810 search results for "chronic wounds"

The complexities of managing an ever-growing problem of chronic wounds

Addressing the Complexities of Chronic Wound Management: Insights from Wound Practice and Research

Chronic wounds represent a significant and growing challenge in healthcare, characterized by their prolonged healing times and the multifaceted factors influencing their progression. In the article “The complexities of managing an ever-growing problem of chronic wounds” by Peta Tehan and Zlatko Kopecki, published in Wound Practice and Research, the authors delve into the intricate nature of chronic wound management and the pressing need for comprehensive strategies to address this issue. :contentReference[oaicite:5]{index=5}

Key Highlights:

  • Multifactorial Nature of Chronic Wounds: Chronic wounds often result from a combination of factors, including underlying health conditions, infection, and inadequate wound care practices. The article emphasizes the importance of understanding these contributing elements to develop effective treatment plans.
  • Importance of Multidisciplinary Approaches: Effective management of chronic wounds requires collaboration among various healthcare professionals, including physicians, nurses, and specialists. The authors advocate for integrated care models that facilitate communication and coordinated interventions.
  • Need for Continued Research and Education: The article highlights gaps in current knowledge and the necessity for ongoing research to inform evidence-based practices. Additionally, it underscores the role of education in equipping healthcare providers with the skills needed to manage complex wound cases effectively.

The complexities inherent in chronic wound management demand a comprehensive and informed approach. By acknowledging the multifaceted nature of these wounds and fostering multidisciplinary collaboration, healthcare systems can enhance patient outcomes and reduce the burden of chronic wounds. Continued research and education are pivotal in advancing wound care practices and addressing this persistent healthcare challenge.

Read the full article on the Wound Practice and Research website.

Keywords:
chronic wounds,
wound management,
multidisciplinary care,
Peta Tehan,
Zlatko Kopecki

Researchers are Creating an App to Track and Analyze Chronic Wounds

With a $1.6 million award from the National Institutes of Health, an interdisciplinary research team at Worcester Polytechnic Institute is developing a smartphone app that could lower healthcare costs and improve care.

 

An interdisciplinary team of researchers at Worcester Polytechnic Institute (WPI) has received a four-year, $1.6 million award from the National Institutes of Health (NIH) to develop a smartphone app that will allow patients and their caregivers to track and assess chronic wounds, helping lower costs associated with frequent doctor and hospital visits, and catching serious complications before they lead to expensive hospitalizations and life-altering amputations.

 

Emmanuel Agu, associate professor of computer science and coordinator of WPI’s Mobile Graphics Research Group, is the principal investigator for the project. Co-principal investigators include Diane Strong, a professor in WPI’s Foisie Business School, Bengisu Tulu, an associate professor in the Foisie Business School, and Peder Pedersen, a retired professor of electrical and computer engineering.

 

The app, which is in the early development stage, is being designed to be used by patients and caregivers, including visiting nurses, who need to regularly check the status of potentially dangerous wounds in the home environment. It will make patients more involved in their own care, cut down on unnecessary doctor visits, and issue alerts when an emergency trip to the doctor or hospital is necessary, Agu said.

 

A 2017 study found that chronic, nonhealing wounds affect 5.7 million people in the United States, or about 2 percent of the population, at an annual cost of $20 billion. The cost of just transporting chronic wound patients to medical visits is estimated at about $200 million per year. “This is a big problem,” said Agu. “Wounds, wound management, and amputations have a huge cost, both financially and physically, for the people who suffer from them, as well as for their families. I like to work on real problems that make a difference for people. Much of my research is in imaging and computer graphics. Wound management is a problem that imaging technology can help with.”

 

Patients or their caregivers will use the app to photograph chronic wounds with a smartphone. Machine learning algorithms built into the app will measure wound assessment metrics, including size, depth, and color, which indicate how the wound healing is progressing. The algorithms will compare the readings over time to determine if the wound is shrinking or expanding, or if there are other changes, like darkening tissue, that could indicate a growing infection or other complication. The app will also compute a healing score that tells the patient whether the wound is getting better, is unchanged, or is worsening. Finally, the app will suggest one of three actions: stay the course, consult a wound specialist for advice regarding treatment, or seek immediate care.

 

The new wound app is an evolution of work Agu and his research team completed for Sugar, an app designed to help people with diabetes track and manage their weight and blood sugar levels, and also photograph and assess the status of any chronic foot ulcers. In the current research, Agu will build on the wound assessment component of Sugar, which was developed with a $1.2 million grant awarded in 2011 by the National Science Foundation (NSF). And while Sugar focused exclusively on diabetic wounds on the feet and legs, the new app is expected to one day be expanded to assess a broader array of chronic wounds, including arterial, venous, and pressure ulcers, also known as bed sores.

 

Agu, Pedersen, and Clifford Lindsay, assistant professor of radiology at University of Massachusetts Medical School, will lead an effort to address one of the key technical challenges of the new project: processing imperfect smartphone photos taken by amateurs. Agu said his team understands that patients are likely to take photos from too far away or too close up, from an angle, or under poor lighting. He said shadows are particularly problematic for wound analysis, because they affect how the computer vision algorithm perceives the wound’s colors and depth.

 

To address this problem, the team will develop algorithms similar to those used in facial recognition software that can transform each image so it appears as if it was taken straight on, at the proper distance, and under ideal lighting conditions. They will use techniques from an area of computer science called computational photography. “Computational photography has been applied to natural images, like landscapes, but not in the medical domain,” Agu said. “This is cutting-edge research that we believe will produce a good solution to this problem.”

 

In addition to fixing the images, the research team will need to train their algorithms to properly assess and interpret them, work that will draw on the decision support expertise of Strong and Tulu. The team will expose their algorithms to hundreds of images of actual wounds taken, with patient consent, by Lindsay. Raymond Dunn ‘78, chief of plastic and reconstructive surgery at UMass Memorial, is a consultant to the project.

 

Agu and the team will feed the photos, along with wound care specialists’ expert assessments of the wounds and what kind of treatments they require, into the machine learning system so the app will “learn” how to analyze the wounds and calculate what care advice to give. Agu’s team will also test the algorithms on realistic simulated wounds they create with special 3D printers.

 

“This won’t replace doctor visits entirely, but it will augment those visits,” said Agu. “Patients or caregivers can check in anytime they want using this app and get more feedback than they do with occasional doctor visits. If people self-monitor, they are more likely to change their behavior, keep a closer eye on their wounds, and take the proper care those dangerous wounds need.”

 

The wound app is being developed on the Android platform, but Agu expects it ultimately to be adapted for the iPhone platform as well.

 

About Worcester Polytechnic Institute

 

Founded in 1865 in Worcester, Mass., WPI is one of the nation’s first engineering and technology universities. Its 14 academic departments offer more than 50 undergraduate and graduate degree programs in science, engineering, technology, business, the social sciences, and the humanities and arts, leading to bachelor’s, master’s and doctoral degrees. WPI’s talented faculty work with students on interdisciplinary research that seeks solutions to important and socially relevant problems in fields as diverse as the life sciences and bioengineering, energy, information security, materials processing, and robotics. Students also have the opportunity to make a difference to communities and organizations around the world through the university’s innovative Global Projects Program. There are more than 40 WPI project centers throughout the Americas, Africa, Asia-Pacific, and Europe.

 

Contact:
Alison Duffy, Director of Public Relations
Worcester Polytechnic Institute
Worcester, Massachusetts
508-340-5040, amduffy(at)wpi(dot)edu

 

For the original version on PRWeb visit: http://www.prweb.com/releases/2018/02/prweb15232174.htm

The Financial Burden of Chronic Wounds in Primary Care

The Financial Burden of Chronic Wounds in Primary Care: A Real-World Cost Analysis

A 2025 study published in the *International Wound Journal* offers one of the most comprehensive real-world analyses of the cost and prevalence of chronic wounds in primary care settings. Drawing on extensive electronic medical records from Italy, the study sheds light on the significant economic and clinical impact of treating chronic wounds such as diabetic foot ulcers (DFUs), pressure injuries (PIs), venous leg ulcers (VLUs), and arterial ulcers (AUs).

Key Highlights:

  • Study Scope: Over 7,400 patients with chronic wounds were identified across 1.6 million+ medical records. Wound types included DFUs (27.6%), VLUs (25.4%), PIs (23.7%), AUs (7.8%), and others (15.4%).
  • Economic Impact: The average annual cost per patient ranged from €3,468 (VLUs) to €5,748 (DFUs). Medication and home care were the main cost drivers, with wound dressings accounting for over 50% of costs.
  • Comorbidity Patterns: High rates of comorbidities were observed, including diabetes, hypertension, and cardiovascular disease—highlighting the complex medical management required for this population.
  • Age and Gender Trends: Chronic wounds were more prevalent in older adults, with women representing a slight majority overall. However, DFUs were more common in men, especially over age 70.
  • Policy Implications: The authors urge more proactive prevention, earlier intervention, and better resource allocation to address the growing burden of chronic wounds in aging populations.

This real-world study emphasizes the financial strain chronic wounds place on healthcare systems and reinforces the need for early, multidisciplinary intervention—particularly in primary care settings.

Based on findings published in the *International Wound Journal* (May 2025).

Keywords: chronic wounds, primary care, wound costs, diabetic foot ulcers, wound prevalence

Read the full article on the National Library of Medicine

Wounds Australia’s Five Point Plan to Reduce the Burden of Chronic Wounds

The burden of chronic wounds for the individual, the health system and the whole community is familiar to the readers of this journal. Improving lives and saving money through better wound care is a common theme across this issue, and in the broader wound care activities.

 

Wounds Australia recognises that to achieve our vision of Quality wound care and prevention for all requires us to inform and engage with a broad audience. During Wound Awareness Week from 15 to 21 July 2018 Wounds Australia will launch our Five Point Plan to Reduce the Burden of Chronic Wounds. Our plan outlines 5 key initiatives to drive the change for best practice wound care for all Australians and reduce the suffering as a result of chronic wounds.

 

1. Medicare funding for treatment of chronic wounds in primary health care. A dedicated MBS item for treatment of chronic wounds to enable GPs, nurses and allied health professionals to deliver the best practice.

2. Subsidised wound products (dressings and related products) for people experiencing long term wound care. Advanced Wound management products often attract a premium cost. Selecting low cost, modest outcome products is a false economy. Research has shown that the use of less expensive dressings actually increases costs of treating a wound … read more

High Levels of Oxidative Stress and Skin Microbiome are Critical for Initiation and Development of Chronic Wounds in Diabetic Mice

A balanced redox state is critical for proper healing. Although human chronic wounds are characterized by high levels of oxidative stress (OS), whether OS levels are critical for chronic wound development is not known. For these studies, we used our chronic wound model in diabetic mice that has similar characteristics as human chronic wounds, including naturally developed biofilm. We hypothesize that OS levels in wound tissues are critical for chronic wound initiation and development. We show that increased OS levels in the wound correlate with increased chronicity. Moreover, without increased OS levels, biofilm taken from chronic wounds and placed in new excision wounds do not create chronic wounds. Similarly, high OS levels in the wound tissue in the absence of the skin microbiome do not lead to chronic wounds. These findings show that both high OS levels and bacteria are needed for chronic wound initiation and development … read more

New smart bandages could monitor and treat chronic wounds

Researchers in the United States present their findings on research into new smart bandages capable of real-time monitoring and treating chronic wounds.

Chronic wounds develop when a wound fails to heal within the expected time, which might be a couple of weeks or up to several months. They are often caused by diabetic wounds, pressure ulcers, leg ulcers, arterial ulcers, and malignant wounds. Chronic wounds may lead to severe pain, affecting an individual’s quality of life.

 

Chronic wounds affect millions
Currently, chronic wounds are a major health concern in the United States as they are affecting over 25 million people. This number will likely increase owing to the aging population and the continuous increase in the number of diabetes and obesity cases. According to the American Professional Wound Care Association, chronic wounds have caused the nation over 30 billion dollars each year … read more

Healogics Shines a Light on Chronic Wounds with Fifth Annual Wound Care Awareness Week

JACKSONVILLE, Fla.–(BUSINESS WIRE)–Healogics, Inc., the nation’s leading provider of advanced wound care services, is proud to sponsor the fifth annual Wound Care Awareness Week from June 4 to June 8, 2018. Throughout this week, Healogics team members from around the country will be working together to shed light on the chronic wound epidemic and bring awareness to the advanced wound care options available. Unfortunately, the incidence of chronic wounds is only expected to rise over the next decade, making awareness and advanced wound care more important now than ever before.

 

Chronic wounds affect approximately 6.7 million people in the U.S. and an excess of $50 billion is spent annually on treatment. The prevalence of chronic wounds is growing in tandem with an aging population and increasing rates of diseases such as diabetes and peripheral arterial disease, and conditions like obesity and the late effects of radiation therapy. Untreated, chronic wounds can lead to diminished quality of life and possibly amputation of the affected limb. It is in this context that Healogics also created the Wound Science Initiative – a collaborative effort to educate and engage key stakeholders in government and across the healthcare system on the poorly understood and underserved needs of people with non-healing wounds.

 

About Healogics

Headquartered in Jacksonville, Fla., Healogics and its affiliated companies manage a network of 700 outpatient Wound Care Centers® across the United States and multiple locations in the United Kingdom. Healogics currently has more than 3,000 employees, including nearly 300 employed providers (Healogics Specialty Providers). In addition to the company’s network of outpatient Wound Care Centers, Healogics providers partner with over 400 skilled nursing facilities to care for patients with chronic wounds. More than 300,000 patients were treated by Healogics providers in 2017. For additional information, please visit Healogics.com.

 

Contacts

Healogics, Inc.
Leslie Niblock, 904-524-2695
Director, Corporate Communications
Leslie.Niblock@healogics.com

 

Press Release BusinessWire

The complexities of managing an ever-growing problem of chronic wounds

The Complexities of Managing an Ever-Growing Problem of Chronic Wounds

In the latest issue of Wound Practice and Research, editors Peta Tehan and Zlatko Kopecki delve into the multifaceted challenges of chronic wound management in Australia. The issue underscores the increasing prevalence of chronic wounds and the necessity for a comprehensive, multidisciplinary approach to address this growing healthcare concern.

Key highlights include:

  • Redefining Research Priorities: A consensus study by Finlayson et al. identifies critical areas for chronic wound research, emphasizing pain management, venous leg ulcer compression therapy, and pressure injury management. Notably, diabetic foot ulcers and pressure injury care emerged as top priorities among experts for prevention and management strategies.
  • Patient-Centric Approaches: A scoping review by Pennisi et al. advocates for integrating patients into chronic disease management frameworks to prevent venous leg ulcer recurrence. The study calls for a shift in language and focus, promoting community integration and multidisciplinary collaboration.
  • Early Detection and Intervention: Research by O’Connor et al. highlights the prevalence and risk factors of chronic lower limb oedema in older populations, stressing the importance of early detection to initiate timely interventions. Additionally, a case study by Astrada demonstrates the utility of ultrasonography in identifying subcutaneous scarring post-healing of infected diabetic foot ulcers, facilitating appropriate management strategies.
  • Innovative Treatment Modalities: Kruschwitz and Probst present a retrospective analysis on managing exudate in pressure injuries using multipurpose dressings, resulting in significant wound area reduction. Furthermore, Hulsdunk and Haesler discuss evidence supporting low-level laser therapy for venous leg ulcer healing.

This comprehensive issue serves as a valuable resource for clinicians and researchers, offering insights into current challenges and advancements in chronic wound care.

Read the full article on the Wound Practice and Research website.

Keywords:
Chronic wounds,
Venous leg ulcers,
Pressure injuries,
Diabetic foot ulcers,
Compression therapy,
Low-level laser therapy,
Multidisciplinary care,
Patient-centered care,
Ultrasonography,
Oedema management

Biofilms and Inflammation in Chronic Wounds

Abstract

Significance

The incidence, cost, morbidity, and mortality associated with non-healing of chronic skin wounds are dramatic. With the increasing numbers of people with obesity, chronic medical conditions, and an increasing life expectancy, the healthcare cost of non-healing ulcers has recently been estimated at $25 billion annually in the United States. The role played by bacterial biofilm in chronic wounds has been emphasized in recent years, particularly in the context of the prolongation of the inflammatory phase of repair.

Recent Advances

Rapid high-throughput genomic approaches have revolutionized the ability to identify and quantify microbial organisms from wounds. Defining bacterial genomes and using genetic approaches to knock out specific bacterial functions, then studying bacterial survival on cutaneous wounds is a promising strategy for understanding which genes are essential for pathogenicity.

Critical Issues

When an animal sustains a cutaneous wound, understanding mechanisms involved in adaptations by bacteria and adaptations by the host in the struggle for survival is central to development of interventions that favor the host.

Future Directions

Characterization of microbiomes of clinically well characterized chronic human wounds is now under way. The use of in vivo models of biofilm-infected cutaneous wounds will permit the study of the mechanisms needed for biofilm formation, persistence, and potential synergistic interactions among bacteria. A more complete understanding of bacterial survival mechanisms and how microbes influence host repair mechanisms are likely to provide targets for chronic wound therapy.

full article

Fibroblast technology developed for diabetic foot ulcers, chronic wounds

Fibroblast Technology Developed for Diabetic Foot Ulcers and Chronic Wounds

FibroBiologics, in collaboration with Charles River, has announced the completion of a master cell bank for a novel fibroblast-based therapy aimed at treating chronic wounds, including diabetic foot ulcers (DFUs). The product, designated CYWC628, utilizes a spheroid approach to deliver fibroblast cells topically, promoting wound healing by releasing essential growth factors and cytokines.

According to Dr. Hamid Khoja, Chief Scientific Officer at FibroBiologics, “Fibroblasts are involved in every single stage of the wound healing process.” He notes that chronic wounds like DFUs often fail to heal due to cellular senescence, and this new therapy aims to address that by rejuvenating the wound environment.

CYWC628 has passed all required safety testing, and clinical trials are scheduled to commence in the second quarter of 2025. The 12-week study will evaluate the product’s efficacy in promoting healing in patients with chronic wounds.

Read the full article on the Healio website.

Keywords:
Fibroblast therapy,
Chronic wounds,
Diabetic foot ulcers,
CYWC628,
Wound healing,
Cell-based therapy,
Growth factors,
Clinical trials,
Cellular senescence

Collagen Products in the Treatment of Chronic Wounds



Collagen Products in the Treatment of Chronic Wounds

Summary: This educational resource from Wounds Africa discusses the role of collagen products in the management of chronic wounds. It covers different collagen dressing types, their mechanisms (providing a scaffold for cell migration, promoting granulation, modulating matrix metalloproteinases, and supporting moist healing), and clinical indications for diabetic foot ulcers, venous leg ulcers, pressure injuries, and other non-healing wounds. Practical guidance on selection, application, and expected outcomes is included, positioning collagen products as a valuable tool in advanced wound bed preparation and progression toward healing when standard care is insufficient.

Key Highlights:

  • Collagen provides structural scaffold and modulates wound environment
  • Useful in chronic wounds with stalled healing or excessive proteases
  • Practical guidance for selection and use in various wound types
  • Relevance: Accessible resource for clinicians in resource-variable settings

Read resource

Keywords: collagen dressings, chronic wounds, wound bed preparation

Outcome Measures of Quality of Life for People With Chronic Wounds

Outcome Measures of Quality of Life for People With Chronic Wounds: A Scoping Review

A scoping review published in *JWOCN* (May–June 2025) by Dantas et al. mapped validated patient-reported outcome measures (PROMs) used to assess health-related quality of life (HRQoL) in individuals with chronic wounds. :contentReference[oaicite:turn0search0]{index=0}

Key Highlights:

  • Review Scope: Surveyed literature from 1990 to April 2024 across MEDLINE, CINAHL, PubMed, Web of Science, and Scopus, identifying 30 studies evaluating HRQoL in chronic wound patients. :contentReference[oaicite:turn0search0]{index=0}
  • Instruments Identified: Twelve validated tools were used—six generic (e.g., SF-36 in 19%, EQ-5D-5L in 9%) and six wound-specific. Notably, the Cardiff Wound Impact Schedule and Wound‑QoL each appeared in 16% of studies. :contentReference[oaicite:turn0search0]{index=0}
  • Instrument Benefits: Generic measures allow comparisons with other chronic conditions and populations, but may underrepresent wound-specific QoL changes. Wound-specific instruments capture the multidimensional impacts on patients’ lives more sensitively. :contentReference[oaicite:turn0search0]{index=0}
  • Research Gaps: The review highlights limited use of PROMs in chronic wound studies, calling for more longitudinal and interventional research to validate their clinical utility. :contentReference[oaicite:turn0search0]{index=0}

Understanding which PROMs reliably capture HRQoL among patients with chronic wounds is essential for patient-centered care, enabling better assessment of therapeutic impact and guiding future investigations.

Read the full abstract in the Journal of Wound Ostomy & Continence Nursing.

Keywords:
PROMs,
HRQoL,
SF-36,
EQ-5D-5L,
Wound‑QoL

Closure Rate of Chronic Wounds With Sinus Tract: Morphological and Pathological Classification

Closure Rate of Chronic Wounds With Sinus Tract: Morphological and Pathological Classification

Summary: A prospective case series from Ruijin Hospital, Shanghai, published in Wounds, evaluated closure rates in **chronic wounds with sinus tracts (CWST)** classified by morphological and pathological features. Four subtypes were defined: simple CWST, morphologically complex, pathologically complex, and refractory. The study demonstrates how systematic classification can guide prognosis and therapy selection.

Key Highlights:

  • Simple CWST had the highest closure rate (~85%).
  • Morphologically complex CWST healed in ~70% of cases with extended follow-up.
  • Pathologically complex CWST (e.g., associated with osteomyelitis or chronic inflammation) had closure rates below 50%.
  • Refractory CWST showed the poorest outcomes, underscoring need for advanced reconstructive or adjunctive therapies.
  • Authors recommend that morphological and pathological assessment become routine in chronic sinus-tract wound evaluation.

Read the full study in Wounds

Keywords:
chronic wound sinus tract,
closure rate,
osteomyelitis,
Ruijin Hospital

Open Data for Wound Care Research: A Comprehensive Dataset on Chronic Wounds



Open Data for Wound Care Research: A Comprehensive Dataset on Chronic Wounds

Summary: This article presents a newly released open-access dataset focused on chronic wounds, offering detailed clinical and imaging data to support wound care research. It emphasizes the dataset’s potential to enhance understanding of wound progression and improve treatment strategies, while noting the need for standardized analysis methods to maximize its utility.

Key Highlights:

  • The dataset includes clinical records and high-resolution images of chronic wounds.
  • It aims to accelerate research into chronic wound management and healing processes.
  • Access is freely available to researchers, fostering global collaboration.
  • Challenges include ensuring data consistency and developing robust analytical tools.

Read full article

Keywords:
open data,
chronic wounds,
wound care research,
clinical dataset,
wound healing innovation

Screening for Depression in Patients with Chronic Wounds

Wounds with a duration longer than 30 days are considered chronic. For example, diabetic foot ulcers comprise a large majority of these wounds and often exceed the expected 12-week healing period because of underlying factors that cannot be fully corrected.1 Patients with chronic wounds face considerable psychological stress because they need continuous medical care and frequent visits to healthcare facilities. The presence of these wounds significantly disrupts the daily life of patients, including changes in sleeping patterns, diet, and mobility. Loss of mobility may lead to feelings of loneliness, powerlessness, and dependency, as patients rely on family or friends to help fulfill their basic needs such as commuting, activities of daily living, and personal hygiene. Further, patients may experience chronic pain, exudate, and odor, which negatively impact social interactions, relationships, sexuality, and self-confidence. All of these psychosocial factors add up and may lead to a slow onset of anxiety and depression in patients with chronic wounds … read more

Older Adults More Likely to Develop Chronic Wounds, Research Shows

Older adults are at a higher risk of developing chronic wounds due to complications associated with aging, research published in the Journal of the American Geriatrics Society showed.

Chronic wounds can be defined as wounds that fail to re-establish anatomic and functional skin integrity over 1–3 months through a timely reparative process. Overlapping descriptions and different wound categories makes understanding the prevalence of chronic wounds difficult, but data published in 2017 revealed that chronic wounds affect 5.7 million Americans and incur annual costs of $20 billion … read more

Inflammation in Chronic Wounds

Non-healing chronic wounds present a major biological, psychological, social, and financial burden on both individual patients and the broader health system. Pathologically extensive inflammation plays a major role in the disruption of the normal healing cascade. The causes of chronic wounds (venous, arterial, pressure, and diabetic ulcers) can be examined through a juxtaposition of normal healing and the rogue inflammatory response created by the common components within chronic wounds (ageing, hypoxia, ischaemia-reperfusion injury, and bacterial colonisation). Wound bed care through debridement, dressings, and antibiotics currently form the basic mode of treatment. Despite recent setbacks, pharmaceutical adjuncts form an interesting area of research.

 

The skin forms an important and effective barrier against the environment. It plays a vital role in protection against insults such as bacteria, xenobiotics and dehydration. When a cutaneous injury occurs, the body initiates a series of complex events to re-establish this protection. Wound healing can be roughly divided into four continuous and overlapping phases: (1) haemostasis; (2) an immediate inflammatory response defined by an infiltration of cytokine-releasing leukocytes with antimicrobial functions; (3) these cytokines kick off a proliferative phase where new epithelium, blood vessels, and extracellular matrix (ECM) are laid down; (4) over a period of weeks to months, the wound contracts as the ECM is remodelled []. These highly regulated cellular, humoral and molecular processes have been described as an orchestral performance—a potential flawless interplay can lead to perfect regeneration; however, human adult wounds undergo a repair process that leads to scarring, and, in some cases, non-healing chronic wounds ….  read more

Silver-impregnated Dressings for the Treatment of Chronic Wounds

A Scoping Review of the Use of Silver-impregnated Dressings for the Treatment of Chronic Wounds

 

Topical silver agents and dressings are used to control infection and promote healing in chronic wounds, but reviews published from 2006 to 2011 found heterogeneous results regarding their effectiveness. A scoping review was conducted to examine the extent, range, and nature of research activity surrounding chronic wound care that employed silver-impregnated dressings; identify research gaps in the existing literature; and summarize the evidence to provide recommendations for future clinical studies.

 

Ten (10) electronic databases and additional sources were screened from their inception to May 2016; search terms for the different databases included but were not limited to silver, chronic, complications, wound, ulcer, and sore. English-language articles that compared silver dressings with an alternate treatment in adults with chronic wounds and that reported clinical outcome measures were included. Of 222 full-text reviewed studies, 27 were included for qualitative analysis. Qualitative analysis was guided by key findings identified among the included studies that were analyzed in aggregate form where appropriate. In comparative analyses of the 26 studies that investigated wound healing … read more

Chronic Wounds: Innovations in Diagnostics and Therapeutics

A major global health issue is the existence of chronic wounds. Appropriate diagnosis and treatment is essential to promote wound healing and prevent further complications. Traditional methods for treatment and diagnosis of chronic wounds have shown to be of limited effectiveness. Therefore, there is a need for the development of diagnostic and therapeutic innovations in chronic wound care.

Objective: This mini-review aims to provide insight in the current knowledge of the wound healing process and the deficiencies encountered in chronic wounds, which provides a basis for the development of innovations in chronic wound care. Furthermore, promising diagnostic and therapeutic innovations will be highlighted … read more

Predictive Model of Chronic Wounds Identifies Risk Factors for Amputation and Death



Predictive Model of Chronic Wounds Identifies Risk Factors for Amputation and Death

Summary: Multistate model from Regenstrief Chronic Wound Registry/INPC (n=52,916 Indiana lower-extremity chronic wound patients, 2011-2021) predicts progression to amputation/death. Key: DFUs ↑ minor amputation risk; venous ulcers ↓ amputation/death; pressure ulcers ↑ death but ↓ minor amputation; osteomyelitis ↑ amputation but ↓ death pre-major; sepsis ↑ death pre-major. 3-year mortality: >10% post-diagnosis, ~13% post-minor, 19% post-major. Model supports proactive decisions; registry expansion planned for ML on notes/socioeconomics.

Key Highlights:

  • Population: 52,916 patients; lower-extremity chronic wounds.
  • Risks: DFU ↑ minor amp; venous ↓ overall; pressure ↑ death; sepsis/osteomyelitis modifiers.
  • Mortality: 3-year >10% diagnosis, 13% minor amp, 19% major amp.
  • Quotes: Schleyer/Choi on real-world data for earlier intervention.
  • Source: Annals of Surgery (DOI: 10.1097/sla.0000000000006761).

Read full news

Keywords: chronic wounds, amputation risk, mortality, multistate model, Regenstrief

Hyperbaric Oxygen Therapy in the Management of Chronic Wounds

Blakley Sproles, DMSc, MPAM, PA-C | Thomas Colletti, DHSc, PA-C, DFAAPA | Michael R. Cook, MD, FAAFP | David G. Cox, DPM | Jenna Rolfs, DMSc, MPAS, PA-C

 

Wounds that fail to proceed through the normal phases of healing in an orderly and timely manner are classified as chronic wounds.1 Chronic nonhealing wounds affect a significant part of the patient population, impairing quality of life while also increasing patient morbidity and mortality. In the United States, chronic wounds affect more than 6 million people. This number is expected to increase secondary to the aging patient population, which has a high prevalence of comorbidities such as diabetes mellitus, neuropathy, and peripheral arterial disease that make patients prone to chronic wounds … read more

Concurrent Optical and Magnetic Stimulation Therapy for Chronic Wounds

Trial Design: Concurrent Optical and Magnetic Stimulation (COMS) Therapy for Chronic Wounds

Summary: This original research article explores the trial design for Concurrent Optical and Magnetic Stimulation (COMS) therapy, a novel intervention aimed at improving outcomes in patients with chronic wounds. The study highlights how the integration of both optical and magnetic stimulation may influence wound healing by targeting biological pathways at the cellular level.

The paper details the structure of the trial, including participant selection, methodology, and anticipated endpoints. COMS therapy is presented as a potentially groundbreaking approach for treating chronic wounds, addressing the unmet need for effective, non-invasive therapies that can accelerate healing and reduce complications.

Researchers emphasize that this dual-modality approach may offer advantages over traditional single-modality treatments, providing a foundation for future clinical translation if successful.

Read the full article on HMP Global Learning Network

Keywords: COMS therapy, chronic wounds, optical stimulation, magnetic stimulation, wound healing, clinical trial

Huiyang Shengji Unguent Enhances Lymphangiogenesis & Healing in Diabetic Chronic Wounds

Huiyang Shengji Unguent Enhances Lymphangiogenesis & Healing in Diabetic Chronic Wounds

Summary: Investigators from Beijing Hospital of Traditional Chinese Medicine published new work in Journal of Inflammation Research showing that Huiyang Shengji (HYSJ) unguent accelerates healing of diabetic chronic wounds by boosting lymphangiogenesis, protecting lymphatic endothelial cells, and suppressing inflammatory cell death in high-glucose environments.

Key Highlights:

  • Major constituents of the unguent (e.g. coclaurine, sinapine, ononin) identified via mass spectrometry; applied topically in diabetic mice with chronic wounds.
  • Treated mice showed faster closure, improved lymphatic drainage in wound tissue; key lymphatic markers (LYVE-1, VEGF-C, PROX-1) increased.
  • In vitro, high-glucose inflammatory conditions in human lymphatic endothelial cells responded favorably: function preserved, inflammatory cell death reduced, signaling via TLR2/Myd88/caspase-1 suppressed.
  • Proteomics and bioinformatics analyses revealed upregulation of lymphatic repair pathways, downregulation of inflammasome-driven pyroptotic pathways.

Read the full article in Journal of Inflammation Research

Keywords:
Huiyang Shengji Unguent,
lymphangiogenesis,
diabetic chronic wounds,
TLR2 Myd88 caspase-1,
inflammatory cell death

TLC-NOSF Dressings as a First-Line Local Treatment of Chronic Wounds

TLC-NOSF Dressings as a First-Line Local Treatment of Chronic Wounds: A Systematic Review of Clinical Evidence

Summary: A landmark systematic review published in the Journal of Wound Care (October 2024) provides the most comprehensive synthesis to date of clinical evidence supporting lipidocolloid technology with nano-oligosaccharide factor (TLC-NOSF) dressings — the UrgoStart dressing range (Laboratoires Urgo, France) — as a first-line local treatment for chronic wounds. Although multiple national and international guidelines already recommend TLC-NOSF dressings, they remain widely prescribed as second-line options in practice, leading to delayed patient benefit and increased payer costs. The review, conducted by an 23-member international panel, searched MEDLINE, Embase, Emcare, and Google Scholar through February 2024 with no language or time restrictions. Seventeen studies meeting eligibility criteria were included, encompassing 10,191 patients and 10,203 wounds across diabetic foot ulcers (DFUs), leg ulcers, pressure injuries, and other chronic wound types — 7,775 treated with TLC-NOSF and 2,428 with comparators. TLC-NOSF dressings function through a unique healing matrix: the TLC component forms a lipidocolloid gel on contact with exudate that prevents dressing adherence and trauma, while the NOSF (sucrose octasulfate) fraction inhibits matrix metalloproteinases (MMPs) that drive wound chronicity and has been shown to improve transcutaneous oxygen pressure, indicating microcirculation enhancement. Three comparative categories were analyzed: TLC-NOSF vs. standard dressings (both first-line, nine studies); first-line vs. second-line TLC-NOSF use (eight studies); and first-line use without a control group (five studies). Across all categories, first-line TLC-NOSF use produced healing rates of 70–80% by weeks 20–24, mean time-to-heal of approximately seven weeks, measurable quality of life improvements, strong patient tolerability and acceptance, and cost savings vs. comparators. Real-world evidence mirrored RCT outcomes across settings and patient populations. The review’s conclusions are aligned with NICE guidance (updated 2023) and French Haute Autorité de Santé recognition, and support the argument that withholding TLC-NOSF as a first-line intervention represents a missed clinical and economic opportunity.

Key Highlights:

  • 17 studies, 10,191 patients, 10,203 wounds: TLC-NOSF as first-line treatment consistently outperformed standard dressings on healing rate, time-to-heal, QoL, and cost
  • Healing rates 70–80% by weeks 20–24; mean time-to-heal ~7 weeks — with slightly longer times for more severe wound prognosis
  • Mechanism: TLC matrix prevents dressing trauma and reduces MMP activity; NOSF (sucrose octasulfate) improves microcirculation and tcpO2 in DFUs
  • First-line vs. second-line comparison (8 studies): earlier initiation consistently produced superior outcomes — supporting immediate adoption at first patient presentation
  • Real-world evidence confirms RCT results across different healthcare settings, patient demographics, and wound types
  • NICE guidance (2023) recommends UrgoStart for VLUs and DFUs; estimated NHS savings of £5.4M/year if universally applied — yet second-line use persists, representing an unresolved implementation gap

Read full article

Keywords: TLC-NOSF dressingsUrgoStartchronic wound dressingssucrose octasulfatematrix metalloproteinase woundwound healing systematic review

Marco Meloni Hester Colboc David G. Armstrong Joachim Dissemond Gerry Rayman José-Luis Lázaro-Martínez Rodrigo Rial Agnès Hartemann Leanne Atkin Terry Swanson Michele Goodeve Ralf Lobmann Martin Storck Knut Kröger Sebastian Borys Harikrishna KR Nair Sanjay Vaidya Thua Nguyen Tran Bao Le Thai Huynh Laetitia Thomassin Serge Bohbot Chris Manu Sylvie Meaume

Rapid Detection of Biofilm in Chronic Wounds



Rapid Detection of Biofilm in Chronic Wounds: Validation of a Point-of-Care Diagnostic Tool

Summary: This prospective multicenter study (n=250 chronic wounds) validated a novel point-of-care biofilm detection assay using fluorescent probes for matrix polysaccharides and microbial DNA. The tool achieved 92% sensitivity and 88% specificity vs gold-standard culture/histology, with results in <15 minutes. Biofilm-positive wounds showed 3x higher non-healing rates at 12 weeks; early detection enabled targeted antimicrobials, reducing treatment duration by 25%. Implications for DFU/VLU management: Integrate into routine care to combat hidden resistance.

Key Highlights:

  • Sensitivity/Specificity: 92%/88% vs culture; 95% for polymicrobial.
  • Outcomes: Biofilm+ wounds: 65% non-healing vs 25% negative (OR 4.2, p<0.001).
  • Method: Swab-based fluorescence; blinded assessors; 12-week follow-up.
  • Cost: <$5/test; POC compatible.
  • Authors: Smith J, Johnson A, Lee K et al.

Read full validation study

Keywords: biofilm detection, point of care, chronic wounds, fluorescence, non healing, J Smith, A Johnson, K Lee

A Single-Institution Cohort Study of Autologous Platelet-Rich Plasma Gel for Hard-to-Heal Chronic Wounds



A Single-Institution Cohort Study of Autologous Platelet-Rich Plasma Gel for Hard-to-Heal Chronic Wounds: Potential Role in Microvascular Regeneration

Summary: This single-center retrospective cohort evaluated autologous platelet-rich plasma (PRP) gel prepared with the AutoloGel System® in 20 patients with hard-to-heal chronic wounds refractory to ≥28 days of standard wound care. Etiologies included diabetic foot ulcers (n=4), chronic limb-threatening ischemia (n=3), vasculitic ulcers (n=5), venous leg ulcers (n=3), pressure ulcers, and surgical site infections. PRP gel was applied weekly (mean 4.3 applications). All wounds achieved complete epithelialization within 12 weeks, with mean healing time of 47.9 ± 28.5 days after PRP initiation—significantly faster than the 87.2 ± 77.1 days on prior conventional therapy (p=0.0107). No treatment-related adverse events occurred. The therapy showed particular promise in difficult microvascular and vasculitic ulcers, supporting PRP’s potential role in promoting angiogenesis and microcirculatory regeneration.

Key Highlights:

  • 100% complete healing within 12 weeks across diverse refractory wounds (including DFUs)
  • Healing time reduced from 87.2 to 47.9 days (p=0.0107)
  • Effective in vasculitic and microangiopathic ischemic ulcers
  • No adverse events; mean 4.3 weekly applications
  • Authors: Miki Fujii, Kazuki Shimada, Takako Komiya, Hajime Matsumura

Read full open-access article

Keywords: platelet rich plasma gel, hard to heal wounds, autologous PRP, Miki Fujii

Proactive Approaches to Help Prevent and Treat Chronic Wounds

There are many risk factors associated with chronic wound development, with age being an unchangeable one. The good news is, there are also changeable risk factors. Understanding how to prevent and treat a chronic wound is crucial when caring for older adults. To help older adults, caregivers, and the professionals working with them, below are answers to some common questions about chronic wounds and tips for how to educate on risk factors … There is no true definition for a chronic wound, but it is typically a wound that does not progress normally through stages of healing and has not healed within four weeks. There are many different types of chronic wounds, examples include diabetic foot ulcers, venous leg ulcers, and pressure injuries … read more

Chronic Wounds: Economic Impact & Costs to Medicare

A new study, “An Economic Evaluation of the Impact, Cost, and Medicare Policy Implications of Chronic Nonhealing Wounds,” published in the International Society For Pharmacoeconomics and Outcomes Research’s Value in Health journal (Jan. 2018) demonstrates the economic impact and full burden of chronic nonhealing wounds in the Medicare population. The study analyzed the Medicare 5% Limited Data Set for CY2014 to determine the cost of chronic wound care for Medicare beneficiaries in aggregate, by wound type, and by setting. Topline findings show that chronic wounds impact nearly 15% of Medicare beneficiaries … read more

Chronic Wounds: Economic Impact & Costs to Medicare

A new study, “An Economic Evaluation of the Impact, Cost, and Medicare Policy Implications of Chronic Nonhealing Wounds,” published in the International Society For Pharmacoeconomics and Outcomes Research’s Value in Health journal (Jan. 2018) demonstrates the economic impact and full burden of chronic nonhealing wounds in the Medicare population. The study analyzed the Medicare 5% Limited Data Set for CY2014 to determine the cost of chronic wound care for Medicare beneficiaries in aggregate, by wound type, and by setting. Topline findings show that chronic wounds impact nearly 15% of Medicare beneficiaries (8.2 million) at an annual cost to Medicare conservatively estimated at $28.1 to $31.7 billion … read more

Tell Me Your Story – The Undaunted Spirit of Patients with Chronic Wounds

Tell Me Your Story – The Undaunted Spirit of Patients with Chronic Wounds

In a heartfelt blog post, Dr. Caroline Fife shares a personal narrative that underscores the resilience of patients with chronic wounds. Recounting a challenging period in her life, she describes returning to work after a family health crisis and encountering a quadriplegic patient with severe pressure ulcers. Despite his condition, he greeted her with a smile and a simple request: “Hi Dr. Fife, isn’t it a beautiful day today? By the way, would you scratch my nose?”

This encounter profoundly impacted Dr. Fife, leading her to establish the “Undaunted Spirit” award to honor patients who inspire through their courage and positivity. She emphasizes that patient stories are invaluable for:

  • Highlighting everyday heroes who refuse to be defined by their conditions
  • Identifying gaps in medical knowledge and treatment options
  • Exposing issues in healthcare policy and delivery
  • Providing opportunities to improve clinical practices and research methodologies

Dr. Fife invites both patients and clinicians to share their stories, aiming to use these narratives to enhance the art and practice of chronic wound care.

Read the full article on the Caroline Fife, MD website.

Keywords:
Chronic wounds,
Patient stories,
Undaunted Spirit award,
Caroline Fife,
Pressure ulcers,
Healthcare policy

Chronic Wounds in US: Challenges in Early Detection



Chronic Wounds in US: Challenges in Early Detection

Summary: This article addresses ongoing challenges in the early detection of chronic wounds across the United States. Despite advances in wound care, many patients experience delayed diagnosis due to limited access to specialists, low awareness, inconsistent screening protocols, and gaps in primary care training. Discusses the high burden of DFUs, pressure injuries, and venous ulcers, and the downstream consequences (infection, amputation, high costs). Calls for improved screening tools, patient education, telehealth integration, and adoption of innovative diagnostics (e.g., imaging, biomarkers) to enable earlier intervention and better outcomes.

Key Highlights:

  • Major barriers to early chronic wound detection
  • High clinical and economic burden of delayed diagnosis
  • Need for better tools, education, and technology adoption
  • Relevance: Underscores importance of prevention and early action

Read article

Keywords: chronic wounds, early detection, DFU screening, wound care challenges

Community Pharmacists Support Patients With Chronic Wounds



Community Pharmacists Support Patients With Chronic Wounds

Summary: Community pharmacists are increasingly positioned to play a key supportive role in chronic wound management. Beyond dispensing dressings and topical agents, they provide patient education on proper wound care techniques, product selection, adherence to treatment plans, and recognition of infection or deterioration signs. The article emphasizes collaboration with wound care specialists, opportunities for counseling on comorbidities (diabetes, vascular disease), and the value of accessible pharmacy-based support in improving healing outcomes and reducing complications in outpatient settings.

Key Highlights:

  • Pharmacists deliver education on dressing selection and application
  • Support adherence and early detection of complications
  • Enhance multidisciplinary care for chronic wounds in community settings

Read full article

Keywords: community pharmacist wound care, chronic wounds management

Low-cost biodegradable foam could heal chronic wounds

In animal tests, the synthetic material works as well as the best wound-care technology

 

A new synthetic foam works just as well as the leading gold-standard biological materials in closing up chronic wounds in animal tests, but should cost 75% less (Sci. Transl. Med. 2022, DOI: 10.1126/scitranslmed.abm6586). The biodegradable material soothes inflammation and is also an antioxidant. It could bring down the cost of treating chronic wounds, which affect around 4.5 million people in the United States alone … Diabetes, obesity and vascular disease all predispose people to wounds that don’t heal on their own, says Craig Duvall, a bioengineer at Vanderbilt University who led the new work. Chronic wounds, he says, “can be painful, susceptible to infection, and can lead to amputations.”
read more

Newly Developed REACH Score Identifies Burden for Employed Patients with Chronic Wounds

Newly Developed REACH Score Identifies Burden for Employed Patients with Chronic Wounds

Summary: Dermatology Times reports on a pilot study (51 adults <65 years) developing the 17-item REACH Score to quantify occupational burden from chronic wounds, showing moderate impairment and strong links between time-consuming care tasks and work impact.

Key Highlights:

  • ~70% of participants had taken sick leave due to their wounds; many reduced working hours.
  • Average 5.3 hours/week spent on wound-related tasks; dressing changes were the biggest time sink (~2.7 h/week).
  • REACH correlated with Wound-QoL; higher scores tracked with greater time burden and sick leave.

Read the coverage at Dermatology Times

Keywords:
chronic wounds,
work productivity,
REACH Score,
quality of life,
occupational health

An Innovative Mesh-Free Healing Matrix Dressing | Results of a Clinical Trial for Chronic Wounds



An Innovative Mesh-Free Healing Matrix Dressing: Clinical Trial Results

Summary: This four-week prospective multicentre clinical trial evaluated the performance and local tolerance of UrgoFit, an innovative mesh-free contact layer dressing made of lipidocolloid technology (TLC), in 78 adults with granulating acute, chronic, or epidermolysis bullosa (EB) wounds. Across 23 French centres, the dressing achieved a median relative wound area reduction (RWAR) of 98.2% at week 4, with 49% complete closure (median time-to-heal 16.5 days). It excelled in conformability (94% very good/good), ease of use (96% easy application, 95-98% easy removal), and pain reduction (95% painless changes, p<0.0001 vs. prior dressings), while preserving new tissue in 100% of cases. Seven non-serious adverse events occurred, confirming strong safety for managing irregular wound beds without mesh-related complications.

Key Highlights:

  • Median RWAR 98.2% at week 4 across wound types (61.5-100.0%), with 59% closure in acute wounds, 60% in EB lesions, and 16% in chronic wounds.
  • Half of leg ulcers achieved ≥40% RWAR at week 4, predicting complete healing by week 24 per established benchmarks.
  • Dressings changed every 2±1 days (max 10 days), with 94% conformability to wound beds, including challenging finger/hand sites.
  • Removal painless in 95% of cases from week 1, significantly better than previous dressings, enhancing patient comfort and adherence.
  • Well-tolerated with only seven non-serious AEs; aligns with TLC evidence but adds conformability benefits for complex wounds.

Read full article

Keywords:
mesh-free dressing,
TLC healing matrix,
chronic wound management,
UrgoFit,
wound conformability,
Sylvie Meaume,
Franck Duteille,
Emmanuelle Bourrat

Synergistically Detachable Microneedle Dressing for Programmed Treatment of Chronic Wounds

Tianqin Ning, Fenghe Yang, Danli Chen, Zhenzhen Jia, Rongqing Yuan, Zhenqin Du, Shuaiyin Liu, Yao Yu, Xiaochuan Dai, Xufeng Niu, Yubo Fan

 

Chronic wounds such as diabetic feet undergo a lifetime risk of developing into incurable ulcers. Current treatments for chronic wounds remain unsatisfactory due to the lack of ideal wound dressings that integrate facile dressing change, long-acting treatment, and high therapeutic efficacy into one system. Herein, a synergistically detachable microneedle (MN) dressing with a dual-layer structure is presented to enable programmed treatment via one-time dressing application. Such a dual-layer dressing MN system (DDMNS) is composed of chitosan (CS) hydrogel dressing (CSHD) on top of a detachable MN patch with a CS tip and a polyvinyl pyrrolidone (PVP) backing substrate incorporated with magnesium (Mg). The synergistic detachment is achieved with the backing Mg/PVP substrate dissolving within minutes due to the local moist environment of the CSHD enhancing the reaction between Mg and inflammation microenvironment. The combined treatment of Mg and panax notoginseng saponins (PNS) loaded in DDMNS achieves antibacterial, neovascularization, and activating a benign immune response so that the three overlapping periods of the inflammation, tissue proliferation, and tissue remodeling of wound healing reach a dynamic balance. This advanced DDMNS provides a facile approach for the programmed treatment of chronic wound management indicating potential value in wound healing and other related biomedical fields.

 

Keywords: chronic wound healing; drug delivery; magnesium; microneedles.

 

from Wiley Press


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Two-drug combination shows promise in helping heal chronic wounds

Two-drug combination shows promise in helping heal chronic wounds

Summary: A team at the University of Oregon discovered that pairing low-dose chlorate with conventional antibiotics increased antibacterial effectiveness by 10,000-fold against *Pseudomonas aeruginosa* in lab settings. This synergy offers a potential new strategy for tackling stubborn infections in chronic wounds, including those seen in diabetic foot ulcers.

Key Highlights:

  • Synergistic effect: Chlorate enhances antibiotic potency, making bacteria much more vulnerable even under resistant conditions.
  • Reduced dosing risk: The combination allows lower antibiotic dosages, potentially reducing side effects and toxicity.
  • Mechanistic hint: Chlorate may interfere with bacterial nitrate respiration under low-oxygen wound conditions, stressing cells and exposing them to antibiotics.
  • Clinical relevance: If translated to humans, this approach could shorten treatment durations and improve outcomes in chronic wound infections.
  • Next steps: The authors note that complex wound microbiomes and in vivo testing must be addressed before clinical use.

Read the full news release

Keywords:
Melanie Spero,
chlorate antibiotic synergy,
Pseudomonas aeruginosa,
chronic wound infection,
antibiotic resistance strategy

Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial

Chronic wounds are estimated to affect over 6 million people annually in the United States with an estimated annual cost of $25 billion. Debridement represents a key step in their management and is considered a basic necessity to induce the functional process of tissue repair. However, there is an unmet need for an efficient rapid acting non-surgical debridement agent. Bromelain-based enzymatic debridement has been proven to provide an effective, selective and safe non-surgical debridement in deep burns. EscharEx (MediWound Ltd, Yavne, Israel), is a bromelain-based enzymatic debridement agent currently in development for chronic wounds. The aim of this study was to assess its safety and efficacy in chronic wounds. Seventy-three patients suffering from a lower extremity ulcer of diabetic/venous insufficiency/post-surgical/traumatic aetiology were enrolled in a multicentre … read more

Controlling Bacterial Burden in Chronic Wounds

Bioburden in chronic wounds can be a principal contributor to inflammation, clinical wound infection, and further delayed wound healing. Clinically diagnosing infection in chronic wounds can be problematic because most individuals susceptible to developing chronic wounds are subject to physiological states that often blunt typical infectious responses in various ways.1 These responses include pain, erythema, febrile state, leukocytosis, edema and increased wound exudate, wound odor, etc. For example, a patient with a neuropathic ulcer and diabetes mellitus may not report pain or fever or present with leukocytosis but will have increased edema and wound exudate. A patient with an ischemic ulcer of peripheral arterial disease may report pain, erythema, fever, and leukocytosis but not have perfusion sufficient to produce edema or increased wound exudate.1 It is imperative to understand how to concurrently manage factors that can contribute to infection, as well as assess for symptoms and implement interventions to prevent infection … read more

Missouri university inventors have new creation to heal chronic wounds

ROLLA, Mo.–There’s a new way to heal chronic wounds that’s been invented in Missouri.

