Potato Peel Extract Reduces MMP-9 Expression During Oral Mucosal Wound Healing in Rats
Summary: True experimental study in 48 Wistar rats with palatal excisional wounds compared 4%/6% Granola potato peel extract gels to 0.1% triamcinolone and placebo. IHC showed both extracts significantly lowered MMP-9 expression (p<0.05) across healing phases (inflammation day 1–3, proliferation day 7, remodeling day 14), with 4% gel most effective (mean 2.27% on day 7 vs placebo 8.54%). Bioactives (flavonoids, tannins) modulated ROS/NF-κB/IL-1β, balancing ECM degradation for faster repair without steroid side effects. Implications extend to skin/DFU where excess MMP-9 stalls healing.
Key Highlights:
- Groups: 4%/6% extract, triamcinolone, placebo (n=12 each).
- MMP-9: ↓ in extracts vs controls (p<0.0001 ANOVA); 4% best (day 3: 4.99% vs placebo 9.03%).
- Phases: Peak day 1–3 placebo; extracts aligned with healing timeline.
- Mechanisms: Antioxidant (ROS inhibition), anti-inflammatory (NF-κB/IL-1β ↓), antibacterial.
- Implications: Natural steroid alternative for mucosal/skin wounds like DFU.
- Authors: Irna Sufiawati, Nur Finita, Wahyu Hidayat et al.
Keywords: potato peel, MMP-9, oral mucosal, wound healing, anti-inflammatory, DFU applications