PtPdNi Trimetallic-Doped MIL-88 Hydrogel Accelerates Healing of Bacterial-Infected Diabetic Wounds
Summary: PtPdNi nanozyme (PPNM) in PVA/SA hydrogel (PPNM-Gel) mimics multiple enzymes (POD/OXD/CAT/SOD/NAD-like) for ROS generation (antibacterial) and scavenging (anti-stress). In vitro: Dose-dependent E. coli/S. aureus killing (>50% colony ↓, 50% biofilm disruption). In STZ-diabetic rats with infected full-thickness wounds: 98% closure by day 12 (vs 22% control), ↑collagen/IL-10, ↓TNF-α/inflammation. Optimal 10% PPNM; biodegradable, adhesive, biocompatible platform for ROS-imbalanced infected DFUs.
Key Highlights:
- Synthesis: Trimetallic doping in MIL-88; PVA/SA crosslinking.
- Antibacterial: ROS-mediated damage + NADH depletion; stronger vs E. coli.
- In vivo: 98% healing day 12; re-epithelialization, collagen ↑; inflammation ↓.
- Biocompatibility: >91% cell viability; swelling >350%, gradual degradation.
- Advantages: Multifunctional, low-cost, scalable for DFU.
- Authors: Yawen Peng, Wenjuan Du, Yating Cui et al.
Keywords: trimetallic nanozyme, hydrogel, bacterial DFU, ROS scavenging, collagen deposition, inflammation