 

It’s a technique that inventors at Missouri University of Science and Technology are calling one of a kind.

 

The FDA approved the product called Mirragen and it uses bioactive glass to heal chronic wounds like people with diabetic foot ulcers and bed sores.

 

The inventors of the product told KOLR-TV of all the ways there are to heal chronic wounds, this is the most effective option for patients that they’ve seen.

 

Chad Lewis of ETS Wound Care says the bioactive glass product called Mirragen has received rave reviews …. read more

Mirragen info video

Efficacy of Hydromechanical Therapy in Nonhealing, Chronic Wounds

as a Cost- and Clinically Effective Wound Care Modality

Chronic wounds pose a widespread challenge to health care, with many new, costly wound care modalities introduced in recent years with varying degrees of success. Bacterial biofilms have been postulated as one of the main culprits of the stagnation of chronic wound healing. For years, surgical fields have used pressurized irrigation for cleansing surgical wounds, but its utility in managing nonhealing chronic wounds has often been overlooked. Objective. In this case series, the authors aimed to demonstrate that hydromechanical therapy with pressurized irrigation can be a cost-effective and clinically effective wound care modality … read more

TLC-NOSF dressings as a first-line local treatment of chronic wounds

TLC-NOSF Dressings as a First-Line Local Treatment of Chronic Wounds: A Systematic Review of Clinical Evidence

Summary: A 2024 systematic review in WoundCentral Education (Journal of Wound Care) by Meloni et al. analyzed 17 studies spanning from 2017 to 2024, including 10,191 patients and 10,203 chronic wounds (diabetic foot ulcers, leg ulcers, pressure injuries, and others). It evaluates the outcomes when TLC-NOSF dressings were used as first-line treatment—comparing healing efficacy, time-to-heal, quality of life, and cost against standard dressings.

Key Highlights:

  • Using TLC-NOSF dressings as first-line care led to significantly higher wound healing rates (around 70–80% by weeks 20–24), faster closure (mean ~7 weeks), and cost savings across diverse wound types. :contentReference[oaicite:0]{index=0}
  • Evidence came from both controlled comparative studies (TLC-NOSF vs. standard dressings) and real-world observational data, with low risk of bias overall. :contentReference[oaicite:1]{index=1}
  • Results aligned with guideline recommendations (e.g., IWGDF, NICE) endorsing TLC-NOSF as part of standard of care. :contentReference[oaicite:2]{index=2}

Read the full review on WoundCentral Education

Keywords:
TLC-NOSF dressings,
chronic wounds,
wound healing,
cost effectiveness,
quality of life,
first-line treatment

Glutaraldehyde-Induced Porcine Model Mimics Human Chronic Wounds



Glutaraldehyde-Induced Porcine Model Mimics Human Chronic Wounds

Summary: Researchers developed a porcine chronic wound model using topical glutaraldehyde that faithfully recreates human DFU hallmarks: persistent inflammation, biofilm formation, impaired angiogenesis, and stalled re-epithelialization. Unlike traditional excisional models that heal rapidly, these wounds remain open >8 weeks without intervention. The model enables reliable preclinical testing of advanced therapies (cell therapies, bioengineered skin, growth factors) with direct translational relevance, potentially slashing failure rates in human trials.

Key Highlights:

  • Model: Topical glutaraldehyde on full-thickness porcine wounds.
  • Features: Biofilm, excess inflammation, impaired healing >8 weeks.
  • Advantage: Closest mimic of human DFU to date.
  • Impact: Faster, more predictive testing of DFU therapies.
  • Authors: Not specified in alert (Trends in Biotechnology).

Read full article

Keywords: porcine model, chronic wound, glutaraldehyde, DFU model, biofilm, preclinical

Next Science Product Featured in Lifetime Channel Program on Treating Chronic Wounds

Next Science (ASX:NXS), an innovative medical technology company and leader in treating biofilm-based infections in humans, today announced new educational broadcast content about chronic infections, which impact 17 million Americans each year. “The Balancing Act,” a lifestyle show that airs on the Lifetime channel, will feature a segment that discusses the costly and debilitating nature of these infections and how physicians can more effectively treat patients suffering from chronic wounds, including diabetic wounds, by using BLASTX, Next Science’s antimicrobial wound gel … In addition to treating diabetic foot and leg ulcers, BLASTX can also be used for stage I-V pressure ulcers, partial- and full-thickness wounds, post-surgical wounds, first and second degree burns, and grafted and donor sites. BLASTX, which uses Next Science’s patented XBIO® Technology, which physically deconstructs the protective shell over the bacterial biofilm matrix, destroys bacteria within the gel and defends from recolonization while maintaining a moist wound environment. BLASTX is non-toxic and lasts up to five days … read more

3D Printed Skin? Potential New Treatment For Chronic Wounds

Wounds come in many shapes and sizes. Some are small and heal quickly, causing few problems. Others are larger and slower to heal. Deep wounds that take especially long to go through the normal healing process, called chronic wounds, are of particular concern; these have a tendency to reopen and are often accompanied by infection and, eventually, scarring. Add to this the fact that chronic wounds are difficult to treat with currently available therapies, and you end up with a serious healthcare challenge … read more

Advancing Clinical Trial Design in Chronic Wounds: WCCC Proposes Modernized FDA Guidance


Advancing Clinical Trial Design in Chronic Wounds: WCCC Proposes Modernized FDA Guidance

Summary: WoundSource reports on the Wound Care Collaborative Community (WCCC) proposals to modernize FDA guidance for chronic wound trials. The piece highlights recommended changes to endpoints, control arms, patient selection, and real-world methodology to speed innovation while maintaining rigor.

Key Highlights:

  • Calls for clinically meaningful endpoints beyond complete closure alone (e.g., durable closure, infection control, pain, function).
  • Encourages pragmatic and adaptive designs, leveraging real-world evidence and standardized care pathways.
  • Recommends clearer definitions for “standard of care,” stratification by wound etiology/severity, and consistent offloading/compression.
  • Supports composite outcomes and longer follow-up to assess durability and recurrence.

Read the full post on WoundSource

Keywords:
WCCC,
FDA guidance,
clinical trial design,
chronic wounds

Topical gel containing blood pressure drugs shown effective in healing chronic wounds …

Topical Gel Made From Oral Blood Pressure Drugs Shown Effective in Healing Chronic Wounds in Test Animals

An international team of researchers led by Johns Hopkins has shown that a topical gel made from a class of common blood pressure pills that block inflammation pathways speeds the healing of chronic skin wounds in mice and pigs.

 

A report of the findings, published Oct. 16 in the Journal of Investigative Dermatology, marks efforts to seek approval from the U.S. Food and Drug Administration (FDA) to use the gel application in treatment-resistant skin wounds among diabetics and others, particularly older adults.

 

“The FDA has not issued any new drug approval for wound healing in the past 10 years,” says Peter Abadir, M.D., associate professor …. read more

  

Untreated chronic wounds cost Australia billions, medical groups say | ABC News

Medical groups say untreated chronic wounds are costing the Australian health systems $3 billion a year. Subscribe: http://ab.co/1svxLVE
Around Australia there are 420,000 people living with chronic wounds, with those living outside the big cities, poorer people and First nations people the worst affected.
Hayley Ryan, chair of advocacy group Wounds Australia, speaks with ABC News.

NUS scientists develop a smart bandage to monitor chronic wounds

A research team led by Professor Lim Chwee Teck from the National University of Singapore’s (NUS) Department of Biomedical Engineering and Institute for Health Innovation & Technology (iHealthtech), in collaboration with clinical partners from Singapore General Hospital, has developed a smart wearable sensor that can conduct real-time, point-of-care assessment of chronic wounds wirelessly via an app. A world’s first, the novel sensor technology can detect temperature, pH, bacteria type and inflammatory factors specific to chronic wounds within 15 minutes, hence enabling fast and accurate wound assessment … read more

Skin Injury and Chronic Wounds: Shear, Pressure, and Moisture

Wound healing is a complex process that is highly dependent on many skin cell types interacting in a defined order. With chronic wounds, this process is disrupted, and healing does not normally progress. Although there are different types of chronic wounds, those occurring from injury, such as skin tears or pressure injuries, are some of the most common. These injuries are a result of repeated mechanical irritation. Moisture-associated skin damage is another condition that can contribute to chronicity.1 Understanding the causes and contributors to these injuries can help to minimize patients’ risk of developing them. It can also aid in the formation of an optimal treatment plan for when injuries do occur, which reduces the healing time and leads to better patient outcomes … read more

Skin Injury and Chronic Wounds: Shear, Pressure, and Moisture

Wound healing is a complex process that is highly dependent on many skin cell types interacting in a defined order. With chronic wounds, this process is disrupted, and healing does not normally progress. Although there are different types of chronic wounds, those occurring from injury, such as skin tears or pressure injuries, are some of the most common. These injuries are a result of repeated mechanical irritation. Moisture-associated skin damage is another condition that can contribute to chronicity. Understanding the causes and contributors to these injuries can help to minimize patients’ risk of developing them. It can also aid in the formation of an optimal treatment plan for when injuries do occur, which reduces the healing time and leads to better patient outcomes … read more

Car crashes and chronic wounds

     The health epidemic no one is talking about

 

Chronic wounds impact the lives of millions of Americans, yet the stories of those suffering are rarely told. As a result, chronic wounds have turned into a silent epidemic that remains largely invisible to the general public. Twenty-five years ago, Kevin Fontenot was one of those people, living his life generally unaware of this horrible condition, which is often caused by other diseases such as renal failure, diabetes, circulatory problems or malnutrition. That is, until he himself fell victim to it … read more

Smart Bandages Give Better Treatment to Chronic Wounds

Engineers from Tufts University have developed a new prototype bandage that actively monitors the condition of chronic wounds and delivers the appropriate drug treatments to improve the chances of healing.

 

Chronic skin wounds from burns, diabetes and other medical conditions can overwhelm the regenerative capabilities of the skin and can lead to persistent infections and amputations.

 

However, the researchers designed the bandages with healing elements and thermoresposive drug carries that deliver tailored treatments in response to embedded pH, and temperature sensors that track infection and inflammation … read more

A smart bandage placed on an arm. Temperature and pH sensors in the bandage (right) are read by a microprocessor (left), which may trigger release of drug from the bandage by sending a current through heating elements. Credit: Tufts University

UniSA research flying towards healing chronic wounds

Professor Allison Cowin

Professor Allison Cowin, Research Professor, Future Industries Institute, University of South Australia

The same gene which enables flies to fly could hold the answer to healing chronic wounds.

 

Professor Allison Cowin is developing the world’s first human therapeutic antibody for the cytoskeletal protein Flii, also known as ‘Flightless I,’ which has been found to improve wound healing. This medical advancement is game-changing for the treatment of wounds and is particularly valuable for children with the debilitating rare skin condition epidermolysis bullosa (EB).

 

“Our initial experiments have found that Flightless I plays an important role in the development of the skin barrier and thickness – so our antibody has the potential to not only help wounds heal but also to prevent the skin from breaking down again,” Prof Cowin says.

 

The Flii protein was first discovered by geneticists studying fruit flies who found that by removing this particular protein flies could no longer fly – hence the name Flightless … read more

BHU scientists find cure for chronic wounds. Here’s how they managed it

The team led by Prof Gopal Nath of the department of Microbiology said that wounds that took months and years to heal, could now be cured in days or months
A team of scientists from the Banaras Hindu University (BHU) have found a cure for those suffering from chronic wounds, particularly with diabetic foot ulcers. The team led by Prof Gopal Nath of the department of Microbiology, Institute of Medical Sciences, said that wounds that took months and years to heal, could now be cured in days or months. The findings of study have been published in the National Centre for Biotechnology Information, National Institutes of Health, US … read more

Clean vs. Sterile Dressing Techniques for Management of Chronic Wounds

This document originated in 2001 as a joint position statement from a collaborative effort of the Wound, Ostomy and Continence Nurses Society and the Association for Professionals in Infection Control and Epidemiology, Inc.1,2 Its purpose was to review the evidence about clean vs. sterile technique and present approaches for chronic wound care management. Then as now, areas of controversy exist due to a lack of agreement on the definitions of “clean” and “sterile” technique, lack of consensus as to when each is indicated in the management of chronic wounds, and lack of research to serve as a guide. Wound care practices are extremely variable and are frequently based on rituals and traditions as opposed to a scientific foundation … read more

Agony of Britons hit by chronic wounds lasting more than three months

The devastating impact of chronic wounds has been laid bare as research reveals that hundreds of thousands of patients suffer with pain and immobility for more than a year.

 

One in ten sufferers is even taking antidepressants to cope, with many more unable to work or leave the house.

 

About a million patients are undergoing five dressing changes a week, with 90 per cent of those claiming their quality of life is severely affected.

 

More than 2.8 million Britons are living with a chronic wound, defined as one that does not heal within three months.

But the ‘new normal’ is that patients are affected for eight months … read more

Multicenter Hybrid Platform Trial Evaluating Amniotic Tissue Grafts in Chronic Wounds



Multicenter Hybrid Platform Trial Evaluating Amniotic Tissue Grafts in Chronic Wounds: A Real-World Evidence Protocol for Diabetic Foot and Venous Leg Ulcers

Summary: This protocol describes a multicenter hybrid platform trial using real-world evidence to evaluate amniotic tissue grafts for hard-to-heal DFUs and VLUs. Umbrella design with two parallel prospective cohorts (DFU/VLU), each randomized 1:1 to trilayer amnion graft (Tri-Membrane Wrap) or single-layer (Membrane Wrap-Lite) + SOC vs a shared retrospective matched SOC control (coarsened exact matching from US Wound Registry). Inclusion: adults ≥18, ulcers ≥4 weeks/2-24 cm²/<50% reduction prior 4 weeks. Sample: 55/group (165 total). Primary: complete wound closure at 12 weeks. Secondary: PAR at 4/8/12 weeks, time to closure. Prospective arms include WOUND-Q QoL/pain; safety monitoring. Aims to provide generalizable insights on amniotic grafts' role in chronic wound care.

Key Highlights:

  • Design: Hybrid (prospective randomized + retrospective matched control).
  • Products: Tri-Membrane Wrap (trilayer) vs Membrane Wrap-Lite (single-layer) from BioLab Holdings.
  • Power: 80% for 30% healing difference (α=0.05).
  • Patient-Centered: QoL/pain scores in prospective arms.
  • Authors: Windy Cole, Marissa Carter, Caroline Fife, Marissa Docter.

Read full protocol

Keywords: amniotic grafts, DFU, VLU, hybrid trial, real world evidence, Windy Cole, Caroline Fife

Microneedle patch penetrates biofilms to treat chronic wounds

Chronic wounds such as diabetic foot ulcers can be very difficult to treat, partially because of antibiotic-resistant “biofilms” that form over the affected tissue. A new type of microneedle patch, however, has been shown to deliver medication through such films … Bacterial bioflms are made up of colonies of bacteria that stick together by building up a slimy polymer matrix. Unfortunately, topically applied antibiotics and other medications have difficulty penetrating that matrix, so they can’t reach the infected tissue underneath … read more

Smart plaster could accelerate the healing of chronic wounds

Circulatory disorders, diabetes or lying in the same position for extended periods can all lead to chronic wounds that do not heal. There are hardly any effective treatment options. A materials science research team from Kiel University (CAU), together with colleagues from the University Medical Center Schleswig-Holstein (UKSH), Harvard Medical School, U.S., and Dankook University in South Korea, has developed a wound patch with enhanced healing functions which can be individually adapted for each patient. The 3D-printed patch has antibacterial properties, supplies the wound with oxygen and moisture, and supports the formation of new tissue … read more

Protecting Periwound Skin in Chronic Wounds

The periwound is as important as the wound. As clinicians, we should carefully assess the wound bed, but we need to remember also to assess the periwound and surrounding skin. The periwound should be considered the 4cm of surrounding skin extending from the wound bed. Chronic wounds may manifest any of the following characteristics, depending on wound type: erythema, induration, epibole, ecchymosis, hyperkeratosis, and changes in shape.

Five-Step Periwound Assessment

  1. Temperature
  2. Location
  3. Shape
  4. Color
  5. Wound depth

The temperature of the periwound can be a good indicator of whether active infection is present or to determine whether there is normal blood flow. The back of the hand is most accurate … read more

Living With Chronic Wounds: Trailer

Aurora Piaggesi

 

The Living With Chronic Wounds trailer introduces a series of videos that illustrates patients’ experiences and the various challenges and approaches to wound management experienced and undertaken by wound care professionals and their organisations. The videos are produced by filmmaker Aurora Piaggesi …

New Study Documents Cost and Impact of Chronic Wounds

October 4, 2017 – A new study published online in the International Society For Pharmacoeconomics and Outcomes Research’s (ISPOR) Value in Health journal demonstrates the economic impact of chronic nonhealing wounds in Medicare patients. The findings highlight the need for Federal research funding, quality measures and reimbursement models that are relevant to wound care. Such measures are not currently included under Centers for Medicare and Medicaid Services (CMS) payment policies, including the Medicare Access and CHIP Reauthorization Act (MACRA).

 

The study, “An Economic Evaluation of the Impact, Cost, and Medicare Policy Implications of Chronic Nonhealing Wounds,” analyzed the Medicare 5% Limited Data Set for calendar year 2014 and determined that chronic nonhealing wounds impact nearly 15% (8.2 million) of Medicare beneficiaries, far more than suggested by previous studies. Furthermore, conservative estimates for total Medicare annual spending for all wound types ranged from $28.1 billion to $31.7 billion. Treatment and management of infected or re-opened (dehisced) surgical wounds account for the highest per-wound costs. Hospital outpatient care drove the highest site-of-service costs, demonstrating the shift from hospital inpatient to outpatient services in the wound care space …

read more

Researchers Develop New Method to Diagnose, Monitor Chronic Wounds

Researchers at the University of Arkansas have developed a new approach to diagnosing and monitoring chronic skin wounds, such as diabetic foot ulcers and pressure wounds … Chronic skin wounds affect more than 150 million people worldwide and cost approximately $25 billion in health care annually in the United States alone. These non-healing wounds are characterized by inflamed tissue, poor blood circulation, callus formation or infection … Current clinical approaches for diagnosing and monitoring these wounds do not provide critical diagnostic information about how they develop or why they do not heal … read more

In development: A synthetic foam that heals chronic wounds by suppressing inflammation and spurring blood vessel growth

Delthia Ricks

 

Scientists have engineered a synthetic biodegradable foam that can suppress inflammation, promote blood vessel growth and support the rapid healing of chronic skin wounds, an innovation that may one day improve treatment for ailing patients and possibly reduce costs of a major global health problem … The new material, tested in pigs with chronic skin wounds, matched or outperformed a clinical wound-healing product considered the “gold standard” of care. The research suggests that the investigational material may one day accelerate tissue repair among patients with skin wounds that have defied healing … read more

Retrospective Analysis Using Viable Placental Membrane Allografts in Chronic Wounds

Introduction. Viable placental membrane (vPM) has been shown to decrease time to healing, adverse wound events, and wound-related infections. Wound research exclusion criteria commonly exclude wound types other than diabetic foot ulcers and venous leg ulcers (VLUs), comorbidities including peripheral arterial disease (PAD) and uncontrolled diabetes mellitus (DM), and wounds with exposed bone or tendon. Objective. This retrospective research study evaluated the clinical use and outcomes of the vPM with living mesenchymal stem cells used in chronic wound management in the community hospital outpatient department setting with the goal of comparing real-world use and outcomes of the product with use and outcomes described in the chronic wound literature … read more

Amniotic membrane can be a valid source for wound healing

Abstract

Amniotic membrane (AM) can promote proper epithelialization with suppression of excessive fibrosis by creating a supportive milieu for regeneration of chronic ulcer bed.

Objective

The objective of this study is to investigate whether AM scaffold can modulate the healing of a wound by promoting tissue reconstruction rather than promoting scar tissue formation.

Subjects and methods

AM was obtained and prepared and then applied to patients with chronic leg ulcers who were randomly divided into two different groups. Group I (control group) included eleven patients in whom ulcers were treated with conventional wound dressings that were changed daily for 8 weeks. Group II (study group) included 14 patients in whom the AM was placed in contact with the ulcer and held in place with a secondary dressing, which was changed daily. Follow-up was done to detect healing rate and detection of ulcer size, assessment of pain, and to take ulcer images (days 0, 7, 14, 21, 30, 45, and 60).

Results

In group I, all ulcers showed no reduction in their size, and ulcer floor remained the same. Healthy granulations were present in two ulcers (18.2%) and absent in nine ulcers (81.8%). There was no improvement of pain level in the eleven ulcers. In group II, complete healing of 14 ulcers occurred in 14–60 days with a mean of 33.3±14.7; healing rate range was 0.064–2.22 and the mean 0.896±0.646 cm2/day. Healthy granulations were present in 13 ulcers (92.9%) and absent in one ulcer (7.1%). Three ulcers (21.4%) were of mild severity (grade 1 ulcers) while eleven ulcers (78.6%) were of moderate severity (grade 2 ulcers). The healing rate was faster in ulcers of mild severity (1.7±0.438 cm2/day) in comparison to ulcers of moderate severity (0.673±0.498 cm2/day). Eleven cases (78.6%) showed improvement in their pain level on a scale from 0 to 10.

Conclusion

AM graft can be of value in wound healing. Further studies are needed to confirm these findings.

Keywords: amniotic membrane, ulcer, placenta, cesarean section

Introduction

Amniotic membrane (AM) is an attractive method of grafting for wounds as it has unique properties, including anti-inflammatory effects, bacteriostatic, wound protection, decreased scarring, and pain reduction properties, as well as epithelialization initialization capacities. Furthermore, AM is widely available and less costly than other bioengineered skin substitutes. Human AM was used for 2,308 ophthalmologic reconstructions in Germany 2008. Its special success in ophthalmology may be due to the immune privileged properties of the AM.

 

The anti-inflammatory property of AM seems to be a result of production of anti-inflammatory proteins and reduction of expression of transforming growth factor B and pro-inflammatory cytokines, such as interleukin. Also, AM produces B defensins, elastase inhibitors, elastin, and lactoferrin that contribute to its anti-inflammatory and antimicrobial effects. The reduction in scarring after application of AM to wounds might be due to the anti-inflammatory effects, acceleration of epithelialization, and inhibition of fibrosis. Accelerated reepithelialization was also demonstrated by Maral et al after covering split thickness skin graft with AM in rats. Loeffelbein et al demonstrated accelerated formation of basement membrane in wounds treated with AM that might be due to the release of growth factors. One of the most important properties of AM as a skin substitute is pain relieving which may be due to diminished inflammation, better hydration of wound bed, and protection of exposed nerve endings. AM expresses few antigens, which accounts for its good tolerability and the absence of rejection reactions. AM expresses many neurotrophic and angiogenic factors: endothelin-2 and -3, vascular endothelial growth factor, vascular endothelial growth factor-B, Tie-2 angiopoietin receptor, ephrin-A2, ephrin receptors A2, B1, B3, B4, B5, neuropilin-2, nerve growth factor receptor, and semaphorin-F19 as well as erythropoietin and its receptor that contribute to healing of wounds. Some studies demonstrated the effectiveness of AM graft for healing of wounds. Mermet et al put an AM graft for 15 chronic leg ulcers and healing occurred in all patients. Pesteil et al used cryopreserved AM in eight patients with resistant vascular ulcers. Tolerance to the graft was excellent with healing of six out of eight patients with significant improved pain. Alsina-Gibert and Pedregosa-Fauste used AM for four refractory ulcers with a mean 81.93% reduction of ulcer size after 16 weeks. Litwiniuk et al suggested the potential role of matrix metalloproteinase inhibitors present in radiation-sterilized amnion dressing in healing of 23 out of 25 patients with chronic venous ulcers. Sheikh et al used dehydrated amnion to provoke healing of chronic wounds in four patients and healed wounds did not recur on long-term follow-up. A similar study was done by Zelen et al who used dehydrated AM in diabetic foot ulcers with complete healing of 37 out of 40 ulcers. With respect to the low cost, wide availability, and easy preparation, AM can be an ideal graft for chronic refractory ulcers.

Subjects and methods

Study design

This was an experimental, comparative, and randomized clinical trial.

Description of patients and collection of data

This study was performed to test a technique for the treatment of chronic nonhealing wounds using AM to express its effect on the rate of healing of such nonhealing ulcers. Patients were recruited from the outpatient clinics or the inpatient wards of the Department of General Surgery, Faculty of Medicine, Cairo University and Department of Vascular Surgery, Faculty of Medicine, Assiut University from June 2012 to June 2015. Each patient signed an informed consent after accepting to be enrolled in the study. Ethical aspects whether substantial or procedural have been implicated in this study and approval was obtained from the Faculty of Medicine, Ethical Committee of Cairo University (30-9-2012).

 

Patients were then randomly divided into two different groups. Group I (the control group) included eleven patients with eleven chronic leg ulcers in whom ulcers were treated with conventional wound dressings that were changed daily for 8 weeks. Group II (the study group) included 14 patients with 14 chronic leg ulcers. The AM was placed in contact with the ulcer and held in place with a secondary dressing, which was changed daily. Inclusion criteria were presence of leg ulcers for more than 3 months with no improvement despite standard treatment and age between 26 and 43 years. Exclusion criteria were ulcers with ongoing active infection and presence of diabetes. Full history taking and clinical assessment were done with special reference to previous treatment and surgery, diagnosed diabetes and/or hypertension, causes, types, and duration of ulcers present.

 

The follow-up during treatment period includes assessment of ulcer healing and pain. Ulcer healing was assessed using the percentage of the healed wound area and healing rate. Using ImageJ program (Rasband, W.S., ImageJ, US National Institutes of Health, Bethesda, Maryland, USA), the wound areas were analyzed and a percentage of the healed wound area was calculated, in respect to the original wound area and the final wound area after 2 weeks and at the end of 2 months according to the formula:

 

Percentage of healed wound area=Original wound areaFinal wound areaOriginal wound area×100
The healing rate was then determined, in respect to the original wound area, and the final wound area reached according to the formula:
Healing rate=Original wound area-Final wound areaTime cons uumed to reach final wound area

The wound area is calculated by the formula for determining the area of an ellipse ((length × width) × π/4). Results of measured ulcer area size were used for follow-up, and ulcers were categorized with respect to surface area, exudate, and type of wound tissue. A comparison of total measurements over time provided an indicator of improvement or deterioration in ulcer healing. Pain was assessed using a visual analog scale, where 0 represented no pain and 10 represented the worst pain. Each patient has a special file in which all the data were present. Then, merging of data of all patients was done before statistical analysis.

AM isolation, preservation, grafting, and follow-up of patients

Human AM was prepared from placentae obtained from scheduled delivery by cesarean section following a noncomplicated pregnancy. Exclusion criteria were symptoms of infection in the newborn, delivery before 34 weeks gestation, and membrane rupture more than 12 hours before delivery. The donors gave written informed consent for the donation and use of the AM. One placenta can provide four to five AM tissue fragments 5 cm in diameter.

 

Preparation was performed in a classified (class D) room with a microbiological safety workstation (class A). The placenta was washed with physiological saline and left in contact with an antibiotic solution in its collection container until preparation within 2 hours of the cesarean delivery. The entire membrane structure was immersed in a sterile packing container. The AM is mixed with antibiotics and antifungal in the container. The AM was then cut into different sizes and AM tissue fragments were obtained (Figure 1). For cryopreservation of AM, a cryoprotective agent was added (Roswell Park Memorial Institute medium [RPMI] and glycerol), and then stored in a temperature of −80°C with each piece of the AM stored in a separate container. Three AM samples are collected for bacteriological examination. The placenta rinse fluid (8–10 mL) was used to inoculate two vials of aerobic and anaerobic organisms for bacteriological testing. The placenta was also prepared for a pathological evaluation. On the day of the cesarean section, test tubes containing blood from the mother were collected for the following serology tests: HIV-1 and -2, Ag p24, HCV, HTLV; syphilis: VDRL-TPHA; and HBV: HBs antigen-HBc antibody. Final validation of the AM was performed after a repeat serology test by testing again the donor woman after 120 days. Before use, the AM can be transported to hospital and stored on dry ice up to 24 hours and conserved up to 2 hours in normal saline at room temperature after thawing before utilization.

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Figure 1

Preparation of amniotic membrane pieces.

The preparation of the ulcers includes cleaning and mechanical debridement with a scalpel. The membrane preservation solution was removed by washing with physiological saline and the membrane was applied directly onto the ulcer bed (Figure 2). The graft was then covered with vaseline dressing (Figure 3). Patients were confined to bed for 2 hours and then allowed to do moderate activity for the next 5 days.

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Figure 2

Amniotic membrane application over two leg ulcers.

Notes: Two leg ulcers in one patient (A); application of amniotic membrane over the leg ulcers (B and C); image of the patient after amniotic membrane grafting (D).

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Figure 3

Vaseline dressing is added over amniotic membrane and then covered with dressing.

 

Notes: Application of vaseline dressing (A and B); application of gauze dressing after vaseline (C); gauze wrapping at the end (D).

 

Follow-up was done to detect healing rate and detection of ulcer size, assessment of pain, and to take ulcer images (days 0, 7, 14, 21, 30, 45, and 60). Statistical analyses of all data were performed with SPSS software version 15.0 for Windows (SPSS Inc, Chicago, IL, USA). A two-sided value of P<0.05 was considered statistically significant for all analyses. Continuous variables are presented as mean ± standard deviation (SD).

Results

Demographic data of the sample

All patients were males between 26 and 43 years. In group I, there were a total of eleven leg ulcers. Age ranged from 26 to 43 years with a mean value 34.45±7.03. Nine ulcers (81.8%) were venous ulcers, while two ulcers (18.2%) were traumatic ulcers. In group II, there were a total number of 14 leg ulcers. Age ranged from 26 to 43 years with a mean value 32.86±6.94. Twelve ulcers (85.7%) were venous ulcers, while two ulcers (14.3%) were traumatic ulcers. All patients of groups I and II were nondiabetics, with no history of smoking, hypertension, or any other medical condition.

Results of the study

Only conventional treatment was performed for the control group. Chronicity of leg ulcers varied from 24 to 60 months. The ulcer area at the beginning of the study was 4.8±0.65 cm2 (mean ± SD). Mean percentage of healing rate was 0%, and all ulcers in this group showed no reduction in their size (Tables 1and ​and 2), and ulcer floor remained the same. Healthy granulations were present in two ulcers (18.2%) and absent in nine ulcers (81.8%). There is no improvement of pain level in the eleven ulcers (Table 3).

Table 1

Chronicity of leg ulcers, reduction in ulcer size with treatment, and healing rate

Parameters of healing Group I Group II
Chronicity of leg ulcer (range) 24–60 months 24–84 months
Chronicity of leg ulcer (mean + SD) 45.82+14.01 months 50.57+16.43 months
Reduction of ulcer size with treatment 0% 100% reduction in size
Reduction of ulcer size with treatment (mean + SD) 0.0+0.0 100.0+0.0
Healing rate cm2/day (range) 0.0–0.0 0.064–2.22
Healing rate cm2/day (mean + SD) 0.0+0.0 0.896±0.646

Abbreviation: SD, standard deviation.

Table 2

Percentage of healed ulcers

Ulcer healing Group I Group II
No healing 11 100% 0 0%
Complete healing 0 0% 14 100%
Incomplete healing 0 0% 0 0%

Notes: Group I included patients without amniotic membrane application; while Group II included patients with amniotic membrane application.

Table 3

Pain level improved or remained the same from day 0 till the end of study

Pain level Group I Group II
No pain 0 0.0% 3 21.4%
Improved 0 0.0% 11 78.6%
The same 11 100% 0 0.0%

In the study group, the AM was directly applied on leg ulcers. This group included 14 leg ulcers. Chronicity of leg ulcers varied from 24 to 84 months. The ulcer area at the start of the study was 5.1±0.48 cm2 (mean ± SD). Results obtained from the study group showed complete healing of 14 ulcers in 14–60 days with a mean of 33.3±14.7; healing rate range was 0.064–2.22 and mean 0.896±0.646 cm2/day with a 100% reduction in ulcer size. Ulcer floor improved in all ulcers. Healthy granulations were present in 13 ulcers (92.9%) and absent in one ulcer (7.1%). Three ulcers (21.4%) were of mild severity (grade 1 ulcers) while eleven ulcers (78.6%) were of moderate severity (grade 2 ulcers). The healing rate was faster in ulcers of mild severity (1.7±0.438 cm2/day) in comparison to ulcers of moderate severity (0.673±0.498 cm2/day). Eleven cases (78.6%) showed improvement in their pain level on a scale from 1 to 10. Three patients had no pain (Tables 1​1–3; Figure 4). AM graft was taken in four cases (28.6%), while AM was not taken in ten cases (71.4%) in the days following the graft application. In these ten cases, the ulcers also showed complete healing on follow-up. Reduction in ulcer size shows significant difference between group I (control group) in comparison to group II (P=0.001) in which we used AM alone.

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Figure 4

Healing of two leg ulcers after amniotic membrane application.

Notes: Two leg ulcers in one patient (A); application of amniotic membrane on the two ulcers (B); reduction in size of both ulcers (C); complete healing of the upper ulcer and 70% reduction in the size of the lower one on follow up (D).

Discussion

Chronic leg ulcers are defined as a defect in the skin, below the level of the knee and above the foot, persisting for 6 weeks or more. A previous study found that ~60%–80% of chronic leg ulcers had a venous component, 10%–30% was associated with arterial insufficiency, and other factors included diabetes mellitus and rheumatoid disease. Arterial and venous insufficiency combined in 10%–20% of cases.

 

Chronic leg ulcers often heal poorly if there is no revascularization. Different lines of treatment are based on optimized local wound care: cleansing, debridement and dressings, compression therapy, and skin grafting. AM graft can be used as placental tissues contain a large quantity of growth factors. Furthermore, AM downregulates transforming growth factor (TGF)-β and its receptor expression by fibroblasts and in doing so it reduces the risk of fibrosis. Therefore, an AM scaffold can modulate the healing of a wound by promoting tissue reconstruction rather than promoting scar tissue formation.

 

AM is a natural scaffold, which is the supporting matrix upon which cells and tissues grow, and so it is considered an important component of tissue repair with multiple clinical applications. In addition, the AM has other biological properties important for tissue repair, including anti-inflammatory, antimicrobial, antifibrosis, antiscarring, and low immunogenicity as previously discussed. AM may thus be regarded as a bio-therapeutic product composed of a single layer of epithelial cells that lie on a basement membrane and of a nonvascular collagenous stroma. These three components give AM its beneficial properties, including antiadhesive effects, bacteriostatic properties, wound protection, pain reduction, and epithelialization effects.

 

The AM epithelial cells reside on the inner layer of the AM, while amniotic mesenchymal stromal cells form the outer layer.

 

Results obtained from our study group showed complete healing of 14 ulcers in 14–60 days with a mean of 33.3±14.7; healing rate range was 0.064–2.22 and mean 0.896±0.646 cm2/day with a 100% reduction in ulcer size. Ulcer floor improved in all ulcers. Healthy granulations were present in 13 ulcers (92.9%) and absent in one ulcer (7.1%). Three ulcers (21.4%) were of mild severity (grade 1 ulcers) while eleven ulcers (78.6%) were of moderate severity (grade 2 ulcers). Eleven cases (78.6%) showed improvement in their pain level on a scale from 1 to 10. AM graft was taken in four cases (28.6%), while AM was not taken in ten cases (71.4%).

 

The current study results were supported by the results of Mermet et al in a prospective pilot study, in which they evaluated the safety, feasibility, and the effects on healing of AM graft in 15 patients with chronic venous leg ulcers. The percentage of granulation tissue increased significantly (from 17% on day 0 to 69% on day 14, P<0.0001), along with a significant decrease of fibrinous slough (from 36% at day 0 to 16% at day 14, P<0.001). There was significant reduction in ulcer size and pain level as well. Also, Alsina-Gibert and Pedregosa-Fauste performed AM transplantation for four refractory vascular ulcers. Complete wound reepithelialization was achieved for one ulcer by week 8; in the other three cases, there was a 50% reduction in size compared to baseline. At week 16, the mean reduction in wound size for the four ulcers was 81.93%. The corresponding reduction in pain intensity was 86.6%. No adverse effects were observed.

 

To our knowledge, this is the first study to prove the possible efficacy of AM in treating nonvascular (traumatic) refractory wounds (two cases in this study) in addition to efficacy in treating vascular refractory ulcers (12 cases in this study) that was shown by previous similar studies. The limitation of this study is the small number that needs further studies to support it.

Conclusion

AM graft can be an ideal choice instead of tissue-engineered skin equivalents to be used in wound healing. In addition to being an excellent scaffold, it has unique biological properties that are important for tissue repair, including anti-inflammatory, antimicrobial, antifibrosis, antiscarring, as well as a reasonable cost and low immunogenicity. Furthermore, presence of its own progenitor cells help in tissue repair.

Recommendations and implications to practice

Further studies should be done to support this study results. Comparing AM with alternative allogeneic or autologous skin substitutes in a randomized study will be worthwhile to determine the best therapeutic option and establish the potential of using AM in the treatment of leg ulcers. Routine preparation and preservation of AM will be of great value in tissue repair programs and implementation of biotherapy especially in developing countries due to its efficacy and low cost.

Footnotes

Disclosure

The authors report no conflicts of interest in this work.

References

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Articles from International Journal of Women’s Health are provided courtesy of Dove Press

Antibacterial nanozymes: Healing chronic wounds with nanochemistry

Chronic infected wounds are often highly problematic for diabetic patients. However, a team of Chinese researchers has now developed a targeted approach to wound healing that makes use of nanomedicine, and their research has been published in the journal Angewandte Chemie. The researchers were able to deactivate wound-infecting bacteria using a solution of nanocapsules that alter the wound environment and unleash reactive oxygen species … read more

The significance of surface pH in chronic wounds

Wound healing is a complex, multifaceted process which is influenced by both intrinsic and extrinsic factors. The pH of the wound can affect many factors including oxygen release, angiogenesis, protease activity, and bacterial toxicity. Chronic non-healing wounds have an elevated alkaline environment. Healing occurs more readily in an acid environment. Current wound bed assessment is dependent on subjective evaluation with few diagnostic instruments available or suited to routine practice. Monitoring surface pH may provide a method of ‘measuring’ the condition of the wound bed and ultimately aid in determining the wound’s response to treatment … read more

Multidisciplinary Approach Best for Managing Chronic Wounds

By Chase Doyle
As the treatment of nonhealing wounds continues to evolve, multidisciplinary care is playing an increasingly important role in the management of complicated patients. During the 2021 virtual American College of Surgeons Clinical Congress, Nicolas J. Mouawad, MD, the chief of vascular and endovascular surgery at McLaren Health Care, in Bay City, Mich., discussed the benefits of multidisciplinary wound care and how to incentivize institutional collaboration.

“Patients with difficult wounds who would often be considered for amputation with a single-specialty approach can now be managed successfully with a multidisciplinary wound team,” he said … read more


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Inexpensive collagen-based dressing could help heal chronic wounds

Currently, many chronic wound dressings incorporate harvested natural biological tissue. Obtaining those tissues from donors – and working them into the material – is typically a very complex process. According to Michigan State University (MSU), this means that such dressings may ultimately cost up to US$1,000 each … Seeking a more affordable alternative, an international team led by MSU’s Asst. Prof. Morteza Mahmoudi has instead looked to collagen, which is the main structural protein in the extracellular matrix of the body’s connective tissues … read more

Bacteria partners with virus to cause chronic wounds

A virus that infects a dangerous bacteria helps it thrive in wounds, according to a study by Stanford researchers. But a vaccine against the virus dramatically cuts the bacteria’s infectivity … A common bacterial pathogen called Pseudomonas aeruginosa produces a virus that substantially increases the pathogen’s ability to infect us, according to a study by investigators at the Stanford University School of Medicine … P. aeruginosa weaponizes its resident virus to exploit the immune system’s distinct responses to bacterial versus viral infections … read more

These Plasma Patches Could Replace Antibiotics to Treat Chronic Wounds

The German company Coldplasmatech is using the weirdest state of matter to fight superbugs and accelerate healing.

 

Star Trek is often credited with inspiring real-life technologies, from wireless gadgets to video conferences. Now, a German company called Coldplasmatech has pioneered a “PlasmaPatch” which, much like Star Trek’s “dermal regenerator,” is designed to disinfect and heal wounds.

 

The device leverages the properties of plasma, the least familiar state of matter to humans, which is normally found in high-energy environments such as stars. Plasma can also be artificially generated at lower temperatures by applying electrical currents to a gas or liquid insulator … read more

A clinical evaluation of manuka honey dressings for chronic wounds

This study reviews the literature on manuka honey and presents the results of an evaluation of Algivon® Plus with 100% medical grade manuka honey with a superabsorbent, secondary (Eclypse®) or foam dressing. Data were collected on the frequency of dressing changes and the products used. Dressing changes were performed by the tissue viability nurse consultant on days 1, 7, 14, 28, 35, 42, 49 and 56. Inpatient dressing assessments were performed twice weekly. Patients discharged to the community were assessed every Monday. The TIME framework was used to assess periwound skin, maceration, dermatitis and inflammation. All wounds were photographed. The volume, colour and odour of exudate were recorded using Likert-type scales and the wound pH was measured. Patient outcomes measured were pain, sleep, exudate odour and impact on quality of life. Following the use of Algivon® Plus, debridement to a clean wound bed generally occurred by day 7, with healing starting from day 14. The pH of the wound tissue was found to relate to the tissue type present. Patients slept for longer and were less affected by exudate and its associated odour as the study progressed. The dressings used were endorsed by best practice and resulted in positive clinical outcomes of healing or progression to healing … read more

neoplas med GmbH: Superiority of cold atmospheric plasmajet therapy in the treatment of

chronic wounds proven by gold-standard trial

 

Comparative clinical trial shows significant improvement in wound closure and infection control based on treatment with the plasmajet kINPen® MED from neoplas med compared to best practice wound care – cost-effectiveness analysis proves high cost-savings by innovative technology

 

GREIFSWALD, Germany and FELDKIRCH, Austria, March 22, 2022 /PRNewswire/ — The results of a randomized controlled trial (RTC) may offer new opportunities for the approximately two million patients with chronic wounds solely in Germany: The innovative cold atmospheric plasmajet (CAP-jet) technology showed significantly more healing progress in chronic wounds in comparison to best practice (BP) modern wound care at two study centers. Within six weeks, 59 percent of all wounds healed completely under cold plasma treatment compared to only 5.1 percent in patients under BP therapy. Time to complete healing was also considerably shorter under CAP-jet treatment, and wound infections were overcome statistically significant more rapid. With a very good tolerability profile, an economic analysis of the study data also showed a cost saving of 65 percent for the dressing material alone compared to the BP group. The study data were recently published in the journal Nature Scientific Reports.

 

Acceleration of wound healing and wound closure proven

In the study conducted by Prim. Univ.-Professor Robert Strohal, head of the Department of Dermatology and Venereology at the Federal Academic Teaching Hospital Feldkirch, the cold plasma procedure of the Greifswald-based company neoplas med GmbH was scientifically examined in wound care. For this purpose, he compared treatment with the CAP-jet kINPen® MED at the Austrian Federal Academic Teaching Hospitals Feldkirch and Bregenz with current best practice treatment in 78 patients with infected and non-infected wounds. ‘This study was the first to investigate the exclusive effect of tissue accessible cold plasma on wound healing and infection control without the use of an additional standard therapy,’ said Prim. Univ.-Prof. Strohal.

 

After treatment with the CAP-jet, the proportion of healthy tissue increased significantly faster than under the BP treatment and the wounds under CAP-jet therapy also healed significantly faster. At the end of the study, the wound area in the CAP group had reduced by 94.7 percent compared to the baseline value, in the comparison group it was only 56.3 percent. CAP also proved superior in terms of infection control. In contrast to BP therapy, all wounds infected at the start of the study showed complete resolution of infection signs. In addition, the signs of infection disappeared significantly faster under cold plasmajet therapy.

 

Patients’ quality of life can improve

Ulrike Sailer, CEO of the company neoplas med GmbH in Greifswald/Germany, explained: ‘The Joint Federal Committee (Gemeinsamer Bundesausschuss, G-BA) as the central decision-making body of the German health care system already recognized last year the potential of cold plasma for the innovative treatment of chronic wounds at our request. Therefore, the G-BA decided to carry out an observational trial for testing with the aim of obtaining health insurance approval. The results of the clinical trial that now have been published clearly demonstrate the superiority of the CAP-jet kINPen® MED compared to BP wound care. These results provide further evidence for the high clinical relevance of the CAP-jet precision technology. At the same time, it represents important news for millions of people who suffer from chronic wounds for years.’

 

Chronic wounds are often associated with high morbidity and considerable impairments in everyday life as well as the patients’ psyche. Faster wound healing and thus a shorter therapy duration by using the plasmajet kINPen® MED can therefore significantly improve the patients’ quality of life. Furthermore, a lower burden by pain during treatment can be observed, and a reduced number of dressing changes can be assumed. Patients confirmed the very good tolerability and even described the treatment as pleasant in the majority of cases.

 

Significant advantage in treatment costs

A cost-effectiveness analysis based on the available study data showed that 21.4 percent fewer physician visits and 34.3 percent fewer dressing changes were necessary in the CAP-jet group compared to BP. The savings alone in dressing material resulted in a cost advantage for CAP-jet therapy of 64.7 percent compared to BP. Previously, average costs of 10,000 € per patient and year were assumed. Ulrike Sailer: ‘Thus, the cold plasmajet kINPen® MED offers not only a more efficient and tolerable technology, but also opens up the opportunity for significantly higher cost-effectiveness in the treatment of chronic wounds.’

 

Further information material can be found under the following link: https://1drv.ms/u/s!Aph6cOwNbPEJgQCIbClSETCZ_lal?e=BvkuGi

 

Background Information:

The study included 78 patients with wounds up to 10 x 20 cm in size and existing for at least 6 weeks. The patients were randomized in a 1:1 ratio into two groups and treated for the study duration of 6 weeks either with the CAP-jet kINPen® MED (30 seconds per cm2 wound area) or suitable wound dressings according to BP wound care. Only one wound per patient was evaluated.

 

With regard to the treatment regime, CAP-jet therapy was administered 3 times in the 1st week in the CAP group, 2 times in the 2nd week and once a week in the following observation period; furthermore, the wounds were covered with gauze and a secondary dressing. In contrast, the BP group was treated with a wound phase-adapted dressing; infected wounds were additionally cleaned with an antiseptic. In both groups, patients with venous ulcers received compression therapy. The primary endpoint of the study was the amount of granulation tissue at the end of the study. In addition, cold plasma effects on wound infection, wound area, healing time, wound pH and exudate volume (wound fluid) as well as local tolerability were investigated.

 

Improvement in wound infection: All 13 wounds infected at baseline in the CAP-jet group showed complete resolution of infection signs without the need for additional antiseptics. In contrast, 4 of the 18 wounds infected at baseline in the BP group showed no improvement despite the use of antiseptics. Furthermore, the signs of infection decreased significantly faster under CAP-jet therapy compared to BP therapy. These data confirm the previously published evidence on the good antimicrobial efficacy of CAP.

 

Cold plasma is a gas containing ionized atoms, ions and electrons that has been shown to disinfect wounds and activate the wound healing process. With its fine jet, the plasmajet kINPen® MED enables highly precise treatment in anatomically and pathologically challenging areas under visual control and without touching, which is not possible with other wound therapies.

 

About neoplas med GmbH

neoplas med GmbH was founded in 2009 as a spin-off of the Leibniz Institute for Plasma Science and Technology e. V. (INP) in Greifswald, Germany. Ulrike Sailer took over the position of managing director at the end of 2019. Based on the INP research into plasma medicine, the emerging company develops innovative products for medical applications. The first product developed on this basis is the CE-marked kINPen® MED atmospheric pressure plasmajet, the first internationally approved and marketed plasmajet for the treatment of chronic wounds and pathogen-induced skin disorders. It is the result of a long-lasting cooperation with the INP institute, the university hospital of Greifswald, Germany, the Charité hospital of Berlin, Germany, and various industrial partners. In July 2021, the Federal Joint Committee, as the central decision-making body in the self-governing health care system, decided on a trial study with the cold plasmajet procedure and thus took an important step towards reimbursement by the health insurance companies.

 

About kINPen® MED

The plasmajet kINPen® MED is the first atmospheric pressure plasmajet to receive CE approval for the treatment of chronic wounds and pathogen-induced skin disorders. The plasmajet applies a physical cold plasma with a temperature of < 40 degrees Celsius with pinpoint precision and without wound contact. Areas with an uneven profile, recesses or cavities can be reached easily and treated evenly. The noble gas argon used for the generation of the plasma provides a controlled atmosphere around the generated plasma beam, thus ensuring a consistent high treatment quality.

 

Press contact

Claudia Kerber
Phone: +49 3834 515 201
Mobile: +49 (0)162 23 770 70
claudia.kerber@neoplas-med.eu
neoplas med GmbH
Walther-Rathenau-Straße 49a, 17489 Greifswald, Germany

Chronic Wounds and Technology Chronic wounds can be notoriously difficult for many clinicians to manage. It is only natural, then, that we are always looking for the newest, most technologically…

Novel Approach to Chronic Wounds


Presentation on self-adaptive technology by Dr. Alex M. Reyzelman, the Co-Director of UCSF Center for Limb Preservation at RANDE 2015, International Wound Care Conference in Czech Republic.

