The Trilogy of Skin Regeneration via Metal-Organic Frameworks Nanomedicine: Precision Management of Refractory Wounds, Pathological Scarring, and Hair Follicle Reactivation
Summary: An IJN review (published Aug 29, 2025) outlines how MOF platforms can span the continuum from diabetic-infected wound healing to scar modulation and hair follicle regeneration, emphasizing metal-specific mechanisms (e.g., Zn, Cu, Ag) and smart, microenvironment-responsive delivery.
Key Highlights:
- MOFs enable antibacterial, anti-inflammatory, and pro-healing actions with tunable, spatiotemporal drug delivery.
- Extended applications include suppressing pathological scarring and re-activating hair follicles for functional regeneration.
- Key caveats: biosafety, long-term clearance, scale-up and manufacturing consistency.
Read the full review in International Journal of Nanomedicine
Keywords:
metal-organic frameworks,
diabetic wound,
scar modulation,
hair follicle regeneration,
nanomedicine