Sickle Cell Leg Ulcers
Summary: This detailed clinical review addresses sickle cell leg ulcers (SCLU), a common and challenging complication of sickle cell disease, particularly in African populations. It covers pathophysiology (vaso-occlusion, hemolysis, endothelial dysfunction), clinical features, diagnostic approach, systemic optimization (hydroxyurea, transfusions, arginine, etc.), and local wound care strategies including debridement, dressings, and compression.
Key Highlights:
- Multifactorial ulcers often around malleoli, very painful and recurrent
- Requires simultaneous hematology and wound care management
- Practical algorithm for systemic optimization and local care
- High relevance in high-prevalence regions
Keywords: sickle cell leg ulcer, SCLU