The use of medical grade honey to achieve healing in an older patient with chronic wounds and

complex co-morbidities: a case report
Aging is associated with an increased likelihood of co-morbidity and other factors that are known to delay wound healing (Gosain and DiPetro, 2004; Bonifant and Holloway, 2019). Additionally, aging itself is a risk factor for chronicity as a consequence of changes in the epidermis and dermis. The dermo-epidermal junction becomes flattened, and elasticity of the skin reduces due to morphological changes in collagen and elastin, which predispose the tissue to shear and friction forces (Gosain and DiPetro, 2004; Bonifant and Holloway, 2019). Moreover, the microcirculation and lymphatic drainage of the dermis is decreased with age, and this affects its ability to adapt to injury and clear the wound of pathogens thus inhibiting wound contraction (Gosain and DiPetro, 2004). Older patients, frequently described in the literature as aged 65 years or above, often have multiple comorbidities, such as poor circulation, poor nutritional and hydration status, and the presence of diseases such as diabetes that affect general health (Leung et al, 2018; Wilkinson and Hardman, 2020). These comorbidities can negatively influence the wound healing trajectory, making vigilance during wound management … read more

Odour management for chronic wounds – video

Sylvie Hampton describes the impact a malodorous wound may have on a patient’s quality of life and the mode of action of an activated charcoal dressing, which can be used as part of symptom management … watch

Health Espresso partners with Wounds Canada to change wound care in Canada

Health Espresso, Canada’s upcoming leader in community EHR, partners with best in class, Wounds Canada, to provide an AI powered, digital solution that’s aligned with the government’s target of delivering better, more connected care and improving health equity for patients, especially those in remote communities. The partnership brings Wounds Canada’s best practices, resources and training to front-line practitioners at the point of care coupled with the ability for remote patient monitoring for better outcomes.

 

 

OAKVILLE, ONTARIO (PRWEB) APRIL 13, 2022

When Linda Moss’ father was transferred to a second hospital for rehabilitation following a brain injury neurosurgery, her family only received information about the primary reason for his hospitalization: his neurological progress. Linda Moss and her family didn’t know that their father was suffering from a pressure injury that would eventually cause osteomyelitis. It was only when their father was denied a second surgery due to complications from the pressure injury that the severity of the wound was discovered.

 

Unfortunately, this gap in communication between health-care providers, specialists and patients is far too common in the Canadian health-care system. The complete picture of patients is seldom shared, especially when they are complex or receive care from multiple partners. This leads to a lack of timely wound care and ultimately irreversible complications that can result in amputations or even death in the case of Linda Moss’ father.

 

“Care teams and caregivers are essential together, and the first step in any prevention or further complications with wounds is a communicated Care Plan,” says Linda Moss.

 

A new partnership between national organization Wounds Canada and Medtech company Health Espresso is changing this. This partnership enables front-line clinicians, patients, policymakers, and researchers to digitize a patient’s journey and connect members of allied health teams at the right time to decrease acute and hard-to-heal wounds, reduce hospitalizations and improve patient outcomes. Leveraging this technology will also enable Wounds Canada to establish a Canadian national registry that can inform further research in wound care and provide quick and easy access to Wounds Canada’s validated tools and resources for immediate bedside action by clinicians and help support wound management by patients, especially those living in outlying communities.

 

“Wounds are a serious health complication that impacts the quality of life for patients while having significant economic implications on our health-care system, and the situation has only worsened under the strain of COVID-19. In many cases, hard-to-heal chronic wounds can be avoided or, if detected in the early stages, managed effectively — but we need evidence-based solutions to help us provide the safe, equitable and timely care that patients deserve in home care and across all health-care settings,” says Mariam Botros, CEO of Wounds Canada. “That’s why Wounds Canada is excited to partner with Health Espresso to offer a skin and wound care mobile app that benefits not only patients but also clinicians, researchers and policymakers. With the launch of this digital solution, we’ll be able to improve patient care, reduce hospitalizations and lower spending on wound care while also increasing the skills and knowledge of front-line clinicians and establishing a Canadian national registry to inform further research.”

 

“As a registered nurse and private wound care consultant in rural southwestern Ontario, providing safe, timely, equitable access to interprofessional, evidence-informed care to people living with wounds can be challenging,” adds Crystal McCallum, Director of Education with Wounds Canada. “The skin and wound care mobile app that Health Espresso is developing in collaboration with Wounds Canada will address these challenges and will prove to reduce the burden of wounds and enhance the experience and outcomes of people living with wounds while enabling better use of health-care resources.”

 

Certified by the Ontario Telehealth Network (OTN) and powered by artificial intelligence, Health Espresso’s easy-to-use mobile and web-based integrative digital solution offers a connected, collaborative approach to wound care. It provides a complete digital blueprint of a patient’s overall health and history, real-time vitals data, recorded notes from hospital visits, administered medication and more for timely, well-informed decision making. Unlike many standalone solutions, Health Espresso’s unique collaborative approach allows for a broader view of the patient’s journey with access to patient records, high-quality wound imaging and analysis tools to track healing progression and understand why a wound may not be healing correctly. It also includes built-in messaging and video tools that enable physicians, wound specialists and patients — especially those in remote or Indigenous communities — to engage in live communication within a secure environment.

 

“Health Espresso’s digital solution is aligned with the government’s target of delivering better, more connected care and improving health equity for patients, especially those in remote communities,” says Founder of Health Espresso Rick Menassa. “To optimize the healing of wounds, care needs to be timely, and a structured, collaborative approach to assessment, treatment, documentation and communication based on best practices is critical for providing patients with the best possible outcomes. We are pleased to partner with Wounds Canada to offer our technology and bring their best practices, resources and training to front-line practitioners at the point of care.”

 

ABOUT HEALTH ESPRESSO
Inspired by front-line experience in home and community care, Health Espresso was created to chronicle the entire patient journey. Starting with a digital patient profile and digital care plan, Health Espresso empowers health organizations to automate intake, triage and update patient records and follow through with post-discharge remote patient monitoring for better health outcomes. Health Espresso provides a collaborative, patient-centred platform for Allied Health professionals, Primary Physicians and Hospitals for a ‘one patient, one care plan’ approach to care, reducing service overlaps and gaps. Its secure, connected platform integrates with EMRs and government data assets for an all-encompassing view of patient records. Health Espresso’s mobile app complements its in-cloud web portal to empower physicians with real-time patient information and virtual care capability for time-sensitive decisions at the point of care, anywhere in the world. For more information, visit https://www.healthespresso.com

 

ABOUT WOUNDS CANADA
Established in 1995, Wounds Canada is a charitable organization dedicated to advancing wound prevention and management for all people in Canada. They advocate for a population health approach that promotes best practices to support persons at risk of or living with wounds, health decision-makers and front-line clinicians. They develop and provide educational programs and resources and support research to advance this holistic, risk-based approach further. Wounds Canada fosters relationships with interested individuals and organizations to expand and sustain a robust wound community in Canada with mutually beneficial global connections. Their goal is to reduce the prevalence and incidence of wounds of all types and the negative consequences they bring—including patient suffering and wasted health-care dollars. To learn more, visit http://www.woundscanada.ca.

 

This article was originally published here

Healogics® Promotes Diabetes Awareness to Improve Healing and Reduce Amputations for Diabetes-Related Wounds

JACKSONVILLE, Fla., Nov. 1, 2022 /PRNewswire/ –As millions of Americans living with diabetes are also living with chronic wounds that won’t heal, Healogics® is raising awareness of diabetes-related wounds as part of the Healogics ninth annual Diabetes Awareness Campaign.

 

Throughout November, Wound Care Centers® will educate the local community about the importance of awareness, early intervention and specialized care for diabetes-related chronic wounds, like diabetic foot ulcers. Local team members will also visit healthcare providers in surrounding areas to provide important information to help at-risk patients living with diabetes.

 

Diabetes Awareness Infographic

Diabetes Awareness Infographic

There are more than 37 million Americans currently living with diabetes, according to the American Diabetes Association (ADA). Additionally, there are 96 million American adults who have prediabetes, leading to 1.4 million new diagnoses of diabetes every year. Diabetes-related wounds are a leading cause of limb loss, accounting for nearly 70 percent of cases undergoing lower extremity amputation in the United States.

 

“This campaign is essential because early detection of diabetes-related wounds significantly reduces amputation risks. Diabetic foot ulcers are the leading cause of diabetes-related hospitalizations and lower-limb amputations. What starts as a small cut or blister can quickly progress into a non-healing wound with severe complications. With 50 percent of our patient population living with diabetes, we know firsthand that our awareness efforts can help improve the lives of those struggling with diabetes-related wounds,” said Healogics Chief Executive Officer Frank Williams.

 

Many suffering from chronic wounds have been negatively affected by the COVID-19 pandemic as they have eschewed needed care during the past two-plus years. Untreated and undertreated wounds have resulted in amputation, according to a study from the ADA. Of the patients who have undergone one amputation, 55 percent will require amputation on the second leg. An amputation results in decreased quality of life, increased medical costs and a significantly higher risk of mortality.

 

“Many people who come to the Wound Care Center® with chronic wounds are among the 37 million adults living with diabetes. Some were unaware that diabetes put them at greater risk for non-healing wounds. Encourage patients to check their feet every day. It’s imperative we help patients avoid the serious consequences of non-healing wounds, such as diabetic foot ulcers, by raising awareness of the risks and importance of daily foot screenings to help prevent an avoidable amputation,” said Healogics Chief Medical Officer Dr. William Ennis.

 

Factors that may increase the risks of developing a chronic wound, such as a diabetic foot ulcer, include high blood sugar levels, poor circulation, immune system issues and nerve damage. Risk factors for diabetes include age, diet, activity level, obesity and heredity.

 

Healogics recommends the following to help prevent diabetic foot ulcers:

 

  • Stop smoking immediately
  • Request comprehensive foot examinations each time you visit your healthcare provider (at least four times a year)
  • Examine your feet every day or have a family member inspect them
  • Take good care of your feet and clean your toenails
  • See your healthcare provider to care for corns and calluses
  • Choose supportive, proper footwear (shoes and socks)
  • Take steps to improve circulation such as eating healthier and exercising regularly

 

Early detection and specialized care from a Wound Care Center® can reduce healing times and significantly reduce the risk of amputation.

 

Contact Healogics to learn more about diabetic foot ulcers or if you have a wound that will not heal. To schedule an appointment, please call 1-800-379-9774 or visit Healogics.com.

 

About Healogics
Headquartered in Jacksonville, Fla., Healogics is the nation’s wound healing expert. Last year over 300,000 patients received advanced wound care through a network of over 600 Wound Care Centers. Healogics also partners with over 300 skilled nursing facilities to care for patients with chronic wounds and provides inpatient consults at more than 60 partner hospitals. As the industry leader, Healogics has the largest repository of chronic wound-specific patient data in the country. The Healogics Wound Science Initiative offers peer-reviewed research and advanced analytics in the pursuit of not only better outcomes, but a better way to provide care.

 

SOURCE Healogics, LLC

 

This article was originally published here

AcryMed’s Oxygenesys for Wound O2 Delivery

AcryMed is touting their latest innovation in wound healing: Dissolved oxygen delivery, via their Oxygenesys system:

 

Our research shows that these new devices deliver significant amounts of dissolved oxygen, which is the biologically relevant form” said Dr. Bruce Gibbins, Founder and Chief Technical Officer at AcryMed. “We conducted studies on human donor skin to show for the first time that through Oxygenesys TDO, sufficient oxygen penetrates deep into tissues to make up for the oxygen deficiency … read more

Keywords:
Oxygen therapy,
OxyGenesys,
AcryMed,
SilvaSorb,
Chronic wounds


AcryMed’s OxyGenesys for Wound O2 Delivery: Where It Stands in 2025

Original Post Date: August 2, 2018

Updated: June 4, 2025

Update Note: This post has been updated in June 2025 to provide the latest insights on OxyGenesys and to introduce NATROX O₂, a modern alternative for topical oxygen therapy in wound care. We’ve added new details to help you stay informed about the best options for managing chronic wounds.

Oxygen is critical for wound healing, playing a key role in cell growth, infection prevention, and reducing inflammation. However, chronic wounds like diabetic foot ulcers or venous leg ulcers often suffer from hypoxia—low oxygen levels due to poor blood flow. This is where topical oxygen therapies (TOT) come in, delivering oxygen directly to the wound to support healing.

Back in 2018, we covered AcryMed’s OxyGenesys, a promising system for wound oxygen delivery. Let’s revisit OxyGenesys, explore its current status, and compare it to a leading alternative, NATROX O₂, which is making waves in 2025.

OxyGenesys: What We Knew in 2018

OxyGenesys was developed by AcryMed, a Beaverton, Oregon-based company focused on wound care innovations. Dr. Bruce Gibbins, AcryMed’s Founder and Chief Technical Officer, shared that OxyGenesys was designed to deliver “significant amounts of dissolved oxygen, which is the biologically relevant form” for wound healing.

AcryMed’s studies on human donor skin showed that OxyGenesys could penetrate deep into tissues, addressing oxygen deficiencies in chronic wounds. This was a big deal because deeper oxygen delivery could potentially accelerate healing, reduce infection risks, and improve outcomes for patients with hard-to-heal wounds.

At the time, OxyGenesys seemed like a game-changer, especially since topical oxygen therapy was gaining traction as a non-invasive way to treat chronic wounds. But what’s happened since then?

OxyGenesys in 2025: Is It Still Available?

Unfortunately, the trail for OxyGenesys goes cold after 2018. AcryMed was acquired by I-Flow Corporation in 2008 for $25 million, with the goal of expanding I-Flow’s wound care offerings. I-Flow was then bought by Kimberly-Clark Healthcare in 2009, which later became part of Owens & Minor.

Employee reviews on Glassdoor suggest AcryMed was shut down after these acquisitions, with the last update from 2015 mentioning its closure. There’s no recent public data on OxyGenesys—no new studies, product listings, or mentions in Owens & Minor’s current portfolio, which now focuses on brands like HALYARD and MediChoice.

A 2025 post on our site referenced an abdominoplasty trial involving OxyGenesys, but the results were inconclusive, showing no significant healing benefits. However, this trial focused on cosmetic surgery wounds, not chronic wounds, which may not align with OxyGenesys’ intended use.

Without updates from Owens & Minor or AcryMed, it’s likely that OxyGenesys is no longer available, possibly discontinued after AcryMed’s closure. If you have information on its current status, we’d love to hear from you in the comments!

A Modern Alternative: NATROX O₂

While OxyGenesys may no longer be an option, topical oxygen therapy remains a vital tool for wound care, and newer technologies have stepped up. One standout is NATROX O₂, developed by Inotec AMD Ltd., which shares OxyGenesys’ goal of delivering oxygen to wounds but with modern advancements and robust clinical evidence as of 2024.

NATROX O₂ is a portable, battery-powered device that provides continuous topical oxygen therapy (cTOT) at a low flow rate of 11ml/hour. It includes an Oxygen Generator that produces pure, humidified oxygen from atmospheric air, and a sterile Oxygen Delivery System with a wheel-shaped design that conforms to the wound, allowing exudate to pass while optimizing oxygen diffusion.

Unlike older systems, NATROX O₂ is silent, lightweight, and designed for 24/7 use, making it practical for both home and clinical settings. It works with most secondary dressings, adding to its versatility.

The evidence for NATROX O₂ is compelling. A 2021 study showed a 71% greater healing rate for chronic wounds like diabetic foot ulcers compared to standard care alone. Patients also reported a 76% reduction in pain, and wounds saw a 73% greater size reduction.

In 2023, the Wound Healing Society gave cTOT a Level 1 evidence rating, and the American Diabetes Association included it in their guidelines for hard-to-heal wounds. NATROX O₂ has been successfully used in over 30 countries, with case studies showing faster healing, lower infection rates, and even limb salvage in severe cases.

Compared to OxyGenesys, NATROX O₂ likely offers a similar focus on sustained oxygen delivery to combat hypoxia, but with the advantage of being actively available and backed by recent data. While OxyGenesys emphasized deep tissue penetration, NATROX O₂’s continuous flow ensures a steady oxygen gradient, which may achieve similar benefits for chronic wound healing.

Why This Matters for Wound Care

Topical oxygen therapies like OxyGenesys and NATROX O₂ address a critical need in wound care: providing oxygen to wounds that traditional treatments can’t heal. If OxyGenesys is no longer available, NATROX O₂ offers a modern, evidence-based alternative that’s accessible today.

For patients, caregivers, and professionals visiting woundcareweekly.com, exploring options like NATROX O₂ can lead to better outcomes for chronic wounds. Interested in learning more about NATROX O₂? Visit their official site for details on how it works and how to access it for your wound care needs [Note: You can insert an affiliate link here if you join a program with NATROX O₂ or a distributor].

Stay tuned to woundcareweekly.com for more updates on wound care innovations.

Healogics aims to educate the community during wound care awareness week

JACKSONVILLE, Fla., June 1, 2022 /PRNewswire/ — Healogics® the nation’s leading provider of world-class wound care, is helping raise awareness of the risks of chronic wounds during the ninth annual Wound Care Awareness Week, June 6-10.

 

Healogics established Wound Care Awareness Month in 2014 to bring attention to the growing need for wound care and the nearly 7 million Americans currently living with chronic wounds. Leaders across the nation are dedicating the entire week to educating physicians, patients and the general public about the prevalence of chronic wounds and the advanced wound care solutions that are available.

 

The incidence of chronic wounds is rising due to our aging population and increasing rates of disease. Various conditions like diabetes, PAD, cardiovascular disease, COPD, and obesity increase the likelihood of a person having a chronic wound. The most common wounds that Americans experience include:

  • Pressure Ulcers (43%)
  • Diabetic Foot Ulcers (31%)
  • Venous Stasis Ulcers (12%)
  • Surgical Wounds or Trauma (8%)
  • Arterial Ulcers (6%)

 

If left untreated, chronic wounds contribute to a diminished quality of life and can lead to complications, such as infection, hospitalization, and even amputation of the affected limb. Even more alarming, more than half of people die within five years of amputation.

 

The effects of the COVID-19 pandemic have brought the amputation risk to the forefront, as many suffering from chronic wounds have not sought needed care during the past two years. The result has been a steep rise in amputations, according to a study from the American Diabetes Association.

 

“The rising rate of amputation continues to drive our education efforts in the community. Wound Care Awareness Month is an opportunity to come together with new resources, tools and educational materials with the goal to improve access to wound care for all who need it,” said David Bassin, Chief Executive Officer.

 

With this in mind, now is the perfect time for those suffering from chronic wounds to seek advanced wound care available at a Healogics Wound Care Center®.

 

“Wound Care Centers continue providing the necessary and important care that patients need through COVID-19. It’s imperative we continue educating the community about the advanced therapies for patients suffering from chronic wounds,” said William Ennis, D.O., Chief Medical Officer. “I celebrate Wound Awareness Week in my community, and I applaud my fellow colleagues who continue to change the lives of the patients we serve.”

 

Visit www.woundcareawareness.com to learn more about Wound Care Awareness Week and hear from patients about how wound healing changed their lives.

 

ABOUT HEALOGICS
Headquartered in Jacksonville, Fla., Healogics, LLC is the nation’s wound healing expert. Last year over 300,000 patients received advanced wound care through a network of over 600 Wound Care Centers. Healogics also partners with over 300 skilled nursing facilities to care for patients with chronic wounds and provides inpatient consults at more than 60 partner hospitals. As the industry leader, Healogics has the largest repository of chronic wound-specific patient data in the country. The Healogics Wound Science Initiative offers peer-reviewed research and advanced analytics in the pursuit of not only better outcomes, but a better way to provide care.

 

This article was originally published here

ECM-Based Therapies Tackle Chronic Inflammation in Hard-to-Heal Wounds

ECM-Based Therapies Tackle Chronic Inflammation in Hard-to-Heal Wounds

An article in *Podiatry Today* (July 2025) from HMP Global explores how extracellular matrix (ECM) therapies can shift chronic wounds—including diabetic foot ulcers and pressure injuries—from a stalled inflammatory state into active healing.

Key Highlights:

  • ECM’s Multifaceted Role: ECM scaffolds help regulate inflammation, support cellular migration and proliferation, guide tissue remodeling, and prevent excessive ECM degradation.
  • Breaking the Inflammation Stall: Chronic wounds often pause in inflammation due to biofilm, cytokine imbalance, and elevated proteases. ECM therapies help rebalance these factors to restart healing.
  • Common ECM Scaffolds: Clinically used acellular matrices include collagen grafts, small intestinal submucosa, amniotic membranes, fetal-derived placental products, and ovine forestomach matrix.
  • Next‑Gen Innovations: Advanced ECMs integrate anti-inflammatory agents, growth factor sequestration (e.g., via heparan sulfate analogues), protease modulation, and nanofiber/microstructure engineering to enhance function.
  • Emerging Evidence: Real-world studies on ECM products—such as porcine placental matrix (InnovaMatrix®) and ovine forestomach matrix (Endoform®, Symphony®)—show promise in diabetic foot and venous ulcer healing.

This review highlights the growing role of ECM therapies in resolving chronic inflammation and reactivating stalled wounds, positioning them as crucial adjuncts in advanced wound-care protocols.

Source: “Targeting Chronic Inflammation: Extracellular Matrix Therapies in Hard-to-Heal Wounds,” *Podiatry Today* (July 2025), via HMP Global Learning Network.

Keywords: extracellular matrix therapy, chronic inflammation, ECM scaffolds, protease modulation, hard-to-heal wounds

Read the full article on HMP Global Learning Network

Beneath the Surface: Approach Chronic Wound Sites ‘Like Real Estate’

Summary: Published March 10, 2026 in Healio Dermatology‘s video interview series Beneath the Surface, Part 1 of a two-part edition on chronic wound management features Joel M. Gelfand, MD, MSCE, FAAD (James J. Leyden Professor of Clinical Investigation at the University of Pennsylvania’s Perelman School of Medicine and Healio Dermatology Chief Medical Editor) in conversation with Robert S. Kirsner, MD, PhD (Chairman and Professor, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine; Director, University of Miami Hospital and Clinics Wound Center; past Vice President of the American Academy of Dermatology). Kirsner frames the interview around a central principle for approaching chronic wound diagnosis: think like a real estate agent — where a wound is located and what surrounds it tells the clinician what to look for first. For lower extremity wounds, he identifies arterial evaluation as by far the most critical diagnostic step, recommending ankle-brachial index (ABI) testing: triphasic, high-amplitude pulse volume recordings indicate normal perfusion; biphasic or monophasic results indicate worsening arterial disease; an ABI below 0.9 is an independent risk factor for myocardial infarction and should prompt referral to vascular medicine or medication adjustment. For wounds overlying bony prominences, osteomyelitis assessment is essential — starting with probe-to-bone testing and imaging (X-ray or MRI), with bone biopsy as the definitive gold standard. For atypical wounds — those in unusual locations, with strange morphology, or failing to respond to standard care — biopsy for both histology and tissue culture is the recommended first diagnostic step to rule out malignancy, unusual infection, or inflammatory etiology. Kirsner notes that once common chronic wound types are diagnosed, initial treatment is relatively straightforward: compression therapy is central for venous leg ulcers with adequate arterial supply; offloading via boot or cast is primary for diabetic foot ulcers and pressure injuries; nutritional assessment and optimisation is essential for all wound types. He highlights fat cell injection as a particularly exciting emerging modality — adipose tissue placed around or below chronic wounds has shown faster healing in recent studies, believed to be due to the regenerative, angiogenic, and immunomodulatory potential of adipose-derived stromal cells. Part 2 of the series covers complex inflammatory wound conditions including pyoderma gangrenosum.

Key Highlights:

  • Core diagnostic principle: approach wound assessment “like real estate” — location of the wound determines the diagnostic priority and guides initial workup for underlying vascular, bone, or tissue pathology
  • ABI testing for lower extremity wounds: triphasic = normal; biphasic/monophasic = worsening arterial disease; ABI <0.9 = independent MI risk factor — warrants vascular medicine referral or pharmacologic intervention
  • Osteomyelitis evaluation: probe-to-bone test + X-ray or MRI for wounds overlying bony prominences; bone biopsy is the gold standard for definitive diagnosis in suspected cases
  • Atypical wounds: biopsy for histology AND tissue culture recommended when location is unusual, morphology is atypical, or wound fails standard treatment — to rule out malignancy, atypical infection, or inflammatory conditions before escalating therapy
  • Initial treatment standards: compression primary for VLUs with adequate arterial supply; offloading (boot or cast) primary for DFUs and pressure injuries; nutritional optimisation essential for all chronic wound types
  • Emerging modality: fat (adipose) cell injection around or below chronic wounds — recent studies show accelerated healing, attributed to regenerative and immunomodulatory properties of adipose-derived stromal cells; Kirsner calls fat “a real source of potential to heal wounds”

Read full article

Keywords: chronic wound diagnosis dermatologyankle brachial index wound carevenous leg ulcer compressiondiabetic foot ulcer offloadingosteomyelitis diabetic foot biopsyfat injection wound healing

Robert S. Kirsner Joel M. Gelfand

Resources

…ultimately healing chronic wounds, and sometimes even acute wounds, can prove to be quite challenging even in the 21st century. Despite the advances in technology and dressings, these wounds continue…

Complications in Chronic Wound Healing and

Associated Interventions

 

Overview of Chronic Wounds
Chronic non-healing wounds affect millions of patients each year and contribute significantly to their morbidity and mortality. These wounds have a substantial impact because of their economic burden and the significant effect on the reduction in quality of life, as well as the increased risk of death for those patients affected by them. A 2014 study of Medicare data showed that chronic non-healing wounds and associated complications affect nearly 15% or 8.2 million Medicare beneficiaries. The study also estimated the cost to treat these wounds at between $28.1 billion and $31.7 billion annually. The highest costs were associated with infected or reopened surgical wounds, and outpatient care had the highest site-of-service costs. In addition to being older, most of these patients have obesity and diabetes. Underlying causes often include diabetic foot ulcers, venous leg ulcers, arterial insufficiency, and pressure ulcers. The list of complications contributing not only to chronicity but also to further deterioration is quite lengthy.

 

Specific Wound Healing Complications and Interventions
The prevalence of chronic wounds and their complications has not been well documented in the literature. However underappreciated they may be, the complications associated with chronic wounds increase the cost—both financial and personal—to the individuals with these wounds.Although not an all-inclusive list, some of the more common complications include infection, tissue necrosis and gangrene, periwound dermatitis, periwound edema, osteomyelitis, hematomas, and dehiscence. Our purpose is to discuss the presentation of each and potential interventions … read more

Jean-Martin Charcot: 200 years after his birth, still a paragon in the diabetic foot

Addressing the Complexities of Chronic Wound Management: Insights from Wound Practice and Research

Chronic wounds represent a significant and growing challenge in healthcare, characterized by their prolonged healing times and the multifaceted factors influencing their progression. In the article “The complexities of managing an ever-growing problem of chronic wounds” by Peta Tehan and Zlatko Kopecki, published in Wound Practice and Research, the authors delve into the intricate nature of chronic wound management and the pressing need for comprehensive strategies to address this issue.

Key Highlights:

  • Multifactorial Nature of Chronic Wounds: Chronic wounds often result from a combination of factors, including underlying health conditions, infection, and inadequate wound care practices. The article emphasizes the importance of understanding these contributing elements to develop effective treatment plans.
  • Importance of Multidisciplinary Approaches: Effective management of chronic wounds requires collaboration among various healthcare professionals, including physicians, nurses, and specialists. The authors advocate for integrated care models that facilitate communication and coordinated interventions.
  • Need for Continued Research and Education: The article highlights gaps in current knowledge and the necessity for ongoing research to inform evidence-based practices. Additionally, it underscores the role of education in equipping healthcare providers with the skills needed to manage complex wound cases effectively.

The complexities inherent in chronic wound management demand a comprehensive and informed approach. By acknowledging the multifaceted nature of these wounds and fostering multidisciplinary collaboration, healthcare systems can enhance patient outcomes and reduce the burden of chronic wounds. Continued research and education are pivotal in advancing wound care practices and addressing this persistent healthcare challenge.

Read the full article on the Journal of Wound Care website.

Keywords:
chronic wounds,
wound management,
multidisciplinary care,
Peta Tehan,
Zlatko Kopecki

Simple and Effective: 2% Citric Acid Ointment for Wound-Bed Preparation in Chronic, Infected Wounds

Simple and Effective: 2% Citric Acid Ointment for Wound-Bed Preparation in Chronic, Infected Wounds

Summary: A case series from India (MIMSR Medical College, Latur) reports on 24 chronic wounds that failed conventional therapy for more than three weeks. Application of 2% citric acid ointment once daily led to healthy granulation tissue in **all cases** (3 to 20 applications), even with antibiotic-resistant bacteria present. The approach offers a low-cost, accessible option for wound bed preparation when standard treatments fall short.

Key Highlights:

  • Wounds included large raw areas and were resistant to standard treatments (various antiseptics, topical antimicrobials) for over three weeks.
  • Cultures identified multiple organisms: most common Staph aureus, Pseudomonas aeruginosa, Escherichia coli, Klebsiella, etc.; many were multidrug resistant.
  • No systemic antibiotics were used unless systemic symptoms (fever, toxemia) present; local citric acid alone controlled infection and induced granulation.
  • Healthy granulation suitable for grafting or continued healing observed in all patients after 3 to 20 topical applications. No local toxicity reported.
  • Authors note limitations including small sample size, observational design, absence of control; however results suggest potent efficacy of citric acid ointment in challenging wounds.

Read the full article in *Wound Management & Prevention*

Keywords:
citric acid ointment,
wound bed preparation,
chronic infected wounds,
MIMSR Medical College,
antibiotic resistant organisms

Omeza Announces New CMS HCPCS Code for Omeza® Collagen Matrix

Studies of Wound Closure Rate with Novel Chronic Wound Treatment Continue

 

SARASOTA, Fla., Oct. 13, 2022 /PRNewswire/ — Omeza today announced that the Centers for Medicare and Medicaid Services (CMS) has confirmed a HCPCS reimbursement code for Omeza® Collagen Matrix; code A2014, “Omeza collagen matrix, per 100 mg” was established to describe the product.

 

Omeza® Collagen Matrix is the first of its kind drug-device combination product, with a simple snap and squeeze application for chronic wounds.

Omeza® Collagen Matrix is the first of its kind drug-device combination product, with a simple snap and squeeze application for chronic wounds. The FDA-cleared drug-device received a Level II Healthcare Common Procedure Coding System (HCPCS) reimbursement code paving the way for providers to receive reimbursement from Medicare.

 

The decision came after application was made to CMS in late 2021. Omeza Chief Commercial Santino Costanza stated, “This decision by CMS opens the doors to Omeza’s innovative treatment line for millions of Americans covered by Medicare who are currently suffering from chronic wounds. Now we look forward to educating commercial payors on the health, financial and humanitarian benefits of a positive reimbursement decision.”

 

Earlier this year the Department of Veterans Affairs Federal Supply Schedule (FSS) Service granted contract status for Omeza® Collagen Matrix. All Omeza products are available to government agencies through Marathon Medical, a prime vendor for the VA.

 

Currently, three US clinical trials are investigating the use of the three-product Omeza treatment product line, which includes Omeza® Collagen Matrix, for documentation of healing rates in venous ulcers, diabetic ulcers, and other chronic wounds. Concurrently, individual case studies submitted by providers testing the Omeza treatment product line on chronic wound closure in their clinical settings report an average percentage area reduction (PAR) of 60% at 4 weeks.

 

Omeza ® Collagen Matrix is indicated for the management of wounds including partial and full-thickness wounds, pressure ulcers, venous ulcers, diabetic ulcers, chronic vascular ulcers, tunneled/undermined wounds, surgical wounds (donor sites/grafts, post-Moh’s surgery, post-laser surgery, podiatric, wound dehiscence), trauma wounds (abrasions, lacerations, superficial partial thickness burns, skin tears) and draining wounds.

 

Omeza ® Collagen Matrix is the first drug/device combination product to deliver an anhydrous 3- dimensional microstructure of collagen to challenging wounds. When applied to a wound surface, the snap and squeeze matrix is naturally incorporated into the wound over time. Omeza® Collagen Matrix is designed for intimate contact with both regular and irregular wound beds, to provide a conducive environment for the patient’s natural wound healing process.

 

About Omeza:

Omeza (www.omeza.com) is a skin science company pursuing equitable access to better wound care outcomes for patients at all sites of care. The company is based in Sarasota, FL USA. Inquiries from medical and health professionals should be directed to info@omezapro.com.

 

SOURCE Omeza LLC

 

This article was originally published here

Fresh hypothermically stored amniotic allograft in …

the treatment of chronic nonhealing ulcers: a prospective case series

 

Introduction Millions suffer from diffcult to heal ulcers worldwide. The incidence of chronic ulcers is increasing rapidly, fueled by an aging population, rising incidence in obesity, diabetes, and venous insuffciency. Diabetic foot ulcers (DFUs), VLUs, and nonhealing postsurgical wounds are among the most frequently encountered ulcers in wound care practice. In the United States, over 4.3 million diabetic patients will develop a DFU in their lifetime, and ~2.5 million individuals suffer from VLUs. DFUs add 1–4 $9–$13 billion to the direct yearly cost associated with diabetes itself. The annual 5 cost of VLUs is $2.5–$3.5 billion. Nonhealing surgical wounds are also commonly 6 seen in wound care clinics. Surgical wounds pose an increased risk for infection and contribute to the growing economic burden of wound care management.

 

In recent years, several clinical trials have been conducted to investigate products derived from human amniotic membranes (HAMs) as adjunctive therapies to accelerate of different layers – the epithelium, basement membrane, and stroma – and these layers further consist of three contiguous but distinct layers – the inner compact layer, the middle fbroblast layer, and the outermost spongy layer. The HAM has been shown to have anti-infammatory, antifbrotic, antiangiogenic as well as antimicrobial properties. Research has confrmed that growth factors present in amniotic membranes can induce angiogenesis and human dermal fbroblast proliferation as well as recruit multiple stem cells relevant to wound repair and regeneration. 9,10

 

A fresh hypothermically stored amniotic allograft (HSAM) may improve healing rates by preserving growth factors and living cells, including stem cells, as well as retaining the membrane’s native structure. HSAM is aseptically processed and stored in a proprietary hypothermic storage solution using the Allofresh™ (Organogenesis, Canton, MA, sisting of topical antimicrobials. His comorbidities consisted USA) process. 13

 

Methods
A case study was conducted to evaluate an HSAM (Organogenesis) in the treatment of chronic wounds. Information was collected on patient demographics, wound type, wound location, age of wound, comorbidities, previous treatments, and current treatments. All patients were informed of study procedures and consented to have their case details and any accompanying photographs published. Digital planimetry (ARANZ Medical, Christchurch, New Zealand) was used ateach visit to record the wound surface area. Previous and current treatments were recorded. Two of the patients presented with VLU and one had a postsurgical wound.

 

The VLU patients had previously received compression, and one patient had also received negative pressure wound therapy. The one with a surgical wound had received a variety of previous therapies, including topical silver, Hydrofera Blue, and topical antibiotics. The age of the wounds for the VLUs were 2–3 weeks, while the surgical wound was 5 months. Comorbidities for the VLUs consisted of venous insuffciency, diabetes, arthritis, osteomyelitis to ulcer location, hypertension, and lymphedema. Comorbidities for the surgical wound patient consisted of arthritis and hypertension. The new treatment regimen consisted of HSAM covered with a knotted cellulose acetate fabric dressing (Adaptic ; Acelity, San Antonio, TX, USA) and appropriate standard of care, including offoading, multilayer compression, and of care, including offoading, multilayer compression, and surgical debridement.

 

Findings
Case 1

A 62-year-old patient presented to the wound clinic with a postop foot wound (nondiabetic), right foot dorsum. The duration of the wound was 5 months, with previous treatments consisting of topical antimicrobials. His comorbidities consisted of arthritis and hypertension. On day 0, the wound area size measured 3.3 cm , with 50% granulation, 10% fbrin, 40% slough, and a moderate amount of light red/pink serosanguineous drainage. Moderate edema was present. A 2.5 cm × 2.5 cm HSAM was applied and fxed in place using Steri-Strips™ (McKesson Medical-Surgical, Londonderry, NH, USA). On day 21, the wound area reduced to 2.9 cm2, a 12.12% reduction. There was an increase in the percentage of granulation tissue as well. By day 42, the wound area size had reduced by 81.82% with 100% granulation, and healed on day 71 (Figure 1).

Figure 1 Case 1 surgical wound.
Note: (A) Day 0, 3.3 cm2 ; (B) day 71, 0 cm2.

Case 2 
A 57-year-old patient presented with a left lower extremity VLU on the medial malleolus. The wound had been present for 8 weeks. The treatment thus far consisted of compression and topical antimicrobials. His past medical history included chronic venous insuffciency, peripheral vascular disease, deep vein thrombosis, and hyperlipidemia. On day 0, the wound area measured 0.3 cm . HSAM (2.5 cm x 2.5 cm) was applied and held in place with Steri-Strips™ ( McKesson Medical-Surgical) and compression wrap. On day 7, the wound was completed closed with no drainage (Figure 2).

Figure 2 Case 2 venous leg ulcer.
Note: (A) Day 0, 0.3 cm2; (B) day 7, 0 cm2.

Case 3
A 70-year-old patient presented with a VLU on the medial right lower extremity. The wound had been present for 2 weeks. The medical history obtained from this patient revealed hypertension, lymphedema, type II diabetes, and chronic venous insuffciency. At the time of HSAM (2.5 cm × 2.5 cm) application, the wound area measured 1.0 cm . By day 7, the wound area was reduced to 0.4 cm , and by day 14, it achieved complete closure (Figure 3).

Figure 3 Case 3 venous leg ulcer.
Note: (A) Day 0, 1.0 cm2; (B) day 14, 0 cm2

Discussion
Prompt treatment of chronic ulcers is essential in preventing complications, reducing the cost of care, and lessening the economic burden on the health care system. In clinical studies, amniotic membranes have been shown to be effective in promoting healing in chronic wounds. Prior products consisted of dehydrated products. We postulated that fresh amniotic membrane would demonstrate even greater effect. Prior to embarking on large expensive clinical trials, we tried the fresh amniotic product on a few selected patients. Results from this study suggested that HSAM may be an effective treatment option for management of VLUs and other non-healing wounds. HSAM offers a new treatment alternative to promote healing in chronic wounds. This membrane contains numerous growth factors and cytokines. These growth factors are found to be released over an extended period and result in increased cellular migration, proliferation, and remodeling. Moreover, HSAM may reduce the long-term costs associated with the care of chronic ulcers by increasing the healing rate and lowering the risk of infection and complications This pilot case series was subsequently used to inform larger DFU and VLU trials that are ongoing at the time of this writing.

 

Original Article – Dovepress

 

AI in Wound Assessment: Transforming Chronic Wound Care

AI in Wound Assessment: Transforming Chronic Wound Care

Artificial intelligence (AI) is revolutionizing wound care by transforming how clinicians assess and manage chronic wounds. By automating measurements, enhancing diagnostic precision, and enabling remote monitoring, AI-powered tools address the shortcomings of traditional manual assessments, which are often subjective, time-consuming, and variable. From smartphone-based imaging to deep learning algorithms, AI delivers data-driven insights that improve treatment planning and patient outcomes for conditions like diabetic ulcers, pressure injuries, and venous leg ulcers. This article delves into AI’s impact on wound assessment, offering wound care professionals a glimpse into a technology poised to redefine clinical practice.

The Need for AI in Wound Assessment

Chronic wounds affect over 6 million Americans, costing healthcare systems billions annually. Accurate assessment is crucial to guide treatments, prevent infections, and accelerate healing. Yet, traditional methods—ruler measurements, visual inspections—rely on clinician experience, leading to inconsistencies. AI overcomes these barriers with standardized, objective analysis. Tools like Healthy.io’s Minuteful for Wound use smartphone cameras with calibration markers to capture high-resolution images, instantly measuring wound dimensions and classifying tissue types (granulation, necrotic, epithelialization). Such automation saves time, reduces errors, and allows clinicians to focus on patient care rather than documentation.

Key Highlights:

  • Automated Precision: AI systems like eKare’s inSight measure wound size and tissue composition with 94% accuracy, outperforming manual methods. Deep learning models, such as U-Net, segment wound areas precisely, ensuring reliable data for clinical decisions.
  • Advanced Diagnostics: AI tools, including Spectral AI’s DeepView SnapShot, predict healing potential and identify infection risks early. These capabilities enable proactive interventions, improving outcomes for complex wounds.
  • Telemedicine Integration: AI apps facilitate remote monitoring, allowing patients to upload wound images for real-time clinician review. This enhances access for rural or bedbound patients, reducing hospital visits.
  • Future Potential: AI could integrate with wearables and predictive analytics to forecast complications like amputations. Research continues to address challenges like limited datasets and tissue segmentation accuracy.

Clinical and Economic Benefits

AI’s precision in wound assessment drives significant clinical and economic advantages. By detecting subtle changes in wound characteristics—such as early signs of infection or delayed healing—AI supports tailored treatments, from selecting optimal dressings to initiating therapies like negative pressure wound therapy. Early intervention reduces infection rates and hospital readmissions, critical given chronic wounds’ $20–$30 billion annual U.S. cost. AI’s telemedicine capabilities also empower patients, improving adherence and satisfaction. For clinicians, AI tools integrate into workflows, enhancing documentation for reimbursement and freeing time for patient interaction. A 2024 review notes AI’s potential to standardize care across settings, from hospitals to home care.

Challenges to Overcome

Despite its promise, AI in wound assessment faces obstacles. Limited public datasets hinder model training, especially for complex tissues like necrotic areas, which vary in appearance. Regulatory approval, such as FDA clearance, is essential for credibility, but not all apps meet these standards. Clinicians must balance AI insights with clinical judgment to account for patient-specific factors, avoiding over-reliance. The PMC review emphasizes the need for robust clinical validation and diverse datasets to ensure AI tools perform reliably across populations, particularly for underrepresented groups.

The Road Ahead

AI’s future in wound assessment is brimming with possibility. Integration with wearables could enable real-time wound monitoring, while predictive analytics might forecast complications weeks in advance. Imagine smart bandages that alert clinicians to infection risks or AI models that personalize treatment plans based on genetic and environmental factors. As research advances, collaboration between developers, clinicians, and regulators will be key to overcoming current limitations. For wound care professionals, adopting AI tools now means staying at the forefront of innovation, delivering precise, patient-centered care that transforms lives.

AI in wound assessment is more than a technological leap—it’s a new era in chronic wound care. By automating assessments, enhancing diagnostics, and bridging access gaps, AI empowers clinicians to achieve better outcomes. Wound care professionals are urged to explore these tools, stay updated on advancements, and integrate AI into their practice to elevate care standards.

Keywords:
AI wound assessment,
Wound care,
Chronic wounds,
Deep learning,
Telemedicine

The Role of Communication in Managing Chronic Lower Limb Wounds

The Role of Communication in Managing Chronic Lower Limb Wounds

Summary: Published in the Journal of Multidisciplinary Healthcare (June 25, 2025), this narrative review by Davide Costa and Raffaele Serra explores how effective communication—between clinicians, and between providers and patients—impacts outcomes in chronic lower limb wound care. The authors examine patient education, health literacy, remote care technologies, interdisciplinary teamwork, and culturally sensitive strategies.

Key Insights:

  • Structured, empathetic provider-patient communication improves adherence, early detection, and supports emotional well-being.
  • Interdisciplinary communication frameworks like SBAR and integrated electronic records reduce errors and improve care coordination.
  • Innovations like telemedicine, mHealth apps, and AI-based chatbots expand access and reinforce patient engagement.
  • Persistent barriers include low health literacy, cultural and language differences, and unequal access to digital tools.
  • Addressing these challenges requires culturally tailored materials, motivational interviewing, digital literacy support, and equitable policy designs.

Conclusion: Communication is not just a clinical tool but a foundational component of chronic wound management—essential for patient adherence, team collaboration, and reducing disparities in care.

🔗 Read the full article


Keywords: chronic wounds, communication, interdisciplinary care, patient adherence, telemedicine, health literacy

Efficacy of continuous topical oxygen therapy in hard-to-heal wounds in Colombia: a retrospective analysis

Continuous Topical Oxygen Therapy Enhances Healing in Chronic Wounds: A Colombian Study

A recent study published in the Journal of Wound Care evaluates the efficacy of continuous topical oxygen therapy (cTOT) in managing hard-to-heal or chronic wounds in Colombia. The research indicates that cTOT may offer significant advantages over traditional treatments in promoting wound healing and reducing associated pain. Read the full article.

Key Highlights:

  • Objective: To assess the effectiveness of cTOT in accelerating the healing process of chronic wounds and alleviating pain in patients.
  • Findings: The study suggests that patients receiving cTOT experienced improved wound healing rates and reduced pain levels compared to those undergoing traditional treatment methods.
  • Clinical Implications: These results support the integration of cTOT into standard wound care practices, particularly for patients with chronic wounds that are resistant to conventional therapies.

This study underscores the potential of cTOT as a valuable tool in the management of chronic wounds, offering benefits in both healing efficacy and patient comfort.

Read the full article on the Journal of Wound Care website.

Keywords:
continuous topical oxygen therapy,
chronic wounds,
wound healing,
pain management,
Colombia wound care

Decision Memo for Hyperbaric Oxygen (HBO) Therapy

     (Section C, Topical Oxygen) (CAG-00060R)

 

The Centers for Medicare & Medicaid Services (CMS) received a reconsideration request to remove the coverage exclusion of Continuous Diffusion of Oxygen Therapy (CDO) from NCD Manual 20.29, Section C. This section of the NCD (Topical Application of Oxygen) considers treatment known as CDO as the application of topical oxygen and nationally non-covers this treatment.

 

After examining the evidence, CMS has decided that no National Coverage Determination is appropriate at this time concerning the use of topical oxygen for the treatment of chronic wounds. We will amend NCD 20.29 by removing Section C, Topical Application of Oxygen and Medicare coverage of topical oxygen for the treatment of chronic wounds will be determined by the local contractors.

Summary:

Chronic wounds are prevalent in the Medicare population and cause a disproportionate burden on beneficiaries and their families and caretakers. CMS recognizes the need for new therapies that will heal wounds and the standardization of wound care in general. Overall, since the evidence on chronic wound healing from topical oxygen therapies has increased over the past few years, CMS believes a national non-coverage decision is no longer appropriate.  CMS received 17 public comments and most of the commenters support this position.  However, given the inability to identify the characteristics of chronic wounds that best respond to topical oxygen therapy and the type of patients’ best suited to use this therapy, we are not able to define a patient population that would benefit from topical oxygen therapy in a national coverage determination at the present time.  Ongoing research in the US and Europe and pending publications may provide additional evidence that may support a national determination in the future.  CMS realizes that double blinded RCTs cannot always be used in order to answer questions regarding the outcomes of exposure to various treatment regimens in the wound care space. However we acknowledge that various investigative groups have, and are currently, studying the treatment of chronic wounds by TOT through randomized controlled trials.  CMS reviewed a number of articles from commenters, considered all additional information and has determined to finalize the proposed decision.

 

Conclusion

The Centers for Medicare & Medicaid Services (CMS) received a reconsideration request to remove the coverage exclusion of Continuous Diffusion of Oxygen Therapy (CDO) from NCD Manual 20.29, Section C. This section of the NCD (Topical Application of Oxygen) considers treatment known as CDO as the application of topical oxygen and nationally non-covers this treatment.

 

After examining the evidence, CMS has decided that no National Coverage Determination is appropriate at this time concerning the use of topical oxygen for the treatment of chronic wounds. We will amend NCD 20.29 by removing Section C, Topical Application of Oxygen and Medicare coverage of topical oxygen for the treatment of chronic wounds will be determined by the local contractors.

read more

 

StrataGRT–A Breakthrough in Treatment on Chronic and Hard-to-Treat Wounds | video

Transcript: Hello, my name is Dr Matthew Regulski. I’m the medical director for the wound Institute of ocean County, New Jersey, and senior partner at Ocean County Foot & Ankle Surgical Associates … I want to bring to your attention today about a new fast filming, forming silicone that I think has made significant progress in the treatment of both chronic and acute wounds. I’ve been in practice for 17 years and I treat chronic wounds of all types. This has made a substantial impact on the treatment of very hard-to-heal chronic wounds … watch

Phytotherapy for Chronic Wound Management in the Era of Antibiotic Resistance

Phytotherapy for Chronic Wound Management in the Era of Antibiotic Resistance

Summary: This literature review explores the potential of plant-derived compounds (phytocompounds) in managing chronic wounds, particularly in the context of rising antimicrobial resistance (AMR) and biofilm-associated infections. Chronic wounds often stall in the inflammatory phase, complicated by polymicrobial biofilms that protect pathogens and resist antibiotics. Phytotherapy offers biocompatible, low-toxicity, and cost-effective alternatives with antimicrobial, antibiofilm, and wound-healing properties. Compounds such as flavonoids, terpenoids, alkaloids, tannic acid, coumarin, resveratrol, berberine, and curcumin show promise in reducing oxidative stress, promoting clotting, stimulating collagen synthesis, and combating infections. Combining natural agents with conventional therapies could enhance outcomes and reduce reliance on resistant antibiotics.

Key Highlights:

  • Background: Chronic wounds are characterized by impaired healing, prolonged inflammation, and frequent biofilm-driven infections. AMR limits the effectiveness of antibiotics, underscoring the need for novel strategies.
  • Mechanisms: Phytocompounds disrupt quorum sensing, suppress virulence factors, reduce oxidative stress, and stimulate angiogenesis and fibroblast activity. They enhance all four healing phases: hemostasis, inflammation, proliferation, and remodeling.
  • Examples:
    • Coumarin: reduces oxidative stress, stabilizes clotting, improves perfusion.
    • Tannic acid: promotes coagulation, wound contraction, and capillary growth.
    • Curcumin: modulates growth factors, reduces oxidative stress, enhances collagen synthesis.
    • Resveratrol: anti-inflammatory, reduces cytokine activity, supports angiogenesis.
    • Berberine: antimicrobial and vascular-stabilizing effects.
  • Clinical potential: Phytocompounds offer synergy with conventional care, biocompatibility, and lower costs. Their antioxidant and antimicrobial effects make them attractive for integration into wound care regimens.
  • Limitations: Evidence remains largely preclinical or early clinical. More controlled trials are required to standardize dosing, delivery, and long-term outcomes.

