The Effect of Beta-Glucan on Wound Healing: A Systematic Review and Meta-Analysis
Summary: Systematic review/meta-analysis (4 studies: 2 RCTs, 2 cohorts; n=644) evaluated topical beta-glucan for wounds. Chronic wounds: OR 2.14 for healing at 12 weeks (p<0.01, I²=0%); sustained benefits to 24 weeks. Acute wounds (burns): no significant epithelization time reduction (MD -1.70 days, p=0.25). Beta-glucan promotes immune activation/tissue repair in chronic; inconclusive for acute. Calls for more RCTs to standardize/confirm.
Key Highlights:
- Chronic: OR 2.14 (2x healing 12 weeks); low heterogeneity.
- Acute: No benefit (high heterogeneity).
- Studies: 2 chronic (likely DFU), 2 acute (burns).
- Limitations: Few studies, heterogeneity.
- Authors: Not specified in summary.
Keywords: beta-glucan, wound healing, meta-analysis, chronic wounds, acute wounds