Exploring the Benefits of Metal Ions in Phage Cocktail for the Treatment of

Methicillin-Resistant Staphylococcus aureus (MRSA) Infection

 

Xinxin Li, Yibao Chen, Shuang Wang, Xiaochao Duan, Fenqiang Zhang, Aizhen Guo, Pan Tao, Huanchun Chen, Xiangmin Li, Ping Qian

 

The Gram-positive Staphylococcus aureus, an important zoonotic pathogen caused bacteremia, endocarditis, and tissue infection in humans and animals, are listed as a “high priority” pathogen by the World Health Organization (WHO). It is estimated that in the absence of new antibiotic alternatives, by 2050, antibiotic-resistant pathogens will cause around 10 million deaths worldwide. The emergence of methicillin-resistant S. aureus (MRSA) and vancomycin-resistant S. aureus (VRSA) have brought challenges to clinical treatment … Bacteriophages (phages), first discovered in the early 20th century, are the most abundant organism in the world … read more