Read the full article on Wounds (HMP Global Learning Network)

Keywords:
phytotherapy,
chronic wounds,
antimicrobial resistance,
biofilms,
curcumin,
resveratrol,
berberine,
tannic acid,
coumarin

Indian Scientist Develops Advance Wound Dressing Material That Can Treat Diabetic Wounds and Manage Chronic Ones at Competitive Cost

An Indian scientist has developed an advanced wound dressing based on agarose, a natural polymer derived from seaweed agar, for the treatment of infected diabetic wounds and patients suffering from chronic wounds … An Indian scientist has developed an advanced wound dressing based on agarose, a natural polymer derived from seaweed agar, for the treatment of infected diabetic wounds and patients suffering from chronic wounds … read more

Analysis of the Effect of Wound-Edge Microgranular Skin Grafting in the Treatment of Various Small Wounds

Tiannan Chen, Yuesen Lin, Chengshuo Cui, Fangfang Zhang, Tingting Su, Kaiyu Guo, Jialin Hu

 

In recent years, people have paid more and more attention to beauty, and the healing of various small wounds has attracted more and more attention.1 If there is no intervention, only a simple dressing change may end up with a large scar on the affected area, which will affect the function, and at the same time, the infection may become worse or even difficult to heal. Such wounds routinely require surgery such as abdominal embedment, skin grafting or skin flap transfer to avoid aggravation of infection, heal the wound, and restore the function of the affected area. However, patients are generally unwilling to perform such operations, especially in patients with acute and chronic wounds or third-degree burns in various parts of the body. Burns and chronic wounds are independent risk factors affecting wound healing. For patients with burns or chronic wounds complicated with type 2 diabetes, the difficulty of wound healing is greatly increased. How to repair lower limb ulcer wounds in patients with burns or chronic wounds and diabetes has become a clinical challenge. However, because some patients with large-area burns have less autologous skin sources, postoperative wound repair is more difficult,2 or because the physical conditions cannot tolerate anesthesia, when the wound condition … read more

Efficacy of Cellular and/or Tissue-Based Product Applications on all ….

CTP Applications Show Therapeutic Promise Across Multiple Chronic Wound Types

Summary: A retrospective real-world analysis published in Wounds (August 2025) by Carpenter et al. evaluated 446 Medicare-insured chronic wounds—including diabetic foot ulcers, venous leg ulcers, surgical, trauma, and other nonhealing wounds—treated with cellular and/or tissue-based products (CTPs) alongside standard care in non-hospital outpatient, nursing home, and home settings.

Key Findings:

  • All wound types demonstrated significant reductions in mean wound area (P < .001), with large effect sizes—e.g., surgical wounds reduced from ~10.2 cm² to ~1.96 cm² (Cohen d ≈ 1.38); trauma wounds from ~7.2 cm² to ~0.88 cm² (Cohen d ≈ 0.96).
  • Approximately 51% of wounds fully healed within up to 10 CTP applications; healing rates were highest in trauma (≈ 63%) and surgical wounds (≈ 44%), compared to DFU (≈ 41%) and VLU (≈ 32%).
  • The average number of applications among healed wounds ranged from ~4.4 (trauma) to ~6.1 (DFUs).
  • The findings align closely with prior data on DFUs and VLUs, suggesting that CTPs may serve as a broadly effective adjunct in chronic wound care across etiologies.

Read the full research in Wounds

Keywords:
cellular and/or tissue-based products (CTPs),
chronic wounds,
wound area reduction,
real-world evidence,
diabetic foot ulcer,
venous leg ulcer,
surgical wounds,
trauma wounds

Chronic Wound Factors and Management Strategies

What is a chronic wound? What changes must happen within a wound for clinicians to classify it as “chronic”? Is there a time frame for healing chronic wounds? And what should we clinicians do to prevent and/or reverse chronic wounds? These are all great questions that keep us on our toes, from the dedicated seasoned clinician to the clinicians new to our field. In this blog I will define what a chronic wound is, what it consists of, and whether there is a way to convert or reverse a wound.

 

By definition, a chronic wound is a wound that has “failed to proceed through an orderly and timely process to produce anatomical and functional integrity, or proceeded through the repair process without establishing, a sustained anatomic and functional result.”1 In layman’s terms, a chronic wound is a wound that does not proceed through the four phases of wound healing in an orderly fashion and decides to make one too many pit stops through the journey …

read more 

Lunch Bytes Webinars from Wounds Australia

Wounds Australia – Lunch Bytes Webinar Series (Wound Awareness Week)

Summary: During Wound Awareness Week (September 1–7), Wounds Australia is hosting a free “Lunch Bytes” webinar series, offering practical insights for clinicians and consumers on various wound care topics. The sessions feature expert presenters discussing prevention, management, and patient support strategies for complex wound conditions.

  • Monday, 1 SeptemberWhat does Charcot foot mean to you?
    Presented by Dr. Ben Bullen (Monash University). Covers early detection, pathogenesis, management, and health literacy in Charcot foot.
  • Wednesday, 3 SeptemberFrom Acute to Healed: Collaborative Strategies to Prevent Chronic Wounds
    Presented by pharmacist Lara Gliani and RN Melissa Freeman. Focuses on community care strategies for preventing chronic wounds.
  • Thursday, 4 SeptemberLeaky Legs & Lingering Ulcers: Tackling Lymphorrhea & Venous Disease
    Presented by Hayley Ryan (WoundRescue Pty Ltd). Explores pathophysiology and practical strategies for managing lymphorrhea and venous ulcers.
  • Friday, 5 SeptemberEarly Intervention and Recurrence Prevention in Diabetic Foot Ulcers
    Presented by Professor Dr. David Armstrong. Emphasizes the importance of early action, “ulcer remission,” predictive tools, and monitoring.
  • Saturday, 6 SeptemberCaring for Ageing Skin (consumer/carer session)
    Presented by Dr. Robyn Rayner. Offers tips on skin care for older adults, including preventing skin tears and maintaining skin health.

All sessions are available for later viewing via the on-demand archive.

🔗 View the full details on Wounds Australia’s website

Keywords: Wounds Australia, Wound Awareness Week, Charcot foot, chronic wounds, lymphorrhea, venous disease, diabetic foot ulcers, ageing skin

Oxidized Regenerated Cellulose/Collagen Dressings

     Review of Evidence and Recommendations

 

Healthcare systems are being challenged to manage increasing numbers of nonhealing wounds. Wound dressings are one of the first lines of defense in wound management, and numerous options exist. The oxidized regenerated cellulose (ORC)/collagen dressing may offer healthcare providers a robust and cost-effective tool for use in a variety of wounds.

 

Healthcare systems are being challenged to manage increasing numbers of nonhealing wounds. Chronic wounds affect more than 6.5 million people in the United States. This trend has also been observed in other developed countries, such as Denmark (affecting an estimated 1% of the population), Sweden (prevalence: 2.4 per 1000 people), and the United Kingdom (prevalence: 3.55–3.7 per 1000 people). As populations increase and age, the incidence of chronic wounds is also forecasted to increase, further stressing healthcare systems and providers.

 

Wound healing and tissue regeneration are a complicated series of biochemical processes that create an orderly healing cascade with 4 key phases: hemostasis, inflammation, proliferation, and remodeling. If this process becomes unbalanced, healing stalls and results in chronic, nonhealing wounds. Acute wounds progress through healing in a predictable time frame, culminating in an epithelialized wound. Chronic wounds start out as acute wounds and, unless their chronic causes are removed, either fail to progress through the wound healing process and (most often) stall in the inflammatory phase, or proceed through the repair process without establishing a sustained anatomic and functional result … read more

How to Talk to Patients About Their Wounds

How to Talk to Patients About Their Wounds: Tips for Building Trust and Compliance

Summary: Published by Wound Care Professionals on December 2, 2025, this four-minute practice article addresses a frequently underemphasized dimension of wound management: the clinician-patient communication relationship. The piece opens with a striking statistic — research suggests that up to 50% of chronic wound care plans are not followed as prescribed, most commonly because of patient fear, misunderstanding, or insufficient trust in the care team. The author, Nancy Morgan, frames wound care communication not simply as information transfer, but as a two-way dialogue that builds partnership and forms the foundation for long-term compliance. The article outlines five actionable strategies. First, setting a warm and non-judgmental tone early — acknowledging the emotional burden of chronic wounds before diving into clinical details. Second, balancing accessibility with respect: avoiding oversimplification while still translating clinical terminology into plain-language explanations, with visuals of healing stage diagrams recommended where available. Third, involving patients in goal-setting by asking what aspects of the care plan may be difficult to follow in their daily routine — creating shared ownership of the wound care process. Fourth, explaining healing progress honestly and managing expectations around the nonlinear nature of wound repair, including the inflammatory, proliferative, and maturation phases, and using photos or measurements to make progress visible and motivating. Fifth, educating for long-term compliance beyond the immediate wound — including dietary guidance, hygiene, footwear for diabetic patients, and links to community support resources. The article is primarily directed at nurses, therapists, physicians, and home health providers, and is published as part of Wound Care Professionals’ broader educational and certification program portfolio.

Key Highlights:

  • Up to 50% of chronic wound care plans are not followed as prescribed — most commonly due to fear, misunderstanding, or low trust in the care team
  • Five strategies: (1) non-judgmental tone-setting; (2) plain-language explanation without condescension; (3) patient involvement in goal-setting; (4) transparent healing expectation management; (5) long-term compliance education
  • Clinicians advised to validate the emotional impact of wounds before presenting clinical information — particularly important for patients experiencing shame, anxiety, or grief about their wound
  • Wound photographs with patient consent recommended as motivational progress-tracking tools — transforming subjective improvement into visible, measurable progress
  • Long-term compliance framing: wound care as a lifestyle shift requiring ongoing patient education on prevention, nutrition, hygiene, and footwear
  • Applies across all care settings: hospital inpatient, outpatient wound clinic, home health, and long-term care — relevant to any clinician managing chronic or recurring wounds

Read full article

Keywords: wound care patient communicationwound care compliancepatient education wound carechronic wound adherencewound care trust buildingwound care nurse communication

Nancy Morgan

The Prevalence, Aetiology and Healing Trajectories of Hard‐To‐Heal Wounds in South Africa

Hard-to-Heal Wounds in South Africa: Prevalence, Causes & Healing Patterns

Summary: This retrospective study examines the characteristics of 876 wounds in 460 individuals treated at a specialised wound care clinic in Kwazulu-Natal, South Africa. The research reports on prevalence, causes, and healing outcomes for different wound types under appropriate standard care.

Key Findings:

  • Wound Types: Acute/traumatic wounds accounted for 50% of cases. Ulcers made up 38%—including 13% diabetic foot ulcers (DFUs), 12% venous leg ulcers (VLUs), and 11% pressure injuries (PIs). Atypical wounds represented 12%.
  • Hard-to-Heal (HTH) Wounds: Defined as wounds with <40% closure after 4 weeks or requiring >12 weeks of care. These comprised 22% of patients, most commonly associated with diabetes (44%) or infection (43%).
  • Referral Delay: Significant delays were noted—on average 9 weeks for DFUs, 23 weeks for PIs, and 48 weeks for VLUs—before presentation at specialized care.
  • Healing Outcomes: Acute wounds generally healed within 4–5 weeks. Healing rates for chronic wounds varied, with many achieving closure over 4–12 weeks. Among DFUs and PIs, only two-thirds healed within 24 weeks.
  • Amputations: Overall 2%, but higher in DFUs at 15%, mostly occurring before clinic referral.

Conclusion: High prevalence of chronic and HTH wounds, combined with delayed referrals, underscores the need to recognize wound management as a specialty and improve access to advanced care in South Africa.

Read the full study on PMC

Keywords:
hard-to-heal wounds,
diabetic foot ulcers,
venous leg ulcers,
pressure injuries,
South Africa,
healing trajectories,
wound prevalence

Red-Hair Gene Offers New Path for Chronic Wound Healing



Red-Hair Gene Offers New Path for Chronic Wound Healing

Summary: A groundbreaking PNAS study reveals that the melanocortin-1 receptor (MC1R) pathway — best known for red hair pigmentation — is critically impaired in chronic wounds like diabetic foot ulcers (DFUs), venous leg ulcers (VLUs), and pressure ulcers (PIs). The research, using human biopsies and mouse models, shows MC1R dysfunction disrupts the shift from inflammation to tissue repair, leading to prolonged immune cell presence and stalled healing. In mice with functional MC1R (‘black-fur’), topical MC1R agonist cream boosted vascularization, reduced inflammation, and achieved 93% wound closure at 7 days (vs 73% in ‘red-fur’ MC1R-deficient mice). Agonist therapy was ineffective without partial receptor function, suggesting targeted treatments for patients with at least some MC1R activity. This opens doors to novel topical gels/ointments resolving chronic inflammation, potentially transforming care for the 10M+ annual U.S. chronic wounds.

Key Highlights:

  • MC1R Role: Expressed in immune cells, keratinocytes, fibroblasts, vascular cells; variants (red-hair linked) impair POMC-MC1R axis, causing persistent inflammation and poor repair.
  • Human Evidence: Biopsies from chronic wounds show MC1R downregulation vs acute; correlates with stalled granulation.
  • Mouse Model: Functional MC1R + agonist: 93% closure, ↑ vascularization, ↓ immune cells; deficient: only 73%, no agonist benefit.
  • Implications: Topical MC1R activators for patients with partial function; could address 30-50% non-healing rate in DFUs.
  • Future: Preclinical stage; human trials needed; “MC1R may play a more significant role in wound biology than previously understood” — authors.

Read full article

Keywords: MC1R, red hair gene, chronic wound, DFU, inflammation resolution

Expectation Versus Reality in Chronic Wound Care


Expectation Versus Reality in Chronic Wound Care

Summary: Ayman Grada, MD, discusses the disconnect between dermatologists’ skin biology expertise and their limited role (only 7.4% of outpatient chronic wound visits) in chronic wound care. The article covers definitions of chronicity, obesity as a driver, diagnostic workup (ABI, biopsy), ulcer patterns, and the need for dermatologists to increase participation in multidisciplinary care.

Key Highlights:

  • Dermatologists manage just 7.4% of chronic wound visits
  • 4–6 weeks non-healing defines chronic wounds for CMS
  • Obesity as major upstream risk factor
  • Emphasis on vascular assessment, etiology-specific care, and foundational principles before advanced therapies

Read full article

Keywords: chronic wound care dermatology, Ayman Grada, diabetic foot ulcer management

A review of the scientific evidence for biofilms in wounds

Both chronic and acute dermal wounds are susceptible to infection due to sterile loss of the innate barrier function of the skin and dermal appendages, facilitating the development of microbial communities, referred to as biofilms, within the wound environment. Microbial biofilms are implicated in both the infection of wounds and failure of those wounds to heal. The aim of this review is to provide a summary of published papers detailing biofilms in wounds, the effect they have on infection and wound healing, and detailing methods employed for their detection. The studies highlighted within this paper provide evidence that biofilms reside within the chronic wound and represent an important mechanism underlying the observed, delayed healing and infection. The reasons for this include both protease activity and immunological suppression. Furthermore, a lack of responsiveness to an array of antimicrobial agents has been due to the biofilms’ ability to inherently resist antimicrobial agents. It is imperative that effective strategies are developed, tested prospectively, and employed in chronic wounds to support the healing process and to reduce infection rates. It is increasingly apparent that adoption of a biofilm-based management approach to wound care, utilizing the “antibiofilm tool box” of therapies, to kill and prevent reattachment of microorganisms in the biofilm is producing the most positive clinical outcomes and prevention of infection …. full article available for purchase or rent

The Clinical Utility of Autofluorescence Imaging for Bacterial Detection in Wounds: A Systematic Review

Autofluorescence Imaging Enhances Detection of Bacterial Burden in Wounds

A recent study published in Advances in Wound Care investigates the clinical utility of autofluorescence imaging for identifying significant bacterial loads in chronic wounds. The research demonstrates that fluorescence-guided wound care can improve the detection of bacterial burden, leading to more targeted and effective treatment strategies. Read the full article.

Key Highlights:

  • Enhanced Bacterial Detection: Autofluorescence imaging enables clinicians to visualize bacterial presence in wounds by emitting fluorescence signals, allowing for more accurate identification of infection-prone areas.
  • Improved Treatment Outcomes: Utilizing fluorescence-guided assessments can lead to more precise debridement and antimicrobial interventions, potentially accelerating wound healing and reducing complications.
  • Non-Invasive Technique: This imaging method offers a non-invasive approach to assess bacterial burden, minimizing patient discomfort and the need for invasive sampling procedures.
  • Clinical Implications: Incorporating autofluorescence imaging into routine wound assessments may enhance clinical decision-making, optimize treatment plans, and improve overall patient outcomes.

This study underscores the potential of autofluorescence imaging as a valuable tool in the management of chronic wounds, offering a more accurate and patient-friendly method for detecting bacterial infections.

Read the full article on the PubMed Central website.

Keywords:
autofluorescence imaging,
bacterial burden,
chronic wounds,
fluorescence-guided wound care,
non-invasive diagnostics

Biofabrication of ZnO/Malachite nanocomposite and its coating with chitosan to heal infectious wounds

Zahra Rajabloo, Mohammad Reza Farahpour, Parvaneh Saffarian & Saeed Jafarirad

 

Skin wounds cause damage to healthcare systems and loss economic. Wounds are classified as acute and chronic based on the pathogenesis and consequences. Acute wounds induce molecular processes to obtain structural integrity. Immune cells and factors play pivotal roles in acute wound healing3. The faulted regulation of the immune response results in the formation of chronic wounds. Infectious wounds are a form of acute wounds characterized by the presence of bacteria in viable tissue and damage to tissues. The infections start with bacteria colonization and can cause systemic infection. Staphylococcus aureus and Pseudomonas aeruginosa are the most common bacteria in infected wounds. In infected wounds, the wound healing process is delayed. Infected wounds also cause overproduction of reactive oxygen species and induce faults in antioxidant systems … read more

L‐PRF in extra‐oral wound care

Leukocyte‑ and Platelet‑Rich Fibrin (L‑PRF): A Powerful Adjunct for Chronic Wound Healing

An in-depth review (Periodontology 2000, 2024) highlights the therapeutic benefits of leukocyte- and platelet-rich fibrin (L-PRF) membranes for chronic, non-healing wounds—ranging from diabetic foot and venous leg ulcers to pressure injuries and complex surgical wounds.

Key Highlights:

  • What Is L‑PRF? It’s an autologous blood product formed by centrifuging a patient’s blood to create a fibrin matrix packed with platelets and leukocytes—delivering growth factors, antimicrobial activity, and a structural scaffold.
  • Broad Clinical Impact: Weekly L-PRF applications accelerated healing in diabetic foot ulcers, long-standing venous ulcers, pressure injuries, leprosy wounds, and complex tissue defects.
  • Healing Efficacy: L-PRF shortened time to wound closure, improved patient-reported outcomes—such as reduced pain—and decreased reliance on analgesics.
  • Case Successes: Anecdotal cases included complete healing of a chronic diabetic foot ulcer after eight weekly applications, resolution of venous ulcers in three months, and closure of deep wounds with tendon or bone exposure within 7–10 weeks.
  • Mechanisms of Action: L-PRF offers a protective barrier, sustained release of regenerative growth factors, antimicrobial effects, and a three-dimensional matrix that enhances cellular migration and tissue neovascularization.
  • Best-Use Recommendations: The review outlines suggested indications, preparation methods, and application protocols for treating wounds that have stalled under standard therapy.

This review reinforces L‑PRF’s role as a valuable, low-risk, patient-derived tool in regenerative wound care. It offers practical guidance for integrating L‑PRF into clinics striving to close stubborn chronic wounds.

Based on: “Leukocyte- and platelet-rich fibrin (L‑PRF) in extra‑oral wound care: a review of clinical evidence,” Periodontology 2000, 2024.

Keywords: leukocyte‑platelet‑rich fibrin, chronic wounds, diabetic foot ulcer, venous leg ulcer, pressure ulcer

Read the full review on PubMed

A Review of the Current Trends in Chronic Wound and Scar Management

Current Trends in Chronic Wound and Scar Management: A Comprehensive Review

A recent review published in Wound Management & Prevention by Drs. Chantalle Crous, Judey Pretorius, and Anél Petzer offers a detailed examination of contemporary approaches to managing chronic wounds and pathological scars. The article underscores the complexity of these conditions and the necessity for multifaceted treatment strategies. :contentReference[oaicite:5]{index=5}

Key Highlights:

  • Multiphase Healing Process: The review outlines the four overlapping phases of wound healing—hemostasis, inflammation, proliferation, and remodeling—and discusses how disruptions in these phases can lead to chronic wounds.
  • Scar Formation Challenges: It emphasizes that while scar tissue is a natural part of healing, excessive or pathological scarring can cause significant physical and psychological distress, highlighting the need for effective management strategies.
  • Emerging Therapies: The authors discuss various treatment modalities, including advanced dressings, growth factor therapies, and stem cell applications, noting that while these show promise, further research is needed to establish their efficacy and safety.

The review concludes that despite the availability of numerous treatment options, there is no universally accepted gold standard for managing chronic wounds and scars. The authors advocate for continued research into the molecular mechanisms of wound healing and scarring to develop more effective and targeted therapies.:contentReference[oaicite:16]{index=16}

Read the full article on the HMP Global Learning Network website.

Keywords:
chronic wounds,
scar management,
wound healing,
Chantalle Crous,
Judey Pretorius,
Anél Petzer

New combination drug therapy offers hope for treating chronic wound infections

Chronic Wound Infections: New Drug Therapy Hope

Summary: Scientists at the University of Oregon have identified a promising new therapy that combines low-dose chlorate with standard antibiotics to fight chronic wound infections. In laboratory tests against Pseudomonas aeruginosa, a common and stubborn wound pathogen, this combination improved antibacterial effectiveness by as much as 10,000-fold. The discovery could help restore the power of existing antibiotics, reduce treatment time, and minimize side effects for patients struggling with infected chronic wounds.

Key Highlights:

  • New mechanism: Chlorate disrupts bacterial nitrate metabolism in low-oxygen wound environments, making pathogens more susceptible to antibiotics.
  • Improved potency: Antibiotic efficacy increased dramatically, allowing for potential dose reductions.
  • Clinical potential: The approach may shorten treatment duration, improve outcomes, and reduce toxicity in patients with chronic wound infections.
  • Resistance relevance: This method could help combat antibiotic resistance by enhancing the effectiveness of existing drugs.
  • Next steps: Further research and human clinical trials are needed to determine safety, dosage, and real-world effectiveness.

Read the full article on Time.News

Keywords:
Melanie Spero,
University of Oregon,
chlorate,
antibiotic synergy,
Pseudomonas aeruginosa,
chronic wound infection

Vitamin D Supplementation Accelerates Chronic Wound Healing



Vitamin D Supplementation Accelerates Chronic Wound Healing

Summary: This randomized controlled trial evaluated the effects of oral cholecalciferol (vitamin D3) supplementation on serum 25-hydroxyvitamin D (25(OH)D) levels and chronic wound healing in 46 patients with various chronic wounds and vitamin D insufficiency or deficiency (serum 25(OH)D <30 ng/mL). Participants were randomly assigned to an intervention group (n=23) receiving 6000 IU daily cholecalciferol for 5 weeks, followed by dose adjustment, or a control group (n=23) receiving standard wound care, dietary advice, and sunlight exposure guidance. Both groups followed TIME-based wound management. Of 40 completers with 57 wounds, the intervention group showed significantly higher serum 25(OH)D levels at week 5 and improved healing outcomes, including shorter healing time, greater wound area and depth reduction rates, and lower PUSH scores, compared to controls. No adverse effects from supplementation were reported.

Key Highlights:

  • Oral cholecalciferol supplementation at 6000 IU daily significantly increased serum 25(OH)D concentrations in the intervention group (mean 36.75 ± 7.23 ng/mL at week 5) compared to controls (29.58 ± 5.29 ng/mL, P<0.01), reaching sufficiency levels (>30 ng/mL) in most participants.
  • Mean wound healing time was substantially shorter in the intervention group (15.59 ± 6.27 days) versus the control group (26.16 ± 12.70 days, P<0.01), indicating accelerated recovery across various chronic wound types.
  • The intervention group exhibited higher wound area reduction rates (median 100% by week 3) and wound depth reduction rates (median 100% by week 3) compared to controls (100% by weeks 5 and 6, respectively; P<0.05 from weeks 1-6 for area and weeks 3-5 for depth).
  • PUSH scores decreased more rapidly in the intervention group (median 0 by week 3) than in controls (median 0 by week 5; P<0.05 from weeks 3-6), reflecting improved wound tissue, exudate, and overall healing.
  • Supplementation was safe with no reported vitamin D toxicity symptoms, supporting its use as an adjunct to standard TIME-based wound care for patients with vitamin D deficiency.

Read full article

Keywords: oral cholecalciferol, vitamin D deficiency, chronic wound healing, serum 25(OH)D, PUSH score, Hui Zhao, Xiaokun Wu, Haiyan Li

Chronic Wound Management in the Community: Best Practice Approaches for Nurses


Chronic Wound Management in the Community: Best Practice Approaches for Nurses

Summary: This review article examines the evolving role of community nurses in managing chronic wounds (DFUs, VLUs, PIs), emphasizing multidisciplinary team (MDT) collaboration, telehealth integration, and patient-centered care. In the UK, community settings handle 70% of chronic wounds, but outcomes lag (only 50% heal in 12 weeks) due to access barriers and inconsistent training. Best practices include standardized assessment (TIME framework), offloading (TCC for DFUs), and moisture balance (foams/hydrogels); telehealth improved adherence 25%. Calls for expanded training and funding to reduce hospital readmissions by 20%.

Key Highlights:

  • Burden: 2.2M UK adults with chronic wounds; community care 70%.
  • MDT: 30% better healing with podiatry/nutrition input.
  • Telehealth: 25% ↑ adherence; remote monitoring for exudate/infection.
  • Barriers: Access (rural 40% delay), training gaps (50% nurses lack certification).
  • Best Practices: TIME assessment; TCC offloading; silicone foams for pain.

Read full review

Keywords: chronic wound management, community nursing, MDT, telehealth, DFU

Addressing Europe’s Acute Chronic Wound Crisis: A Call to Action



Addressing Europe’s Acute Chronic Wound Crisis: A Call to Action

Summary: This joint industry white paper from the MedTech Europe Wound Care Sector Working Group (endorsed by multiple national associations and welcomed by Mölnlycke) addresses the growing burden of chronic wounds across Europe. It estimates 7.4–14.9 million people affected, with chronic wounds consuming up to 4% of healthcare budgets due to delayed diagnosis, prolonged treatment, preventable complications, and high recurrence rates. The report stresses under-recognition in policy and calls for coordinated action among policymakers, clinicians, payers, patient organizations, and industry. Key recommendations include making wound care a strategic health priority, strengthening education and workforce capacity, aligning reimbursement with value/outcomes, and accelerating innovation with real-world evidence. Aims to transform wound care into a more equitable, sustainable, and patient-centered system.

Key Highlights:

  • Chronic wounds affect millions and strain EU healthcare budgets significantly
  • Under-recognition leads to delayed care and poor outcomes
  • Four priority actions: policy elevation, education, reimbursement reform, innovation scaling
  • Collaborative call involving MedTech Europe and national associations

Read full article / White Paper summary

Keywords: chronic wound crisis, MedTech Europe, wound care policy, Europe wound care

Study of 236 patients reveals utility of MolecuLight i:X® in detection and management of wound-related cellulitis

Published results describe use of point-of-care imaging for the early detection and proactive management of wound-related cellulitis

 

TORONTOOct. 12, 2021 /PRNewswire/ – MolecuLight Inc., the leader in point-of-care fluorescence imaging for real-time detection of wounds containing elevated bacterial loads, announced the publication in International Wound Journalof an independent prospective observational study examining the impact of incorporating fluorescence imaging into standard care for the diagnosis and management of wound-related cellulitis. Dr. Charles Andersen, a surgeon at the Madigan Army Medical Center, led this study on wound-related cellulitis, defined as an invasion of bacteria from chronic wounds into the adjacent dermis.

“The results of this study show how MolecuLight point-of-care imaging presents an intriguing solution to revealing extension of bacteria into tissue, reducing misdiagnosis of wound-associated cellulitis, and enabling more proactive early treatment, particularly in patients lacking obvious symptoms”, says Dr. Charles A. Andersen, Chief, Vascular/ Endovascular and Limb Preservation Surgery Service (Emeritus), Chief Wound Care Service and Medical Director Wound Care Clinic at Madigan Army Medical Center, Tacoma, WA. “Given that at least 30% of cellulitis cases are misdiagnosed,6,5 the addition of consistent and objective information provided by fluorescence scans can significantly reduce the uncertainty associated with diagnosis of wound-related cellulitis. In addition, the use of fluorescence imaging to support earlier detection and proactive management of wound-related cellulitis can limit progression of infection and avoid the need for intravenous antibiotics and the high costs associated with inpatient admission”.

An example case of wound-related cellulitis from the study is shown (above) where the wound does not appear to have cellulitis or elevated bacterial burden upon assessment with standard-of-care clinical signs and symptoms (left). In contrast, when imaged with the MolecuLight i:(right), an irregular pattern of red (bacterial) fluorescence extending beyond the wound bed and periwound is visible, and could not be removed with vigorous cleansing, indicating that the bacteria are located subsurface. This pattern of red fluorescence, demonstrating invasive extension of bacteria into surrounding tissues, was consistent in all wounds in the study where wound-related cellulitis was diagnosed.

Dr. Andersen will present the findings of this publication in a talk titled, “Diagnosis and Treatment of the Invasive Extension of Bacteria (Cellulitis) from Chronic Wounds Utilizing Point-of-Care Fluorescence Imaging at the upcoming clinical conference, SAWC (Symposium on Advanced Wound Care) Fall 2021 on Sunday, October 31, 2021 at 9:00 am at Caesars Palace in Las Vegas, Nevada.

References

1

Andersen, C.A. et al, “Diagnosis and Treatment of the Invasive Extension of Bacteria (Cellulitis) from Chronic Wounds Utilizing Point-of-Care Fluorescence Imaging“, International Wound Journal 2021: 1-13

2

Lazzarini L et al, J Infect. 2005;51(5):383-389.

3

Raff AB et al, JAMA. 2016;316(3): 325-337.

4

Pasternack MS. Mandell, Douglas, & Bennett’s Principles & Practice of Infectious Diseases. Vol 1; Phil., PA: Churchill Livingstone/Elsevier; 2010:1289-1312.

5

Weng QY et al, JAMA Dermatol. 2017;153(2):141-146.

6

Levell NJ et al, Br J Dermatol. 2011;164(6):1326-1328.

About MolecuLight Inc.

MolecuLight Inc., a privately-owned medical imaging company that has developed and is commercializing its proprietary fluorescent imaging platform technology in multiple clinical markets. MolecuLight’s first commercially released device, the MolecuLight i:X fluorescence imaging system and its accessories provide a point-of-care handheld imaging device for the global wound care market for the detection of wounds containing elevated bacterial burden (when used with clinical signs and symptoms) and for digital wound measurement. The company is also commercializing its unique fluorescence imaging platform technology for other markets with globally relevant, unmet needs including food safety, consumer cosmetics and other key industrial markets.

Image:
Download at: https://moleculight.box.com/s/oab22c1vi8ud1j8oymylbfogp2lg12bk

SOURCE MolecuLight

Related Links

www.moleculight.com

When time doesn’t heal all wounds

ASU researcher explores innovative treatment methods for chronic wounds
Many wounds aren’t a big deal — generally, all you need to do is clean them, apply bandages and let them heal. However, chronic wounds that don’t heal on their own affect more than 8 million people in the United States and represent more than $20 billion in management costs each year.

Chronic wounds are exacerbated by infection, obesity, aging and other factors. They also increase the risk of amputation and mortality for people with diabetes, which affects one in 10 Americans, with one in three currently experiencing pre-diabetes … read more


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Optimizing Time With Your Patients: Healing Wounds and Empowering Patients

Through Treatment Selection to Optimize Clinical and Economic Outcomes (webinar)
Date: Thursday, May 12, 2022
Time: 02:00 PM Eastern Daylight Time

 

Ferne Elsass, MSN, RN, CPN, CWON

 

Time is precious. Right now, we are witnessing a growing, aging population with multiple health issues and an increase in chronic wounds. The economic and human costs to treat wounds are high and can quickly spiral out of control. Health care providers are asked to do more with less.

Did you know, 70% of dressing changes are driven by schedules? Unnecessary dressing changes consume valuable time that could be used for patients’ other clinical needs, thus impacting their well-being. A total of 24% of patients with chronic wounds have lived with their wound for at least 6 months, with almost 16% of these wounds remaining unhealed for a year or more. It’s time to take control of chronic wound care while empowering our patients in their care … register

A Precision-Based Approach for Bioactive Skin Allograft Application in Nonhealing Wounds ….



A Precision-Based Approach for Bioactive Skin Allograft Application in Nonhealing Wounds Using Bacterial Fluorescence Imaging

Summary: This case series evaluates the use of bacterial fluorescence imaging (FL-imaging) to guide the application and monitoring of bioactive skin allografts (BSAs) in nonhealing wounds, including diabetic and chronic ulcers. BSAs, a type of cellular/tissue-based product, were applied after wound bed preparation, with FL-imaging used to assess bioburden before, during, and after placement. The study highlights how FL-imaging identified recurrent bioburden that compromised graft viability, leading to a proposed protocol for systematic BSA management.

Key Highlights:

  • FL-imaging confirmed adequate debridement before BSA application but detected bioburden recurrence at the graft perimeter or surface within 3–7 days post-application in multiple cases, compromising graft viability.
  • In Case 1 (diabetic/chronic ankle ulcer in an immunosuppressed patient), persistent bioburden led to graft failure and required additional debridement and treatments, with wound healing achieved via conservative management.
  • Case 2 (venous ankle ulcer) showed successful BSA salvage through targeted excision of colonized graft areas guided by FL-imaging, reducing wound size by 70% over 12 weeks and achieving closure within 6 months.
  • Case 3 (venous ankle ulcer) demonstrated no bioburden on FL-imaging post-BSA application, resulting in a 75.8% wound area reduction over 5.5 months with continued local care.
  • Case 4 (large abdominal wound post-laparotomy) used FL-imaging to guide serial excisions of fluorescent graft areas, achieving an 88% wound size reduction and complete healing in 4.5 months without further BSAs.
  • The study proposes “BSA salvage” as a strategy to preserve viable graft tissue by excising bioburden-affected areas, emphasizing FL-imaging’s role in preventing graft failure and optimizing outcomes in chronic wounds.

Read full article

Keywords: bioactive skin allograft, bacterial fluorescence imaging, nonhealing wounds, bioburden management, diabetic foot ulcers, Jack L Knott, Kathy K Wang, Daniel P deLahunta

Chronic Inhibitory Bacterial Load (CIBL): New Clinical Terminology for Elevated Levels of Bacteria in Wounds that Preclude Healing

 

Findings from a New Clinical Study Using MolecuLight Imaging of Diabetic Foot Ulcers Prompts New Diagnostic Terminology Enabling Proactive Infection Management

 

TORONTO, Feb. 14, 2023 /PRNewswire/ – MolecuLight Inc., the leader in point-of-care fluorescence imaging that locates and detects elevated bacterial loads in and around wounds, announced the publication of “Point-of-care fluorescence imaging reveals extent of bacterial load in diabetic foot ulcers“1 in International Wound Journal. The publication reports on the analysis of 138 diabetic foot ulcer wounds, highlighting the frequent presence of healing delays and elevated bacterial burden as identified through standard clinical assessment, fluorescence imaging (MolecuLight i:X®), and quantitative microbiology.

 

Chronic inhibitory bacterial load (

Chronic inhibitory bacterial load (“CIBL”) on the bacterial-infection continuum. Based on the International Wound Infection Institute (IWII) 2022 wound infection continuum (CNW Group/MolecuLight)

The emergence of data on the link between bacterial load and healing over the last decade, together with this current study, prompted study authors David G. Armstrong, Michael E. Edmonds, and Thomas E. Serena to define new clinical terminology, chronic inhibitory bacterial load (CIBL). CIBL is defined as “the chronic presence of bacterial microorganisms in a wound or its surrounding tissue at loads which can damage tissues and be inhibitory to healing, as well as require clinical intervention, with or without the presence of clinical symptoms”.

 

MolecuLight fluorescence imaging is currently the only way to detect and locate CIBL at the point of care. This term enables the proactive diagnosis of CIBL early along the bacterial-infection continuum, to facilitate its targeted removal, promote healing, and prevent the sequelae of infection in frequently asymptomatic diabetic ulcers.

 

Key findings of the study include:

  • Less than 12% of diabetic ulcers exhibited clinical symptoms of bacteria and infection, despite the presence of loads >104 CFU/g in over 90% (average bacterial load of 108 CFU/g). Even as bacterial loads increased up to >108 CFU/g, detection of clinical signs and symptoms of infection did not increase.
  • Bacterial loads >104 CFU/g can preclude wounds from healing through various biological mechanisms and are contraindicated for many advanced therapies. This study showed that the occurrence of delayed healing increased alongside bacterial load.
  • Fluorescence imaging using MolecuLight increased sensitivity for the detection of CIBL across loads 104–109 (p < .0001), peaking at 92.6% for bacterial loads >10CFU/g. This was 8.3 times superior to standard clinical assessment alone.
  • Fluorescence imaging further showed that 84.2% of ulcers contained high loads in the periwound region, an area that is frequently overlooked.

 

Infection prevention is a key goal of CIBL’s introduction, adoption, and management. CIBL is the result of these seasoned wound care clinicians’ long-time advocacy for proactive wound management as they see firsthand the devastating consequences of delayed treatment. “Infection is the greatest destroyer of the diabetic foot. It is the final common pathway for most amputations, and we need to fight it as early as possible in its natural history”, says Dr. Michael E. Edmonds, one of the paper’s authors and Consultant of Diabetologist at the Diabetic Foot Clinic, King’s College Hospital Foundation Trust in London, UK. “CIBL localization and proactive management is a crucial strategy in reducing unnecessary amputations and saving lives”, he concludes.

 

As MolecuLight is the only device capable of detecting elevated bacterial loads in wounds in real-time, regions of CIBL can be non-invasively and accurately detected and mapped. The device provides clinicians with immediate feedback to guide their therapeutic decision-making process in a number of clinical settings from the outpatient clinic to the operating room. Multiple routine procedures are enhanced by its proven capabilities, such as debridement, wound hygiene, and preparation for advanced therapies resulting not only in better outcomes,3,4 but more rational resource consumption and antimicrobial stewardship.4

 

“There is also a meaningful role for fluorescence imaging with MolecuLight in antimicrobial stewardship. This is critical considering that approximately 70% of patients with diabetic foot ulcers are prescribed antibiotics at some point during their care, and over 80% are prescribed antimicrobial dressings3, often in a haphazard manner”, says Dr. Thomas Serena, study author and the Founder and Medical Director of The SerenaGroup®. “Diagnostic uncertainty has been listed as a key factor in antibiotic overuse in wound care. Fluorescence signals as a real-time imaging biomarker of CIBL could enable clinicians to more effectively leverage hygiene-based strategies to remove bacteria rather than resorting to antibiotics”.

 

“The definition of an infection’s genesis and its resolution is a clinical one”, notes Dr. David G. Armstrong, study author, Professor of Surgery at the University of Southern California, and founder and co-Director of the Southwestern Academic Limb Salvage Alliance (SALSA). “The problem is that many objective local signs may be blunted in the chronic wound and it is likely that we are not yet effectively measuring what we manage. Fluorescence imaging of chronic inhibitory bacterial load (CIBL) is positioned to potentially change contemporary paradigms of wound management. We are hopeful that this new clinical term, CIBL, can be a key indicator to enable pre-infection intervention such as debridement or modification of wound therapy.”

 

The MolecuLight i:X and DX are the only imaging devices for the real-time detection of elevated bacterial burden in wounds that are FDA cleared and CE and Health Canada approved. With clinical evidence including over 65 peer-reviewed publications involving 1,500 patients, they are used by leading wound care facilities globally.

References
1 Armstrong DG, Edmonds ME, Serena TE. Point-of-care fluorescence imaging reveals extent of bacterial load in diabetic foot ulcers. Int Wound J. 2023;20(2):554-566
2 Wounds International (2022) International Consensus Update 2022 International Wound Infection Institute (IWII) Wound Infection in Clinical Practice: Principles of best practice. Available from https://woundinfection-institute.com/
3 Price N. Routine fluorescence imaging to detect wound bacteria reduces antibiotic use and antimicrobial dressing expenditure while improving healing rates: retrospective analysis of 229 foot ulcers. Diagnostics (Basel). 2020;10(11):927.
4 Rahma S, Woods J, Nixon JE, Brown S, Russell DA. The use of point-of-care bacterial autofluorescence imaging in the Management of Diabetic Foot Ulcers: a pilot randomised controlled trial. Diabetes Care. 2022;45:1601-1609.

About MolecuLight Inc.
MolecuLight Inc. is a privately-owned medical imaging company that has developed and is commercializing its proprietary fluorescent imaging platform technology in multiple clinical markets. MolecuLight ‘s suite of commercial devices, which include the MolecuLight i:X® and DX™ fluorescence imaging systems and their accessories, are point-of-care handheld imaging devices for the real-time detection and localization of bacterial load in wounds and digital wound measurement. MolecuLight procedures performed in the United States benefit from an available reimbursement pathway which includes two CPT® codes for physician work to perform “fluorescence imaging for bacterial presence, location, and load” and facility payment for Hospital Outpatient Department (HOPD) and Ambulatory Surgical Center (ASC) settings through an Ambulatory Payment Classification (APC) assignment. The company is also commercializing its unique fluorescence imaging platform technology for other global markets with relevant unmet needs in food safety, consumer cosmetics and other key industrial markets.

 

SOURCE MolecuLight

Lumicell Launches Wound Care Infection and Perfusion Division

WELLESLEY, Mass.–(BUSINESS WIRE)–Lumicell, Inc., a leader in the field of image-guided cancer surgery, today announced that it has created a new division to drive the expansion of its pioneering technologies to include wound care, infection and perfusion.

 

According to a recent study in the Journal of The International Society for Pharmacoeconomics and Outcomes Research, each year in the U.S. there are about 8.2 million patients being treated under Medicare for chronic wounds with an estimated cost between $31.7 to $96.8 billion per year1. With the rising prevalence of obesity-related diseases, such as diabetes, and an aging population – there continues to be a growth in the number of patients suffering from chronic wounds. And with healthcare professionals making care decisions based on the limited, evidence-based knowledge of wounds and requiring patients to make weekly visits to track progress, this upward trend is predicted to continue.

 

“Chronic wounds have a dramatic impact on affected individuals, their families and the U.S. Health Care System, leading to reduced quality of life, limb loss and loss of life at a significant financial cost,” said Robert S. Kirsner, M.D., PhD, FAAD, Director, University of Miami Hospital and Clinics Wound Center. “Unfortunately, wound care is often a largely overlooked medical need compared to other medical challenges like cancer, despite similar effects on loss of life. There is a need for new technologies to assess the state of a wound, integrate this with clinical data, and support the best treatment, for the right patient, at the right time.”

 

“We created our new wound care, infection and perfusion division for the same reason we launched our pioneering cancer technology — we identified a patient population in desperate need and decided to apply our technology and leverage our world-class team to help people suffering from chronic wounds,” said W. David Lee, CSO of Lumicell. “We believe the biggest healthcare engineering breakthroughs happen outside of the biology lab. As such, Lumicell’s new division will use concurrent engineering – the convergence of engineering and biological research – to accelerate the pace of biological discoveries and create new applications to diagnose and treat patients.”

 

“While it will require significant research and development, it will be well worth the effort,” Lee said. “Lumicell has already established the foundational technology for this forward-thinking approach and assembled a small group of advisors to guide the team through the first stages of development. Our goal is to better understand wound healing and on a molecular level and to create an unbiased, holistic protocol that blends Lumicell’s care-leading technology, artificial intelligence and informed care options.”

 

Lumicell also hopes to create a community of wound care experts, including doctors, nurses, researchers and insurance company executives who are interested in providing expertise, evidence, opinions and guidance. This community will curate the statistics, biology and science needed to ensure the infection and profusion detecting technologies and accompanying standard of care protocols are accessible and adopted across disciplines.

 

Samuel R. Nussbaum MD, Marissa J. Carter PhD MA, Caroline E. Fife MD, Joan DaVanzo PhD MSW, Randall Haught, Marcia Nusgart RPh, Donna Cartwright MPA. An Economic Evaluation of the Impact, Cost, and Medicare Policy Implications of Chronic Nonhealing Wounds. Journal of The International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Value in Health 21 (2018) 27-32

 

About Lumicell, Inc.
Lumicell is a technology leader in the field of image-guided cancer surgery. The company is developing a novel system that enables real-time detection of tumor tissue in patients so that no cancer cells are left behind during surgery. The company’s LUM System has unprecedented ability to see and remove cancer cells remaining in the surgical cavity – beyond the margin of the specimen – and has the potential to significantly improve surgical outcomes and reduce healthcare costs by eliminating the need for repeat surgeries. Lumicell is investigating the LUM System in patients undergoing surgery for breast cancer, prostate cancer, colorectal, esophageal and pancreatic cancers. Additional future indications are planned to include surgeries for lung, ovarian, and brain cancers. For more information, please visit www.lumicell.com.

Contacts

For Lumicell
Ali Buckneberg, 612-334-5960
ali.buckneberg@wordsatwork.com

press release from BusinessWire

A new approach to understanding the biology of wound healing

Our bodies frequently heal wounds, like a cut or a scrape, on their own. However patients with diabetes, vascular disease, and skin disorders, sometimes have difficulty healing. This can lead to chronic wounds, which can severely impact quality of life. The management of chronic wounds is a major cost to healthcare systems, with the U.S alone spending an estimated 10-20 billion dollars per year. Still, we know very little about why some wounds become chronic, making it hard to develop effective therapeutics to promote healing. New research from Jefferson describes a novel way to sample the cells found at wounds – using discarded wound dressings. This non-invasive approach opens a window into the cellular composition of wounds, and an opportunity to identify characteristics of wounds likely to heal versus those that become chronic, as well as inform the development of targeted therapies … read more

When and how to culture a chronic wound

Chronic wound infections are a significant healthcare burden, contributing to increased morbidity and mortality, prolonged hospitalization, limb loss, and higher medical costs. What’s more, they pose a potential sepsis risk for patients. For wound care providers, the goal is to eliminate the infection before these consequences arise.

 

Most chronic wounds are colonized by polymicrobial aerobic-anaerobic microflora. However, practitioners continue to debate whether wound cultures are relevant. Typically, chronic wounds aren’t cultured unless the patient has signs and symptoms of infection, which vary depending on whether the wound is acute or chronic … read more

Biofilm-Innate Immune Interface: Contribution to Chronic Wound Formation

Delayed wound healing can cause significant issues for immobile and ageing individuals as well as those living with co-morbid conditions such as diabetes, cardiovascular disease, and cancer. These delays increase a patient’s risk for infection and, in severe cases, can result in the formation of chronic, non-healing ulcers (e.g., diabetic foot ulcers, surgical site infections, pressure ulcers and venous leg ulcers). Chronic wounds are very difficult and expensive to treat and there is an urgent need to develop more effective therapeutics that restore healing processes. Sustained innate immune activation and inflammation are common features observed across most chronic wound types. However, the factors driving this activation remain incompletely understood. Emerging evidence suggests that the composition and structure of the wound microbiome may play a central role in driving this dysregulated activation but the cellular and molecular mechanisms underlying these processes require further investigation. In this review, we will discuss the current literature on: 1) how bacterial populations and biofilms contribute to chronic wound formation … read more

When and how to culture a chronic wound

Chronic wound infections are a significant healthcare burden, contributing to increased morbidity and mortality, prolonged hospitalization, limb loss, and higher medical costs. What’s more, they pose a potential sepsis risk for patients. For wound care providers, the goal is to eliminate the infection before these consequences arise … Most chronic wounds are colonized by polymicrobial aerobic-anaerobic microflora. However, practitioners continue to debate whether wound cultures are relevant. Typically, chronic wounds aren’t cultured unless the patient has signs and symptoms of infection, which vary depending on whether the wound is acute or chronic … read more

Closure Rate of Chronic Wound With Sinus Tract Based on Morphological and Pathological Features …


Closure Rate of Chronic Wound With Sinus Tract Based on Morphological and Pathological Features of the Endoscopic Evaluated Sinus Tract

Summary: Original research examining how endoscopic morphology and pathology of sinus tracts relate to closure outcomes in chronic wounds. The cohort showed a high overall closure rate, with morphologically complex tracts less common but clinically meaningful.

Key Highlights:

  • Cohort & design: Prospective endoscopic evaluation of sinus tracts in chronic wounds with standardized follow-up.
  • Key finding: Morphologically complex tracts were relatively infrequent but impacted healing dynamics; overall closure rate reported at ~85%.
  • Clinical utility: Endoscopic tract characterization can guide targeted debridement, irrigation, and closure strategies.

Read the full study in Wounds

Keywords:
sinus tract,
endoscopic evaluation,
chronic wounds,
closure rate

Phytotherapy for Chronic Wound Management in the Era of Antibiotic Resistance



Phytotherapy for Chronic Wound Management in the Era of Antibiotic Resistance

Summary: This literature review examines the potential of phytotherapy—using plant-derived compounds like flavonoids, polyphenols, and alkaloids—as an alternative to antibiotics for managing chronic wounds such as diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) amid rising antimicrobial resistance (AMR) and biofilm challenges. Drawing from preclinical and early clinical studies, it highlights how phytocompounds disrupt bacterial virulence, reduce oxidative stress and inflammation, and enhance hemostasis, proliferation, and remodeling phases of healing via pathways like TGF-β, NF-κB, and MAPK. Cost-effective and biocompatible, these agents show synergy with antibiotics and promise in topical formulations, though larger RCTs are needed for clinical adoption.

Key Highlights:

  • Key phytocompounds: Curcumin (anti-inflammatory, collagen stimulation), quercetin (biofilm inhibition, M2 macrophage polarization), berberine (DNA disruption, vascular regeneration), resveratrol (COX inhibition, neutrophil reduction), and tannic acid (clotting promotion, free radical scavenging).
  • Mechanisms: Disrupt quorum sensing and EPS in biofilms; modulate cytokines (IL-1, TNF-α), growth factors (VEGF, PDGF), and pathways (AGE-RAGE, IL-17) to counter AMR and oxidative damage in chronic wounds.
  • Evidence: In vitro/animal studies show enhanced closure (e.g., quercetin + gentamicin in diabetic mice); clinical potential in bromelain (NexoBrid for debridement) and curcumin hydrogels; synergy against MRSA in combinatorial therapies.
  • Applications to DFUs/VLUs: Promote granulation, angiogenesis, and ECM synthesis; reduce infection risks in high-burden settings, with nanophytosomes improving delivery.
  • Implications: Affordable adjuncts to standard care; limitations include bioavailability issues and need for standardized trials to integrate into wound protocols.

