYWC628, FibroBiologics DFU, fibroblast spheroids

From a Pragmatic Clinical Staging of Distal Symmetrical Polyneuropathy to a Continuum of Diabetes Severity



From a Pragmatic Clinical Staging of Distal Symmetrical Polyneuropathy to a Continuum of Diabetes Severity: New Ideas, New Challenges

Summary: In this editorial, Anastasios Tentolouris and Péter Kempler discuss two emerging frameworks: a pragmatic five-stage clinical staging system for distal symmetrical polyneuropathy (DSPN) and the broader Diabetes Severity Classification (DSC). These tools move beyond binary diabetes classification toward a continuum model that better reflects complication risk, enabling earlier identification of high-risk patients for intensified foot care and prevention strategies.

Key Highlights:

  • New pragmatic DSPN staging system from early vulnerability to advanced ulceration risk
  • Diabetes Severity Classification (DSC) as a multi-axial continuum model
  • Strong potential to improve risk stratification and foot ulcer prevention
  • Calls for validation and integration into routine clinical practice

Read full editorial

Keywords: DSPN staging, diabetes severity classification, diabetic neuropathy staging

Charcot Neuro-Osteoarthropathy: A New Risk Class is Needed?



Charcot Neuro-Osteoarthropathy: A New Risk Class is Needed?

Summary: In this prospective single-centre observational study, researchers compared patients with chronic (post-remission) Charcot neuro-osteoarthropathy (CNO) to IWGDF high-risk (class 3) patients without CNO. Chronic CNO was associated with markedly higher re-ulceration (70.4% vs 33.1%) and amputation rates (18.5% vs 7.6%) during standard follow-up. When CNO patients received intensified surveillance (≤30-day intervals) in the second year, re-ulceration dropped dramatically to 18.5%. The authors propose that chronic CNO warrants its own dedicated high-risk category in future IWGDF stratification systems.

Key Highlights:

  • Chronic CNO identified as a distinct ultra-high-risk phenotype
  • Significantly higher ulcer recurrence and amputation rates vs standard IWGDF class 3
  • Intensified surveillance (≤30 days) reduced re-ulceration by ~74%
  • Supports adding CNO-specific risk class and more frequent monitoring

Read full article

Keywords: Charcot neuro osteoarthropathy, Charcot risk class, IWGDF risk stratification

Dehydrated Human Amnion/Chorion Membrane to Treat Venous Leg Ulcers



Dehydrated Human Amnion/Chorion Membrane to Treat Venous Leg Ulcers: A Cost-Effectiveness Analysis

Summary: This analysis evaluated the economic value of dehydrated human amnion/chorion membrane (dHACM) as an adjunct therapy for venous leg ulcers. dHACM achieved higher healing rates compared to standard care, leading to reduced overall treatment costs through faster closure, fewer dressing changes, and lower complication rates. The study supports its cost-effective role in managing chronic venous ulcers.

Key Highlights:

  • Higher complete healing rates with dHACM
  • Reduced total cost of care despite higher upfront product cost
  • Fewer clinic visits and complications
  • Strong value proposition for refractory venous leg ulcers

Read full article

Keywords: dHACM venous ulcer, amniotic membrane cost effectiveness, venous leg ulcer treatment

Use of Hypothermically Stored Amniotic Membrane on Diabetic Foot Ulcers



Use of Hypothermically Stored Amniotic Membrane on Diabetic Foot Ulcers: A Multicentre Retrospective Case Series

Summary: This multicentre retrospective study assessed hypothermically stored amniotic membrane (HSAM) in real-world treatment of diabetic foot ulcers. The advanced tissue product supported consistent healing across multiple centres, demonstrating good integration, reduced healing time, and low complication rates. Results reinforce HSAM as a reliable option for hard-to-heal DFUs.

Key Highlights:

  • Strong healing outcomes in a multicentre real-world setting
  • Effective for chronic, non-healing DFUs
  • Favourable safety and integration profile
  • Practical adjunct for advanced wound care teams

Read full article

Keywords: hypothermically stored amniotic membrane, HSAM DFU, amniotic membrane wound

Use of Three-Dimensional Acellular Collagen Matrix in Deep or Tunnelling Diabetic Foot Ulcers



Use of Three-Dimensional Acellular Collagen Matrix in Deep or Tunnelling Diabetic Foot Ulcers: A Retrospective Case Series

Summary: This retrospective case series evaluated the application of a three-dimensional acellular collagen matrix in patients with deep or tunnelling diabetic foot ulcers. The matrix provided excellent scaffold support, promoting robust granulation tissue formation even in challenging cavity wounds. Most patients achieved complete healing with reduced need for more invasive interventions, highlighting its utility as an adjunct in complex DFU management.

