Biofilm-Host Immune Crosstalk at the Diabetic Foot Ulcer Interface: Molecular Mechanisms and Therapeutic Implications
Summary: This comprehensive review examines the intricate crosstalk between microbial biofilms and the host immune system in diabetic foot ulcers. It details how biofilms perpetuate chronic inflammation, impair healing, and contribute to antibiotic resistance, while highlighting promising therapeutic strategies to disrupt harmful interactions and restore effective wound repair.
Key Highlights:
- Detailed molecular mechanisms of biofilm persistence in DFUs
- Impact on host immune dysregulation and chronic inflammation
- Role of biofilms in delayed healing and infection
- Emerging targets for novel antibiofilm and immunomodulatory therapies
Keywords: biofilm DFU, diabetic foot ulcer immune, antibiofilm therapy