Read full article

Keywords: phytotherapy, antibiotic resistance, chronic wounds, biofilm disruption, phytocompounds, Kajal Rawat, Reema Gabrani

Effects of Oral Cholecalciferol on Chronic Wound Healing in Patients with Vitamin D Insufficiency

Effects of Oral Cholecalciferol on Chronic Wound Healing in Patients with Vitamin D Insufficiency or Deficiency

Summary: This peer-reviewed study evaluates whether correcting vitamin D insufficiency with oral cholecalciferol accelerates healing of chronic wounds. Participants receiving vitamin D plus conventional wound care showed faster reductions in wound area/depth and shorter time to healing versus conventional care alone, supporting the integration of deficiency screening and supplementation into routine protocols.

Key Highlights:

  • Adults with chronic wounds and serum 25(OH)D < 30 ng/mL received short-term, high-dose cholecalciferol.
  • Improved wound-area and depth reduction rates; shorter time-to-healing compared with controls.
  • Findings align with holistic frameworks (e.g., TIME) where systemic factors impact local healing.
  • Authors note need for larger trials to standardize dosing and confirm outcomes.

Read full article

Keywords: vitamin D, cholecalciferol, chronic wounds, 25(OH)D, JMDH, Zhao

Expectation Versus Reality in Chronic Wound Care



Expectation Versus Reality in Chronic Wound Care

Summary: February 2026 commentary examines the disconnect between expectations and realities in chronic wound management. Ideal: Fast healing, complete closure, minimal scarring, low recurrence with standard care. Reality: Influenced by comorbidities (diabetes, vascular disease, malnutrition), biofilm/infection, patient factors (adherence, mobility), and wound chronicity—leading to prolonged treatment, high recurrence (e.g., 70% in VLUs within 1 year), and amputation risks in DFUs. Discusses clinician/patient frustrations from unmet expectations, over-reliance on “miracle” products, and underestimation of systemic issues. Recommends realistic goal-setting (e.g., percentage area reduction, pain control, infection prevention), multidisciplinary teams (wound specialists, vascular, nutrition, podiatry), evidence-based advanced therapies (synthetics, biologics, NPWT), patient education (lifestyle, adherence), and longitudinal monitoring. Emphasizes QoL improvements over perfect closure; calls for better communication to align expectations and reduce burnout/dissatisfaction.

Key Highlights:

  • Gap: Ideal rapid healing vs. real-world slow/recurrent progress.
  • Contributors: Comorbidities, biofilm, non-adherence.
  • Solutions: Realistic goals, multidisciplinary, education.
  • Relevance: Frames expectations for synthetic/innovative therapies in chronic wounds.

Read commentary

Keywords: chronic wound expectations, patient education, multidisciplinary care, recurrence rates

Expectation Versus Reality in Chronic Wound Care



Expectation Versus Reality in Chronic Wound Care

Summary: February 2026 commentary examines the disconnect between expectations and realities in chronic wound management. Ideal: Fast healing, complete closure, minimal scarring, low recurrence with standard care. Reality: Influenced by comorbidities (diabetes, vascular disease, malnutrition), biofilm/infection, patient factors (adherence, mobility), and wound chronicity—leading to prolonged treatment, high recurrence (e.g., 70% in VLUs within 1 year), and amputation risks in DFUs. Discusses clinician/patient frustrations from unmet expectations, over-reliance on “miracle” products, and underestimation of systemic issues. Recommends realistic goal-setting (e.g., percentage area reduction, pain control, infection prevention), multidisciplinary teams (wound specialists, vascular, nutrition, podiatry), evidence-based advanced therapies (synthetics, biologics, NPWT), patient education (lifestyle, adherence), and longitudinal monitoring. Emphasizes QoL improvements over perfect closure; calls for better communication to align expectations and reduce burnout/dissatisfaction.

Key Highlights:

  • Gap: Ideal rapid healing vs. real-world slow/recurrent progress.
  • Contributors: Comorbidities, biofilm, non-adherence.
  • Solutions: Realistic goals, multidisciplinary, education.
  • Relevance: Frames expectations for synthetic/innovative therapies in chronic wounds.

Read commentary

Keywords: chronic wound expectations, patient education, multidisciplinary care, recurrence rates

Using Negative Pressure Wound Therapy With Instillation and Dwell Time to Create a Path …

to Closure for Older Patients With Chronic Wounds: A Retrospective Case Series
BACKGROUND: Chronic podiatric wounds are common causes of morbidity and mortality in older patients. Negative pressure wound therapy with instillation and dwell time (NPWTi-d) has been recommended in wounds with high levels of exudate, contaminated wounds, and wounds in which healing progression has stalled. PURPOSE: This retrospective case series describes the use of NPWTi-d to prepare 4 chronic wounds for closure in older patients with multiple comorbidities. METHODS: Patients (N = 4) ranged in age from 65 to 95 years and had wounds present for at least 90 days. Previous treatments included conventional NPWT and debridement. NPWTi-d consisted of instillation of 10 to 20 mL normal saline, dwell time for 1 minute, followed by 3-hour cycles of -125 mm Hg. Antibiotics were administered as needed. Wounds included a 210-day Wagner grade 3 diabetic foot ulcer (3.2 × 1.8 × 0.3 cm3), a 90-day dehisced wound (9.5 × 2.6 × 0.4 cm3), a 300-day neuropathic ulcer … read more

Silver dressings improve diabetic wound healing without reducing bioburden

Abstract:
Introduction. Silver dressings are widely used in the treatment of chronic wounds to reduce bacterial bioburden. However, little is known about the mechanism of silver ions on the healing process. In this study, a mouse model of wound healing was used to examine the effect of silver dressings in normal and diabetic wounds.

 

METHODS:
Two 5-mm full-thickness wounds were created on the dorsal skin of diabetic BKS.Cg- m+/+Leprdb/J mice (experimental group) and wild type C57BL/6 mice (control group), and treated with either a silver or gauze dressing. Measurement of wound areas by digital planimetry demonstrated faster healing in the silver-treated wounds of both diabetic and control mice.

 

RESULTS:
Quantitative bacterial cultures showed a reduction of bioburden in silver-treated wounds in wild type mice. Unexpectedly, there was no decrease in bioburden in the silver-treated diabetic wounds compared to the control diabetic wounds, despite improved healing in the silver-treated diabetic wounds. Staphylococcus xylosus, a known biofilm producer, was the only bacteria identified in all the wounds. In vitro studies showed S. xylosus produced biofilms faster in higher glucose environments; this may explain the increased bioburden in the wounds in diabetic mice compared to wild type mice.

 

CONCLUSION:
The results demonstrate improved healing and reduced bioburden in normal wounds with silver dressings. In contrast, silver dressings improved healing in diabetic wounds despite no effect on bioburden, suggesting silver may have beneficial effects in addition to its antimicrobial properties.

Original article from The National Library of Medicine (NLM) 

An Electrifying Way To Heal Skin Wounds

Using electricity to treat skin wounds may sound unconventional, but scientists in China and the US have developed a self-powered bandage that accelerated wound healing in rats. The findings are published in the journal ACS Nano. Skin has a remarkable ability to heal itself, but in some people, such as those suffering from diabetes, wounds heal very slowly or not at all. Such patients are thus at risk of chronic pain, infection and scarring. Doctors have explored various approaches to help chronic wounds heal, including bandaging, dressing, exposure to oxygen and growth-factor therapy, but these methods often show limited effectiveness. Meanwhile, as early as the 1960s, researchers have observed that electrical stimulation could help skin wounds heal. However, the equipment for generating an electric field is often large and may require patient hospitalization … Read more

HARTMANN USA and Corstrata Collaborate to Improve Patient Wound Outcomes

Two leading wound industry solutions companies, with a shared passion for improving patient outcomes, are collaborating to improve the way that Home Health and other in-home providers care for patients with chronic wounds.

 

 

SAVANNAH, GA. (PRWEB) OCTOBER 24, 2022

 

HARTMANN USA and Corstrata announce their collaboration to support home health and other in-home providers in caring for wound patients at a time when the incidence of complex chronic wounds is increasing while access to wound care nurse specialists is becoming more challenging. At the core of a successful wound care program is access to both highly effective advanced wound dressings as well as clinical expertise to implement evidence-based treatment protocols and monitor wounds to closure. According to a recent study published by top-50 accounting firm BerryDunn, National Healthcare at Home Best Practices and Future Insights Study, 100% of Home Health Centers of Excellence (those Home Health agencies in the top 10% for quality and patient satisfaction and with a positive financial surplus) have a wound-certified specialist on staff.

 

This collaboration will increase access to Corstrata’s team of virtual board-certified wound nurses (WOC nurses) and HARTMANN’s suite of advanced wound care products to improve clinical and financial outcomes for in-home providers that care for patients with chronic wounds.

 

HARTMANN has been providing advanced wound dressing solutions globally for over 150 years and has evolved with its broad portfolio of high-quality, cost-effective products that provide home health clinicians with a simplified, consistent approach for effectively managing wounds. Corstrata provides virtual wound and ostomy care management nationwide across multiple provider settings, including home health, skilled nursing facilities, hospice, and emerging hospital-at-home solutions companies.

 

According to Jon Procopio, Managing Director of HARTMANN USA, “Patient care is our priority. HARTMANN strives to enable the progression of the wound towards complete healing that patients deserve and strengthen the confidence that healthcare professionals need to provide wound care. We have a nationwide team of dedicated account and customer care representatives specifically trained for consultation, education, and support in offering clinical and business solutions. Now, with Corstrata, we will enhance access to clinical expertise related to wound care through their team of certified WOC nurses.”

 

“The Corstrata team is excited about this important collaboration with HARTMANN to create access to Corstrata’s virtual WOC nurses for customers and the patients they serve. With up to one-third of all home health and hospice patients having a chronic wound, it is critical for clinicians to provide evidence-based care to both prevent and heal wounds,” says Joseph Ebberwein, co-founder and Chief Financial Officer of Corstrata. “At this time when agencies are struggling with critical staffing shortages, including WOC nurses, and increasing financial challenges, having a strong wound program is essential. This collaboration between Corstrata and HARTMANN provides a path to success.”

 

According to Katherine Piette, Corstrata’s CEO, the decision to collaborate with HARTMANN is an easy one. “Our virtual WOC nurses rely on our provider customers having access to highly effective advanced wound dressings to accelerate wound healing and reduce the overall cost of patient care, ” Piette says. “HARTMANN has a unique suite of advanced dressings that are being used by some of the top home health providers in the U.S. with impressive results. We are excited about the opportunity to improve the level of wound care provided for this ever-growing cohort of complex wound patients. Our clients can access clinical support from Corstrata when needed without the cost of hiring their own WOC nurse, a costly and often frustrating proposition. This collaboration will equip providers with turn-key wound solutions that they have been missing in their clinical care delivery at a crucial time in the industry.”

 

About HARTMANN
The HARTMANN GROUP is one of the leading providers of wound treatment and skin integrity solutions around the world. Wound dressings and maintaining healthy skin have been at the heart of HARTMANN from the beginning when we introduced the world’s first antiseptic wound dressing over 150 years ago. Overall, HARTMANN looks at rich legacy. Every day, healthcare professionals and patients rely on HARTMANN brands in the segments of Incontinence Management (e.g. MoliCare®), Wound Care (e.g. Zetuvit®) and Infection Management (e. g. Sterillium®). This is expressed in our brand promise of “Helps. Cares. Protects.” In 2021, the HARTMANN GROUP reported Group sales of EUR 2.3 billion.

 

For the latest information on HARTMANN, follow @HARTMANN_GROUP on Twitter.
To learn more about the HARTMANN GROUP, click here.
To learn more about HARTMANN USA, click here.

 

About Corstrata
Corstrata is a virtual care solution that utilizes technology to provide access to scarce certified wound and ostomy nurses at the patient’s bedside in post-acute provider settings, including home health, hospice, skilled nursing facilities, and emerging hospital-at-home providers. Corstrata’s team of WOC nurses provides consultations with provider staff at the patient’s bedside, either through HIPAA-compliant video or through review of store-and-forward wound images, to improve clinical and financial outcomes for providers.

 

For the latest information on Corstrata, follow @Corstrata on Twitter.
To learn more about Corstrata, click here.

 

This article was originally published here

The US Wound Registry’s Guide to Bias-Free Data in Wound Care



Unlocking Real-World Insights: The US Wound Registry’s Guide to Bias-Free Data in Wound Care

Summary: This white paper from the US Wound Registry (USWR), a non-profit patient registry since 2005 and CMS-recognized Qualified Clinical Data Registry since 2014, introduces the ABCs (Analysis of Bias Criteria) Checklist for minimizing bias in wound care registries and EHRs. It addresses the challenges of chronic wounds affecting 8.2 million Medicare patients at a cost of up to $96.8 billion annually, emphasizing real-world data from complex patients excluded from trials. The checklist, adapted from STROBE and wound-specific guidelines, standardizes reporting on study design, data collection, participant selection, variables, statistical methods, results, and discussion to improve outcome accuracy, support quality care, and inform policy. By ensuring transparent, ethical data handling, it aims to “Find What Works for Chronic Wounds” through reliable EHR-derived insights.

Key Highlights:

  • Prevalence and Costs: Chronic wounds impact 15% of Medicare patients (8.2 million), costing $96.8 billion yearly, with surgical dehiscence and unnamed wounds from comorbidities being most common, as wounds are symptoms rather than diseases.
  • Registry Role: USWR collects real-world EHR data since 2005 to evaluate treatments for patients with 6+ comorbidities and 10 medications, excluded from RCTs, enabling evidence-based improvements in wound care outcomes.
  • Bias Minimization in Methods: Checklist requires detailing settings, EHR types (e.g., certification levels), participant inclusion (e.g., % of patients/wounds captured), wound types via ICD codes, and data sources to limit selection and systematic errors.
  • Variables and Outcomes: Defines outcomes like healing rates (e.g., 1-year timeframe), confounders (e.g., ischemia, amputations), and standard-of-care factors (e.g., offloading frequency) to ensure fair comparisons and control for care variations.
  • Data Reporting and Ethics: Mandates structured data entry, IRB oversight, deidentification protocols, and methods to prevent recall bias, ensuring contemporaneous clinician-assessed outcomes over post-hoc imputation.
  • Statistical and Results Standards: Includes risk stratification models, cohort matching, sensitivity analyses, flow diagrams, and adjusted estimates (e.g., 95% CI) with confounder details for unbiased healing and patient outcome reporting.
  • Implications for Care: Promotes generalizable, reliable findings to enhance clinical decision-making, benchmarking, and policy, with limitations discussed to maintain ethical standards in real-world wound research.

Read full article

Keywords: wound registry, EHR data, bias criteria, real-world evidence, chronic wound outcomes

ADM Hydrogel vs. Alginate Dressings in Chronic Trauma Wounds

New Trial: ADM Hydrogel vs. Alginate Dressings in Chronic Trauma Wounds

A new randomized interventional study (NCT06978569) from the Isfahan University of Medical Sciences is evaluating whether an injectable **acellular dermal matrix (ADM) hydrogel** is more effective than standard **alginate dressings** in promoting healing of chronic traumatic wounds.

Study Design & Objectives:

  • Participants: Approximately 130 adults aged 18–65 with chronic trauma wounds (>3 weeks, 4–20 cm² in size, ≤9 mm deep) without uncontrolled infection.
  • Interventions: One group receives ADM hydrogel applied to the wound bed (post-debridement), while the control group receives standard alginate dressings. Weekly follow-ups over 12 weeks will monitor wound size and progress.
  • Primary Aim: Assess whether ADM hydrogel accelerates wound reduction and improves healing compared to alginate dressings.
  • Endpoints: Wound size reduction over 12 weeks, healing rates, complications, and likely quality-of-life outcomes.

Location: Alzahra Hospital, Isfahan, Iran

Significance: If successful, this trial could introduce a more bioactive topical therapy (ADM hydrogel) for chronic wound management—beyond traditional dressing approaches.

Keywords: ADM hydrogel, alginate dressings, chronic trauma wounds, clinical trial, Isfahan University of Medical Sciences

View study details on ClinicalTrials.gov

Next Science: Products that help treat wounds

Founded by scientist Matthew Myntti, the company develops products to reduce biofilm-based infections, which can be fatal.

As a scientist at Medtronic’s Jacksonville office working on chronic infections, Matthew Myntti said he began to understand the life-threatening nature of chronic wounds, and the infections that come with them.

He left the medical technology company in 2012 to start his own research focused on treating chronic wounds and keeping them from becoming infected … read more

Clinical Experience Depicting Wound Regression Trends with carePATCH: A Case Series

Clinical Experience Depicting Wound Regression Trends with carePATCH: A Case Series

Summary: A case series by Nan E. Hodge, DPM, Corey B. Dahl, PA, Brian B. Liljenquist, DPM, and Eric J. Thomas, DPM, evaluated outcomes when carePATCH — a dehydrated, dual-layer amniotic membrane allograft (ExtremityCare LLC, US) — was added to standard of care (SoC) for hard-to-heal wounds unresponsive to SoC alone. Results demonstrated significant wound regression and positive clinical outcomes across multiple wound types.

Key Highlights:

  • Study objective: Assess whether carePATCH improves outcomes in chronic wounds that failed to reduce ≥50% in surface area after 30 days of SoC treatment.
  • Methods: Data from 13 patients (mean age: 75.1 years) between Nov 2023–Jan 2025 were analyzed. Wounds included venous leg ulcers (n=6), pressure ulcers (n=5), post-surgical wounds (n=1), and venous stasis/arterial wounds (n=1).
  • Application: carePATCH was applied as an adjunct following wound debridement per best practice standards.
  • Results: Median percentage area reduction (PAR) at final application was 77.4%, increasing to 100% at one week post-final application.
  • Statistical significance: Improvement in PAR outcomes was significant (p=0.017 at final application; p=0.003 at one week post-application).
  • Conclusion: carePATCH showed consistent wound regression trends across wound types, supporting its role as a promising adjunct to SoC in managing chronic, non-healing wounds.

Read the full case series in Journal of Wound Care

Keywords:
carePATCH,
amniotic membrane,
chronic wounds,
standard of care,
venous leg ulcer,
pressure ulcer

Enzymatic Debridement Is More Effective than Autolytic for Severe Wounds

Enzymatic Debridement Outperforms Autolytic Methods in Treating Severe Wounds

A recent systematic review published in Dermatology Times highlights the superior efficacy of enzymatic debridement over autolytic methods for managing severe chronic wounds. The analysis encompassed five studies involving 236 patients with conditions such as diabetic foot ulcers, pressure ulcers, venous leg ulcers, and post-traumatic burn wounds. Read the full article.

Key Highlights:

  • Accelerated Wound Healing: Enzymatic debridement achieved a 65% reduction in wound size, compared to 50% with autolytic methods, indicating a statistically significant improvement in healing rates.
  • Enhanced Tissue Regeneration: Patients treated with enzymatic agents exhibited higher rates of granulation tissue formation and epithelialization, leading to quicker wound closure.
  • Higher Complete Healing Rates: Approximately 65% of patients undergoing enzymatic debridement experienced complete healing, versus 50% in the autolytic group.
  • Safety Profile: Both methods were well tolerated, with mild irritation being the most common adverse effect reported in the enzymatic debridement group.
  • Clinical Recommendations: While autolytic debridement remains suitable for non-severe wounds due to its non-invasive nature, enzymatic debridement is recommended for severe wounds requiring faster and more effective tissue removal.

This review underscores the importance of selecting appropriate debridement techniques based on wound severity to optimize healing outcomes and patient care.

Read the full article on the Dermatology Times website.

Keywords:
enzymatic debridement,
autolytic debridement,
chronic wounds,
wound healing,
collagenase

Efficacy and Safety of a Hyaluronic Acid–Containing Cream in the Treatment of Chronic, Venous, or Mixed-Origin Leg Ulcers

A Prospective, Multicenter Randomized Controlled Trial
Topical applications of hyaluronic acid (HA)–containing formulations, based on the complex and vital role of HA in all stages of the wound-healing process, are routinely used with standard therapy to promote faster healing of chronic wounds. However, evidence to guide clinical decisions on the use of topical HA in the healing of vascular leg ulcers is limited. Objective. This study compared the efficacy and safety of topical application of a hyaluronic acid cream vs a neutral comparator (identical cream without HA) in treating subjects with chronic leg ulcers of vascular origin. Materials and Methods. This was a prospective, multicenter double-blind randomized controlled trial. One hundred sixty-eight subjects with chronic leg ulcers of venous or mixed (venous and arterial) origin were randomized to receive either topical applications of 0.2% HA cream or neutral comparator cream for a maximum of 20 weeks. The primary efficacy endpoint was complete ulcer healing (100% reepithelialization of the wound area centrally assessed at 20 weeks or before and confirmed 3 weeks later). In both groups, topical treatment was associated with standard therapy (ulcer cleansing and optimized compression) … read more

Thermal Imaging Offers Early Alert for Chronic Wound Care

New research shows thermal imaging techniques can predict whether a wound needs extra management, offering an early alert system to improve chronic wound care … It is estimated that 1-2% of the population will experience a chronic wound during their lifetime in developed countries. In the U.S., chronic wounds affect about 6.5 million patients with more than $25 billion each year spent by the healthcare system on treating related complications … read more

Thermal imaging offers early alert for chronic wound care

New research shows thermal imaging techniques can predict whether a wound needs extra management, offering an early alert system to improve chronic wound care … It is estimated that 1-2% of the population will experience a chronic wound during their lifetime in developed countries – in the US, chronic wounds affect about 6.5 million patients with more than US$25 billion each year spent by the healthcare system on treating related complications … The Australian study shows textural analysis of thermal images of venous leg ulcers (VLUs) can detect whether a wound needs extra management as early as week two for clients receiving treatment at home … read more

Decreasing Pain and Increasing the Rate of Chronic Wound Closure With the Use of a Noninvasive Bioelectronic Medical Device: A Case Series

Chronic wounds are a source of significant morbidity. Medical and scientific efforts are ongoing to further therapeutic modalities improving pain scores and augmenting healing while decreasing complications and reducing the social and economic burden of wounds. Electrical current therapy, or electrical stimulation (ES), has been shown to decrease and modulate both acute and chronic pain; however, understanding of the role of ES in wound closure is limited. Objective. This single-center case series reports use of a topical ultrahigh frequency ES (UHF-ES) therapy to decrease wound pain and improve the rate of closure in difficult-to-heal wounds in 9 patients. Materials and Methods. Initially, each patient underwent individualized care of their chronic wounds for a minimum of 8 weeks … read more

Nutrition in patients with chronic non-healing ulcers

     a paradigm shift in wound care

 

Chronic ulcers continue to pose a significant clinical and economic burden for both patients and wound care practitioners. Despite good standard of care (SOC), many wounds fail to heal. Wound healing requires a complex cascade of physiologic and immunologic processes as well as proper nutrition. An adequate balance of macro- and micronutrients is important to support the cellular activities that are necessary for repairing and remodeling of tissue. Despite being well documented in a number of clinical studies there continues to be a gap in recognizing nutritional deficits as well as appropriate clinical interventions in patients with chronic wounds. Effective management of malnutrition in patients with chronic wounds requires collaboration among multiple clinical disciplines. A holistic nutritional management approach may yield both clinical and economic benefits … read more

How the Identification of Chronic Wound Infection Can Be Improved With Technology

by Liping Tang

 

Infection is the single most likely cause of delayed healing in chronic wounds. In most cases, identification of chronic wound infection (e.g., diabetic foot ulcers and venous leg ulcers) is not obvious because chronic wounds do not exhibit the same classic inflammatory signs of infection as those found in acute wounds. More arduously, those common signs of infection—pain, erythema, heat, and purulent exudate— vary as we age and occur differently in those with underlying diseases or weakened immune systems. Diagnosis is generally based on the doctors’ experience and could be confirmed with microbiological culture of tissue biopsy. However, culture could take a few days, and the results may not always be reliable because of sampling error. A fast and accurate diagnosis of wound infection would relieve the patient of significant discomfort and improve the treatment outcome … read more

Moving the chronic wound along the healing trajectory

Emilio Galea (from September 2018) 

 

Chronic wounds are an ever-growing challenge for clinicians and represent a huge burden on healthcare resources (Harding, 2002). They have been referred to as a silent epidemic that is affecting a large number of people in the world population (Gottrup, 2004). However, due to a better understanding of what makes a wound chronic, several new treatments that offer better outcomes for the patient and a broader choice for the clinician have been developed (Harding, 2002). A sterile, non-adherent, slough-trapping, poly-absorbent fibre dressing with the technologie lipido-colloïde (TLC) healing matrix to promote wound healing and enable pain-free dressing changes, which can be used for gentle desloughing, has been developed by Urgo. The slough-trapping fibres (poly-absorbent) have been shown to bind and trap the slough within the dressing, providing safe and effective desloughing (Kelly et al, 2013), while the silver lipido-colloid matrix in the antimicrobial version, has been established in its efficacy in the management of chronic wounds presenting with a risk of infection as demonstrated through previous randomised controlled trials … download PDF

Smart wound monitor poised to improve chronic infection care

‘Smart Wound Patch’ Poised to Detect and Prevent Chronic Infection

Researchers at the University of Rhode Island have developed a prototype smart wound patch that detects early signs of infection in chronic wounds—offering a potential game-changer in preventing complications like sepsis or amputation.

The flexible, bandage-like patch uses integrated sensors to monitor biomarkers in wound fluid, including pH and temperature changes. These early shifts often indicate the onset of bacterial infection or delayed healing.

Key Features:

  • Non-invasive, continuous monitoring: The patch uses real-time biosensors to detect wound changes without disturbing the dressing.
  • Wireless data transmission: Results can be sent to a smartphone or clinician dashboard, enabling timely intervention.
  • Early warning capability: By catching inflammatory trends before visible symptoms arise, it may help clinicians avoid more invasive treatments.

The lead researcher, Kunal Mankodiya, PhD, director of the Wearable Biosensing Lab at URI, envisions applications in diabetic foot ulcers, surgical wounds, and pressure injuries—where early detection of infection is critical to preventing chronicity and escalation.

Clinical Implications: With further testing and development, smart wound technologies like this could reduce hospitalizations, improve outcomes in hard-to-heal wounds, and decrease long-term care costs. The team is working toward FDA approval and future commercial deployment.

Keywords: Kunal Mankodiya, smart wound patch, chronic wounds, infection detection, wearable biosensors, University of Rhode Island

Read the full article at Medical Xpress

Wound Bed Temperature May Help Identify Chronic Wound Infection

Wound Bed Temperature May Help Identify Chronic Wound Infection

Summary: A cross-sectional study from researchers at the University of Galway evaluated whether thermal imaging—specifically wound bed temperature—can aid clinicians in assessing potential infection in chronic wounds. A total of 267 patients with ulcers, including diabetic foot, pressure, venous, and arterial etiologies, were imaged using an infrared (IR) camera in a routine clinic setting.

Key Findings:

  • The temperature at the center of wounds strongly correlated with the average wound bed temperature (R² = 0.977), suggesting that a single-point measurement may accurately reflect the whole wound.
  • A modest correlation (Pearson r = 0.32) was found between the temperature difference (wound vs. periwound skin) and clinician-assessed infection status.
  • Thermal imaging offers a non-contact, low-cost, and easy-to-use tool that could complement visual assessment—particularly when clinical signs of infection are unclear.

This study suggests that incorporating wound temperature measurement could enhance early detection of infection and support clinical decision-making, especially in challenging nonhealing wounds.

Read the full study

Keywords: wound bed temperature, thermal imaging, chronic wound infection, non-contact assessment, University of Galway

When and how to culture a chronic wound

When and How to Culture a Chronic Wound

Summary: In a Wound Care Advisor article, Marcia Spear, DNP, ACNP-BC, CWS, CPSN explains that chronic wounds should only be cultured when there are clear clinical signs of infection—recognizing that “classic” signs may not always be present.

Key Highlights:

  • Cultures are warranted when additional signs are present: increased pain, necrotic tissue, delayed healing, or wound bed deterioration—even without classic infection indicators.
  • Quantitative tissue biopsy remains the gold standard for accuracy, but the Levine swab technique is a validated and practical alternative in clinical settings.
  • Proper technique matters: swab after cleansing and gentle debridement, ideally focusing on the most suspicious or non-healing area for meaningful results.

Read the full article on Wound Care Advisor

Keywords:
wound culture,
chronic wound,
Levine technique,
tissue biopsy,
Marcia Spear

Closure Rate of Chronic Wound Sinus Tract Based on Morphological & Clinical Factors

Closure Rate of Chronic Wound Sinus Tract Based on Morphological & Clinical Factors

Summary: This original research article examines how morphological features and clinical parameters affect the closure rate of chronic wound sinus tracts. The authors analyze multiple patient and wound-related factors to identify predictors of successful closure in challenging wound types.

Key Highlights (Inferred or based on abstract metadata):

  • The study assesses the relationship between sinus tract morphology (e.g., depth, branching) and wound closure success.
  • Clinical variables—such as patient comorbidities, wound duration, and previous interventions—are correlated with outcomes.
  • Results likely identify which morphological and clinical factors are favorable or unfavorable for closure, aiding in treatment planning.
  • Authors provide recommendations on stratifying cases based on risk and tailoring interventions accordingly.

Read the full article on HMP Global Learning Network

Keywords:
sinus tract closure,
morphological factors,
clinical predictors,
chronic wounds

Research terminology in chronic wound research: a scoping review protocol


Research terminology in chronic wound research: a scoping review protocol

Summary: This protocol outlines a scoping review to catalog and standardize terminology used in chronic wound research—aiming to improve comparability, reporting quality, and evidence synthesis across studies and registries.

Key Highlights:

  • Plans to map definitions for wound etiology, severity, “standard of care,” and outcome measures.
  • Identifies inconsistencies that hinder meta-analysis and guideline development.
  • Will propose a harmonized lexicon aligned with consensus frameworks and registries.
  • Intended to support regulators, payers, and investigators with clearer standards.

Read the protocol in WPR

Keywords:
scoping review,
terminology,
chronic wounds,
standardization

Functionally Enriched Human Polymorphisms Associate to Species in the Chronic Wound Microbiome


Functionally Enriched Human Polymorphisms Associate to Species in the Chronic Wound Microbiome

Summary: This open-access study conducted a microbiome genome-wide association (mbGWAS) across >500 patients with chronic wounds, linking human genetic variants to relative abundance of specific bacterial species. The results show that host genetics partially shape wound microbial communities, revealing 193 candidate loci across 25 genomic regions associated with 16 bacterial species. These findings suggest a genetic influence on wound colonization and healing trajectories.

Key Highlights:

  • Identified 193 candidate variants across 25 genomic regions linked to 16 wound bacterial species.
  • Per-species heritability estimates ranged up to 20%.
  • Functional annotation showed enriched pathways in extracellular matrix organization, immune signaling, and transport.
  • Species associated via genetics co-occurred with known pathogens such as *Staphylococcus aureus*.
  • Genetic distance among patients correlated with overall microbiome dissimilarity.

Read full article

Keywords:
chronic wound microbiome,
genetic variants,
mbGWAS,
host-microbiome interactions,
bacterial community structure

Closure Rate of Chronic Wound With Sinus Tract Based on Morphological and Pathological ….



Closure Rate of Chronic Wound With Sinus Tract Based on Morphological and Pathological Features of the Endoscopic Evaluated Classification

Summary: This prospective case series at Ruijin Hospital (2017-2021) evaluated the endoscopic evaluated classification (China-Lu system) for chronic wounds with sinus tracts (CWST), categorizing 89 patients into simple, morphologically complex, pathologically complex, or refractory types based on tract branches and features like fibrosis/necrosis. Using endoscopy for precise assessment and debridement, the study achieved an overall 86.52% closure rate post-treatment, with simple wounds excelling at 97.83% and refractory types lagging at 14.29%. The classification aids prognosis and guides interventions, emphasizing endoscopy’s role in overcoming limitations of imaging for complex 3D morphologies in wound care.

Key Highlights:

  • Patient cohort: 89 adults (mean age 53 years, 51.7% male); common sites: lower extremities (31), abdomen (25); etiologies: pressure ulcers (30), trauma (26); comorbidities: diabetes (17), paraplegia (17).
  • Classification: Simple (46 patients, single tract, no features: 97.83% closure); morphologically complex (13, multiple tracts: 84.62%); pathologically complex (23, single tract with features: 86.96%); refractory (7, multiple tracts with features: 14.29%).
  • Treatment: Endoscopic debridement, foreign body removal, drainage; closure defined as fibrous connection without cavity persistence.
  • Outcomes: Overall 86.52% closure; refractory failures linked to incomplete drainage and comorbidities; endoscopy revealed hidden branches/necrosis missed by CT.
  • Implications: Classification predicts healing; calls for advanced endoscopic tools and multicenter validation to improve refractory CWST management.

Read full article

Keywords: chronic wound sinus tract, endoscopic classification, wound closure rate, China-Lu system, refractory wounds, Xian Ma, Yakupu Aobuliaximu, Di Zhang

Biological Mechanisms and Clinical Challenges of Platelet-Rich Plasma in Chronic Musculoskeletal Pain and Wound Care



Biological Mechanisms and Clinical Challenges of Platelet-Rich Plasma in Chronic Musculoskeletal Pain and Wound Care

Summary: This review examines platelet-rich plasma (PRP)’s mechanisms—growth factor release (PDGF, TGF-β, VEGF) for immunomodulation and tissue repair—in chronic musculoskeletal pain and wound healing, including DFUs. PRP accelerates re-epithelialization and fibroblast migration in wounds, but 40% of DFU trials fail due to unregulated preparation (centrifugation 1500–3000 rpm, anticoagulant variability), yielding inconsistent platelet concentrations (500,000–1,500,000/μL) and growth factor release. A 2024 meta-analysis confirms instability; multi-omics (genomics/proteomics) is proposed for precision PRP, emphasizing standardization to overcome reproducibility issues in diabetic ulcer management.

Key Highlights:

  • Mechanisms: PRP releases EGF/VEGF for angiogenesis; supports fibroblast migration in DFUs.
  • Challenges: 40% negative DFU outcomes from variable PRP (Ajay 2021); Peng meta-analysis (2024) confirms.
  • Training Gap: Unregulated kits lead to waste; multi-omics for personalized dosing.
  • Implications: Standardize for chronic wounds; potential 52% efficacy boost with optimization.
  • Authors: Haizhou Zhou, Qianjie Huang, Yichao Chen, Jianmin Wang, Hui Jiang (Nov 7, 2025).

Read full article

Keywords: platelet rich plasma, diabetic ulcer, PRP variability, growth factors, multi omics

Addressing Australia’s Chronic Wound Problem



Addressing Australia’s Chronic Wound Problem

Summary: This editorial outlines Australia’s chronic wound burden (affecting 3% of population, costing $7B/year) and proposes a national roadmap during Wound Awareness Week, including a 5-point plan for enhanced education, aged care worker upskilling, and sector consensus. It highlights research on DFU patient experiences, wound terminology standardization, polyhexanide efficacy, and antimicrobial stewardship, while announcing the journal’s shift to digital-first from 2026 for sustainability.

Key Highlights:

  • 5-Point Plan: Education boost, aged care training, consensus building, research investment, policy advocacy.
  • Research Spotlight: Qualitative DFU experiences, terminology scoping, polyhexanide meta-analysis, AMS outcomes.
  • Digital Shift: Opt-in physical copies from 2026; promotes global access.
  • Burden: 3% prevalence; $7B cost; calls for eradication via collaboration.
  • Event: Canberra meeting with government/peak bodies for roadmap.

Read full editorial

Keywords: chronic wounds, Australia, 5-point plan, DFU experiences, antimicrobial stewardship, Peta Tehan, Zlatko Kopecki

The role of bacteria and biofilms in non-healing wounds

Broadcast times available: 8:00 AM (UK), 11:00 AM (UK), 15:00 PM (UK)

 

Evidence has proven the positive effects of topical oxygen therapy on chronic, hard-to-heal wounds. It is becoming widely accepted that hard-to-heal wounds contain biofilm and that the presence of biofilm delays and/or prevents healing. This webcast will inform practitioners about the issue of biofilm and how it affects wound chronicity, as well as how topical oxygen therapy may help to kickstart stalled healing. The NATROX study has shown that topical oxygen therapy has a positive effect on biofilm in chronic wounds, and this webcast will provide practical guidance so this can be applied in practice to improve healing outcomes ….. read more

Opinion: Addressing the Neglect of “Other” Open Wounds Beyond DFUs, VLUs, and Pressure Injuries

Opinion: Addressing the Neglect of “Other” Open Wounds Beyond DFUs, VLUs, and Pressure Injuries

Summary: An opinion piece in the Journal of Wound Care (2025) argues that healthcare systems and research frameworks disproportionately emphasize well-defined hard-to-heal wounds—such as diabetic foot ulcers (DFUs), venous leg ulcers (VLUs), and pressure ulcers (PUs)—while neglecting a large category of “other” open wounds. These include surgical incisions, trauma-related lacerations, punctures, or unspecified wounds coded under ICD-10 classifications. The authors contend that overlooking these wounds perpetuates inefficiencies, inflates costs, and worsens patient suffering. Integrating comprehensive strategies across all wound categories, regardless of etiology, is essential for patient-centered and equitable wound care.

Key Highlights:

  • ICD-10 coding context: “Other” wounds are often labeled under codes such as S01 (head), S41 (shoulder and arm), S81 (knee and lower leg), or T14.1 (unspecified), encompassing trauma wounds, bites, and open injuries that resist neat categorization.
  • Exclusion from guidelines: DFUs, VLUs, and PUs dominate protocols and resource allocation because their etiologies are specific, while surgical or trauma wounds that linger in outpatient care remain marginalized.
  • Outpatient burden: Surgical wounds may dehisce, trauma wounds may linger, and wounds in patients with comorbidities (e.g., autoimmune or hematological conditions) often fall outside existing guideline frameworks.
  • Systemic inefficiency: By excluding “other” wounds from research and reimbursement models, healthcare systems underestimate true prevalence, under-resource outpatient management, and limit innovation in holistic care.
  • Proposed solution: Building on reimbursement frameworks like those by Tettelbach et al., the authors advocate for equal rigor in managing “other” wounds, integrating them into clinical guidelines, and expanding funding for non-categorized wound care.

Read the full opinion piece in Journal of Wound Care

Keywords:
open wounds,
ICD-10 wound codes,
diabetic foot ulcer,
venous leg ulcer,
pressure injury,
surgical wounds,
trauma wounds,
Tettelbach

Healthy.io and Innovive Health Announce Groundbreaking New Partnership That Could Change

the Future of Wound Care Management

 

BOSTON, April 6, 2022 /PRNewswire/ — Healthy.io, the global leader in transforming the smartphone camera into a medical device, and Innovive Health, a data-driven home health care agency serving complex behavioral health patients, today announced a new partnership through which up to 700 Innovive nurses will use Healthy.io’s digital wound management service, Minuteful for Wound to enhance and extend patient care. The partnership illustrates how clinicians can use smartphone technology to track and treat chronic wounds like diabetic ulcers while enabling them to do their job more efficiently.

 

Innovive Health aims to revolutionize the treatment and care of chronic wounds in its vulnerable patient population by combining the company’s patient-centered, data-driven approach to home health care with Healthy.io’s smartphone-based service designed to enable healthcare providers to perform consistent and accurate wound measurement. Innovive Health’s ultimate goal is to improve continuity of care and allow clinicians to focus more of their time on patient care.

 

“We are thrilled about this partnership with Innovive Health,” said Healthy.io US General Manager Paula LeClair. “Innovive provides care to some of society’s most vulnerable and underserved communities, which aligns perfectly with Healthy.io’s mission. Together, we can change the way nurses use technology to monitor patients quickly and efficiently. COVID-19 brought to light the need for technology like our wound care product, which is key to helping nurses save precious time monitoring patients.”

 

“We’ve seen the ways Healthy.io has successfully changed wound care management and we are excited to partner with them to help our nurses accurately and consistently monitor chronic wounds. Any nurse can use this technology, which will result in more equitable patient care,” said Innovive Health’s CEO Joseph McDonough. “Innovive Health’s commitment to excellence coupled with Healthy.io’s vision-based medical technology can improve patient care for those suffering from particularly complex chronic wounds.”

 

Through this partnership, Innovive Health’s nurses use a smartphone to scan a wound before uploading the scan into a portal that allows them to assess whether the healing is proceeding properly. The AI-powered computer vision system analyzes wounds with optimal accuracy, automatically calibrating images for scale, lighting, dimensions, and 3D structure.

 

Healthy.io is confident this partnership will make it easier for nurses to manage wound care. Nurses using the Healthy.io wound management tool reported 85% faster documentation compared to standard methods and 67% reduction in their time for follow-up visits.

 

About Healthy.io

 

Healthy.io transforms the smartphone camera into a medical device to deliver healthcare at the speed of life. The company’s at-home urinalysis and digitized wound care services enable providers and healthcare systems to close gaps in access and care while increasing patient satisfaction. Healthy.io is a global leader in digital health and is a recipient of the CNBC 2020 Disruptor 50 Award, Fast Company’s World’s Most Innovative Companies 2020 Award, and the Financial Times 2020 Boldness in Business Award. The company is based in Tel Aviv and has offices in Boston and London.

 

About Innovive Health

 

As one of the leading home care health agencies in Massachusetts, Innovive Health has been delivering strong clinical outcomes for more than two decades and is transforming healthcare through an innovative model of patient-centered, data driven, full-service home care. Innovive Health provides high quality nursing, therapy and services to some of the region’s most vulnerable and underserved populations in the safety and comfort of their homes and communities. For more information, visit https://innovivehealth.com.

 

Media contact:

Kate Lucadamo
Vice President at Marathon Strategies
Kate@marathonstrategies.com

 

For Innovive Health
Travis Small
tsmall@sloweymcmcanus.com

SOURCE Healthy.io; Innovive Health

 

This article was originally published here

Advancing Wound Care With 3-D Imaging: Clinical Applications, Performance and Future Directions

Enhancing Healing of Chronic Wounds via Novel Bioengineered Growth Factor Scaffold (DOI 10.1111/wrr.70089)

Summary: A recent experimental study in Wound Repair & Regeneration investigates a bioengineered scaffold designed to deliver growth factors over an extended period, aiming to support healing in chronic or refractory wounds. The scaffold combines biomaterials engineered for sustained release with growth factors known to enhance angiogenesis and epithelial cell proliferation. Comparative in vivo tests demonstrate accelerated closure and enhanced vascular density in treated wounds compared to standard care controls.

Key Highlights:

  • The scaffold material is designed for biocompatibility and controlled degradation, allowing gradual growth factor release over multiple weeks.
  • In vivo models (rodent chronic wounds) showed not only faster wound closure but also superior quality of the regenerated tissue—denser capillary networks and better epidermal thickness / integrity.
  • Histologic analysis indicated reduced inflammatory infiltration and improved collagen architecture in scaffold-treated wounds.
  • The study underscores that combining biomaterial scaffolds with growth factor delivery may overcome limitations of growth factor therapies alone, such as rapid diffusion/degradation and inconsistent retention at wound sites.

Read the full article in Wound Repair & Regeneration

Keywords:
bioengineered scaffold,
growth factor delivery,
chronic wound,
angiogenesis,
controlled release

Assessment of Non-Healing Wounds in Clinical Practice



Assessment of Non-Healing Wounds in Clinical Practice: Towards a Holistic and Systems-Based Approach

Summary: This article reviews the assessment of non-healing wounds, advocating a holistic, systems-based approach that integrates patient history, comorbidities, and environmental factors with accurate diagnosis to optimize management. Drawing on current guidance, it stresses multidisciplinary evaluation for chronic wounds like diabetic foot ulcers and venous leg ulcers, where delayed healing affects 2-3% of the population and costs billions. Key steps include comprehensive history-taking, vascular/neurological exams, and biopsy for malignancy, emphasizing early referral to prevent progression to infection or amputation, with tools like the TIME framework for structured care.

Key Highlights:

  • Prevalence: Non-healing wounds affect 2-3% of populations, with diabetic ulcers leading to 20% amputation risk if untreated.
  • Holistic Assessment: Include psychosocial factors, nutrition, mobility; use tools like PUSH or Bates-Jensen for objective scoring.
  • Diagnostic Tools: Doppler for vascularity, monofilament for neuropathy; biopsy for suspected cancer or vasculitis.
  • Systems Approach: Multidisciplinary teams (podiatry, vascular, nutrition) improve closure rates by 40%.
  • Implications: Early, comprehensive evaluation reduces costs and enhances QoL; calls for standardized protocols.

Read full article

Keywords: non-healing wounds, holistic assessment, systems-based approach, diabetic ulcers, multidisciplinary care, Aby Mitchell

Nuo Therapeutics Announces Publication of Final Decision Memo for Autologous Blood Derived Products for Chronic Non-Healing Wounds by Centers for Medicare

HOUSTONApril 20, 2021 /PRNewswire/ — Nuo Therapeutics, Inc. (OTC Pink: AURX) (“Nuo” or the “Company”), today announced the recent publication of the final decision memo for Autologous Blood-Derived Products for Chronic Non-Healing Wounds (CAG-00190R4).  On April 13, 2021, Centers for Medicare & Medicaid Services (CMS) concluded in its final coverage decision memo (available at the URL at the bottom of this release) that Medicare will cover autologous platelet-rich plasma (PRP) for treatment of chronic non-healing diabetic wounds (DFUs) under section 1862(a)(1)(A) of the Social Security Act.  This final decision follows the favorable proposed decision memo which was published December 21, 2020 and followed by a thirty-day public comment period.  In its final decision memo, CMS concluded that the coverage for DFUs would be for a duration of 20 weeks and limited to devices whose FDA cleared indications include the management of exuding cutaneous wounds such as DFUs.  Coverage of autologous PRP beyond 20 weeks for DFUs and for the treatment of all chronic, non-healing wounds will be determined by local Medicare Administrative Contractors (MACs) … continue

Medilight develops light system to heal wounds

European project makes bandage that bathes wound in blue light to speed recovery.

 

With the objective of using light to improve wound healing and within the framework of the European project MEDILIGHT, Swiss company CSEM and six partners have developed a new solution for treating chronic wounds. This portable device delivers blue light to improve and accelerate the healing process. The prototype was first presented this week at the project wrap-up event on July 2nd, at the URGO Laboratories in Dijon, France.

Chronic wounds are often difficult to treat, because they do not follow the typical injury healing process or time-frame. The resulting burden is significant, affecting over 40 million patients worldwide and costing healthcare systems an estimated €40 billion annually.

Blue light is known for its anti-microbial and anti-inflammatory effects in the initial stages of the healing process; it does not damage tissue, unlike the hazardous UV light. However, clear evidence of the beneficial effects of blue-light irradiation in the later stages of wound healing was still missing, thus hindering the development of effective solutions for complete therapy … read more

Predicting Chronic Wound Healing Time Using Machine Learning

Chronic wounds have risen to epidemic proportions in the United States and can have an emotional, physical, and financial toll on patients. By leveraging data within the electronic health record (EHR), machine learning models offer the opportunity to facilitate earlier identification of wounds at risk of not healing or healing after an abnormally long time, which may improve treatment decisions and patient outcomes. Machine learning models in this study were built to predict chronic wound healing time … read more

Managing the Surge: Delayed Chronic Wound Care During COVID-19

A growing body of research, as well as first-hand accounts from clinicians on the ground, indicate that a significant percentage of patients with chronic wounds have delayed preventative and emergent wound care during the COVID-19 pandemic.1 While it will take time to assess the full impact of these trends, existing evidence suggests delayed wound care can result in more severe infections, increased hospital admissions, and lead to more amputations.2 Therefore, it will be critical for providers, hospitals, outpatient departments, payers and policymakers to understand and plan for a surge in patients with untreated and unmanaged non-healing wounds and related acute-on-chronic complications as a result of delayed care during the COVID-19 pandemic … read more

Chronic Wound Management

     Optimizing the Wound Healing Environment

 

Chronic wounds are any types of wounds that have failed to heal in 90 days. Identifying the cause of a chronic wound is most important in the healing process. We as clinicians must help bolster advanced wound care by sharing advances in education in evidence-based treatment, prevention, and wound assessment.

 

A wound must go through hemostasis, inflammation, proliferation, and remodeling, along with various cellular contributions. The scaffolding of the extracellular matrix is what provides the elasticity and tensile strength to the skin structure. Various proteins such as collagen, fibronectins, elastins, and laminins make up this vital matrix to aid and complete the process of wound closure. We see extracellular matrix damage mostly in our geriatric population … read more

Connected sensors for the prevention of chronic ulcers

As advancements in connectivity and miniaturization of electronics are made, smart sensors are beginning to find traction within the wound care pathway. IDTechEx has published a report titled Advanced Wound Care Technologies 2018 – 2028 and have previously reported on why disruption is needed in wound care in the next 10 years. Here, we explore a few connected devices that can contribute to the prevention of chronic wounds of pressure ulcers (PUs) and diabetic foot ulcers (DFUs).

 

Sensors for the Prevention of Pressure Ulcers MedicusTek have created the Sensable Care system which relies on a connected sensor pad or sensor mattress for detection of patient positioning to prevent pressure ulcer formation. By tracking patient position over time, the Sensable Care system can determine which areas of the patient are being exposed to prolonged pressure and notify caregivers accordingly for repositioning. The system resets if the patient successfully repositions themselves, thus decreasing the burden on caregivers where possible. Moreover, caregivers can receive immediate feedback as to whether their repositioning efforts were adequate in reliving the excessive pressure.

Read more at: https://www.wearabletechnologyinsights.com/articles/14270/connected-sensors-for-the-prevention-of-chronic-ulcers

Combating Biofilms In The Chronic Wound

Given the complexity of biofilm in lower extremity wounds, these authors offer a closer look on how biofilm develops, keys to eradicating biofilm and emerging modalities that may have an impact in the future.

 

We all encounter biofilms on a regular basis in our practices. A biofilm is a complex polymicrobal community of bacteria and fungi that develops on foreign materials, necrotic debris, exposed bone, and within the bed of chronic wounds. When James and colleagues examined the biopsies of 50 chronic wound beds, 60 percent contained a biofilm.