Key Highlights:

  • Effective for deep, tunnelling, and undermined DFUs
  • Rapid granulation and wound filling observed
  • Well-tolerated with good integration
  • Potential to simplify management of cavity wounds

Read full article

Keywords: 3D acellular collagen matrix, tunnelling DFU, cavity wound healing

Sickle Cell Leg Ulcers



Sickle Cell Leg Ulcers

Summary: This detailed clinical review addresses sickle cell leg ulcers (SCLU), a common and challenging complication of sickle cell disease, particularly in African populations. It covers pathophysiology (vaso-occlusion, hemolysis, endothelial dysfunction), clinical features, diagnostic approach, systemic optimization (hydroxyurea, transfusions, arginine, etc.), and local wound care strategies including debridement, dressings, and compression.

Key Highlights:

  • Multifactorial ulcers often around malleoli, very painful and recurrent
  • Requires simultaneous hematology and wound care management
  • Practical algorithm for systemic optimization and local care
  • High relevance in high-prevalence regions

Read full review

Keywords: sickle cell leg ulcer, SCLU

Formulation and Assessment of Wound-Healing Potential of a Gel Formulation Containing Propolis and Green Tea Extracts



Formulation and Assessment of Wound-Healing Potential of a Gel Formulation Containing Propolis and Green Tea Extracts

Summary: Researchers developed and tested a topical gel combining propolis and green tea extracts. The formulation demonstrated favorable stability, sensory characteristics, and significant wound-healing activity in animal models, performing comparably to a commercial positive control. Histopathology confirmed enhanced tissue regeneration and collagen deposition, highlighting the synergistic potential of these natural ingredients.

Key Highlights:

  • Stable gel with good sensory properties
  • Significant improvement in wound closure and histology vs controls
  • Comparable performance to commercial benchmark
  • Promising natural alternative for wound management

Read full article

Keywords: propolis green tea wound, natural wound gel

NaCl vs Distilled Water in Wound Healing – Is Traditional Wound Care Still Effective?



NaCl vs Distilled Water in Wound Healing – Is Traditional Wound Care Still Effective?

Summary: This in vivo experimental study on 27 Wistar rats compared daily irrigation with 0.9% NaCl versus distilled water (aquadest) on full-thickness wounds. Distilled water demonstrated statistically significant improvements in re-epithelialisation, granulation tissue formation, and reduction in inflammation compared to NaCl. Results challenge the long-held standard of normal saline and suggest distilled water as a safe, low-cost, and potentially more effective alternative for wound irrigation.

Key Highlights:

  • Distilled water superior for re-epithelialisation (p=0.018) and granulation (p=0.022)
  • Significant reduction in inflammatory response with aquadest (p=0.039)
  • NaCl showed no statistically significant benefits across parameters
  • Supports reconsideration of traditional saline as the default irrigant

Read full article

Keywords: distilled water wound irrigation, NaCl wound healing, wound irrigation

Incorporating Cultural Safety in Wound Management



Incorporating Cultural Safety in Wound Management

Summary: Editors James Charles, Zlatko Kopecki, and Peta Tehan introduce a special issue dedicated to disparities in chronic wound care among Aboriginal and Torres Strait Islander peoples. The issue highlights the need to integrate traditional Indigenous knowledge with evidence-based practice, improve access, and deliver culturally meaningful care to reduce amputation rates and health inequities.

Key Highlights:

  • Focus on cultural safety and Indigenous knowledge in wound care
  • Addresses significant disparities in chronic wounds and DFUs
  • Calls for community co-designed, holistic care models
  • Guest edited by Prof. James Charles

Read full editorial

Keywords: cultural safety wound, Indigenous wound care, First Nations DFU

The Challenges Faced by Clinicians in Providing a Telehealth Service for Aboriginal Patients with Diabetic Foot Complications



The Challenges Faced by Clinicians in Providing a Telehealth Service for Aboriginal Patients with Diabetic Foot Complications in Rural and Remote Western Australia

Summary: Authors Johanna Lee van Rooyen and Donna Evelyn Larsen present two case reports of Aboriginal patients from remote Western Australia with severe diabetic foot infections. The cases illustrate key challenges: late presentation, limited local resources, workforce transience, poor image quality in telehealth, and the need for culturally safe care. Multidisciplinary collaboration and strong regional relationships are essential for better outcomes.

