Preparation Methods of Hydrogel Microspheres and Recent Advances in Their Application for Treating Diabetic Wounds
Summary: This IJN review (published Aug 30, 2025) details manufacturing routes for hydrogel microspheres—microfluidics, spray/electrospray, emulsions, phase separation, photomask, 3D printing—and synthesizes their roles in diabetic wound therapy, from controlled drug delivery to infection control and macrophage polarization.
Key Highlights:
- Manufacturing toolkits include microfluidic chips/capillaries for tight size control and complex core-shell designs.
- Therapeutic functions: promote proliferation/migration, angiogenesis, immune modulation, and precise release kinetics.
- Translational hurdles: prep complexity, cost, scalability, and real-world implementation challenges.
Read the full review in International Journal of Nanomedicine
Keywords:
hydrogel microspheres,
diabetic wounds,
microfluidics,
controlled release,
angiogenesis