 

Planktonic or free-floating bacteria are more aggressive and divide more rapidly. Changes in gene expression allow them to secrete hydrolase enzymes and exotoxins, resulting in more rapid local tissue invasion. As a bacterial colony develops, environmental stimuli induce the cells to engage in quorum sensing, a gradient-based recruitment strategy used to summon additional bacteria to the developing biofilm and alter the phenotypic expression of bacteria within the community. Free-floating planktonic bacteria adhere to the wound bed using very weak molecular interactions … read more

Use of a purified reconstituted bilayer matrix in the management of chronic diabetic foot ulcers

improves patient outcomes vs standard of care: Results of a prospective randomized controlled multi-center clinical trial

 

The prevalence of diabetes in the United States continues to rise, with the disease now affecting 34.2 million, with an estimated additional 84 million at risk of progressing to diabetes in the coming years.1 The lifetime incidence of DFUs among diabetics is 19% to 34%, with recurrent ulceration reported as approximately 40% at 1 year and 60% at 3 years.2 Management is challenging and associated with substantial socio-economic burden approaching $40 billion annually in direct costs.3 Approximately 70% of DFUs resolve with standard wound care therapies. However, the natural healing cascade is arrested in the remaining 30%, which ultimately become chronic wounds.4, 5 Patients with chronic wounds typically suffer loss of function, recurrent infection, and significant morbidity.6 Amputations are reported in up to 20% of cases with an associated mortality of 70% at 5 years post-amputation … read more

Nanotechnology Effective in Chronic Wound Healing?

The incidence of chronic wounds is increasing due to aging population and the augment of people afflicted with diabetes. Knowledge on the biological mechanisms underlying these diseases, there is a lot of medical technologies to conventionally treat the wound however wound healing differs from person to person … Several nanotechnologies have been developed demonstrating unique characteristics that address specific problems related to wound repair mechanisms. A review in Advance wound care journal, focused on the most recently developed nanotechnology-based therapeutic agents and evaluated the efficacy of each treatment in diabetic models … The success of topically administered growth factors in chronic wounds is limited. Due to their short in vivo half-life, low absorption rate through the outermost skin later around the wound, as well as rapid elimination by exudation before reaching the wound bed, might limit the efficacy of growth factors topical application … Conventional medications containing growth factors need to be applied in high doses and/or be repeatedly administrated over a long period, leading to important side effects and increasing the cost of the therapy. Presently, platelet-derived growth factor , fibroblast growth factor, and epidermal growth factor are widely studied for their application … read more

A Combined Multistep Reconstruction of the Heel After Skin Tumor Resection in Posttraumatic Chronic Ulcers

Multistep Heel Reconstruction After Marjolin Ulcer Resection

A case series in *Wounds* (June 17, 2025) details four patients undergoing multistep reconstruction of the heel following resection of Marjolin ulcers—aggressive skin cancers arising in chronic wounds. Researchers used a biosynthetic extracellular matrix (BECM) combined with negative pressure wound therapy (NPWT) to achieve durable closure without traditional flap surgery.

Key Highlights:

  • Patient Population: Four adults with posttraumatic chronic leg ulcers, including a 58-year-old male with diabetes, venous insufficiency, obesity, smoking, and a Marjolin ulcer on the heel. :contentReference[oaicite:1]{index=1}
  • Multistep Protocol:
    1. Wide surgical excision of tumor + placement of BECM with 28 days of NPWT
    2. Application of split-thickness skin graft and 7 additional days of NPWT

    :contentReference[oaicite:2]{index=2}

  • Outcomes: All four patients achieved stable wound closure by day 38, with good scar quality and high patient satisfaction. No tumor recurrence or complications occurred during 12 months of follow‑up. :contentReference[oaicite:3]{index=3}
  • Clinical Advantages: The BECM + NPWT approach avoids flap surgery, reduces donor-site issues, offers shorter operative time and hospital stay, and delivers a robust tissue fill that restores heel contour and function. :contentReference[oaicite:4]{index=4}
  • First in the Literature: This is the first reported use of combined biosynthetic matrix and NPWT for heel reconstruction following Marjolin ulcer resection. :contentReference[oaicite:5]{index=5}

A multistep reconstruction strategy using biosynthetic scaffold plus NPWT offers a practical, less invasive solution for complex heel defects—achieving functional and aesthetic outcomes without flaps or extensive surgery.

Read the full case series in Wounds (HMP Global Learning Network).

Keywords:
Marjolin ulcer,
biosynthetic extracellular matrix,
NPWT,
heel reconstruction,
case series

Granulox for managing chronic non-healing wounds

Medtech innovation briefing [MIB296]Published: 10 May 2022

The technology described in this briefing is Granulox … Granulox is a topical sterile haemoglobin spray for managing chronic non-healing wounds … The innovative aspects are that, unlike other oxygen delivery technologies, it is designed to allow oxygen to diffuse through wound exudate … It can also be used in various settings without costly consumables, electrical power or full or partial body coverage in a chamber … The intended place in therapy would be alongside standard care for people with chronic non-healing wounds … The main points from the evidence summarised in this briefing are from 8 studies (1 meta-analysis, 2 randomised controlled trials and 5 observational studies) including a total of 530 people … Seven studies were based in the UK and are generalisable to the NHS … The evidence suggests that Granulox may improve the management of chronic non-healing wounds … Key uncertainties around the evidence are that sample sizes are small, and most studies were not randomised and had a short follow-up period … read more

One Call Announces New Wound Resource Program with Broadspire®

One Call, the nation’s leading provider of workers’ compensation care management services, and Broadspire®, a subsidiary of Crawford & Company® and a leading global third-party administrator, today announced a partnership to develop a customized patient-centric wound resource program to improve wound healing of injured workers.

 

The primary goal of wound care is to provide optimal conditions for the natural reparative processes to take place on their own. One Call’s new wound resource program, in partnership with Broadspire, utilizes evidence-based protocols to proactively identify injured workers who either have a non-healing wound or may be at risk for developing wounds.

Wounds that have continued for more than 30 days are 36-69 percent less likely to heal. Chronic wounds affect 5.7 million people in the U.S. at an annual cost of $20 billion.[1] Pressure ulcers are among the most common chronic wounds. According to the Agency for Healthcare Research and Quality (AHRQ), pressure ulcers account for more than 17,000 lawsuits annually and are the second most common claim after wrongful death. Sadly, about 60,000 patients die as a direct result of a pressure ulcer each year.

 

“Pressure ulcers and other chronic wounds have an enormously detrimental impact on function and overall healing,” said Dr. Marcos Iglesias, chief medical officer at Broadspire … read more

Foot Health Awareness: Hyperbaric Oxygen Therapy’s Critical Role In Limb Preservation

CūtisCare Shares How HBOT is Impacting Limb Preservation

 

BOCA RATON, Fla., April 5, 2022 /PRNewswire/ — CūtisCare USA, a leading provider of wound care management services to hospitals and physicians, is raising awareness through its Hyperbaric Aware initiative of the successes we have seen with limb preservation when hyperbaric oxygen therapy, HBOT, is a part of a treatment plan. Diabetes is a complex disease to treat and manage. However, we are starting to see amputation rates decline when HBOT is incorporated into the treatment plan for those with chronic wounds. Research shows that the vast majority of non-traumatic amputations to the lower extremity are preventable, making the need for diversification in treatment plans stronger than ever before.

 

When administered correctly, pressurized oxygen helps speed cell repair and form new blood vessels from just one treatment. Repeated exposure gives a lifeline to ischemic tissue and promotes the healing process of chronic wounds, specifically those suffering from diabetic foot ulcers.

 

There are approximately 200 non-traumatic lower-limb amputations performed each day in the United States associated with diabetes. These patients often experience restrictions to the supply of blood needed to support healthy tissue due to restricted circulation. As a result, amputation was far too often the only option for seriously infected wounds that were unresponsive to treatment.

 

Experts in the field are incorporating hyperbarics as an adjunct therapy. Dr. Louis Pilati, MD, Kettering Medical Center Network and CutisCare Medical Advisor Board physician, recommends the use of HBOT for patients suffering from diabetic foot wounds and has become an advocate for HBOT after seeing the results firsthand. “Use of hyperbaric oxygen in treating these patients has been shown to reduce the risk of major amputation. These patients are complicated and require a team approach. This should include vascular surgery, foot and ankle surgeons, and infectious disease specialists along with the wound care and hyperbaric medicine team.”

 

There is hope for this vulnerable patient population. Healthcare systems that have established dedicated healthcare clinics that are using HBOT are showing significant reductions in amputation rates. CūtisCare offers hospitals customized management solutions to begin providing next-level care for their patients. Committed to the growth and success of each hospital or physician practice. Visit cutiscare.com to access more information regarding the benefits of hyperbaric oxygen therapy, or even to find a CutisCare Wound Care Center of Excellence.

 

About CūtisCare

Headquartered in Boca Raton, Florida, CūtisCare works with hospitals, academic medical centers, hospital systems, and physicians to design customized outpatient and office-based wound care and hyperbaric oxygen (HBOT) solutions. With more than 25 years of management experience, a commitment to research, and driven by ethics and a culture of compliance, CūtisCare collaborates with its partners to reach and heal people with chronic wounds.

 

For more information, visit https://cutiscareusa.com or CutisCare LLC | LinkedIn.

 

Media Contact: Kelly Caceres, (904) 446-0708, kcaceres@cutiscareusa.com

Valsartan nano-filaments alter mitochondrial energetics and promote faster healing in diabetic rat wounds

Chronic wounds are a common and debilitating condition associated with aging populations that impact more than 6.5 million patients in the United States. We have previously demonstrated the efficacy of daily topical 1% valsartan in treating wounds in diabetic mouse and pig models. Despite these promising results, there remains a need to develop an extended-release formulation that would reduce patient burden by decreasing the frequency of daily applications. Here, we used nanotechnology to self-assemble valsartan amphiphiles into a filamentous structure (val-filaments) that would serve as a scaffold in wound beds and allow for steady, localised and tunable release of valsartan amphiphiles over 24 days. Two topical treatments of this peptide-based hydrogel on full-thickness wounds in Zucker Diabetic Fatty rats resulted in faster rates of wound closure. By day 23, all val-filament treated wounds were completely closed, as compared to one wound closed in the placebo group. Mechanistically, we observed enrichment of proteins involved in cell adhesion and energetics pathways … read more

A strain-programmed patch for the healing of diabetic wounds

 

Georgios Theocharidis, Hyunwoo Yuk, Heejung Roh, Liu Wang, Ikram Mezghani, Jingjing Wu, Antonios Kafanas, Mauricio Contreras, Brandon Sumpio, Zhuqing Li, Enya Wang, Lihong Chen, Chuan Fei Guo, Navin Jayaswal, Xanthi-Leda Katopodi, Nikolaos Kalavros, Christoph S. Nabzdyk, Ioannis S. Vlachos, Aristidis Veves & Xuanhe Zhao

 

Diabetic foot ulcers and other chronic wounds with impaired healing can be treated with bioengineered skin or with growth factors. However, most patients do not benefit from these treatments. Here we report the development and preclinical therapeutic performance of a strain-programmed patch that rapidly and robustly adheres to diabetic wounds, and promotes wound closure and re-epithelialization. The patch consists of a dried adhesive layer of crosslinked polymer networks bound to a pre-stretched hydrophilic elastomer backing, and implements a hydration-based shape-memory mechanism to mechanically contract diabetic wounds in a programmable manner on the basis of analytical and finite-element modelling. In mouse and human skin, and in mini-pigs and humanized mice, the patch enhanced the healing of diabetic wounds … read more

Using patient-reported experiences to inform the use of foam dressings for hard-to-heal wounds

Using Patient‑Reported Experiences to Guide Foam Dressing Use in Hard‑to‑Heal Wounds

A review led by Kevin Woo and co-authors, published in *Journal of Wound Care* (Nov 2024), highlights the importance of incorporating patient-reported outcomes—such as pain, odor, itch, drainage, and self-care capabilities—when selecting foam dressings for chronic wounds. The expert panel calls for greater collaboration across clinical, research, and industry sectors to address these needs.

Key Highlights:

  • Holistic Dressing Selection: Foam dressing choice must balance wound characteristics with patient experiences to improve quality of life and adherence. :contentReference[oaicite:1]{index=1}
  • Identified Outcome Domains: The review identifies five core categories—wound-related pain, odor, itch, exudate volume, and self-management capacity—as critical to patient-centered care. :contentReference[oaicite:2]{index=2}
  • Accountability Across Sectors: Authors urge clinicians, researchers, and industry to adopt shared responsibility in designing dressings that meet both clinical efficacy and patient comfort metrics. :contentReference[oaicite:3]{index=3}
  • Population Impact: Hard-to-heal wounds affect approximately 1.67 per 1000 people globally and impose significant health and economic burdens. :contentReference[oaicite:4]{index=4}

By centering patient-reported experiences in product evaluation and development, this review promotes more person-focused wound care strategies and improved outcomes.

Read the full article in the Journal of Wound Care (via Wound Central).

Keywords:
patient-reported experience,
foam dressings,
hard‑to‑heal wounds,
wound‑related pain,
self‑management

Artificial intelligence will heal wounds!

Artificial intelligence will heal wounds!

Summary: Researchers at the University of California, Santa Cruz have developed an AI-powered “smart bandage” called a-Heal that monitors wounds autonomously and delivers targeted therapy. In preclinical porcine models, the device achieved ~25% faster wound closure by combining image analysis, electrical stimulus, and localized drug delivery.

Key Highlights:

  • Smart bandage design: The device includes an onboard camera to capture wound images periodically and feed them into an AI system.
  • Autonomous treatment: If healing slows, the device can trigger electrical stimulation or dispense fluoxetine (anti-inflammatory action) directly to the wound.
  • Performance: In 22-day porcine trials, wounds healed ~25% faster compared to controls.
  • Closed-loop learning: The system uses reinforcement learning to optimize treatment over time.
  • Clinical implications: May eventually support management of chronic wounds, reduce provider burden, and accelerate healing in human patients.

Read the full article on ShiftDelete.Net

Keywords:
Samet Kelebek,
AI bandage,
smart dressing,
wound imaging,
electrical stimulation,
fluoxetine wound therapy

Monofilament Fibre Debridement Pad for Patients with Unhealed Wounds After Six Months

An Audit to Assess the Impact of Prescribing a Monofilament Fibre Debridement Pad for Patients with Unhealed Wounds After Six Months

Summary: Published May 2, 2021 in the Journal of Wound Care (Vol. 30, No. 5, pp. 381–388; DOI: 10.12968/jowc.2021.30.5.381; PMID: 33979215) by Joanna Burnett, Andrew Kerr, Margaret Morrison, and Abbe Ruston, this NHS prescribing audit provides real-world economic evidence for the impact of introducing the Debrisoft monofilament fibre debridement pad into wound-care practice in England. Debrisoft — a sterile pad of densely packed monofilament fibres (Lohmann & Rauscher) — has robust evidence as a rapid and effective mechanical method for removing dry skin, biofilm, and devitalised tissue from acute and chronic wounds with minimal patient discomfort. It received NICE Medical Technology Guidance (MTG17) recommending adoption based on modelled cost savings versus comparators including saline/gauze, hydrogels, and larval therapy. However, the NICE guidance itself acknowledged that post-implementation, real-world evidence of prescribing impact was limited at the time of evaluation. This audit addresses that gap. Using a dataset obtained from the NHS Business Services Authority for 486 uniquely identified patients who had been newly prescribed the monofilament fibre debridement pad, the audit analysed prescribing records over 6 months following first prescription. The analysis focused on changes in wound-care prescribing costs, prescription frequency, and dressing product use before and after Debrisoft introduction. Results demonstrated a significant reduction in overall wound-care prescribing costs associated with Debrisoft introduction, supporting the NICE cost-saving model in a real-world NHS community setting. The authors note several methodological considerations: the dataset reflects prescribing patterns rather than direct clinical outcomes (wound healing or wound area reduction); confounding factors such as concurrent clinical interventions cannot be fully isolated; and the population reflects patients with unhealed wounds of mixed aetiology and severity. Nevertheless, the audit provides the kind of health system-level prescribing data that complements clinical effectiveness studies and reinforces the economic argument for Debrisoft adoption in community wound care pathways.

Key Highlights:

  • NHS prescribing database: 486 patients newly prescribed Debrisoft monofilament fibre debridement pad across England; data sourced from NHS Business Services Authority — provides real-world prescribing impact evidence absent from earlier NICE MTG17 modelling
  • Cost reduction finding: introduction of Debrisoft associated with significant reductions in overall wound-care prescribing costs over 6-month follow-up period — consistent with and supporting the NICE cost-saving projections (£77–£484 per patient versus comparators in earlier modelling)
  • Debrisoft mechanism context: monofilament fibres physically disrupt and lift devitalised tissue, slough, biofilm, and debris; NICE-recommended as the best-evidenced mechanical debridement method for community use; effective across wound aetiologies including venous ulcers, DFUs, pressure injuries, and post-surgical wounds
  • Evidence context: the 2021 Burnett audit is one of only a few post-NICE real-world prescribing studies; complements the earlier Roes et al. 2019 clinical outcome and practitioner satisfaction studies and the Schultz et al. 2018 biofilm removal evidence
  • Methodological note: outcomes are prescribing-based rather than wound healing endpoints; confounders present; population is heterogeneous — authors recommend complementary prospective trials with standardised wound assessment tools to confirm cost-effectiveness and clinical healing outcomes
  • Access: article published in the Journal of Wound Care (MAG Online Library/Magonlinelibrary); full text requires journal subscription or institutional access; abstract and PMID 33979215 available via PubMed

Read full article

Keywords: monofilament debridement pad NHSwound care prescribing costsDebrisoft clinical evidenceNICE MTG17 wound debridementwound bed preparation community nursingchronic wound debridement audit

Joanna Burnett, Andrew Kerr, Margaret Morrison, Abbe Ruston

Classifying Obesity as a Chronic Disease with W. Timothy Garvey, MD

Classifying Obesity as a Chronic Disease: Insights from Dr. W. Timothy Garvey

In a recent HCPLive interview, Dr. Garvey discusses the Lancet Commission’s updated obesity framework, highlighting the shift toward defining obesity as a chronic, adiposity-based disease. This approach recognizes both “preclinical” and “clinical” stages of obesity and acknowledges its wide-ranging health complications.

Key Highlights:

  • Adiposity-Based Chronic Disease (ABCD): Dr. Garvey emphasizes replacing “BMI-defined obesity” with the term “adiposity-based chronic disease,” reflecting true pathophysiology and treatment focus.
  • Preclinical vs Clinical Obesity: “Preclinical obesity” refers to excess body fat without complications, while “clinical obesity” includes adiposity linked to metabolic or physiologic issues.
  • Chronic Disease Status: Obesity is a lifelong condition with measurable morbidity and mortality risks, comparable to diabetes or hypertension.
  • Guideline Adoption: Major organizations like ACE and the European Association for the Study of Obesity now support this classification, aligning treatment standards globally.

Dr. Garvey’s insights call for recognition of obesity as a biologically driven chronic disease that extends beyond simple weight metrics, urging clinicians to apply comprehensive, pathology-centered strategies in assessment and management.

Watch the full interview on the HCPLive website.

Keywords:
adiposity-based chronic disease,
obesity classification,
preclinical obesity,
chronic disease,
Dr. Garvey

High-Intensity Laser Therapy Deemed Effective for Chronic Refractory Wounds, Research Says

High-intensity laser therapy (HILT) combined with wound dressing was superior to conventional wound care, according to a recent study.

High-intensity laser therapy (HILT) is a promising treatment for chronic refractory wounds and should be considered for use with other treatments, according to a study published in BMJ Open.

According to the researchers, HILT does not only reduce wound size. It can also shorten wound healing time, accelerate inflammatory absorption, and increase collagen synthesis and tensile strength. “The therapeutic effects of HILT on chronic refractory wounds are significant and far more superior to those of conventional wound dressing,” the authors said.

Low-level laser therapy (LLLT) has been used on skin wounds … read more

Clinical Challenges in Diagnosing Infected Wounds

Given the impact of infection on delayed wound healing, determining the presence of colonization and infection is imperative to achieving healed outcomes. Chronic wounds are always contaminated, and timely implementation of management and treatment interventions is a key component of the plan of care.

 

Diagnosis of infection can be a very challenging task to say the least, and it is further complicated by the presence of biofilms for which no diagnostic tool is currently available. If not addressed in a timely manner, these local infections can become systemic, leading to sepsis, multiple organ failure, and death. The first steps are a complete and thorough history and a physical examination of the whole patient, not just the patient’s wound, while taking into account both primary and secondary findings to understand the host response.

 

Having a thorough understanding of the principles of chronic wound care and of the current diagnostic modalities available is essential to the improvement of clinical outcomes and cost reduction related to the complication of wound infection. Our focus is on the challenges to diagnosing wound infection, including accurately determining risk factors, differentiating colonization from infection, and understanding the gold standard for diagnosing wound infection … read more

Clinical Challenges in Diagnosing Infected Wounds

Given the impact of infection on delayed wound healing, determining the presence of colonization and infection is imperative to achieving healed outcomes. Chronic wounds are always contaminated, and timely implementation of management and treatment interventions is a key component of the plan of care.

 

Diagnosis of infection can be a very challenging task to say the least, and it is further complicated by the presence of biofilms for which no diagnostic tool is currently available. If not addressed in a timely manner, these local infections can become systemic, leading to sepsis, multiple organ failure, and death. The first steps are a complete and thorough history and a physical examination of the whole patient, not just the patient’s wound, while taking into account both primary and secondary findings to understand the host response.

 

Having a thorough understanding of the principles of chronic wound care and … read more

From Chronic to Curable? RHEACELL is Developing a Novel Cell-Therapy Agent for the Treatment of Chronic Venous Ulcers

Heidelberg-based biopharmaceutical company is conducting a follow-up study with highly purified stem cells (AMESANAR (R) ) for the treatment of previously incurable chronic ulcers.

Heidelberg, 19. October 2021 – More than 80,000 people in Germany suffer from chronic venous ulcers (CVU). Triggered by venous insufficiency, wounds and weeping ulcers can develop that may not heal for years. Severely affected patients experience intense pain every day. Until now, there has been no effective treatment – but this could change soon … read more

Contact Dermatitis to Common Wound Care Products Exacerbates Chronic Ulcers

Contact Dermatitis from Common Wound Care Products May Worsen Chronic Ulcers

A recent study highlighted by HCPLive reveals that contact dermatitis triggered by standard wound care products may significantly impede the healing of chronic ulcers. Conducted at the Wound Healing Institute of Southeast Wisconsin, the study emphasizes the overlooked impact of allergic reactions in patients with non-healing wounds.

Key Highlights:

  • Widespread Sensitivities: 15 out of 16 patients with chronic ulcers tested positive for contact dermatitis in patch tests using commonly applied wound care products.
  • Delayed Healing: Allergic reactions to these products can worsen chronic ulcers and interfere with effective treatment.
  • Diagnostic Implications: The study calls for broader awareness and improved diagnostic testing to identify contact dermatitis in chronic wound care patients.

This research underscores the importance of considering allergic reactions as a complicating factor in chronic ulcer management, urging clinicians to incorporate allergy assessments into routine wound evaluations.

Read the full article on the HCPLive website.

Keywords:
contact dermatitis,
chronic ulcers,
wound care products

Healogics 8th Annual Diabetes Awareness Campaign, Chronic Wound Healing through Specialized Care

Healogics, the nation’s leading provider of world-class wound care services, is proud to announce the eighth annual Diabetes Awareness Campaign throughout the month of November, which is National Diabetes Awareness Month. The Healogics wound care specialists, at the more than 600 Healogics Wound Care Centers® nationwide, will be raising awareness of the importance of early intervention and specialized care for diabetes-related chronic wounds, such as diabetic foot ulcers … Diabetic foot ulcers are a leading cause of lower-limb amputations and according to the American Diabetes Association, an average of 10 Americans will undergo an amputation due to diabetes every hour. Of the 34.2 million Americans currently living with diabetes, up to 25% may develop a diabetic foot ulcer. These hard-to-heal wounds often go undetected due to the lack of feeling in the lower extremities due to nerve damage caused by diabetes … read more

Novel Cellulose Fibre-Based Flexible Plasmonic Membrane for Point-of-Care SERS Biomarker Detection in Chronic Wound Healing

Wound management is stretching the limits of health systems globally, challenging clinicians to evaluate the effectiveness of their treatments and deliver appropriate care to their patients. Visual inspection and manual measurement of wound size are subjective, often inaccurate and inconsistent. Growth factors, such as pro-inflammatory cytokines and proteases, play important roles in cutaneous wound healing. However, little is known about the point-of-care monitoring of the changes in such markers during the healing process. Here, we explore the capability of surface-enhanced Raman spectroscopy (SERS) as a viable point-of-care platform to monitor the changes of these surrogate indicators of healing status in chronic wounds …. read more

Evidence for Person-centred Care in Chronic Wound Care

Chronic wounds affect an estimated 2.21 per 1000 population. They are a significant source of morbidity and affect individuals physically, psychologically, socially and financially. Person-centered care is one approach to improve patient outcomes in wound care as it values patients’ perspectives, beliefs and autonomy and considers the person as a whole within the cultural context in which care is provided.

Integra LifeSciences reveals FDA warning letter over chronic wound treatment

Integra LifeSciences (NSDQ:IART) today revealed its receipt of a warning letter sent by the FDA last week about quality system issues at a Boston-area plant that makes products to treat chronic wounds … Plainsboro, N.J.-based Integra said the FDA inspected the plant last October and November, resulting in a Form 483 covering the problems found there. The facility makes extracellular bovine matrix products that accounted for less than 4% of Integra’s sales last year, the company said … read more

Healogics Releases Software to Improve Chronic Wound Care Experience

JACKSONVILLE, Fla.–(BUSINESS WIRE)–Healogics®, the wound healing experts, today announced the launch of two new applications that support efforts to improve the patient experience and save time for clinicians and physicians, all while increasing the quality and consistency of patient care. Clinical OptimizationSM and Decision SupportSM, applications on Healogics’WoundSuiteSM platform, enable the critical connection between people living with chronic wounds and their multi-disciplinary healthcare team for collaborative, evidence-based, patient-centered care.

 

“Over the past year, Healogics has been working tirelessly to ensure that the care teams at our Wound Care Centers® have access to the best software available to help more people heal. We are excited about the launch of these new applications, and their ability to support more in-depth documentation, accurate wound measurements and, most importantly, better patient outcomes,” said David Bassin, Healogics CEO.

 

Healogics Clinical Optimization provides clinicians and physicians with patient-focused insights starting with the daily team huddle. Additionally, this application supports them throughout the Healogics Patient Care ProcessSM, a six-sigma lean productivity process used in each Wound Care Center. Clinical Optimization provides a one-click patient summary that eliminates all of the arduous and time-consuming paper processes built around EMRs. By concisely presenting the essential patient information, physicians can now go through medical surveillance, a process designed to monitor patient healing, with case managers before ever walking into a patient’s room. This allows more time for meaningful patient interaction.

read more

Microcurrent as an adjunct therapy to accelerate chronic wound healing

     and reduce patient pain

 

The primary aim is to assess the efficacy of microcurrent, a form of electrical stimulation, as an adjunct therapy in accelerating healing in chronic wounds by reducing wound size and pain level. The secondary aim is to assess the qualitative changes in these parameters: inflammatory symptoms, vasodilation, sleep quality, gait and frequency of bowel movement … read more

Reducing infection in chronic leg ulcers with an activated carbon cloth dressing

Chronic wounds are likely to have an increased bioburden, which in turn increases the risk of local infection. Indeed, infection is one of the most frequent complications of non-healing wounds, resulting in longer treatment times, increased risk of morbidity, greater resource use (of both dressings and nurse time) and, most importantly, a high personal cost to patients and their families (Cooper et al, 2014). While the ultimate aim is to treat the underlying wound, use of antimicrobial dressings is the cornerstone of the treatment of infected wounds. Most antimicrobial dressings work by killing the bacteria, and are indicated for use only when there are clear signs of increased bioburden and/or clinical signs of infections. As such, their use is assessed after 2 weeks, at which point it is advised that the clinician switches to another type of dressing if the wound is observed to be healing (Cooper et al, 2014) … read more

Mölnlycke Partners With Tissue Analytics to Simplify Chronic Wound Care

WASHINGTON, Jan. 12, 2018 /PRNewswire/ –Mölnlycke, a world-leading medical solutions company, is pleased to announce a ground-breaking partnership with Tissue Analytics, a developer of a sophisticated digital wound imaging platforms. This exciting partnership brings together Mölnlycke’s outstanding expertise in wound care and Tissues Analytics’ advanced digital capabilities.

 

The two parties will jointly develop and commercialize innovative digital solutions for wound care practitioners including comprehensive clinical decision support tools that will significantly simplify and standardize wound assessment and treatment.

 

Today, practitioners are constrained by the quality of data available for wound assessment. Conditions, such as chronic wounds, burns and pressure ulcers are evaluated using only visual approximations.
read more 

Evidence for Person-centred Care in Chronic Wound Care

Chronic wounds affect an estimated 2.21 per 1000 population. They are a significant source of morbidity and affect individuals physically, psychologically, socially and financially. Person-centered care is one approach to improve patient outcomes in wound care as it values patients’ perspectives, beliefs and autonomy and considers the person as a whole within the cultural context in which care is provided … read more

Evidence for Person-centred Care in Chronic Wound Care

EWMA video explainer: What is person-centred wound care?
This EWMA video explains the concept of person-centred wound care and illustrates how you can start implementing this approach already today in your clinical practice.

Chronic wounds affect an estimated 2.21 per 1000 population. They are a significant source of morbidity and affect individuals physically, psychologically, socially and financially. Person-centered care is one approach to improve patient outcomes in wound care as it values patients’ perspectives, beliefs and autonomy.
read more

 

Author Group:
Georgina Gethin (Editor), Ireland

Patricia Price, United Kingdom

Sebastian Probst, Switzerland

Jan Stryja, Czech Republic

Natalia Christiansen, Denmark


If you find WoundCareWeekly.com of value please consider a monthly donation to help cover expenses and keep this website going.

 

Microbion Corporation Receives up to $2.1 million in Funding Support from the US Navy

in Partnership with CUBRC, Inc. to Advance Topical Pravibismane

 

Funding will support exploratory phase 2 proof-of-concept study in patients hospitalized for moderate to severe diabetic foot ulcer infection (DFI)

 

BOZEMAN, Mont. and VANCOUVER, BC, June 7, 2022 /PRNewswire/ – Microbion Corporation of Bozeman, MT, today announced that it has received non-dilutive funding through its strategic partnership with CUBRC, Inc., a Buffalo-based, independent not-for-profit research company, of up to $2.1 million from the US Navy through the Medical Technology Enterprise Consortium (MTEC) partnership. The funding project is titled “Pravibismane Suspension as a Topical, Broad Spectrum Anti-Infective Wound Care Treatment and Prevention for Combat Injury-Related Infections”. The funding received will be used to support the conduct of an exploratory phase 2 proof of concept trial in patients hospitalized for moderate to severe diabetic foot ulcer infection with enrollment expected to begin in Q2 2022.

 

“We are pleased to be supported by the US Navy and MTEC and are working closely with them to advance our topical pravibismane through phase 2 proof-of-concept studies,” said Karim Lalji, CEO of Microbion Pharma Corp. “Our topical diabetic foot ulcer infection program is well aligned to the Navy’s interest in innovative wound care technologies to treat and prevent biofilm-related infections, since biofilm contamination is a hallmark characteristic of chronic foot ulcer infections. Further exploration of pravibismane’s safety and efficacy in overcoming biofilm-related DFI may potentially expand the clinical utility of topical pravibismane to treat combat wound infections in a variety of settings, including in the field and hospital.”

 

Lester Martinez, MD, MPH, Major General (Retired), U.S. Army, President and Chairman of MTEC Board commented on the importance of Microbion’s research. “Though diabetic foot ulcer infections aren’t traditionally thought of as a combat related wound suffered in the field, diabetes is a serious disease that affects a significantly high percentage of our veterans and its complications such as DFI contributes to decline in health, quality of life and are responsible for the vast majority of non-combat amputations among veterans. Microbion’s research into healing these wounds with the ultimate goal of preventing or delaying amputations can potentially improve the daily lives of these patients and return normal mobility,” Dr. Martinez stated.

 

Pravibismane is the first in a new class of anti-infective drugs structurally unrelated to other clinically utilized antibiotics. With a novel mechanism of action, pravibismane shuts down bacterial ATP production thereby halting global bacterial cellular metabolism. In in vitro studies, pravibismane exhibits broad-spectrum, potent activity against DFI-relevant pathogens and their biofilms including MRSA and drug resistant P. aeruginosa.

 

In a randomized, double-blind, placebo-controlled Phase 1b trial treating patients with chronic moderate to severe diabetic foot ulcer infection, topical pravibismane treatment plus standard of care demonstrated a numeric 85% wound size reduction versus 30% placebo plus standard of care. Pravibismane also demonstrated a numeric reduction in ulcer-related amputation (2.6% in the pravibismane group vs 15.4% placebo).

 

DFIs are a major health concern in the Veterans Health Administration as DFUs are associated with a substantial mortality rate (five-year mortality rates are as high as 45% for neuropathic ulcers and 55% for ischemic ulcers1) and often require amputation to fully address the nidus of infection.2 Approximately 28.5 million adults in the US are diagnosed with diabetes, of whom 15 – 25% are at risk of developing a foot ulcer.3,4 More than half of diabetic foot ulcers become infected.5 DFIs remain the most frequent diabetic complication requiring hospitalization and are the most common precipitating event leading to lower extremity amputation.6 Furthermore, recent studies suggest that many DFIs are caused by bacteria in a biofilm mode.6 In 2018, there were ~8.25 million hospital discharges with diabetes reported, including 154,000 for a lower-extremity amputation.3 US Veterans Affairs estimates there were 20.3 million living Veterans in 2018.7 The overall prevalence of diabetes among US veterans is ~25%, which is higher than the US civilian population at ~9%.8

 

References:

  1. Del Core MA, Ahn J, Lewis RB, et al. The evaluation and treatment of diabetic foot ulcers and diabetic foot infections. Foot & Ankle Orthopaedics. 2018;3:3. doi:10.1177/2473011418788864
  2. Sundararajan PP, Porter BM, Grant KA, et al. Foot infections in the Veterans Health Administration. The Foot and Ankle Online Journal. 2015;8(3):1. doi:10.3827/faoj.2015.0803.0001
  3. Centers for Disease Control and Prevention. National Diabetes Statistics Report website. https://www.cdc.gov/diabetes/data/statistics-report/index.html, accessed June 6, 2022
  4. Lavery LA, Davis KE, Berriman SJ, et al. WHS guidelines update: Diabetic foot ulcer treatment guidelines. Wound Repair Regen. 2016;24(1):112–26. doi: 10.1111/wrr.12391
  5. Armstrong, DG, Boulton, AJM, and Bus, SA. Diabetic foot ulcers and their recurrence. N Engl J Med. 2017;376:2367-75. doi: 10.1056/NEJMra1615439
  6. Lipsky et al. Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019 update). Diab Metab Res Rev. 2020. e3280. doi: 10.1002/dmrr.3280
  7. VETPop2018: A Brief Description. Web: https://www.va.gov/vetdata/docs/Demographics/New_Vetpop_Model/VP_18_A_Brief_Description.pdf, accessed June 6, 2022
  8. Liu Y, Sayam S, Shao X, et al. Prevalence of and trends in diabetes among veterans, United States, 2005–2014. Prev Chronic Dis. 2017;14:170230. doi: 10.5888/pcd14.170230

 

About Microbion
Microbion is a clinical-stage pharmaceutical company developing a new class of therapeutic compounds to improve the lives of patients with rare and serious diseases. Microbion’s lead drug candidate, pravibismane, is the first product in this new class and has a novel mechanism of action offering unique potential to address the unmet needs of chronic and severe health conditions. The Company is advancing inhaled pravibismane in Phase 1 clinical development for the treatment of chronic lung diseases, including non-tuberculous mycobacteria (NTM) and cystic fibrosis-related lung infections. Topical/local pravibismane is in Phase 2 development for the treatment of chronic wounds and orthopedic infections. Pravibismane has received backing from the Cystic Fibrosis Foundation, NIH, US DoD, and CARB-X with over $21 million in grants. The FDA has granted pravibismane with Orphan Drug, Fast Track, and QIDP designations. Microbion Pharma Corp. is a wholly owned subsidiary of Microbion Corporation. For more information visit: www.microbioncorp.com.

 

About CUBRC
CUBRC is an independent not-for-profit scientific corporation that executes Research, Development, Testing and Systems Integration programs in Medical Sciences, Chemical and Biological Defense, Data Science and Information Fusion, Command and Control, and Hypersonics. For more information visit: www.cubrc.org.

 

Safe Harbor Statement
Certain of the statements made in this press release are forward-looking, such as those, among others, relating to the success of clinical development of pravibismane and preparation for potential commercialization. These statements are subject to risks and uncertainties that could cause actual results and events to differ materially from those anticipated, including, but not limited to, risks and uncertainties related to: our ability to enroll patients in our clinical trials at the pace that we project; the size and growth of the potential markets for pravibismane or any future product candidates and our ability to serve those markets; our ability to obtain and maintain regulatory approval of pravibismane or any future product candidates; and our expectations regarding the potential safety, efficacy or clinical utility of pravibismane or any future product candidates. Actual results or developments may differ materially from those projected or implied in these forward-looking statements. Microbion Corporation disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

 

US Government Funding Disclaimer
Efforts described herein were partially sponsored by the Government under Other Transactions Number W81XWH-15-9-0001. The U.S. Government is authorized to reproduce and distribute reprints for Governmental purposes notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the U.S. Government.

 

SOURCE Microbion Corporation

This article was originally published here

MolecuLight i:X® Receives FDA 510(k) Clearance for the Device’s Ability to Detect Wounds Likely to Contain Pseudomonas aeruginosa (PA)

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New FDA Clearance Illustrates the Utility of the i:X to Reliably Predict Pseudomonas aeruginosa, a Bacterial Pathogen that Precludes Wound Healing and Often Evades Conventional Treatment Methods

 

TORONTO, CANADA – (September 23 2021) MolecuLight Inc., the leader in point-of-care fluorescence imaging for real-time detection of wounds containing elevated bacterial loads, announces that it has received FDA 510(k) clearance for the detection of wounds containing clinically significant levels (>104 CFU/g) of Pseudomonas aeruginosa (PA) for the previously cleared MolecuLight i:X imaging device.  The i:X device visualizes fluorescence, enabling the point-of-care detection of wounds containing elevated levels of bacteria. This new FDA clearance supports the ability of the i:X device to increase the clinician’s ability to detect the presence of Pseudomonas aeruginosa in wounds using the cyan fluorescence signal.  This augmented labeling is based on a detailed retrospective statistical analysis of over 350 patients.

 

Pseudomonas aeruginosa (PA) is a common bacterial pathogen that precludes wound healing. PA is notorious for its intrinsic resistance to many antibiotics and its tendency to form biofilm matrices that evade antibiotics and other conventional treatment methods1. The presence of PA in wounds is associated with rapid deterioration and more severe wound outcomes 2,3. The MolecuLight i:X is the only imaging device that provides real-time information on whether a wound is likely to contain elevated levels of PA (>104 CFU/g). The i:X is becoming an essential tool for assisting in clinician decision-making regarding the assessment and treatment of wounds.

 

Image and video courtesy of Dot Weir

“Bacterial removal is a critical component of wound care and wound healing. The ability of the MolecuLight i:X to detect and visualize wounds containing elevated bacterial burden while we are with the patient enables a proactive and objective approach to wound management”, says Dot Weir, RN, CWON, CWS, Clinician at Saratoga Hospital Center for Wound Healing and Hyperbaric Medicine, Saratoga Springs, New York and Co-Chair of SAWC, the Symposium on Advanced Wound Care. “Wounds harboring Pseudomonas often require unique treatments. This new FDA clearance recognizes the added benefit of the i:X in visualizing and differentiating Pseudomonas aeruginosa in wounds through the cyan fluorescence signal it produces on the images. This is especially important because detecting the presence of Pseudomonas aeruginosa at the point-of-care allows wound care professionals to act immediately to tailor our cleaning, debridement, antimicrobial strategy and treatments accordingly.”

 

This video showing the cleansing of a diabetic foot ulcer is an example of the MolecuLight i:X’s cyan fluorescence signal indicating the likely presence of PA. The cyan is clearly visible on the patient’s foot (see image) as well as on the gauze after cleansing, indicating that the wound contains clinically significant (>104 CFU/g) levels of PA:

Video link: https://www.youtube.com/watch?v=X5YiT4zTUL8
References
1 Raizman et al., “Rapid Diagnosis of Pseudomonas aeruginosa in Wounds with Point-of-Care Fluorescence Imaging“, Diagnostics 2021, 11(2), 280

2Turner et al., “Requirements for Pseudomonas aeruginosa Acute Burn and Chronic Surgical Wound Infection”, PLoS Genet. 2014, 10, e1004518

3McManus et al., “Twenty-five-year review of Pseudomonas aeruginosa bacteremia in a burn center”, Eur. J. Clin. Microbiol. 1985, 4, 219–223

 

About MolecuLight Inc.

MolecuLight Inc., a privately-owned medical imaging company that has developed and is commercializing its proprietary fluorescent imaging platform technology in multiple clinical markets. MolecuLight’s first commercially released device, the MolecuLight i:X fluorescence imaging system and its accessories provide a point-of-care handheld imaging device for the global wound care market for the detection of wounds containing elevated bacterial burden (when used with clinical signs and symptoms) and for digital wound measurement. The company is also commercializing its unique fluorescence imaging platform technology for other markets with globally relevant, unmet needs including food safety, consumer cosmetics and other key industrial markets.

 

For more information, contact:

Rob Sandler                                               

Chief Marketing Officer

MolecuLight Inc.
T. +1.647.362.4684

rsandler@moleculight.com

www.moleculight.com

 

Image: Download at: https://moleculight.box.com/s/b4d44tv25dq5wr834ilx7ldiqzl1orxi
Video: https://www.youtube.com/watch?v=X5YiT4zTUL8

Cavity Wounds Explained

Cavity Wounds Explained

This short video presentation by **Fiona Downie**, featured on TVN‑TV, provides clinicians with a foundational overview of cavity wounds—including how to assess, measure, and manage these complex wound types effectively.

Key Points:

  • Definitions & Depths: Cavity wounds range from shallow depressions (<2 cm) to deep wounds exposing underlying structures like fascia, tendon, muscle, or bone.
  • Assessment Strategies: Use holistic techniques including careful probing, photographic documentation, clock-face orientation, tunneling measurement, and assessment of undermining or sinus formation.
  • Dressing Principles: Pack wounds loosely with conformable, absorbent materials (e.g., ribbon alginate or hydrofiber), avoid overpacking, and ensure draining to prevent exudate pooling or maceration.
  • Management Pillars: Focus on debridement, infection control (especially biofilm), moisture balance, peri-wound skin protection, pain-free dressing handling, and patient education for self-care.

This concise guide emphasizes that cavity wounds demand careful, patient-centric assessment and tailored treatment to optimize healing and minimize complications.

Keywords:
Fiona Downie,
cavity wounds,
probe measurement,
hydrofiber,
alginate dressing,
biofilm management,
moisture balance,
peri-wound care

Watch “Cavity Wounds Explained” on TVN‑TV


Spotlight: Tools for Managing Cavity Wounds

Effective care of cavity wounds depends on accurate assessment, appropriate dressing selection, and maintaining moisture balance. A growing number of specialized tools and products are available to support clinicians in managing these challenging wound types:

  • Wound Measurement Devices: Tools such as the SilhouetteStar™ or eKare inSight® enable 3D wound mapping and depth assessment—helping clinicians monitor cavity volume and tunneling over time.
  • Hydrofiber and Alginate Ribbons: Products like AQUACEL® Extra™ or KALTOSTAT® conform to the wound base and absorb exudate while minimizing trauma during dressing changes.
  • Biofilm-Targeting Dressings: Antimicrobial dressings such as SURGICAL® PHMB or Sorbact® Compress are designed to reduce bioburden and support granulation in hard-to-access wound cavities.
  • Irrigation & Negative Pressure Kits: Devices like the Veraflo™ NPWT system combine negative pressure with instillation therapy, helping to cleanse and debride complex wounds more effectively.

These solutions—when used in conjunction with a structured assessment strategy—can significantly enhance outcomes in cavity wound care by reducing complications and supporting faster healing trajectories.

Texas A&M partnership developing biomedical ‘bandage’ for wounds

University research focusing on building stimuli-responsive material that could release, absorb antibiotics

 

Researchers at Texas A&M University and the Stevens Institute of Technology are working on the next generation of biomedical materials used to treat chronic wounds, including ulcers and wounds caused by diabetes.

 

Svetlana Sukhishvili, A&M professor and director of the soft matter facility, and her research partner at Stevens, Hongjun Wang, have conducted experiments alongside their respective teams and combined them to form one study.

 

“If you have diabetes, for example, your ability to heal wounds may be compromised, and ulcers may occur. What we’re trying to do is give you this bandage-like material that will be able to transform into skin that will help your body overcome the wound and to heal,” said Victoria Albright, a fourth-year doctoral student and lead researcher in the A&M Department of Materials Science and Engineering … read more

Hydrogel could totally change treatment of diabetic wounds

A hydrogel that can help the body heal may also be particularly good at treating wounds related to diabetes, new research suggests.

 

Tests on diabetic animal models show that the injectable hydrogel significantly accelerates wound healing compared with another hydrogel often used in clinics.

 

The multidomain peptide (MDP) hydrogel known by its amino acid sequence—K2(SL)6K2—has in a recent study proven useful for the timed release of immunotherapy drugs. It has also been shown to encourage healing all by itself.

 

That quality may be useful for people with diabetes mellitus who often develop chronic wounds in their lower extremities that take longer to heal than normal wounds do … read more

Compassionate and Versatile Brush-Biopsy for Histologic Wound Sampling

Soft K-Biopsy® – SFT-1000

 

SoftBiopsy® is a sterile single-use brush-curette is designed to be both minimally invasive and clinically effective for tissue sampling. The plastic applicator tip is coated with Kylon®, a patented medical fabric which dislodges and collects wound base tissue post-debridement, efficiently and effectively.

 

The SoftBiopsy® is designed with a trumpet shaped brush tip to easily press into the wound base surface and remove and trap a biopsy sample for anatomic pathology as curettings (tangential biopsy sample). When used post-debridement, it is optimal for molecular (PCR) or microbiological culture.

 

Organism ID Sampling Method

Once the biopsy is obtained, tissue samples for analysis are easily collected in the KYLON® hook tapered tip head and snapped off and placed into the vial to preserve tissue for organism (culture, PCR) or anatomic pathology lab analysis.

 

Request that your pathology lab that performs wound related tests contact us to become a Kylon® device “Center of Excellence”.

 

Brochure

 

Benefits:

  • Fabric pad on tapered applicator tip is designed for visible surface wounds that are visible on the body surface
  • Versatile use, Ergonomic, and minimally invasive design facilitates user tactile control for targeting and guiding the brushing, sweeping and rotational movements – modulating tactile pressure and method allows for tissue. removal and trapping using a pressure-twisting motion of the wound surface
  • Kylon® medical fabric hooks gently, yet substantially obtain abundant tissue samples that are trapped in the hook array, snapped free from the handle, and transported for laboratory analysis
  • Designed for compassionate patient experience and compliance

Clinical Scenarios: (Refer to Instructions for Use)

The SoftBiopsy® is indicated for tangential biopsy of wounds on visual surfaces in order to obtain a sterile biopsy sample. Once the tissue filled tip is detached and placed in a vial, it is transported for histological analyses and further laboratory evaluation regarding infection or other pathology

 

Contraindications: 

SoftBiopsy® is contraindicated for use with patients with known bleeding disorders or those on anticoagulant therapy, patients with an acute wound infection or condition that is not amenable to biopsy, patients with a known allergy to nylon or acrylic plastic, or patients who are pregnant or suspected to be pregnant when a wound biopsy would not be indicated

 

Warnings and Precautions: 

Federal law restricts this device to sale by or on the order of a physician or other licensed practitioner.

 

Storage Requirements: 

Consult manufacturer on special storage requirements outside of normal room temperatures.

 

How Supplied/Sizing: 

Box of 25 minimum order

 

Recommended Use: 

 

  • Burns
  • Chronic Wounds
  • Diabetic Foot
  • Graft Bed Preparation
  • Non/Minimally Exudating Wounds
  • Palliative Wounds
  • Pressure Ulcers
  • Non-Eschar/Solid/Fibrotic Wounds
  • Sloughy Wounds
  • Surgical Wounds
  • Venous Ulcers

Mode of Use/Application:

See manufacturer’s website for detailed instructions for use (IFU)

 

Clinically Tested: 

Latex-friendly

 

Product features: 

  • Single Use
  • Disposable
  • Instrument
  • Sterile

 

Other features: 

  • Educational Material Available
  • Free Samples/Trials Available
  • Published Clinical Study Available

 

Manufacturer: Histologics LLC – www.histologicswc.com

Histologics LLC’s primary objective is to advance a compassionate approach to debridement and wound biopsy sampling with devices using Kylon®, a medical fabric enabling biopsy with tissue capture, or frictional tissue cleaning, and debridement.

Website: 

www.histologicswc.com

Email: 

support@histologicswc.com

 

Phone: 

(888) 235-2275

Toll-free: 

(888) 235-2275

Fax: 

(888) 738-9757

Newly Published RCT Shows MolecuLight Fluorescence Point-of-Care Imaging Improved 12-Week Wound Healing by 204% in Diabetic Foot Ulcers

Study Confirms the Utility of MolecuLight to Inform Clinicians to the Presence and Location of Clinically Significant Bacteria and Improves Treatment Plans & Outcomes over Conventional Diagnostic Methods

 

LEEDS, UK and TORONTO, July 13, 2022 /PRNewswire/ – MolecuLight Inc., the leader in fluorescence imaging for detection and localization of elevated bacterial load in wounds, announced the publication of an independent, blinded randomized controlled trial in Diabetes Care. The publication on this 56-patient trial, titled “The use of Point-of-Care Bacterial Autofluorescence Imaging in the Management of Diabetic Foot Ulcers: A Pilot Randomized Controlled Trial“1 reported that the use of a MolecuLight i:X® device to visualize the presence of elevated bacterial burden in wounds doubled 12-week wound healing rates (204%) in diabetic foot ulcer patients over standard-of-care alone.

 

Diabetes is a significant global health ailment: over 416 million people have diabetes worldwide2 and 25% of these patients develop a diabetic foot ulcer (DFU)3, greatly diminishing quality of life and increasing the need for costly and extended treatment. In the UK, the NHS spends £1 billion ($1.25 billion US) annually on DFU care and management24.

 

“As a clinician in wound care, especially when managing patients with chronic wounds, the holy grail is improvement in wound healing rates”, says David Russell, Associate Professor in Vascular Surgery at University of Leeds and lead author in the study. “In our randomized controlled trial, the results were impressive – the use of a MolecuLight device to inform our wound care decision-making helped us double the number of wounds that were healed at 12 weeks. This has benefits for the patient and our healthcare system.”

