Tag: Wound bed preparation

Relief Therapeutics Reports Two Publications of Positive Data on Nexodyn(R) AOS for Hard-to-Heal Ulcers

GENEVA, SWITZERLAND / ACCESSWIRE / October 20, 2021 / RELIEF THERAPEUTICS Holding SA (SIX:RLF)(OTCQB: RLFTF) (” Relief “), a biopharmaceutical company seeking to provide patients therapeutic relief from serious diseases with high unmet need, today announced that its wholly owned subsidiary, APR Applied Pharma Research SA (” APR “), reported two papers published in the peer reviewed Journal of Wound Care , concluding that the company’s Nexodyn(R) acid-oxidizing solution (AOS), developed with APR’s proprietary Tehclo(R) technology, may represent a valuable therapeutic addition to standard of care (SOC) for the management of hard-to-heal ulcers requiring long periods of treatment. The data also confirmed the safety of Nexodyn(R) AOS.

Conducted by Elia Ricci, M.D., Director of the Difficult Wound Healing Unit, St. Luca Clinic, Department of Surgery A, Pecetto Torinese (TO), Piedmont, Italy, the prospective case series evaluated the clinical impact of Nexodyn(R) AOS in addition to SOC. Between February 2015 and February 2017, a total of 60 patients with hard-to-heal ulcers of various etiologies took part in the study. Patients were treated for 70 days with Nexodyn(R) AOS and the usual SOC wound dressings. The follow-up study, also conducted by Dr. Ricci, included a subset of 31 patients (51.7%) whose wounds had not fully healed by day 70, who opted to continue with treatment for another 22 weeks (for a total treatment time of 32 weeks) … read more

Made Easy: Wound bed preparation

Wound bed preparation (WBP) assists clinicians to identify and address the barriers of wound healing to create an optimal wound healing environment. WBP is a multifaceted approach that includes cleansing and debridement to enhance the effectiveness of therapeutic measures and prepare the wound for healing (Falanga, 2000; Schultz et al, 2003). The COVID-19 pandemic has led to an increase in supported self-care, but this has focused mainly on ensuring the supply of wound dressings, and that patients can identify wound deterioration and change dressings. As the effects of the pandemic continue, there is an opportunity to formalise a supported self-care framework for patients and carers that includes WBP.

MADE EASY: WOUND BED PREPARATION

Wound Bed Preparation Best Practices: Optimizing the Wound For Closure

Wound bed preparation is an important component of wound management. Gaps in knowledge of how and why to prepare a wound bed properly for conventional or advanced wound care modalities may delay or impede healing outcomes. This presentation will describe how to prepare a wound bed properly to allow for optimal healing. It will define the term “wound bed preparation” and how it can aid in the management of tissue necrosis and maintain a proper bioburden balance of the wound’s environment. The concept of “TIME” will be used to evaluate a wound’s readiness to progress into the healing phases. The healing phases of hemostasis, inflammation, proliferation, and maturation will be reviewed, and the focus of each phase when preparing the wound bed for treatment will also be discussed. The presentation will conclude by outlining methods of preparing a wound bed for conventional or advanced treatment modalities, including “BEAMS” debridement methods, conventional and advanced dressings, cellular products, and wound vacuum application … Register Now

The TIME Model of Wound Bed Preparation: Frequently Asked Questions

On July 24, 2018, I presented a webinar on the topic of the TIME (tissue management, infection or inflammation, moisture balance, and edge of wound) model of wound bed preparation as part of WoundSource’s Practice Accelerator series on wound bed preparation. Preparing a wound for healing is key to ensure that chronic wounds convert to healing wounds. The TIME mnemonic for wound bed preparation assists clinicians and bedside nurses to think critically when making decisions on treatment options. During the image-driven presentation, I discussed such topics as:

Use of the TIME mnemonic to evaluate various wound challenges
A review of terms related to the TIME wound bed preparation model
Visual guidance on different wound types and wound descriptors to determine appropriate next steps for wound healing

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Controlling Bacterial Burden in Chronic Wounds

Bioburden in chronic wounds can be a principal contributor to inflammation, clinical wound infection, and further delayed wound healing. Clinically diagnosing infection in chronic wounds can be problematic because most individuals susceptible to developing chronic wounds are subject to physiological states that often blunt typical infectious responses in various ways.¹ These responses include pain, erythema, febrile state, leukocytosis, edema and increased wound exudate, wound odor, etc. For example, a patient with a neuropathic ulcer and diabetes mellitus may not report pain or fever or present with leukocytosis but will have increased edema and wound exudate. A patient with an ischemic ulcer of peripheral arterial disease may report pain, erythema, fever, and leukocytosis but not have perfusion sufficient to produce edema or increased wound exudate.¹ It is imperative to understand how to concurrently manage factors that can contribute to infection, as well as assess for symptoms and implement interventions to prevent infection … read more

Restoring the Wound Base: The Role of Tissue Management

Successful utilization of the TIME model for wound bed preparation requires a working knowledge of chronic wound tissue types. In addition, building on this foundational knowledge is the development of accurate wound assessment skills. These components combined will assist the clinician in implementing the appropriate interventions for each wound.

Viable Chronic Wound Tissue Types
The term “viable” describes vascular tissue with dynamic biological activity.

Epithelium: This should be dry to touch and can appear white or light pink; it is composed of restratified keratinocytes arising from the basement membrane of the dermis.

Granulation: This appears light pink to red and should be moist with a bumpy texture. Capillaries give granulation tissue its characteristic color, and collagen made from fibroblasts provides structural support. If granulation tissue is pale (poor perfusion), dark red or ruddy (vascular congestion or stasis), or “bubbly” or friable (bleeds with very gentle contact), it is technically considered non-viable because it will not support migrating epithelial cells … read more

Surgical wound dehiscence: Improving prevention and outcomes

Surgical wound dehiscence (SWD) is almost certainly under-reported, not least because of variation in the interpretation of what constitutes SWD. As a result, patients with SWD may not receive optimal treatment and may experience additional surgical site complications, increased mortality, prolonged hospital stays and readmission. Following a meeting in July 2017, an international panel of clinical experts developed a consensus document to raise awareness of SWD, to aid identification of patients at increased risk and to provide practical guidance in prevention and management. This document has the endorsement of the World Union of Wound Healing Societies (WUWHS) and ultimately aims to improve outcomes for patients … read more