Topical Oxygen Therapy Increases Complete Wound Closure in Diabetic Foot Ulcers: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Summary: This systematic review and meta-analysis evaluated the effect of topical oxygen therapy (TOT) on complete wound closure in diabetic foot ulcers (DFUs). Three randomized controlled trials (n=171 TOT; n=154 control) were pooled. TOT used alongside standard care significantly increased the likelihood of complete wound closure at 12 weeks compared to standard care or sham (Risk Ratio 1.53, 95% CI 1.14–2.05). Heterogeneity was low (I² ≈ 24%). Sensitivity analyses using random-effects models confirmed a similar benefit.
Key Highlights:
- Complete closure at 12 weeks: RR 1.53 (95% CI 1.14–2.05) favoring TOT
- Low heterogeneity across the three included RCTs (I² ≈ 24%)
- DerSimonian–Laird random-effects model: RR 1.50 (95% CI 1.07–2.10)
- Authors conclude TOT improves healing but call for larger trials with standardized endpoints
Keywords: topical oxygen therapy, TOT DFU, diabetic foot ulcer meta analysis