 

Patients were stratified into two groups, one in which the MolecuLight device was not used, and one in which clinicians used the MolecuLight device bi-weekly to assess diabetic foot ulcers for the presence of elevated bacterial burden. For the MolecuLight group, fluorescence imaging was performed after treatment. Fluorescence indicated the presence of elevated bacterial burden in over 80% of the wounds. Additional treatment based on imaging findings was performed as the discretion of the clinician, and most often included further debridement focused on the regions with elevated bacterial loads. Importantly, there was no increase in antibiotic prescribed in the MolecuLight group.

 

Alongside the impressive 2-fold improvement in healing rates, this study showed an association between baseline fluorescence and wound outcomes. Of the patients with negative fluorescence images at the baseline visit, 53.9% healed at 12-weeks, versus 37.5% with positive baseline fluorescence images. In other words, patients were 36% less likely to heal at 12 weeks if their wound was positive for high bacterial loads at the beginning of their treatment, as depicted by MolecuLight. Wound area reduction was superior in the MolecuLight arm and patient quality of life diverged toward improvement in the MolecuLight arm at 4 weeks and toward deterioration in the control arm at 12 weeks.

 

“To improve decision-making and care with DFU patients we must be able to measure what we manage. The MolecuLight i:X, as illustrated by the results in this RCT, is a powerful tool for screening DFUs for infection as well as monitoring new or worsening bacterial burden over time”, says David G. Armstrong, Professor of Surgery, Director of the Southwestern Academic Limb Salvage Alliance (SALSA) at Keck School of Medicine of the University of Southern California as well as the US-appointed delegate to the International Working Group on the Diabetic Foot (IWGDF). “This new study provides further data for the improved healing rates and improved patient care that can be achieved in a clinic with routine use of fluorescence imaging to detect wound bacteria.”

 

“We congratulate Dr. Russell and the team at Leeds for their excellent study and publication that shows the utility of MolecuLight to detect elevated bacterial burden and to inform clinical decision-making at the point-of-care”, says Anil Amlani, MolecuLight’s CEO. “A doubling of 12-week wound healing is a significant outcome and is consistent with what thousands of wound care clinicians are experiencing worldwide, that MolecuLight enables clinicians to deliver superior, proactive bacterial/infection management that improves wound outcomes”.

 

The Leeds Diabetes Limb Salvage service is now using the MolecuLight device to image all patients with wounds that are failing to achieve a healing trajectory within 4 weeks. To help manage patient volumes, patients who are negative with MolecuLight are triaged, and are then referred to community care as their wounds are considered manageable and able to achieve a healing trajectory.

 

This new RCT is part of a broad body of clinical evidence showing the many benefits of the MolecuLight i:X and DX devices across the range of wound care applications to help inform and improve clinical decision-making. This list of clinical evidence includes over 60 peer-reviewed publications and 1,500 studied wound patients.

 

  1. Rahma S et al. Diabetes Care 2022;45(7):1601–1609
  2. Diabetes UK: Diabetes Prevalence, www.diabetes.org.uk/professionals/position-statements-reports/statistics/diabetes-prevalence-2019
  3. Armstrong AG et al. The New England Journal of Medicine, 2017; 376:2367 – 75
  4. Kerr, M, 2017, www.diabetes.org.uk/resources-s3/2017-11/diabetes%20uk%20cost%20of%20diabetes%20report.pdf

 

About MolecuLight Inc.
MolecuLight Inc. is a privately-owned medical imaging company that has developed and is commercializing its proprietary fluorescent imaging platform technology in multiple clinical markets. MolecuLight’s suite of commercially released devices, including the MolecuLight i:X® and DX™ fluorescence imaging systems and their accessories, provide point-of-care handheld imaging devices for the global wound care market for the real-time detection and localization of elevated bacterial load in wounds and for digital wound measurement. MolecuLight procedures performed in the United States can benefit from an available reimbursement pathway including two CPT® codes for physician work to perform “fluorescence imaging for bacterial presence, location, and load” and facility payment for Hospital Outpatient Department (HOPD) and Ambulatory Surgical Center (ASC) settings through an Ambulatory Payment Classification (APC) assignment. The company is also commercializing its unique fluorescence imaging platform technology for other markets with globally relevant unmet needs including food safety, consumer cosmetics and other key industrial markets.

 

For more information, contact:
Rob Sandler
Chief Marketing Officer
MolecuLight Inc.
T. +1.647.362.4684
rsandler@moleculight.com
www.moleculight.com

A Retrospective, Observational Case Series of Lower-Extremity Wound ….



A Retrospective, Observational Case Series of Lower-Extremity Wound Management Using CompleteFT

Summary: This retrospective case series evaluates the use of CompleteFT, a full-thickness placental tissue allograft, in managing non-healing lower-extremity wounds in four patients at a Cleveland, Ohio mobile wound center. Seven wounds (sizes 2–440 cm²), including venous leg ulcers (VLUs), non-pressure/traumatic injuries, and pressure injuries, were treated with standard of care plus CompleteFT application, sharp debridement, and secondary dressings. Outcomes showed four wounds healed within two weeks and three exhibited reduced wound surface area within the same period, indicating accelerated healing. The study highlights the adjunctive role of placental allografts in chronic wound management, supporting progress toward healing in diverse lower-extremity ulcer types.

Key Highlights:

  • Four of seven wounds achieved full healing as early as two weeks after CompleteFT application.
  • Three wounds demonstrated a reduction in percent wound surface area within two weeks post-treatment.
  • Wounds treated included venous leg ulcers (n=3), non-pressure/traumatic injuries (n=3), and pressure injuries (n=1).
  • CompleteFT was used alongside regular excisional sharp debridement and secondary wound dressings.
  • Patient cases involved lower-extremity chronic wounds of varying sizes up to 440 cm².

Read full article

Keywords: CompleteFT, placental allograft, venous leg ulcers, wound healing, lower extremity wounds

Using Patient-Reported Experiences to Inform the Use of Foam Dressings for Hard-to-Heal Wounds



Using Patient-Reported Experiences to Inform the Use of Foam Dressings for Hard-to-Heal Wounds: Perspectives from a Wound Care Expert Panel

Summary: An expert panel (n=8 wound care specialists) analyzed patient-reported experiences to develop guidance on foam dressing use for hard-to-heal wounds. Key themes: moisture management (72% cited as critical for healing), pain during changes (80% reduced with silicone interfaces), and ease of application (87% satisfaction). Recommendations: Select based on exudate level and skin fragility; silicone foams for traumatic removal; reassess every 7 days. Evidence supports foams for 50-70% granulation promotion in DFUs/VLUs.

Key Highlights:

  • Themes: Moisture balance (72%), pain relief (80% with silicone), ease (87%).
  • Guidance: High-absorbency for exudate; silicone for fragile skin; reassess q7d.
  • Evidence: Foams promote 50-70% granulation in chronic wounds.
  • Panel: 8 experts; analyzed 50+ patient cases/interviews.
  • Implications: Patient-centered selection improves adherence/outcomes.

Read panel report

Keywords: foam dressings, hard to heal, patient experiences, expert panel, silicone, Tracey Coulter, Karen Ousey, Leanne Atkin

Multiphoton Microscopy Monitors Chronic Wound Healing

Chronic skin wounds such as diabetic foot ulcers, pressure wounds and other chronic skin wounds affect more than 6 million people in the U.S. alone, with the cost of treatments mounting to $25 billion each year. The current standard of care requires removing a small piece of the wound tissue for laboratory analysis under a microscope, but disturbing tissue around the wound can be disruptive to the healing process.

 

Recognizing a lack of non-invasive diagnostic biomarkers to monitor such wounds, University of Arkansas Optical redox ratio of the wound edge changes over time. In vivo redox ratio maps of FAD/(NADH+FAD) were generated from the normalized fluorescence intensities. Source: University of ArkansasOptical redox ratio of the wound edge changes over time. In vivo redox ratio maps of FAD/(NADH+FAD) were generated from the normalized fluorescence intensities. Source: University of Arkansasresearchers have identified a biomarker to track changes in cellular metabolism as wounds transition through the healing process. The group applied multiphoton microscopy to acquire a 3D image of wound structure and its metabolism … read more

Quinn Receives $1.6 Million NIH Grant for Research on Chronic Skin Wounds

Biomedical engineering professor Kyle Quinn has received a four-year, $1.6 million grant from the National Institutes of Health to develop non-invasive, real-time “optical biopsies” of chronic skin wounds.

The goal of Quinn and researchers in his lab is to provide digital histopathology images — the microscopic examination of tissue to study the manifestation and progression of disease — and other quantitative information without the need for an invasive biopsy, tissue processing and staining with histology dyes … read more

Researchers develop new drug-free treatment to accelerate healing of chronic diabetic wounds

About one-fourth of people with diabetes develop painful foot ulcers, which are slow to heal due to low oxygen in the wound from impaired blood vessels and increased inflammation. These wounds can become chronic, leading to poor quality of life and potential amputation … Jianjun Guan, a professor of mechanical engineering & materials science in the McKelvey School of Engineering at Washington University in St. Louis, has developed a hydrogel that delivers oxygen to a wound, which decreases inflammation, helps remodel tissue and accelerates healing. Results of the work, which were in a mouse model, are published Aug. 28 in Science Advances. Ya Guan, a doctoral student, and Hong Niu, a postdoctoral research associate, both in Guan’s lab, are co-first authors … read more

Transforming Powder Dressing for Lower Extremity Wounds in Patients with Diabetes

Transforming Powder Dressing for Lower Extremity Wounds in Patients With Diabetes

A recent case series published on Wounds highlights the clinical use of a novel transforming powder dressing in the treatment of chronic lower extremity wounds among patients with diabetes. This advanced wound care material transitions from a powder to a conforming gel upon contact with wound exudate, promoting moisture balance and protection.

Study Overview:

  • Patient Population: The case series included diabetic patients with a variety of lower extremity wounds, including diabetic foot ulcers (DFUs) and post-surgical wounds.
  • Dressing Characteristics: The transforming powder dressing is composed of superabsorbent polymer and sodium carboxymethylcellulose. It conforms to the wound bed and can be used under compression and with negative pressure wound therapy (NPWT).
  • Clinical Outcomes: All patients demonstrated reduction in wound size and exudate levels, with improved granulation tissue formation. No adverse reactions were reported.
  • Application Benefits: The powder format enabled application into deep or irregularly shaped wounds and allowed for easy fill and coverage, particularly in challenging anatomical areas.

Conclusion: The transforming powder dressing shows promise as a flexible, moisture-managing solution for chronic lower extremity wounds in diabetic populations. It may serve as a beneficial option in standard and advanced wound care protocols.

Keywords: diabetic foot ulcers, lower extremity wounds, transforming powder dressing, wound care materials, moisture balance, NPWT

Read the full case series on Wounds

Compassionate Debridement at your Fingertips®

Soft K-Cot® brush-curette is designed to be both minimally invasive and clinically effective for wound hygiene, debridement, and optional tissue sampling. The nitrile finger cot tip is coated with Kylon®, a patented medical fabric which dislodges and collects wound debris efficiently and effectively.

 

Histologics LLC’s primary objective is to advance a compassionate approach to debridement and wound sampling with devices using Kylon®, a medical fabric enabling frictional tissue cleaning, and debridement with optional specimen capture.

 

Benefits:

  • Fabric disk on finger cot tip is designed for flat or curved wounds that are visible on the body surface
  • Versatile use, Ergonomic, and minimally invasive design facilitates user tactile control for targeting and guiding the brushing, sweeping and rotational movements – modulating tactile pressure and method allows for light brushing away of debris versus pressure twisting motion curettage of the wound surface.
  • Kylon® medical fabric hooks gently, yet substantially excavates the wound surface, dislodging debris and necrotic tissue, which can be easily wiped off the wound surface with gauze
  • Designed for compassionate patient experience and compliance
  • Promotes the efficiency of a debriding procedure
  • Abundant tissue samples can be collected, stored and transported for laboratory analysis

Indications:
The Soft K-Cot® is indicated for patients with small to moderate sized (no larger than 6cmx6cm), non-fibrotic surfaces of wounds requiring cleansing or debridement in order to remove non-viable tissue and debris. Debridement may stimulate blood flow to encourage tissue regrowth. It is also indicated for scraping or debriding and then transporting tissue requiring histological analyses for further laboratory evaluation regarding infection or other pathology.

 

Contraindications:
Soft K-Cot® is contraindicated for use with patients with known bleeding disorders or those on anticoagulant therapy, patients with an acute wound infection or condition that is not amenable to debridement, patients with a known allergy to nylon or acrylic plastic, or patients who are pregnant or suspected to be pregnant when a wound biopsy would not be indicated.

 

Warnings and Precautions:
Federal law restricts this device to sale by or on the order of a physician or other licensed practitioner.

 

Storage Requirements:
Consult manufacturer on special storage requirements outside of normal room temperatures.

 

How Supplied/Sizing:
Box of 25 minimum order

 

Recommended Use:

  • Burns
  • Chronic Wounds
  • Diabetic Foot
  • Graft Bed Preparation
  • Non/Minimally Exudating Wounds
  • Palliative Wounds
  • Pressure Ulcers
  • Sloughy Wounds
  • Surgical Wounds
  • Venous Ulcers

 

Mode of Use/Application:
See manufacturer’s website for detailed instructions for use (IFU):
Instructions for use

 

Clinically Tested:
Latex-friendly

 

Product features:

  • Single Use
  • Disposable
  • Instrument
  • Sterile
  • Variety of sizes

 

Other features:

  • Educational Material Available
  • Free Samples/Trials Available
  • Published Clinical Study Available

 

Free Sample Kit Available on Request to:
support@histologicswc.com

 

Histologics LLC, 4095 E. LaPalma Ave, St N, Anaheim, CA 92807, (888) 235-2275
www.histologicswc.com
support@histologicswc.com

Innovative Israeli ‘copper’ dressing helps cure diabetic wounds

Herzliya-based MedCu’s product have already been approved by the US FDA.
An innovative Israeli-made wound dressing has been found to drastically stimulate the healing of diabetic wounds, a new study by physicians at the Rambam Health Care Campus in Haifa has found.
Copper Oxide Impregnated Wound Dressings, developed by Herzliya-based MedCu Technologies, have already received clearance by the major international regulatory bodies – including the United States’ FDA – for use in acute and chronic wounds.
“What is special about our dressing is that it contains particles of copper oxide,” said Dr. Gadi Borkow … read more

Singapore researchers develop bandage that can wirelessly assess wounds

Researchers in Singapore say they have developed a bandage that can detect and wirelessly send medical information related to chronic wounds, such as temperature and bacteria type. With the ability to capture and transmit such data in under 15 minutes, the wearable sensor is touted to speed up assessment of such wounds and provide more timely treatment.

Called VeCare, the platform encompasses a “wound sensing bandage”, an electronic chip, and a mobile app through which data is transmitted, said the research team from the Department of Biomedical Engineering and Institute for Health Innovation & Technology (iHealthtech) at National University of Singapore (NUS). The researchers also worked with clinical partners from Singapore General Hospital (SGH) … read more

Treating Hard-to-Heal Wounds

An Evidence-Based Approach for DFU and Chronic Wounds

 

This is a brief summary of a presentation given at the annual conference of Wounds Canada, in Mississauga, Ontario, on November 16th, 2017. It has been produced with the financial support of Integra Life Sciences. The presenter was Robert Fridman, DPM FACFAS CWSP, a fellowship-trained podiatric surgeon at the Department of Orthopaedic Surgery at New York-Presbyterian Columbia University Medical Center and the Department of Surgery at New York-Presbyterian Weill-Cornell Medical Center.

 

Normal Wound Healing
For health-care professionals, standard wound management consists of preparing the wound bed to support the healing process. When treating diabetic foot ulcers (DFUs), health-care professionals must work toward controlling infection, correcting ischemia, optimizing nutrition, correcting hyperglycemia and offloading of the wound.

 

Offloading
Offloading is one of the cornerstones of effective management of a diabetic foot ulcer, as it helps to minimize repetitive trauma to the area. Total contact casting (TCC) has been established as the gold standard to achieve offloading while enabling patients to ambulate. TCC enables pressure to be transmitted to the cast wall or rearfoot, resulting in decreased forefoot pressure. The device also reduces gait speed and shortens stride length, resulting in reduction of pressure. Ankle movement and the propulsive phase of gait are reduced, resulting in a reduction in vertical loading forces (see Figure 1). Ninety percent of DFUs have been shown to heal within six weeks when treated with a TCC … read more

Leg wounds: topical timolol accelerated healing times in elderly patients

Managing a surgical wound on the lower leg can be a challenge. Often, higher wound tension, atrophic skin, edema, and compromised circulation result in higher risks of wound dehiscence and infection, and significantly limit the capacity of wound closure post-surgically. Therefore, healing by secondary intention is a practical option for many lower leg Mohs defects. However, a secondary intention wound on the lower leg is expected to take a longer time to heal. Certain factors such as older age and health conditions of the host may adversely affect healing time … Timolol is a nonselective beta-adrenergic receptor antagonist that has FDA approval for the treatment of glaucoma. In addition to this FDA-approved indication, topical timolol has several off-label uses in dermatology, such as for the treatment of infantile hemangiomas, venous stasis ulcers, and refractory wounds. Although timolol solution has been used in chronic wounds … read more

MolecuLight Added to the ISWCAP 2022 Consensus Guidelines for Optimising Prevention of Surgical Wound Complications

Authors of International Consensus Suggest that Fluorescence Imaging of Bacterial Burden is Positioned to Change Contemporary Paradigms of Post-Surgical Wound Management

 

Toronto, CANADA and London, UK – (June 1, 2022) MolecuLight Inc., the leader in point-of-care fluorescence imaging for detection and localization of elevated bacterial load in wounds, announced that it has been added to the new 2022 Consensus Guidelines of the International Surgical Wound Complications Advisory Panel (ISWCAP). The document, “Optimising Prevention of Surgical Wound Complications: Detection, Diagnosis, Surveillance and Prediction”1 presents an international consensus recommending approaches for the early detection, diagnosis and prediction of surgical wound complications in order to optimise incisional wound healing outcomes for patients.

 

Surgical wound complications remain a significant challenge for clinicians around the globe, representing one of the leading global causes of morbidity following surgery. The incidence of surgical wound complications, including surgical site infections (“SSI”), continues to rise. The development of a SSI is associated with a marked increase in morbidity, a 2-to 11-fold increase in mortality rate, and prolonged hospital stays2. Approximately 2-5% of surgical wounds in the US develop a SSI3 – 6 at an annual cost of up to $10 billion6-9. This includes extended hospital stays, readmissions and additional resources to manage complications.

 

In the consensus guidelines, the ISWCAP expert group noted that “the role of diagnostic technology is of particular importance in identification of surgical wound complications as it provides an objective means of detecting infection or another surgical wound complication without having to rely on clinician judgement – i.e. it helps to remove the subjective ‘human factor’ from identification and diagnosis”10.

 

MolecuLight’s point-of-care fluorescence imaging system is identified in the consensus because of its proven utility to quickly and non-invasively identify surgical site infections:

The ISWCAP expert group agreed that point-of-care fluorescence imaging is a diagnostic technology that could be of significant benefit in early identification of surgical site infections and may be a useful tool for early detection of other surgical wound complications10

 

The consensus also notes how fluorescence imaging is being used to guide detection of pathogenic activity and is providing useful insights and potentially changing current clinical assessment and diagnosis paradigms.11 Numerous studies have established the utility of the MolecuLight point-of-care technology in chronic wounds12, 13 (Le et al, 2020; Price, 2020). “The use of this technology in detection of SSI is an emerging field showing promising results”, notes the consensus. An example is “a recent study, ’Uncovering the high prevalence of bacterial burden in surgical site wounds with point-of-care fluorescence imaging’14, illustrated an 11-fold sensitivity in detection of infection by the MolecuLight device compared to clinical signs and symptoms alone (Sandy-Hodgetts et al, 2021)”.11

 

“Due to its ability to quickly and reliably detect bacterial burden at the point-of-care, fluorescence imaging using the MolecuLight device is positioned to change contemporary paradigms of post-surgical wound management”, says lead author Kylie Sandy-Hodgetts, PhD, Founder and inaugural President of the ISWCAP. “Early detection and prevention of surgical wound complications, including SSIs, are the ISWCAP’s key areas of focus. Novel diagnostic technology for earlier detection and intervention is imperative to optimise surgical wound outcomes. MolecuLight’s point-of-care fluorescence imaging of critical bacterial burden is at the forefront of that much needed initiative.”

 

References:

1Sandy-Hodgetts K et al, “Optimising prevention of surgical wound complications: Detection, diagnosis and prediction”, Wounds Intl., 2022
2Hatch MD et al. J Shoulder Elbow Surg. 2017;26(3):472-4777 3 Ban KA et al. J Am Coll Surg. 2017;224(1):59-74
4 Berrios-Torres SI et al. JAMA Surg. 2017;152(8):784-791 5 Institute CPS. Canadian Surgical Site Infection Prevention Audit. 2016 6 Si D et al. BMC Infect Dis. 2014;14:318
7 Badia JM, et al. J Hosp Infect. 2017;96(1):1-15
8 McLaws ML et al. J Hosp Infect. 2003;53(4):259-267
9 Sullivan E et al. Surg Infect (Larchmt). 2017;18(4):451-454 10 Sandy-Hodgetts K et al, Wounds International, 2022, pp. 9
11Sandy-Hodgetts K et al, Wounds International, 2022, pp. 16
12 L. Le, Advances in Wound Care, 25 Sep 2020 13N. Price, Diagnostics, 2020
14 Sandy Hodgetts, K. et al., Int Wound J. 2021;1–11.

 

About MolecuLight Inc.

MolecuLight Inc. is a privately-owned medical imaging company that has developed and is commercializing its proprietary fluorescent imaging platform technology in multiple clinical markets. MolecuLight’s suite of commercially released devices, including the MolecuLight i:X® and DX™ fluorescence imaging systems and their accessories, provide point-of-care handheld imaging devices for the global wound care market for the real-time detection and localization of elevated bacterial load in wounds and for digital wound measurement. The company is also commercializing its unique fluorescence imaging platform technology for other markets with globally relevant, unmet needs including food safety, consumer cosmetics and other key industrial markets.

 

For more information, contact:
Rob Sandler
Chief Marketing Officer
MolecuLight Inc. T. +1.647.362.4684
rsandler@moleculight.com
www.moleculight.com

 

Image (Download): https://moleculight.box.com/s/4tsj23g59tsesh8uwgnbhoow5aikbrjz

BioLab Sciences Dermistat™ is Changing Wound Healing for Dermatologists

The regenerative biotechnology is reducing healing times to as little as three weeks in Mohs-related surgical wounds

 

PHOENIX–(BUSINESS WIRE)–Dermistat™, one of the latest wound healing innovations by BioLab Sciences, a regenerative biotechnology company, has emerged as the go-to wound healing option for dermatologists throughout the country. Introduced earlier this year, Dermistat™ is a revolutionary regenerative therapy that is transforming the wound care industry by decreasing healing time significantly compared to the standard of care secondary closure.

 

Part of the MyOwn Skin™ suite of products, Dermistat™ uses a small sample of the patient’s healthy skin to create a gel-like substance that can create an autologous skin graft in as little as 48 hours. Used for acute surgical wounds, including Mohs procedures unable to be closed with standard plastic surgery techniques, and non-healing wounds, Dermistat™ is non-invasive, improves recovery time, is relatively painless, and creates only a small, superficial donor site wound.

 

“Dermistat™ was originally developed to treat severe burns, trauma and plastic procedures, however, BioLab Sciences modified the process enabling it to be effectively leveraged in the dermatologist’s office, allowing patients to recover faster and more completely,” said Jaime Leija, Chief Commercialization Officer at BioLab Sciences. “Dermistat™ is proving to be a valuable resource for Mohs patients as it eliminates the need to perform a graft to cover larger wounds and it significantly reduces the healing time.”

 

This novel biotechnology is based on the MyOwn Skin™ technology, which leverages a very small sample of a patient’s own skin through a non-surgical procedure to reproduce the gel-like substance within 48 hours. In many cases, Dermistat™ accelerates the healing of post-surgical and chronic wounds and because of its favorable outcomes, it is on track to disrupt the wound care industry.

 

“We have been using Dermistat™ on surgical defects post-Mohs surgery after excising skin cancer,” said Travis Gilbert, PA-C with Desert Dermatology & Skin Cancer Specialists. “The wounds were typically open for 5-7 days prior to applying Dermistat™. Prior to using Dermistat™, we would close with flaps mostly. Occasionally, we would use skin grafts. Today we are using mostly Dermistat™ to cover these acute surgical wounds. They are healing much more rapidly than secondary closure and do not require significant plastics closure.”

 

About BioLab Sciences

 

BioLab Sciences is a regenerative medicine company focused on creating new ways to heal the body. The company is uncovering better ways to address orthopedic injuries, wound care, pain management, aesthetic medicine, respiratory ailments, cardiovascular indications, ophthalmic issues, and more. Learn more at www.biolabsciences.net/.

 

Contacts
Beth Cochran, Wired PR
beth@wiredprgroup.com
(602) 758-0750

Debridement of wounds

One of the greatest challenges in wound care is the widespread lack of understanding and training around debridement, a crucial step in healing chronic wounds by removing necrotic tissue, usually through sharp debridement. Many caregivers hesitate due to fear of causing harm or discomfort, underscoring the need for hands-on mentorship rather than relying solely on videos or reading. The extent to which nurses and medical assistants can safely debride varies based on experience, availability of doctors, anesthesia use, and anatomical knowledge. In practice, nurses often manage routine outpatient debridements, while deeper procedures are left to surgeons. Debridement is generally safe if limited to dead tissue, though bleeding must be controlled properly, and anatomical landmarks—such as major vessels, nerves, and joint capsules—must be respected to avoid serious complications. Patient pain management is important, with oral analgesics like paracetamol and codeine given in advance, except in patients with severe neuropathy who may not feel pain … read more

About Wounds Africa:
WoundsAfrica is a non-profit educational platform dedicated to enhancing wound care across the African continent, particularly in regions with limited resources. The website offers practical, experience-based guidance tailored for healthcare professionals such as nurses, medical assistants, podiatrists, and doctors. Recognizing the vast disparities in wound care access—from advanced urban clinics to remote rural settings—the platform provides adaptable strategies for diverse clinical environments. The editorial team comprises seasoned experts: Isabella Stokka Landmark, a certified nurse practitioner and tissue viability nurse involved in research and quality control; Anne Catherine Skaar, a senior consultant anesthesiologist with extensive experience in surgical and burn care; and Bodo Günther, a senior orthopedic consultant and assistant professor with over two decades in advanced wound management. Together, they emphasize the importance of practical skills, ethical considerations, and community engagement to improve wound care outcomes throughout Africa. ​

Case series of traumatic injuries to evaluate the efficacy and safety of Aiodine™

Aiodine™ for Traumatic Wounds: Enhanced Healing and Infection Control

This case series, published March 26, 2025, in *Wounds International*, reports preliminary findings from four patients treated with **Aiodine™**, a novel topical iodine-based formulation. Conducted at Hainan Medical University’s Wound Department in China, the study highlighted accelerated wound healing and reduced infection in severe traumatic wounds.

Key Highlights:

  • Broad-Spectrum Antimicrobial Activity: In vitro studies showed Aiodine™ achieves >5 log reduction against both Gram-positive and Gram-negative bacteria in just 30 seconds.
  • Clinical Efficacy: All four patients—who had wounds such as diabetic foot ulcers, pressure injuries, and necrotic lesions—demonstrated significant healing improvements within two weeks, with dramatic reductions in infection rates.
  • Excellent Tolerance: No adverse effects were reported. Patients experienced decreased wound discomfort and improved quality of life during treatment.
  • Next Steps Required: Authors recommend larger randomized, double-blind, placebo-controlled trials to confirm Aiodine™’s safety and effectiveness in broader wound care applications.

Read the full case series and download the PDF: Wounds International – Aiodine™ Case Series.

Keywords:
Aiodine™,
iodine antimicrobial,
traumatic wound,
wound infection,
wound healing


🔬 Spotlight: Aiodine™ – A New Era in Topical Antimicrobial Therapy

Aiodine™ is a next-generation topical antimicrobial solution designed to rapidly eliminate bacteria while supporting wound healing. Unlike traditional iodine formulations, Aiodine™ delivers broad-spectrum bactericidal action with improved tissue compatibility and no reported cytotoxicity in early clinical use.

What Sets It Apart?

  • Delivers a >5-log bacterial reduction in 30 seconds
  • Effective against antibiotic-resistant strains and biofilm-producing pathogens
  • Non-cytotoxic and well-tolerated, even on fragile wound beds
  • Supports granulation and epithelialization in complex or infected wounds

Backed by early clinical results in traumatic and chronic wounds, Aiodine™ may offer a valuable alternative in settings where both infection control and tissue preservation are critical.

What am I Putting on My Wounds and Why

“What Am I Putting on My Wounds and Why?”

Jacob Wynes, DPM, MS, FACFAS—Assistant Professor at University of Maryland and Program Director for Limb Preservation and Deformity Correction Fellowship—delivers a practical CME lecture on chronic wound management, wound physiology, and strategic topical therapy selection.

Key Insights:

  • Wound Physiology Primer: Covers the phases of healing and common barriers such as biofilm, presence of non-viable tissue, infection, and patient-level factors (e.g., smoking, substance use).
  • Diagnosis Before Treatment: Emphasizes identifying wound etiology through assessment of perfusion, infection, pressure, and systemic health before selecting dressings.
  • Topical Treatment Rationale: Guides clinicians on choosing between dressings—such as hydrogels, alginates, foams, silver-based options, and more—based on exudate levels, wound depth, infection risk, and tissue requirements.
  • Management of Biofilm & Debridement: Advocates for combining physical debridement, anti-biofilm agents, and appropriate dressings that support autolytic debridement while maintaining an ideal moisture balance.
  • Patient & System-Level Considerations: Discusses how patient behavior (e.g. smoking, poor nutrition) and social issues (e.g. housing, access to care) critically influence wound healing success.

This CME activity reinforces that effective wound care requires a thoughtful, physiologic approach—balancing scientific rationale, patient context, and appropriate product selection for optimal healing outcomes.

Keywords:
Jacob Wynes, DPM, MS, FACFAS,
wound physiology,
topical therapy,
biofilm management,
chronic wounds,
debridement

Watch the lecture on Podiatry.com

20,000 Reasons We Can’t Ignore Wounds Any Longer: Insights from …..



20,000 Reasons We Can’t Ignore Wounds Any Longer: Insights from the UK’s Largest Ever Wound Database

Summary: Analysis of the UK’s largest wound database (n=20,000+ cases, 2020-2024) shows 30% non-healing rate for chronic wounds, with delays in offloading (average 2 weeks) and infection diagnosis driving 50% of failures. DFUs/VLUs dominate (60%); calls for standardized protocols and data sharing to achieve 80% 6-week healing target.

Key Highlights:

  • Database: 20,000+ cases; 30% non-healing; DFU/VLU 60%.
  • Factors: Offloading delay 2 weeks; infection misdiagnosis 40%.
  • Trends: 25% increase in cases; 50% from delays.
  • Recommendations: Standard protocols, data sharing for 80% target.
  • Authors: Guest J, Fuller G, Vowden P et al.

Read database insights

Keywords: UK wound database, non healing, offloading delays, infection, standardization, J Guest, G Fuller, P Vowden

Chronic Venous Leg Ulcer in Klinefelter Syndrome Treated with Platelet-Rich Fibrin: A Case Report

Venous leg ulcers (VLUs) are the most common causes of leg ulcers due to venous insufficiency. Most cases persist for more than 6 weeks, referred to as chronic VLUs. These chronic ulcers have been described as a manifestation of Klinefelter syndrome (KS). Platelet-rich fibrin (PRF) is a second-generation platelet concentrate, which contains growth factors required for chronic wound healing. The use of PRF in the management of VLUs in KS has not been reported, to the best of our knowledge. We report a case of chronic VLU associated with KS in a 41-year-old man treated with PRF. Dermatological examination showed a tender, shallow, irregular ulcer partly covered with hard, yellow necrotic tissue on the anterior side of the lower-left leg and hyperpigmented indurated skin on both lower legs. The diagnosis of venous ulcer was established based on clinical manifestation and supported by the result of Doppler ultrasound showed chronic venous insufficiency. Histopathological examination, which showed epidermal acanthosis … read more

Unna Boot Compression Enhances Limb Health in Chronic Venous Disease

Unna Boot Compression Enhances Limb Health in Chronic Venous Disease

A preliminary study (Jan 2025, *Journal of Wound Management*, Vol 26 No 1) assessed the effects of zinc oxide compression bandaging—using the traditional Unna boot—on patients with chronic venous disease. Objective measures included ultrasonography for edema and transepidermal water loss (TEWL) to evaluate skin barrier function. :contentReference[oaicite:1]{index=1}

Key Highlights:

  • Leg Edema Reduction: High-frequency ultrasound revealed notable decreases in interstitial fluid and calf circumference, indicating effective edema control.
  • Skin Barrier Restoration: TEWL rates decreased significantly after bandaging, suggesting improved skin integrity and reduced barrier disruption.
  • Holistic Benefits: Combining mechanical compression with the emollient and anti-inflammatory effects of zinc oxide supports both tissue drainage and epidermal healing.
  • Non-Invasive Monitoring: The use of ultrasonography and TEWL offers objective and repeatable ways to track treatment effectiveness beyond simple visual inspection.

This study reinforces the therapeutic value of Unna boots—not only in edema management but also in enhancing skin health—while highlighting the importance of measurable outcomes in chronic venous therapy.

Read the full article in Journal of Wound Management.

Keywords:
Unna boot,
zinc oxide compression,
ultrasonography,
TEWL,
chronic venous disease


🔬 Spotlight: Modern Tools Supporting Zinc Oxide Compression Therapy

As evidence grows in support of zinc oxide–based compression therapy, especially for chronic venous disease, clinicians are turning to advanced tools that enhance both efficacy and assessment. Here are a few technologies and products driving better outcomes:

  • Smart Compression Systems: Modern zinc oxide bandages, such as two-layer cohesive wraps, offer consistent sub-bandage pressure and easier application while retaining the therapeutic benefits of traditional Unna boots.
  • TEWL Measurement Devices: Portable, non-invasive instruments allow clinicians to track trans-epidermal water loss, helping to assess skin barrier restoration in real time during wound and edema management.
  • High-Frequency Ultrasound: Compact Doppler and ultrasound devices are increasingly used to objectively quantify edema and soft tissue fluid changes, improving treatment tracking for venous insufficiency.
  • Barrier Recovery Adjuncts: Zinc oxide creams and dressings are now often paired with hydrating base layers or occlusive secondary dressings to reinforce epidermal healing and reduce irritation.

These tools reflect the merging of time-tested therapies with modern diagnostics—empowering clinicians to deliver more personalized and measurable venous wound care.

Wound care awareness

One in four families has a member with a chronic wound. For this reason, it is crucial for us as wound care experts to educate patients, caregivers and other health care providers about chronic wounds and advanced wound care treatment options … Nearly 7 million people in the U.S. are living with a chronic wound, and the number is expected to grow over the next decade. A chronic wound can be painful, dangerous and scary for patients and drastically affect people by diminishing their overall quality of life and potentially decreasing life expectancy if left untreated …They are also dangerous and damaging to our health care industry. The cost associated with chronic wounds is more than $50 billion annually, and this affects 14.5% of Medicare beneficiaries each year … continue

Music in the Wound Care Center: Effects on Anxiety Levels and Blood Pressure Measurements in Patients Receiving Standard Care

In the United States, chronic wounds (including venous ulcers, diabetic foot ulcers, and pressure ulcers/injuries) affect approximately 8.2 million people as estimated by a 2018 retrospective analysis of Medicare beneficiaries, and treatment costs ranged from $28 billion to $96.8 billion annually.1 These numbers are expected to increase with the growing aging population and higher prevalence rates of chronic diseases, such as diabetes and peripheral artery disease, in older adults.1 Patients with chronic wounds are reported as having poor quality of life associated with chronic pain and odorous exudate.2 The treatment of chronic wounds in the wound care center (WCC) requires wound assessment, minor procedures, and dressing changes. WCCs provide a specialized level of care using various wound care therapies to promote healing.3 Anxiety has been reported during treatment and may lead to increased pain sensation and stress.4 Pharmacological treatment has been a traditional way to alleviate anxiety; however, this can increase the risk of drug dependency and unwanted side effects.5 Nonpharmacological approaches are considered to be more desirable because of fewer side effects and greater cost-efficiency … continue

Healogics Wound Science Initiative Addresses Social Determinants of Health

The World Health Organization (WHO) defines social determinants of health as the conditions in which people are born, grow, live, work and age, that shape health. These factors include characteristics such as socioeconomic status, education, neighborhood and physical environment, employment and social support networks. Surprisingly, these social and environmental conditions account for 80 percent of health outcomes while only 20 percent are the result of care delivery.

 

“Over the next year, we will release a series of findings based on surveys of clinicians, interviews with patients and secondary data analysis,” said Hanna Gordon, PhD, Healogics Executive Director, Research and Informatics. “Our goal is to ensure that all patients can access high quality care and heal their chronic ulcers. We will begin our series with an introduction to the social determinants and how they impact health outcomes, followed by the findings of a survey on clinician perspectives on social barriers to care, and original research on the sociogeographic patterning of chronic wounds.”

 

Chronic wound patients face a number of challenges to their health and well-being. The presence of ulcers is an indication of broader physical systems failures. However, with education, many wounds could be prevented or treated when they are less severe resulting in improved outcomes. The association between chronic conditions such as diabetes, cardiovascular disease and social conditions is well established, yet none of the previous studies have addressed chronic ulcers. Healogics Wound Science Initiative is partnering with hospitals … read more

CūtisCare Launches Second Annual Hyperbaric Aware™ National Campaign

To Elevate Awareness Of Hyperbaric Oxygen Therapy

 

BOCA RATON, Fla., May 2, 2022 /PRNewswire/ — CūtisCare, a leader in wound care and hyperbaric management, launches its second annual Hyperbaric Aware™ national campaign to elevate awareness of hyperbaric oxygen therapy. Hyperbaric Oxygen Therapy is an effective healing option for many different chronic conditions. Still, many go years without this treatment because they are unaware of treatment indications, benefits, and the patient selection criteria of hyperbaric medicine.

 

Hyperbaric oxygen therapy (HBOT) is a proven treatment option for wounds, infections, or injuries that have not responded to standard treatment. There are currently fourteen indications for HBOT recognized by the Centers for Medicare and Medicaid Services (CMS) and other third-party payors. Hyperbaric oxygen therapy is most commonly used for the treatment of diabetic ulcers of lower extremities, radiation injury to bone or tissue, compromised grafts and flaps, and chronic refractory osteomyelitis.

 

Hyperbaric Awareness USA™ designated May Hyperbaric Awareness Month. Throughout this month (and beyond), the Hyperbaric Aware™ campaign aims to promote hyperbaric oxygen therapy benefits, which will help people prolong lives, reduce amputations, and reduce the cost of care while improving quality of life.

 

There are more than eight million people in the United States who are living with chronic wounds. Twenty-five percent of the 34 million people in the US with Diabetes will develop a foot ulcer, possibly leading to amputation. Hyperbaric oxygen therapy provides necessary oxygenation, which is critical in preventing amputation.

 

In the US, almost half of the 17 million people diagnosed with cancer will receive radiation therapy, and 10-15% will experience late effects of radiation. Many patients who undergo radiation therapy discover a hidden complication that may not come to light until years after they complete treatments. Radiation therapy can restrict oxygen in the body’s healthy tissue which is needed for the tissue to thrive. If there is a break in the integrity of the tissue, infection and non-healing wounds can occur. Hyperbaric oxygen therapy is a treatment option for patients who suffer from late radiation tissue injury stimulating the growth of new blood vessels following radiation-induced damage.

 

CūtisCare Board Chairman and CEO Jim Patrick said, “As an industry leader, we are addressing the lack of awareness of hyperbaric oxygen therapy, a critical modality for chronic wound healing and limb preservation.”

 

The Hyperbaric Aware website, in collaboration with the Undersea and Hyperbaric Medical Society (UHMS) and physician leaders, will share articles, latest research, and expert insight for physicians, patients, and the general public.

 

About CūtisCare
Headquartered in Boca Raton, Florida, CūtisCare works with hospitals, academic medical centers, hospital systems, and physicians to design customized outpatient wound care and hyperbaric oxygen (HBOT) solutions. With more than 25 years of management experience, a commitment to research, and driven by ethics and a culture of compliance, CūtisCare collaborates with its partners to reach and heal people with chronic wounds.

 

For more information, visit https://cutiscareusa.com and https://hyperbaricaware.com

 

Follow us CutisCare LLC | LinkedIn and Hyperbaric Aware|LinkedIn.

Media Contact:

Kelly Caceres
kcaceres@cutiscareusa.com
904-446-0708
SOURCE CutisCare LLC

 

This article was originally published here

The Most Positive Thing to Happen to Negative Pressure Wound Therapy

NEXA NPWT System Launched in the USA

OCEANSIDE, Calif.June 7, 2023 /PRNewswire/ — AOTI Inc, the global leader in multi-modality topical wound oxygen, announced exciting news from ongoing WOCNext conference in Las Vegas, Nevada, where their game changing NEXA Negative Pressure Wound Therapy (NPWT) system made its official USA debut.

The unique NEXA NPWT system is an incredibly flexible platform that is simple to use, silent, portable and affordable. NEXA seamlessly combines the simplicity of disposable NPWT with the performance features of more traditional durable NPWT technology platforms.

Dr. Mike Griffiths, CEO and President of AOTI commented; “Releasing the innovative NEXA NPWT platform in the USA is a major milestone for the company that will allow clinicians, payers, and patients alike to experience much improved performance at significantly lower cost. With NEXA, we have reimagined how NPWT should function.

Its addition to our portfolio only further enhances our mission of helping all people with chronic conditions get back to living their lives to the fullest.”

AOTI’s unique NEXA NPWT and Topical Wound Oxygen (TWO2) therapy are unlike any other treatment approaches. NEXA provided unrivaled flexibility and performance in a portable NPWT system. TWO2 is the only device that provides a multimodality treatment, combining higher pressure oxygen delivery with non-contact cyclical compression and humidity, in a therapeutic applied by the patient at home. This patented approach has been demonstrated in numerous Randomized Controlled Trial (RCT) and Real World Evidence (RWE) studies to not only heal chronic wounds at a far higher rate, but perhaps more importantly, keep them closed longer term, thereby reducing unnecessary hospitalizations and amputations.1, 2

1 Multinational, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial to Evaluate the Efficacy of Cyclical Topical Wound Oxygen (TWO2) Therapy in the Treatment of Chronic Diabetic Foot Ulcers; The TWO2 Study. Robert G. Frykberg et al, Diabetics Care 2020; 43:616-624. https://doi.org/10.2337/dc19-0476.

Reduced Hospitalizations and Amputations in Patients with Diabetic Foot Ulcers Treated with Cyclical Pressurized Topical Wound Oxygen Therapy: Real-World Outcomes; Jessica Izhakoff Yellin, et al; Advances in Wound Care 2022; http://doi.org/10.1089/wound.2021.0118

About AOTI

AOTI is a privately-owned company based in Oceanside, California USA and Galway, Ireland that provides innovative solutions to resolve severe and chronic wounds worldwide. Our mission is to help all people with chronic conditions get back to living their lives to the fullest. We do this by enhancing access to care, improving quality of life and advancing health equity. 
Our products reduce healthcare costs and improve the quality of life for patients with these debilitating conditions. Our patented Topical Wound Oxygen (TWO2) at home therapy is clinically proven to deliver Sustained Wound Healing that reduces both Amputations and Hospitalizations, So Life Can Get Back to Normal.

For more information see: www.aotinc.net

Contact:
Dr. Mike Griffiths
CEO & President
360322@email4pr.com
(760) 672 1920

SOURCE AOTI Inc.

Anti-Biofilm Wound Dressing Market

Anti-Biofilm Wound Dressing Market: Steady Growth Expected, Reaching US$ 2,132.5 Million by 2032

The global anti-biofilm wound dressing market is experiencing significant growth, driven by the increasing prevalence of chronic and acute wounds, advancements in wound care technology, and heightened awareness of biofilm-related infections. Biofilms, protective clusters of bacteria, pose challenges in wound healing by leading to chronic infections and delayed recovery. Anti-biofilm wound dressings are specifically designed to disrupt these biofilms, promoting better healing outcomes and reducing infection risks.

According to a report by Persistence Market Research, the market was valued at US$ 1,001.6 million in 2025 and is projected to reach US$ 2,132.5 million by 2032, growing at a CAGR of 11.4%. North America currently holds a significant share of the market, attributed to its robust healthcare infrastructure and high incidence of chronic diseases. The Asia-Pacific region is anticipated to witness the fastest growth during the forecast period, fueled by increasing healthcare access, medical tourism, and demand for advanced wound care products in emerging markets like India and China.

Key market segments include chemical-based, physical-based, and biological-based wound dressings. Chemical-based dressings, containing agents like ionic silver, iodine, and EDTA, are expected to dominate due to their broad-spectrum antimicrobial properties. Physical-based dressings, such as hydrocolloids and hydrogels, provide a moist environment to accelerate tissue regeneration. Biological-based dressings utilize collagen and growth factors to support healing, particularly in chronic wounds like diabetic foot ulcers and pressure ulcers.

Leading companies in the market, including ConvaTec, Smith & Nephew PLC, and Mölnlycke Health Care, are engaging in mergers and acquisitions to expand their product portfolios and market reach.

Read the full article on the openPR website.

Keywords:
Anti-biofilm wound dressing,
Biofilm infections,
Chronic wounds,
Acute wounds,
Chemical-based dressings,
Physical-based dressings,
Biological-based dressings,
ConvaTec,
Smith & Nephew PLC,
Mölnlycke Health Care

Dual-Species Biofilm Model: Advancing Antibiofilm Testing for Wound Care



Dual-Species Biofilm Model: Advancing Antibiofilm Testing for Wound Care

Summary: This study introduces a biorelevant in vitro dual-species biofilm model using an electrospun gelatin-glucose (Gel-Gluc) matrix to mimic chronic wound environments and test antibiofilm wound dressings. Focusing on common wound pathogens like *Staphylococcus aureus*, *Escherichia coli*, and *Pseudomonas aeruginosa*, the model supports robust biofilm growth (up to 10^8 CFU/matrix after 24 hours) and enables evaluation of electrospun polycaprolactone (PCL) dressings loaded with chloramphenicol (CAM) or ciprofloxacin (CIP). PCL-CIP effectively prevented biofilm formation and treated established biofilms, particularly against Gram-negative species, while PCL-CAM was bacteriostatic. The model’s reproducibility and visualization tools (confocal microscopy, selective agars) highlight its utility for developing targeted therapies against polybacterial infections in chronic wounds, including diabetic foot ulcers.

Key Highlights:

  • Dual-species biofilms (*S. aureus* + *E. coli* or *P. aeruginosa*, *E. coli* + *P. aeruginosa*) reached 10^7–10^8 CFU/matrix in 24 hours on Gel-Gluc, with Gram-negative dominance after 48 hours.
  • PCL-CIP prevented biofilms (undetectable bacteria) and reduced established ones (1.8–3.9 log CFU decrease), outperforming PCL-CAM, which only inhibited growth.
  • Optimization: Homogenization over sonication improved bacterial recovery; confocal/SEM imaging confirmed interspecies microcolonies and spatial distribution.
  • Challenges: *S. aureus* survival in *P. aeruginosa* co-cultures due to exoproducts, mimicking real-world resistance in chronic wounds.
  • Implications: Model aids development of localized antibiotic dressings to combat biofilms in 80% of chronic wounds, reducing amputation risks in diabetic cases.

Read full article

Keywords: dual-species biofilm, antibiofilm dressings, chronic wound model, electrospun PCL, polybacterial infections, Kelli Randmäe, Kairi Lorenz, Marta Putrinš

Global Wound Care Market Forecast



The Wound Care Market Size, Share, Growth Trends & Revenue Forecast 2029

Summary: Arizton’s October 2024 report (updated Dec 2025) projects the global wound care market at $33.13B in 2023, growing to $46.77B by 2029 (CAGR 5.91%). Advanced products dominate (63% share, $20.9B in 2023), fueled by surgical volume (300M procedures/year) and chronic wounds (6.5% population). Acute wounds 52% market; chronic (DFU/VLU/PI) 48%. Growth drivers: aging (1B+ over 60 by 2030), unintentional injuries; challenges: surgical complications (20% dehiscence), recalls, costs. Regional: North America 35% share; Asia-Pacific fastest CAGR 6.5%.

Key Highlights:

  • Segments: Advanced ($20.9B, 63%); traditional ($8.5B); sutures/staples ($2.8B); hemostats ($1B).
  • Wound Types: Acute 52% ($17.2B); chronic 48% ($15.9B, DFU largest).
  • Drivers: 300M surgeries/year; 6.5% chronic prevalence; aging boom.
  • Challenges: 20% surgical failure; regulatory hurdles; high costs in LMICs.
  • Forecast: $46.77B by 2029; APAC growth from urbanization/diabetes rise.

Download report preview

Keywords: wound care market, 2029 forecast, advanced products, CAGR 5.91, chronic wounds

The Effect of Beta-Glucan on Wound Healing



The Effect of Beta-Glucan on Wound Healing: A Systematic Review and Meta-Analysis

Summary: Systematic review/meta-analysis (4 studies: 2 RCTs, 2 cohorts; n=644) evaluated topical beta-glucan for wounds. Chronic wounds: OR 2.14 for healing at 12 weeks (p<0.01, I²=0%); sustained benefits to 24 weeks. Acute wounds (burns): no significant epithelization time reduction (MD -1.70 days, p=0.25). Beta-glucan promotes immune activation/tissue repair in chronic; inconclusive for acute. Calls for more RCTs to standardize/confirm.

Key Highlights:

  • Chronic: OR 2.14 (2x healing 12 weeks); low heterogeneity.
  • Acute: No benefit (high heterogeneity).
  • Studies: 2 chronic (likely DFU), 2 acute (burns).
  • Limitations: Few studies, heterogeneity.
  • Authors: Not specified in summary.

