Biofilm-Host Immune Crosstalk at the Diabetic Foot Ulcer Interface: Molecular Mechanisms and Therapeutic Implications
Summary: This in-depth review explores how biofilms in diabetic foot ulcers interact with the host immune system, leading to persistent inflammation, impaired healing, and increased infection risk. The authors discuss key molecular pathways and emerging strategies to disrupt harmful biofilm-immune crosstalk for better clinical outcomes.
Key Highlights:
- Detailed mechanisms of biofilm persistence in DFUs
- Impact on host immune dysregulation
- Potential targets for novel antibiofilm therapies
- Implications for improving healing rates in chronic DFUs
Keywords: biofilm DFU, diabetic foot ulcer immune, antibiofilm therapy