Key Highlights:

  • Late presentation and delayed specialist access in remote communities
  • Difficulties with telehealth (image quality, supply chain, staff training)
  • Importance of cultural safety, Aboriginal Liaison Officers, and family involvement
  • Need for sustained multidisciplinary support beyond metropolitan centres

Read full article

Keywords: telehealth DFU, Aboriginal diabetic foot, rural wound care

Armstrong Keynotes Symposium Among Leading Experts in Malta to Address Limb Preservation



Armstrong Keynotes Symposium Among Leading Experts in Malta to Address Limb Preservation #ActAgainstAmputation

Summary: Professor David G. Armstrong keynoted a landmark interdisciplinary symposium in Valletta, Malta, focused on limb preservation in diabetes. Co-chaired by Dr. Corinne Scicluna and Luke Saliba (President of the Association of Podiatrists of Malta), the event showcased Malta’s success in dramatically reducing amputation rates through team-based care. Speakers emphasized collaboration, technology, and patient-centered approaches to combat the global diabetic foot crisis.

Key Highlights:

  • Prof. Armstrong’s keynote: “Limb Preservation in Diabetes: A Marriage of Team, Technology, and Tenacity”
  • Malta reduced EU-highest amputation rates through interdisciplinary efforts
  • Focus on biomechanics, vascular care, mental health, and emerging technologies
  • Strong call for global collaboration in limb salvage

Read full article

Keywords: David Armstrong, limb preservation, Malta diabetic foot

Lakewood-Amedex Reports Positive Antimicrobial Resistance Data for Lead Candidate Targeting Infected Diabetic Foot Ulcers



Lakewood-Amedex Biotherapeutics Announces Positive Antimicrobial Resistance Data for Lead Candidate Targeting Infected Diabetic Foot Ulcers

Summary: Lakewood-Amedex reported encouraging preclinical data showing minimal resistance development to its novel Bisphosphocin antimicrobial compounds in models relevant to infected diabetic foot ulcers (DFU). With resistant pathogens complicating 15–20% of DFU cases and a massive economic burden, this candidate offers a potential new option with a low propensity for resistance — an important advantage over traditional antibiotics.

Key Highlights:

  • Low resistance emergence in antimicrobial testing against DFU-relevant pathogens
  • Addresses critical need in infected DFUs where resistance is common
  • Supports further development of novel bisphosphocin technology

Read full announcement

Keywords: Bisphosphocin DFU, infected diabetic foot ulcer, antimicrobial resistance wound

Digital Health Service for Diabetic Foot Ulcer Risk Stratification



Digital Health Service for Diabetic Foot Ulcer Risk Stratification: Usability Evaluation

Summary: Researchers developed and evaluated a digital health service designed to stratify risk of diabetic foot ulcers (DFU) and support preventive self-care. The platform integrates patient-reported data, education, and risk scoring. Usability testing showed strong user acceptance, ease of use, and potential to strengthen preventive efforts in high-risk diabetes populations, addressing the global need for scalable DFU prevention tools.

Key Highlights:

  • Digital tool combining risk assessment with patient education and monitoring
  • High usability scores from both patients and healthcare providers
  • Supports early identification and timely preventive interventions
  • Addresses lifetime DFU risk (up to 34%) through accessible technology

Read full open-access article

Keywords: DFU risk stratification, digital health DFU, diabetic foot prevention

Design of Novel Orthotic Insoles Based on Partition Infilling of TPMS Structures



Design of Novel Orthotic Insoles Based on Partition Infilling of TPMS Structures

Summary: This study presents a new approach to designing patient-specific orthotic insoles using triply periodic minimal surface (TPMS) lattice structures with optimized partition infilling. The goal is to achieve better plantar pressure redistribution, improved comfort, and reduced peak pressures — key factors in preventing and managing diabetic foot ulcers (DFU). Finite element analysis and mechanical testing demonstrated superior performance compared to traditional designs, offering a promising pathway for advanced offloading solutions.

