Piperacillin-tazobactam-Induced Pneumonitis: A Clinical Case Study

William Urbas, DPM, FACFAS, Deep N. Shah, DPM MBA, and Alex Pilkinton, DPM

 

This case study involves a 46-year-old male patient admitted with a localized necrotizing soft tissue infection of the right foot that developed an unusual and rare delayed hypersensitivity pneumonitis from the antibiotic Piperacillin-tazobactam … Drug hypersensitivity reactions present in multiple ways and have various presentations in timing. Piperacillin-tazobactam is a fourth-generation penicillin antibiotic combining a penicillin molecule (piperacillin) with a beta-lactamase inhibitor (tazobactam). Piperacillin-tazobactam is US Food and Drug Administration (FDA)-approved for 30-minute intravenous infusion at 2.25g, 3.375g, or 4.5g doses to help cover a broad spectrum of … read more


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