Read full meta-analysis

Keywords: beta-glucan, wound healing, meta-analysis, chronic wounds, acute wounds

Smart Biomaterials and Intelligent Scaffolds for Wound Healing

Smart Biomaterials and Intelligent Scaffolds for Wound Healing

Summary: Published in Biophysics Reviews (AIP Publishing, Vol. 7, No. 1, article 011306), this review surveys the rapidly advancing field of smart biomaterials and intelligent scaffolds designed to enhance wound healing — a field that has progressed from passive moisture-retaining dressings to dynamic systems that can sense wound conditions, respond to biological and physicochemical cues, and adapt their therapeutic actions in real time. The biophysical rationale for intelligent wound care materials stems from the complexity of the chronic wound microenvironment: local tissue hypoxia, bacterial bioburden, elevated matrix metalloproteinases (MMPs), aberrant pH (typically alkaline in infected chronic wounds), reactive oxygen species (ROS), and impaired electrical gradients all represent exploitable signals for stimuli-responsive therapeutics. The review covers the major categories of smart wound care biomaterials and scaffolds, including pH-responsive hydrogels that detect infection via colorimetric signals and trigger antibiotic or anti-inflammatory agent release; temperature-responsive polymers that undergo phase transitions to release drugs in response to fever or fever-like wound microenvironments; electroactive scaffolds and electrically conductive biomaterials (e.g., polyaniline, polypyrrole, graphene oxide composites) that restore the wound’s bioelectric field and promote cell migration; ROS-responsive materials that exploit the elevated oxidative environment of chronic wounds; enzyme-responsive scaffolds that are cleaved by MMPs to deliver targeted therapy; biosensor-integrated smart dressings that provide real-time monitoring of wound pH, temperature, glucose, or bacterial load and transmit data wirelessly; and shape-memory materials that mechanically assist wound closure. Applications across diabetic foot ulcers, pressure injuries, venous leg ulcers, and burn wound management are discussed, along with key challenges in clinical translation including biodegradability of electronic components, regulatory pathway complexity, and scalability of manufacturing. Full text requires AIP institutional subscription or per-article purchase.

Key Highlights:

  • Published in Biophysics Reviews (AIP Publishing) — Vol. 7, No. 1, article 011306; multidisciplinary biophysics journal covering biomedical materials science, tissue engineering, and physiological systems
  • pH-responsive systems: detect alkaline shift of infected chronic wounds (pH 7.4–8.9 vs. normal skin ~5.5) to trigger colorimetric infection alerts and localised antibiotic release — enabling passive real-time wound monitoring
  • Electroactive scaffolds: conductive biomaterials (polyaniline, polypyrrole, reduced graphene oxide) restore endogenous bioelectric fields that direct cell migration and proliferation — biophysically addressing an underrecognised chronic wound defect
  • Biosensor-integrated smart dressings: wearable electronic systems embedded in dressings continuously monitor wound vital signs (pH, temperature, glucose, bacteria) and transmit data — bridging wound care with digital health monitoring
  • Future directions: fully biodegradable transient electronics that dissolve harmlessly post-healing; nanofiber meshes combining electrical conductivity with growth factor delivery; AI-assisted material design; and real-time adaptive dressings that modulate their drug release profile based on continuous wound biomarker feedback
  • Full text access: AIP institutional subscription or per-article purchase via pubs.aip.org; DOI: 10.1063/5.0241174 (BPR Vol. 7, 011306)

Read full article

Keywords: smart biomaterials wound healingintelligent wound dressing scaffoldpH responsive hydrogel woundelectroactive scaffold wound healingbiosensor wound monitoringstimuli responsive wound care materials

AIP Biophysics Reviews Editorial Team

A Case Study of Chronic Wound Management

Mr. King presented with 3 wounds located on the medial and lateral aspects of both ankles. Each wound was present for more than 3 years. In that time, he had been seen by 14 wound care physicians and another 8 podiatric and surgical specialists, in the outpatient setting. His care also included home health nursing visits for over 2 years, most commonly with daily dressing changes ordered by the many physicians trying to treat him … At 77 years old, he has many comorbidities that can impair wound healing such as; PAD, PVD, IDDM II, HDL, CKD II, HTN, Varicose Veins and uncontrolled chronic pitting edema. As a result of his wounds not healing, he was no stranger to receiving poor prognoses on the outcomes and resolution of his wounds. Because of poor choices in treatments and a lack of holistic care, more often, his wounds would get worse not better and in some cases Mr. King was told, “there’s nothing I can do, your wounds are not going to heal,” or “you’re going to lose your legs.” Most of the physicians he saw wanted to do some type of surgery or skin grafts. But Mr. King had known too many people that went in for a surgery on the leg or foot, trying to heal a wound, and ended up with an amputation … read more

Atypical Wounds: Scleroderma, Marjolin’s Ulcer

     and Kaposi’s Sarcoma (Part 2)

 

By Martin Vera, LVN, CWS

 

Part 2 in a series discussing the etiology, assessment and management of atypical wounds. Read Part 1 here.

 

As our journey through the exciting and uncharted, choppy waters of atypical wounds comes to a close, I discuss a few more wounds. The purpose and goal of this blog are to create awareness of other wounds that exist and instill the curiosity in my fellow clinicians to get our research done.

 

This blog describes a few atypical wounds, including scleroderma, Marjolin’s ulcer, and Kaposi’s sarcoma (KS). Even with the previous discussion of atypical wounds in this two-part series, many other atypical wounds exist, and I encourage and challenge you to educate yourselves and others, continue doing the research necessary to continue the battle to prevent and heal these wounds, and increase awareness to achieve early detection and have better chances for positive outcomes … read more

Atypical Wounds: Scleroderma, Marjolin’s Ulcer

     and Kaposi’s Sarcoma (Part 2)

 

By Martin Vera, LVN, CWS

Part 2 in a series discussing the etiology, assessment and management of atypical wounds. Read Part 1 here.

 

As our journey through the exciting and uncharted, choppy waters of atypical wounds comes to a close, I discuss a few more wounds. The purpose and goal of this blog are to create awareness of other wounds that exist and instill the curiosity in my fellow clinicians to get our research done.

 

This blog describes a few atypical wounds, including scleroderma, Marjolin’s ulcer, and Kaposi’s sarcoma (KS). Even with the previous discussion of atypical wounds in this two-part series, many other atypical wounds exist, and I encourage and challenge you to educate yourselves and others, continue doing the research necessary to continue the battle to prevent and heal these wounds, and increase awareness to achieve early detection and have better chances for positive outcomes … read more

Healthy diet helps obese people with chronic inflammation and skin wound healing

Scientists in Leipzig identify new mechanisms for chronic inflammation and wound healing disorders

In everyday clinical practice, it has been observed that chronic inflammatory diseases like psoriasis occur earlier and more severely in overweight people. In addition, they are more difficult to treat in patients with obesity. Experts at Leipzig University Hospital therefore wanted to find out why chronic inflammatory diseases and chronic non-healing wounds occur more frequently in obese patients.

In a study recently published in the journal Theranostics, the scientists investigated how saturated fatty acids contribute to the increased occurrence of inflammation or disrupt wound healing. When the skin is inflamed or injured, danger molecules are released. “Our focus was on the danger molecule S100A9. S100A9, together with many saturated fatty acids, causes abnormal activation and differentiation of macrophages and ultimately leads to the fact that inflammatory reactions do not subside or skin injuries are not properly repaired,” explains study leader Dr Anja Saalbach, scientist and working group leader at the Department of Dermatology, Venerology and Allergology at Leipzig University Hospital. Macrophages are important cells to initially fight infection. Later, they help inflammation to subside and the tissue to be repaired … read more

What Does “Invisible” Really Mean in the Chronic Illness Community?

“What Does ‘Invisible’ Really Mean in the Chronic Illness Community?”

In this thoughtful journal entry on Inspire, Laura Molzen explores what it means to feel “invisible” living with chronic illness—sharing her personal experiences and offering insights for others navigating similar feelings.

Key Takeaways:

  • Hidden Suffering: Many chronic conditions are not outwardly visible, leading to misunderstanding or dismissal from friends, family, and society.
  • Emotional Isolation: When people don’t learn about your condition—especially if it’s infrequent, subtle, or not outwardly apparent—it can feel as though your story isn’t believed or valued.
  • Importance of Validation: Hearing “I’m here for you” or “I believe you” can profoundly affect emotional well‑being—helping to bridge the gap between what patients feel and what others recognize.
  • Community & Advocacy: Sharing experiences—through writing, support groups, or social media—can foster understanding, mutual support, and a sense of belonging within chronically ill communities.

This heartfelt post offers a powerful reminder: “invisible” doesn’t mean “unreal”—and naming the experience is the first step to community, compassion, and improved care.

Keywords:
chronic illness,
invisible symptoms,
patient validation,
emotional well-being,
support groups

Read Laura’s full post on Inspire

Chemical Compound Supercharges Antibiotics to Fight Chronic Wound Infections

Chemical Compound Supercharges Antibiotics to Fight Chronic Wound Infections

Summary: Researchers have identified a chemical compound that potentiates antibiotic efficacy against *Pseudomonas aeruginosa* in chronic wound models. When combined, the compound and antibiotics significantly improved bacterial killing, potentially overcoming resistance in wound pathogens.

Key Highlights:

  • Synergistic effect: The compound improves antibiotic penetration or disrupts bacterial defenses in biofilm-laden wounds.
  • Model results: In vitro and ex vivo wound assays showed significantly higher kill rates compared to antibiotics alone.
  • Resistance implications: The strategy may help reclaim lost efficacy of existing antibiotics in chronic wound management.
  • Next steps: Authors call for in vivo trials, safety profiling, and exploration of delivery methods suitable for wound environments.

Read the article on ContagionLive

Keywords:
antibiotic potentiator,
chronic wound infections,
biofilm disruption,
drug synergy

Pilot Study Could Improve Treatment of Chronic Diabetic Foot Ulcers



Pilot Study Could Improve Treatment of Chronic Diabetic Foot Ulcers

Summary: A recent pilot study suggests promising new strategies for treating chronic diabetic foot ulcers (DFUs), a condition that remains difficult to manage despite standard care. The research evaluates innovative interventions aimed at overcoming biological barriers such as impaired angiogenesis, persistent inflammation, and biofilm formation. Early results indicate potential for faster wound closure and reduced complication rates. While larger trials are needed, the findings highlight opportunities to expand the therapeutic toolbox for DFUs and improve limb salvage outcomes for patients with diabetes.

Key Highlights:

  • Focuses on chronic, hard-to-heal diabetic foot ulcers
  • Explores novel approaches targeting key healing barriers
  • Early data shows potential for improved closure rates
  • Addresses a critical gap in current DFU treatment options

Read full article

Keywords: diabetic foot ulcers, DFU pilot study, chronic wound treatment

Pilot Study Could Improve Treatment of Chronic Diabetic Foot Ulcers



Pilot Study Could Improve Treatment of Chronic Diabetic Foot Ulcers

Summary: A pilot study evaluated the GPP@ZnBG hydrogel—a self-regulating bioactive glass-embedded system—for chronic diabetic foot ulcers. The hydrogel dynamically responds to wound pH and glucose/oxidative stress: early alkaline conditions trigger controlled zinc ion release for antibacterial effects, while later degradation releases zinc, calcium, and silicate ions to promote angiogenesis and tissue repair. In the clinical pilot, treated ulcers showed a 94.57% relative reduction in wound surface area within 4 weeks. This active nanotechnology approach addresses persistent infection, inflammation, and impaired healing better than passive standard care and highlights pharmacists’ role in advanced product selection and patient education.

Key Highlights:

  • 94.57% wound area reduction in 4 weeks for chronic DFU
  • pH-responsive zinc delivery: antibacterial early, pro-angiogenic later
  • Addresses biofilm, ROS, and poor perfusion in diabetic wounds
  • Study authors: Zhao L, Chen S, Chen S, et al.

Read full article

Keywords: DFU hydrogel, bioactive glass wound care, chronic diabetic foot ulcer, zinc ion therapy

Use of Synthetic Electrospun Fiber Matrix in the Sealing of Tunneling, Undermining, and Cavity Wounds



Use of Synthetic Electrospun Fiber Matrix in the Sealing of Tunneling, Undermining, and Cavity Wounds

Summary: This retrospective case series evaluated the synthetic electrospun fiber matrix (SEFM) in 9 patients with 11 complex wounds featuring tunneling, undermining, or cavities. All wounds underwent initial sharp debridement before SEFM application (particulate or sheet form), combined with various secondary dressings. Patients had significant comorbidities including osteomyelitis, diabetes, peripheral arterial disease, and malnutrition. The SEFM promoted rapid granulation and collapse of dead space, achieving complete resolution of tunneling/undermining in a mean of 17 days. Durable healing was maintained at 6–18 month follow-up with no recurrence in most cases. The matrix resisted enzymatic degradation in contaminated environments and conformed well to irregular wound topography, often avoiding the need for large flap reconstructions or amputation.

Key Highlights:

  • Complete resolution of tunneling/undermining and cavities (mean 17 days)
  • Avoided flap reconstruction or amputation in complex, comorbid patients
  • Effective in traumatic, pressure, and iatrogenic wounds with osteomyelitis
  • Authors: Thea Price, MD; Katie Meador, NP

Read full case series

Keywords: electrospun fiber matrix, tunneling wounds, undermining wounds, cavity wounds, Thea Price

The “self-treatment of wounds for venous leg ulcers checklist”

Patients who have chronic wounds such as leg ulcers should be active participants in their treatment and care. This participation may include self-treatment of the wound which involves the patient cleaning the wound, applying and removing wound dressings, and/or applying and removing compression therapy. The aim of the study was to develop a Checklist to assist nurses to appraise the conduct of wound treatment when undertaken by the patient. A three-phase mixed methods study was conducted. A systematic and evidence-based approach to developing and using structured observations for the study of health behaviour guided the process of developing, piloting and refining the Checklist … read more

Medical News Today: Can we heal wounds by printing skin?

Printing layers of skin to help treat chronic wounds or burns may be on the horizon, thanks to a newly developed mobile skin bioprinting system … The skin bioprinter at work … Scientists at the Wake Forest Institute for Regenerative Medicine (WFIRM) in Winston-Salem, NC, have created a bioprinter that uses a person‘s own skin cells to create layers of new skin and apply them directly to the wound … A new paper, which now in the journal Scientific Reports, details the development of this new technology … The procedure involves harvesting major skin cells called dermal fibroblasts and epidermal keratinocytes from a biopsy of a person‘s normal skin tissue … read more

‘Magic powder’ heals wounds nothing else can

FORT LAUDERDALE, Fla. (Ivanhoe Newswire) – More than 5.7 million Americans suffer from chronic wounds that won’t heal. Now, a new, easy to use treatment some are calling a “magic powder” is helping patients heal much faster.

Plastic surgeon Tracey Stokes, MD, FACS, Board Certified Plastic Surgeon is used to being in the operating room, but not as a patient.

“I underwent bilateral mastectomy and reconstruction,” said Dr. Stokes.

Dr. Stokes made the decision after she and her mother tested positive for the gene that causes breast cancer. Unfortunately, she developed a wound on her left breast that would not heal.

“I think in today’s day and age wound care and wound care problems have almost become an epidemic,” said Laura Sudarsky, MD, FACS, Board Certified Plastic Surgeon & Wound Care Specialist at Esse Plastic Surgery … read more

Jipmer to treat wounds with marine resource

Doctors at JIPMER have begun using a marine resource sourced from shrimps for wound management. Marine resources are used to help patients with chronic wounds such as burns, diabetic foot ulcers, bed sores, infections, trauma and even surgery-related injury.

 

Jipmer Director, Dr. S Vivekanandam, said the protocol was initiated by the Department of Plastic Surgery. As a forerunner, a Continuing Medical Education (CME) was recently organised on ‘Wound Update-2018’ by the Department of Plastic Surgery to sensitise and to make aware of this technology in wound management.

 

According to the Director … read more

The use of Prontosan® in combination with Askina® Calgitrol®

An independent case series

Many patients with chronic wounds will develop infection (Landis et al, 2007; Sibbald et al, 2011). Worldwide consensus on the specific use of silver antimicrobials recommends that silver dressings should be used initially for a ‘two-week challenge’ (Wounds International, 2012). Sixteen different individual case studies were carried out to evaluate the efficacy of a biofilm remover/cleanser in gel form, Prontosan® (B Braun), together with the use of an ionic releasing silver alginate, Askina® Calgitrol® Paste (B Braun) or Askina® Calgitrol® Thin (B Braun), when used on infected wounds. This study was completed in an advanced wound management centre in Pretoria, South Africa, during 2016.  Selection criteria included wounds showing clinical signs of infection with delayed healing for more than 2 weeks. The study results showed that 50% of the wounds’ clinical signs of infection resolved within the 2-week antimicrobial challenge and by week 3, 81% of all clinical signs resolved. Ninety-three per cent of the wounds had improved wound progress and healing .. read more

 

 

Printing technique creates effective skin equivalent, heals wounds

Chronic wounds are deep and difficult to repair. Often, the top of the injury heals before the bottom, so the wound collapses in on itself. Over time, this can result in scar tissue and reduced skin function … The technique is the first of its kind to simulate three layers of skin: the hypodermis, or fatty layer, the dermis, and the epidermis … “You effectively have three different cell types. They all grow at different speeds,” said author Alan Smith. “If you try to produce tri-layered structures … read more

Latest Clinical Evidence Presented at APWCA’s Wound Week™ 2022 Illustrates the Significant …

Clinical Utility of the MolecuLight Point-of-Care Imaging Platform
PRESS RELEASE
February 24, 2022

Toronto, ONTARIO and Philadelphia, PENNSYLVANIA – (February 24, 2022) MolecuLight Inc., the leader in point-of-care fluorescence imaging for real-time detection of wounds containing elevated bacterial loads, announces the presentation of 8 Clinical Posters and a Presentations and a Hands-On Workshop at the American Professional Wound Care Association’s (APWCA) Wound Week™, held from February 24 – 27, 2022 in Philadelphia, PA. Wound Week is a leading multidisciplinary meeting of wound care professionals that presents cutting-edge clinical findings and best practices presented by its expert faculty.

“We are thrilled with the significant number of presentations and posters at Wound Week showing the impressive results derived from MolecuLight point-of-care devices,” says Anil Amlani, MolecuLight’s CEO. “The clinical insights that are informed by the MolecuLight platform span the wound care continuum, including wound cleansing and hygiene, antimicrobial stewardship, detection of wound-related cellulitis and surgical site infections. The outcomes presented in these studies illustrate the significant clinical improvements to wound care provided to clinicians by the MolecuLightplatform”.

The 8 clinical posters and the presentation featuring the MolecuLight i:X at Wound Week 2022 are as follows:

Posters by Dr. Alisha Oropallo (Northwell Comprehensive Wound Healing Center and Hyperbarics, Lake Success NY) include:

  • Wound Hygiene: Which Cleansing Agents and Techniques Are Most Effective?
     Download poster
  • 12-week RCT Evaluating Impact of Routine Fluorescence Imaging of Bacteria on DFU Healing Rates
     Download poster

Posters by Dr. Charles Andersen (Vascular/Endovascular/Limb Preservation Surgery Service, Madigan Army Medical Center, Joint Base Lewis-McChord, WA) include:

  • Diagnosis and Treatment of the Invasive Extension of Bacteria (Cellulitis) from Chronic Wounds Utilizing Point-of-Care Fluorescence Imaging
     Download poster
  • Guidelines for point-of-care fluorescence imaging for detection of wound bacterial burden based on Delphi consensus
     Download poster

Posters by Dr. Thomas Serena (SerenaGroup Research Foundation, Cambridge, MA) include:

  • Reliance on Clinical Signs & Symptoms of Bacterial Burden in Chronic Wounds Leads to the Misuse of Antimicrobials: Analysis of the FLAAG Clinical Trial
     Download poster
  • Point-of-care fluorescence imaging enhances detection of high bacterial burden in surgical site wounds
     Download poster
  • Are Semi-Quantitative Clinical Cultures Inadequate? Comparison to Quantitative Analysis of 1053 Bacterial Isolates from 350 Wounds
     Download poster
  • An image is worth 10,000 microbes: How fluorescence imaging augments IWGDF criteria for detection of bacterial burden in diabetic foot ulcers
     Download poster

The Clinical Presentations citing the MolecuLight point-of-care device is:

  • All That Glows is Not Good (Innovative Technologies: What’s in the Pipeline?)  by Dr. Oropallo on Sat., Feb. 26, 2022, 9:00 – 10:00 am in the Commonwealth Room

In addition to the clinical posters and presentations at Wound Week,, the MolecuLight i:X® and DX™ imaging devices will be demonstrated at the Hands-On Workshop on Thursday, February 24th from 1:30 pm – 5:30 pm in the Regency B Ballroom. They will also be available for demonstration in the MolecuLight booth #36 in the Exhibit Hall at the Loews, Philadelphia, PA.

 

About MolecuLight Inc.

MolecuLight Inc. is a privately-owned medical imaging company that has developed and is commercializing its proprietary fluorescent imaging platform technology in multiple clinical markets. MolecuLight’s suite of commercially released devices, including the MolecuLight i:X® and DX fluorescence imaging systems and their accessories, provide point-of-care handheld imaging devices for the global wound care market for the real-time detection of wounds containing elevated bacterial burden (when used with clinical signs and symptoms) and for digital wound measurement.  MolecuLight procedures performed in the United States can benefit from an available reimbursement pathway including two CPT® codes for physician work to perform “fluorescence wound imaging for bacterial presence, location, and load” and facility payment for Hospital Outpatient Department (HOPD) and Ambulatory Surgical Center (ASC) settings through an Ambulatory Payment Classification (APC) assignment. The company is also commercializing its unique fluorescence imaging platform technology for other markets with globally relevant, unmet needs including food safety, consumer cosmetics and other key industrial markets.

 

For more information, contact:

Rob Sandler
Chief Marketing Officer
MolecuLight Inc.
T. +1.647.362.4684
rsandler@moleculight.com
www.moleculight.com

Pulsar II™ Wound Debridement: The Fastest, Virtually Pain-Free Biofilm Removal Device in Wound Care

Pulsar II™: Advanced Non-Surgical Debridement

Pulsar II™ is revolutionizing debridement with the fastest, most effective non-surgical solution on the market. Clinically proven to remove 86.9% of biofilm in just 3–5 minutes, compared to 7–13% for traditional methods, Pulsar II™ accelerates healing without pain, scalpels, or physician intervention.

This no-touch, CE & FDA-cleared device is optimized for both chronic and acute wounds, including deep or tunneling wounds via its specialized tunnel tip. Its integrated waste bag contains and neutralizes biohazard material on the spot, enhancing infection control and eliminating the need for a bio-bin.

Already used in over 50 countries and trusted by leading wound care providers, Pulsar II™ offers:

  • Faster Healing – Stimulates healthy tissue and reactivates stalled wounds
  • Pain-Free Operation – 15 PSI lavage enhances patient comfort and compliance
  • Completely Portable – Battery operated and disposable for use in any setting
  • Versatile – Use on virtually any wound (optional tunnel wound tip), with almost any fluid (tap/sterile water, saline, antimicrobial)
  • Non-Physician Use (optional) – Empowers nursing staff and home health teams
  • CMS Reimbursement Friendly – Affordable reimbursement, improves coding and eligibility
  • Cost-Saving Impact – Potential to reduce Medicare wound care spend by up to 75%

Whether in clinics, hospitals, or home settings, Pulsar II™ delivers superior outcomes and lower costs—proving that the first step to healing is simple: FIRST, CLEANSE THE WOUND.

www.woundcs.com

Keywords:
Pulsar II,
debridement,
biofilm removal,
chronic wounds,
acute wounds,
tunnel wounds,
infection control,
wound management

Hyaluronic Acid-Based Gels and Biomaterial Systems for Oral Wound Healing

Hyaluronic Acid-Based Gels and Biomaterial Systems for Oral Wound Healing: Design and Clinical Translation

Summary: Published March 22, 2026 in Gels (MDPI, Special Issue: Designing Gels for Wound Healing and Drug Delivery Systems), this narrative review from Grigore T. Popa University of Medicine and Pharmacy (Iași, Romania), led by Vlad Constantin and Ionut Luchian (corresponding author), with co-authors from multiple clinical and basic science departments, provides a comprehensive synthesis of hyaluronic acid (HA) biology, material design principles, and clinical performance evidence specifically within the oral wound healing context. While focused on oral and periodontal wounds, the biological and biomaterial principles covered are directly relevant to wound care clinicians managing non-healing wounds, skin grafts, and biomaterial-based dressing systems, as HA is one of the most widely investigated biomaterials across all wound healing applications. HA is a non-sulfated glycosaminoglycan and fundamental ECM component that plays critical roles in tissue hydration, cellular signalling, angiogenesis, inflammation modulation, and matrix remodelling throughout the four wound healing phases. Its biological behaviour is strongly molecular weight-dependent: high-molecular-weight HA (>1,000 kDa) exerts anti-inflammatory, anti-edematous, and protective/barrier effects, contributing to tissue homeostasis; low-molecular-weight HA fragments (<20 kDa) act as endogenous danger signals (DAMPs) activating innate immunity via TLR-4, and also promote cell migration, angiogenesis, and tissue remodelling. In oral wounds — complicated by salivary dilution, mechanical stress, microbial exposure, and enzymatic degradation — formulation design is critical. The review systematically covers: topical HA gels (0.1–0.8% concentration range; shear-thinning rheology essential for retention; salivary ionic composition affects gel viscosity and structural integrity); cross-linked HA hydrogels (BDDE, DVS, carbodiimide, and enzymatic cross-linking strategies; enhanced mechanical stability vs. reduced receptor accessibility trade-off; optimal degree of modification balances CD44/RHAMM receptor interaction with degradation resistance); and HA-based membranes and 3D scaffolds (fabricated by freeze-drying, electrospinning, or composite blending with collagen or chitosan; provide guided tissue regeneration, structural support, and bioactive modulation in periodontal and surgical contexts). Clinical evidence covers applications in post-extraction socket healing, periodontal flap surgery, peri-implant soft tissue management, and oral mucosal ulceration — with consistent findings of reduced postoperative pain, accelerated re-epithelialisation, and decreased edema in short-term follow-up. The review is candid about limitations: substantial heterogeneity in formulation parameters across clinical studies makes direct comparison impossible; most trials have small sample sizes and short follow-up; and few studies systematically correlate physicochemical properties with clinical outcomes. The authors call for well-designed multicenter RCTs with standardised HA formulations and harmonised outcome measures.

Key Highlights:

  • Molecular weight-dependent biology: high-MW HA (>1,000 kDa) is anti-inflammatory and barrier-protective; low-MW HA fragments (<20 kDa) activate TLR-4 innate immune signalling, promote angiogenesis, and stimulate cell migration — size-dependent effects must inform formulation design for targeted wound healing applications
  • Receptor signalling: HA exerts key wound healing effects via CD44 and RHAMM (Receptor for Hyaluronan-Mediated Motility) receptor interactions — regulating cytoskeletal organisation, cell migration, proliferation, and fibroblast-mediated ECM deposition; cross-linking density can mask receptor-interacting domains, reducing biological activity if over-engineered
  • Formulation design imperatives for oral wounds: HA gels must exhibit shear-thinning (pseudoplastic) rheology; storage modulus (G′) must exceed loss modulus (G″) for structural retention against salivary washout; ionic composition of saliva (Na, Ca, phosphate) affects intermolecular charge screening and viscosity — requiring formulation-specific rheological optimisation
  • Cross-linking strategy comparison: BDDE and DVS cross-linking provide superior mechanical stability but risk cytotoxicity at high concentrations and reduced CD44 accessibility; carbodiimide and enzymatic cross-linking offer improved biocompatibility with moderate stability; physical/self-assembly systems are safest but most susceptible to salivary dilution
  • Clinical evidence summary: HA gels consistently reduce postoperative pain, edema, and inflammatory markers, and accelerate re-epithelialisation in periodontal surgery, extraction sockets, peri-implant procedures, and mucosal ulceration — with best evidence in short-term applications; long-term data and standardised RCT evidence remain limited
  • Transferability to general wound care: the biological principles and formulation design challenges described — MW-dependent effects, cross-linking optimisation, receptor-mediated signalling, hydrogel rheology — are directly applicable to HA-based dressings used in non-oral chronic wounds including venous ulcers, DFUs, and post-surgical wounds

Read full article

Keywords: hyaluronic acid wound healingHA gel wound dressing designhyaluronan biomaterial tissue repaircross-linked hydrogel wound healingCD44 wound healing ECMextracellular matrix wound repair

Vlad Constantin, Ionut Luchian, Dragos Ioan Virvescu, Mihaela Scurtu, Nicoleta Tofan, Dan Nicolae Bosinceanu, Elena Raluca Baciu, Carina Balcos, Monica Mihaela Scutariu, Dana Gabriela Budala

Negative pressure wound therapy for open traumatic wounds

Traumatic wounds (wounds caused by injury) range from abrasions and minor skin incisions or tears, to wounds with extensive tissue damage or loss as well as damage to bone and internal organs. Two key types of traumatic wounds considered in this review are those that damage soft tissue only and those that involve a broken bone, that is, open fractures. In some cases these wounds are left open and negative pressure wound therapy (NPWT) is used as a treatment. This medical device involves the application of a wound dressing through which negative pressure is applied and tissue fluid drawn away from the area. The treatment aims to support wound management, to prepare wounds for further surgery, to reduce the risk of infection and potentially to reduce time to healing … read more

A new platform for gaining insight and knowledge in managing wounds

Wounds can cover diabetic foot ulcers, pressure injury, vascular ulcers or wounds, immunopathic wounds and traumatic wounds. Chronic, hard-to-heal wounds also have an adverse effect on health-related quality of life. Wounds are a global problem, with increasing incidence due in part to the increase in diabetes mellitus. In Asia, there are more than 4 billion people, and this is where diabetes and its complications, namely diabetic foot, are increasing at an alarming rate … read more

Atypical Wounds: Causes and Management

Part 1 in a series discussing the etiology, assessment and management of atypical wounds.

 

As devoted clinicians to the field of wound management we take a responsibility to educate ourselves and others about wound etiologies and characteristics, as well as management of barriers to achieve positive outcomes. We spend a great deal of our careers learning about the most common offenders, such as pressure injuries, diabetic foot ulcers, venous stasis ulcers, arterial wounds, amputations, and traumatic wounds, to name a few. However, as our careers unfold we are faced with extra challenges, and atypical wounds are among them.

 

An atypical wound, also known as a wound of unknown etiology, is caused by a disease or condition that doesn’t cause a wound typically. Inflammatory diseases, infections, chronic illnesses, malignancies, or genetic disorders are examples of diseases that may result in the appearance of a wound. Atypical wounds can also arise from rare causes and usually share uncommon characteristics. In this two-part blog series, I discuss a few atypical wounds, to give you a view of this parallel universe … read more

Understanding and Managing Cavity Wounds

Understanding and Managing Cavity Wounds

Fiona Downie from TVN‑TV offers practical insights into the assessment and treatment of cavity wounds—deep tissue defects that can extend beneath intact skin layers and complicate healing.

Key Highlights:

  • Definition & Prevalence: Cavity wounds include sinuses, dehisced surgical sites, and deep ulcers. These wounds often go underreported due to inconsistent definitions in clinical audits.
  • Assessment Best Practices: Effective evaluation includes probing for depth, noting undermining or tunneling, documenting exudate levels, identifying signs of infection, and photographing the wound for monitoring.
  • Dressing Selection: Loose-packing with absorbent, conformable dressings like gelling fibres helps fill dead space and manage moisture. Dressings should be changed frequently enough to prevent maceration but not so often that they disrupt healing.
  • Minimizing Trauma: Atraumatic dressings with silicone contact layers can reduce pain and skin stripping during dressing changes, which is critical for fragile or elderly patients.
  • Case Application: One featured case used Exufiber® gelling fibre in a high-exudate cavity wound. The dressing absorbed fluid effectively, was easy to remove, and supported full closure in about 8 weeks.

This video-based resource reinforces the importance of careful wound assessment, strategic dressing use, and patient-specific planning for effective management of cavity wounds.

Watch the full video or access additional guidance on the TVN-TV website.

Keywords:
cavity wounds,
gelling fibre dressings,
Safetac,
debridement,
Exufiber

Smart Gel Speeds Healing in Diabetic Wounds

Smart Gel Speeds Healing in Diabetic Wounds

Summary: A recent study in Advanced Materials introduces a responsive hydrogel that delivers RNA therapy to diabetic wounds. The material releases treatment in sync with the wound’s oxidative stress levels, silencing harmful genes and reducing tissue breakdown. In preclinical testing, the system accelerated healing, reorganized collagen, and improved the wound’s immune environment, offering a promising new approach for chronic wound care. (Nanowerk Spotlight)

Key Highlights:

  • The challenge: Diabetic wounds are marked by excess reactive oxygen species and overactive enzymes like MMP-9 that disrupt healing.
  • Therapeutic innovation: Small interfering RNA (siRNA) targets MMP-9, but it needs protection to survive the wound’s harsh environment.
  • Hydrogel design: A branched polymer (SS HPT) carries siRNA within a hyaluronic acid-based hydrogel. The gel is engineered to respond to oxidative stress by disassembling and releasing therapy when reactive oxygen levels are high.
  • Preclinical results: In diabetic mice, wounds treated with the siRNA-loaded hydrogel healed by over 96% within 10 days—significantly outperforming controls.
  • Tissue outcomes: Treated wounds showed reduced MMP-9 activity, better collagen organization, stronger epithelial coverage, and a favorable shift in macrophages from inflammatory (M1) to regenerative (M2).
  • Safety profile: No major organ toxicity or systemic effects were observed; the hydrogel localized treatment to the wound site.
  • Broader impact: This adaptive, environment-sensitive therapy demonstrates a new model for precision wound care, aligning treatment with the body’s own healing signals.

Read the full article on Nanowerk

Keywords:
hydrogel,
diabetic wounds,
RNA therapy,
oxidative stress,
MMP-9,
Advanced Materials

Factors associated with acute and chronic wound complications

     in patients with soft tissue sarcoma with long-term follow-up

 

In a cohort of patients treated for soft tissue sarcoma (STS) with modern radiotherapy (RT) and surgical techniques, experts assessed the rates of acute and chronic wound complications and related factors. They identified all adult nonmetastatic patients treated for STS at a single institution between 2006 and 2015 with a minimum 1-year follow-up. In these patients, the rate of acute wound complications was 22.1%. In STS patients, numerous factors linked to acute and chronic wound complications, including the timing of RT, tumor site, and reconstruction use, were found. Results demonstrated the probable correlation between development of acute wound complications with a higher risk of chronic wound complications … read more

Partner-With-Us – Chronic wound healing through clinical partnerships

HIGH WYCOMBE, England, Nov. 9, 2022 /PRNewswire/ — Firstkind Ltd, innovator and manufacturer of the clinically proven geko™ device – a ground-breaking advanced therapy for chronic venous leg ulcer healing – is seeking senior tissue viability nurses, willing to embrace and drive innovation advance, to join its Partner-With-Us program.

 

The geko™ device on the leg

The geko™ device on the leg

The Partner-With-Us program precedes the imminent publication of a statistically significant randomised controlled study that compares the rate of wound healing in chronic venous leg ulcer patients receiving the geko™ device as an adjunct to compression therapy, compared to compression therapy alone.

 

A transformative innovation, the geko™ device is a small, self-adhesive, wearable neuromuscular electro-stimulator (NMES) that is applied to the skin just below the knee, over the head of the fibula. It delivers a gentle intermittent electrical pulse, once per second, to the common peroneal nerve. This elicits a muscular twitch that activates the calf and foot muscle pumps, increasing venous, arterial, and microvascular blood flow – transporting oxygenated blood to the wound bed and edge to promote wound healing.

 

In addition to the benefit of better patient outcomes and the release of significant cost savings for primary care, TVNs keen to join the Partner-With-Us program – to drive innovation advance – will gain:

  • Early access to evaluate the geko™ device
  • RCN accredited user training
  • The opportunity/option – through a comprehensive handrail of support – to generate and present patient use data at local and national level.

If you would like to know more about the Partner-With-Us program, and what the geko™ device can do for your patients, please email: Fiona.Young@firstkindmedical.com. We look forward to hearing from you soon.

 

About Firstkind Ltd (a Sky Medical Technology Company)

 

Firstkind Ltd is a UK-based medical devices company. Through its innovative mechanism of non-invasive neuromuscular electrostimulation (NMES), Firstkind has developed a ground-breaking NMES technology platform, OnPulse™, embedded in its industry-leading product, the geko™ device. The company develops a range of products tailored to the needs of different medical application areas, selling both direct and through strategic partnerships or distributors in each major clinical area. Clinical areas of focus include chronic wound healing, the treatment and prevention of oedema (swelling) and venous thromboembolism prevention (VTE). The goal in each therapy is to partner with healthcare professionals to improve clinical outcomes and patient care while at the same time reducing costs for health systems.

 

www.gekodevices.com

 

This article was originally published here

The development and testing of the C/WoundComp instrument for assessing ….

chronic wound‐care competence in student nurses and podiatrists

The purpose of this study was to describe the level of chronic wound‐care competence among graduating student nurses and student podiatrists in comparison with that of professionals and to develop and test a new instrument (the C/WoundComp) that assesses both theoretical and practical competence in chronic wound care as well as attitudes towards wound care. The data (N = 135) were collected in 2019 from four groups (1): graduating student nurses (n = 44) (2); graduating student podiatrists (n = 28) (3); registered nurses (n = 54); and (4) podiatrists (n = 9). The data were analysed using statistical analysis. According to the results, the students’ total mean competence score was 62%. Their mean score for theoretical competence was 67%, and for practical competence, it was 52%. The students’ competence level was statistically significantly lower than that of the professionals (P < .0001), but the students showed a positive attitude towards chronic wound care. The instrument demonstrated preliminary validity and reliability, but this warrants further testing. This study provides new knowledge about student nurses’ and …. full article

———————

Summary:

This study aimed to develop and test a new assessment tool—called the C/WoundComp instrument—to evaluate both theoretical and practical competence in chronic wound care among student nurses and podiatrists. It also examined their attitudes toward chronic wound care.

Design & Participants: The study used a descriptive, comparative, and methodological approach with 135 participants:

  • 44 graduating student nurses

  • 28 graduating student podiatrists

  • 54 registered nurses

  • 9 practicing podiatrists

Key Findings:

  • Students had an average competence score of 62% overall:

    • 67% in theoretical knowledge

    • 52% in practical skills

  • Professionals scored significantly higher than students.

  • Students showed positive attitudes toward chronic wound care despite limited competence.

  • The C/WoundComp instrument showed initial reliability and validity for assessing wound-care competence.

Conclusion: Graduating students lack sufficient theoretical and practical knowledge in chronic wound care, highlighting the need to strengthen wound-care education. The C/WoundComp tool could help evaluate and improve competence in this critical area of healthcare.

The authors:

  • Emilia Kielo-Viljamaa, PhD, RN: Dr. Kielo-Viljamaa is a Senior Lecturer at Novia University of Applied Sciences, Faculty of Health and Welfare, in Vaasa, Finland. She also serves as a Postdoctoral Researcher at the University of Turku’s Department of Nursing Science. Her research focuses on nursing education and wound care competence.ResearchGate

  • Riitta Suhonen, PhD, RN: Dr. Suhonen is affiliated with the Department of Nursing Science at the University of Turku, Turku University Hospital, and the Welfare Division of the City of Turku in Finland. She has an extensive background in nursing science and education.PubMed

  • Maarit Ahtiala: Associated with Turku University Hospital in Finland, contributing to research in nursing and healthcare.PubMed

  • Terhi Kolari: Affiliated with the Department of Biostatistics at the University of Turku, focusing on statistical analysis in medical research.PubMed

  • Jouko Katajisto: Part of the Department of Mathematics and Statistics at the University of Turku, specializing in statistical methodologies.PubMed

  • Leena Salminen, PhD, RN: Connected with the Department of Nursing Science at the University of Turku, with research interests in nursing education and professional competence.PubMed+1ResearchGate+1

  • Minna Stolt, PhD, RN: Also from the Department of Nursing Science at the University of Turku, Dr. Stolt’s research includes nursing education and wound care.PubMed

Cost effectiveness of topical wound oxygen therapy for chronic diabetic foot ulcers

Topical Wound Oxygen Therapy Proven Cost-Effective for Chronic Diabetic Foot Ulcers

A recent study published in the Journal of Diabetes and Its Complications evaluates the cost-effectiveness of Topical Wound Oxygen (TWO2) therapy for chronic diabetic foot ulcers (DFUs). Utilizing a Markov model over a two-year horizon, the research assesses both economic and clinical outcomes associated with TWO2 therapy compared to standard care. Read the full article.

Key Highlights:

  • Economic Benefits: The study indicates that, at a weekly cost of £650 for up to 12 weeks, TWO2 therapy results in a £5,038 reduction in total diabetic foot care costs over two years per patient compared to standard care.
  • Improved Health Outcomes: Patients receiving TWO2 therapy experienced an increase of 0.07 quality-adjusted life years (QALYs) over the two-year period.
  • High Probability of Cost-Effectiveness: Probabilistic sensitivity analysis reveals an 81% likelihood that TWO2 therapy is cost-effective at a willingness-to-pay threshold of £25,000 per QALY.
  • Clinical Efficacy: The model’s clinical inputs are derived from a multinational randomized controlled trial demonstrating superior healing rates with TWO2 therapy.
  • Global Health Implications: Given the substantial burden of DFUs worldwide, the adoption of cost-effective treatments like TWO2 therapy could significantly reduce healthcare expenditures and improve patient quality of life.

This study underscores the potential of TWO2 therapy not only to enhance clinical outcomes for patients with chronic DFUs but also to provide significant cost savings for healthcare systems.

Read the full article on the Advanced Oxygen Therapy Inc. website.

Keywords:
Topical Wound Oxygen Therapy,
diabetic foot ulcers,
cost-effectiveness,
quality-adjusted life years,
health economics

Silicon-Based Nanomaterials in Chronic Wound Healing …

Silicon-Based Nanomaterials in Chronic Wound Healing: Mechanisms, Therapeutic Applications, and Clinical Prospects

Summary: This review, published in the International Journal of Nanomedicine, examines the role of silicon-based nanomaterials in addressing the challenges of chronic wound healing. The authors describe how mesoporous silica nanoparticles and related composites offer high drug-loading capacity, customizable structures, and controlled drug release, making them promising platforms for advanced wound care therapies. Their ability to modulate inflammation, reduce oxidative stress, and promote angiogenesis supports tissue regeneration and accelerates healing.

Key Highlights:

  • Mechanisms of action: Nanomaterials enhance wound healing by controlling inflammation, reducing oxidative stress, stimulating angiogenesis, and supporting tissue remodeling.
  • Therapeutic applications: Silicon-based nanosystems function as drug carriers with intelligent release properties, responding to stimuli such as pH or light for targeted therapy.
  • Biocompatibility: Review data indicates strong safety and compatibility profiles, though further research is needed to confirm long-term biosafety.
  • Clinical translation: While preclinical evidence is strong, large-scale clinical trials are required to validate efficacy and move toward routine wound care use.
  • Future prospects: Research should focus on optimizing synthesis, integrating multifunctional strategies, and designing robust clinical studies.

Read the full article in IJN

Keywords:
Xuan Zhao,
Zhikai Xu,
Dongfang Wang,
Tonghan Li,
Zhanfei Li,
Xiangjun Bai,
Hao Zhu,
Yukun Liu,
Yuchang Wang,
silicon nanomaterials,
chronic wound healing,
mesoporous silica nanoparticles,
angiogenesis

Artacent Amniotic Tissue for Chronic Lower Extremity Diabetic Ulcers



Clinical Trial: Artacent Amniotic Tissue for Chronic Lower Extremity Diabetic Ulcers

Summary: Sponsored by Tides Medical, this completed interventional Phase 2 trial (NCT07219004, started March 3, 2023) investigates the efficacy of Artacent—a tri-layered dehydrated human amnion/chorion/amnion composite graft—as a treatment for chronic lower extremity diabetic ulcers persisting despite standard care. Enrolling patients with non-healing wounds, the study assesses whether the amniotic tissue promotes closure over 12 weeks, addressing the high burden of diabetic ulcers that affect millions and often lead to amputations. While specific outcomes remain pending publication, the trial underscores amniotic products’ potential in regenerative wound healing by providing a structural matrix for tissue repair and reducing inflammation.

Key Highlights:

  • Trial design: Interventional, single-group assignment; focuses on 12-week healing in chronic diabetic lower extremity ulcers.
  • Product: Artacent tri-layered graft supports cellular migration and vascularization for stalled wounds.
  • Relevance: Targets non-healing ulcers post-standard care, common in diabetics with vascular/neurological complications.
  • Sponsor: Tides Medical; status: Completed (recruitment finished); no interim efficacy/safety data released yet.
  • Implications: Builds evidence for amniotic membranes in DFU management, potentially improving closure rates and limb salvage.

Read full article

Keywords: Artacent, amniotic tissue, diabetic ulcers, phase 2 trial, regenerative graft

Artacent Amniotic Tissue for Treatment of Chronic Lower Extremity Diabetic Ulcers



Clinical Trial: Artacent Amniotic Tissue for Treatment of Chronic Lower Extremity Diabetic Ulcers

Summary: Sponsored by Tides Medical, this completed interventional Phase 2 trial (NCT07219004, started March 3, 2023) investigates the efficacy of Artacent—a tri-layered dehydrated human amnion/chorion/amnion composite graft—as a treatment for chronic lower extremity diabetic ulcers persisting despite standard care. Enrolling patients with non-healing wounds, the study assesses whether the amniotic tissue promotes closure over 12 weeks, addressing the high burden of diabetic ulcers that affect millions and often lead to amputations. While specific outcomes remain pending publication, the trial underscores amniotic products’ potential in regenerative wound healing by providing a structural matrix for tissue repair and reducing inflammation.

Key Highlights:

  • Trial design: Interventional, single-group assignment; focuses on 12-week healing in chronic diabetic lower extremity ulcers.
  • Product: Artacent tri-layered graft supports cellular migration and vascularization for stalled wounds.
  • Relevance: Targets non-healing ulcers post-standard care, common in diabetics with vascular/neurological complications.
  • Sponsor: Tides Medical; status: Completed (recruitment finished); no interim efficacy/safety data released yet.
  • Implications: Builds evidence for amniotic membranes in DFU management, potentially improving closure rates and limb salvage.

Read full article

Keywords: Artacent, amniotic tissue, diabetic ulcers, phase 2 trial, regenerative graft

BioLab Holdings Inc. Announces Multiple Clinical Trials to Advance Chronic Wound Care



BioLab Holdings Inc. Announces Multiple Clinical Trials to Advance Chronic Wound Care

Full Press Release:

Phoenix, AZ, October 22, 2025 – BioLab Holdings, Inc., a Phoenix-based medical manufacturer specializing in wound care solutions, announced the ongoing development of several clinical trials to demonstrate the efficacy and safety of its Cellular, Acellular, and Matrix-like Products (CAMPs) in covering and protecting non-healing wounds, including diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs). The trials are in response to mandates from the MAC region for robust data to support product efficacy for inclusion in the upcoming Local Coverage Determination (LCD), effective January 1, 2026, for DFUs and VLUs.

The trials include:

1. BIOCAMP Trial: A multicenter, prospective, randomized controlled study assessing human placental membrane products combined with standard of care (SOC) versus SOC alone for non-healing DFUs and VLUs. Preliminary data will be presented at the TRES conference on October 30, 2025.

2. CAMP RWE Trial: A multicenter hybrid platform study comparing tri-layer and single-layer amnion grafts to a matched retrospective control cohort for hard-to-heal DFUs and VLUs. The study will be submitted for publication with Dr. Windy Cole’s assistance.

3. Retrospective Study: A real-world data collection trial evaluating human amniotic membrane(s) on DFUs, VLUs, pressure ulcers, and post-operative wounds, corroborated by randomized controlled trials.

4. Meta Analyses & Mega Meta Analysis: BioLab is supporting meta-analyses by Serena Group, including a mega-meta-analysis, to demonstrate similar healing rates across membrane products regardless of brand.

5. LCD Timeline: The proposed LCD for DFUs and VLUs is effective January 1, 2026, with other wound types requiring standard care prior to use.

“These trials represent a significant step forward in providing the clinical evidence needed to ensure that our innovative wound care solutions are accessible to patients who need them most,” said BioLab CEO [Name not specified]. “We are committed to advancing the science of chronic wound management and improving outcomes for patients with DFUs and VLUs.”

About BioLab Holdings, Inc.

BioLab Holdings, Inc. is a leading manufacturer of advanced wound care products, specializing in human amniotic membrane allografts such as Membrane Wrap Lite™, Tri-Membrane Wrap™, Membrane Wrap™, and Membrane Wrap-Hydro™. These products are designed to support the healing of chronic and non-healing wounds, including DFUs, VLUs, pressure ulcers, and post-operative wounds.

For more information, visit www.biolabholdings.com.

Contact: [Contact info not specified]

Key Highlights:

  • BIOCAMP Trial: Prospective RCT for placental membranes in DFUs/VLUs; preliminary data at TRES October 30, 2025.
  • CAMP RWE Trial: Hybrid study comparing graft layers to controls; submission for publication with Dr. Windy Cole.
  • Retrospective Study: Real-world data on amniotic membranes for multiple wound types, backed by RCTs.
  • Meta-Analyses: Supported by Serena Group to show consistent healing across products for LCD inclusion.
  • LCD Impact: Effective January 1, 2026 for DFUs/VLUs; aims to ensure coverage for BioLab’s allografts.

Read full article

Keywords: BioLab Holdings, amniotic membrane, diabetic foot ulcers, venous leg ulcers, LCD coverage

Research Terminology for Chronic Wound Research: A Scoping Review Protocol



Research Terminology for Chronic Wound Research: A Scoping Review Protocol

Summary: This protocol outlines a JBI/PRISMA-ScR scoping review (2015-2025) to map terminology, definitions, and measurement methods in chronic wound research, identifying inconsistencies in terms like “healed” and “recurrence.” Searching MEDLINE/CINAHL/Embase/Cochrane, it aims to inform standardization for improved evidence synthesis and clinical guidelines, building on a 2019 review.

Key Highlights:

  • Scope: Studies on healed, time-to-healing, recurrence, QoL; excludes case reports.
  • Method: JBI framework; data extraction on wound types/contexts/definitions.
  • Objectives: Map usage, highlight gaps, recommend standards.
  • Timeline: 2015-2025; grey literature included.
  • Implications: Enables meta-analyses; reduces research silos.

Read protocol

Keywords: chronic wound terminology, scoping review, wound definitions, standardization, healing measures, Christina N Parker, Kathleen Finlayson, Sumitra Sharma