Tag: Abdullah Durhan

Effect of Topical Application and/or Systemic Use of Red Ginseng Extract on Wound Healing

in Rats With Experimentally Induced Diabetes

 

Mehmet Esat Duymus MD, Hulya Ayik Aydin MD, Abdullah Bulgurcu MD, Zeynep Bayramoglu MD, Abdullah Durhan MD, Salih Tuncal MD, Mevlut Recep Pekcici MD, Kemal Kismet MD

 

Red ginseng (Rg) is traditional medicine that has been used for many years in Asian and European countries, especially Korea, China, and Japan. The major components of Rg are ginsenosides, Rg1, Rb1, Rb2, and Rb3, each with its own pharmacological effect. In vivo studies have been conducted to evaluate the hepatoprotective effect of Rg in chronic liver disease and its vasoprotective effect in heart disease. In addition, an in vitro study revealed that Rg extract may stimulate wound healing by increasing growth factors on fibroblast obtained from diabetic patients. A similar effect of Rg extract has been observed on full-thickness skin wounds in rats. In another study conducted in patients with colorectal cancer, oral intake of Rg was shown to have no effect on blood cytokine levels and biochemical parameters, but oral Rg used in combination with chemotherapy regimen was found to reduce cancer-related fatigue … read more