Key Highlights:

  • TPMS-based lattices with strategic partition infilling for optimized stiffness and pressure relief
  • Significant reduction in peak plantar pressures relevant to DFU prevention
  • Advanced 3D printing enables personalized, lightweight, and breathable insoles
  • Potential for scalable manufacturing of preventive diabetic footwear

Read full open-access article

Keywords: TPMS orthotic insoles, DFU prevention offloading, 3D printed insoles

Diabetic Foot Ulcers: Offloading, Surgery, and Beyond



Diabetic Foot Ulcers: Offloading, Surgery, and Beyond

Summary: At SAWC Spring 2026, Drs. Paul Kim and Johanna-Marie Richey stressed that successful DFU management requires correcting biomechanical abnormalities rather than focusing solely on wound closure. The session covered comprehensive assessment (perfusion, infection, biomechanics), non-operative offloading strategies, and selective surgical interventions (e.g., flexor tenotomy, metatarsal osteotomy, Achilles lengthening) to reduce recurrence and preserve function.

Key Highlights:

  • Biomechanical evaluation and weight-bearing imaging are essential
  • Prioritize adequate offloading before considering surgery
  • Surgery should target specific mechanical deformities
  • Goal is durable healing with a functional, stable residual foot

Read full article

Keywords: DFU offloading, diabetic foot surgery, biomechanical DFU

Technology-Enhanced Diabetic Foot Ulcer Management



Technology-Enhanced Diabetic Foot Ulcer Management

Summary: In this interview, Dr. Jonathan Johnson, MD, MBA, CWSP, highlights emerging imaging technologies that go beyond visual assessment for diabetic foot ulcers. Tools such as fluorescence imaging (for bioburden), thermal imaging (for perfusion/infection), and digital measurement enable earlier detection of complications, better documentation, real-time decision-making for debridement and offloading, and more standardized care in diverse settings.

Key Highlights:

  • Fluorescence and thermal imaging detect infection/ischemia earlier than visual exam
  • Digital tools improve documentation, measurement accuracy, and continuity
  • Supports better decisions on debridement, offloading, and vascular referral
  • Scalable across outpatient, home, and hospital environments

Read full article

Keywords: DFU imaging, fluorescence wound imaging, technology DFU

Mobile Wound Care FAQs: A Primer for Clinicians



Mobile Wound Care FAQs: A Primer for Clinicians

Summary: This clinician-focused guide addresses common questions about mobile wound care, a model where specialists deliver assessment and treatment directly to patients in homes, long-term care, or assisted living settings. It improves access, enables earlier intervention, reduces complications, and supports better outcomes for mobility-limited and medically complex patients while complementing rather than replacing clinic-based care.

Key Highlights:

  • Delivers care at the patient’s location instead of requiring travel
  • Particularly beneficial for older adults and those with limited mobility
  • Enhances early intervention, care coordination, and continuity
  • Complements traditional wound clinics rather than replacing them

Read full article

Keywords: mobile wound care, home based wound care, DFU access

C-Reactive Protein-to-Albumin Ratio Improves Prediction of 6-Month Major Adverse Limb Events in Patients with Diabetic Foot Ulcers



C-Reactive Protein-to-Albumin Ratio Improves Prediction of 6-Month Major Adverse Limb Events in Patients with Diabetic Foot Ulcers

Summary: This retrospective study evaluated the prognostic utility of the C-reactive protein-to-albumin ratio (CAR) in patients with diabetic foot ulcers (DFU). CAR, a simple and inexpensive inflammatory biomarker calculated from routine labs, emerged as a strong independent predictor of 6-month major adverse limb events (MALE), including major amputation and revascularization. Incorporating CAR into existing risk models significantly improved discrimination and net reclassification. The authors propose CAR as a practical tool for early identification of high-risk DFU patients who may benefit from more aggressive multidisciplinary intervention.

Key Highlights:

  • CAR independently predicts 6-month MALE in DFU patients
  • Improves predictive performance of traditional risk models
  • Low-cost biomarker readily available from standard bloodwork
  • Potential for better risk stratification and timely limb-preservation strategies

Read full open-access article

Keywords: CRP albumin ratio DFU, major adverse limb events, DFU prognosis