Diabetic peripheral neuropathy (DPN), one of the most frequent diabetic microvascular complications, is characterized by symmetrical, bilateral distal motor and predominantly sensory abnormality, starting distally and gradually spreading proximally in a glove-and-stocking distribution. It is estimated that DPN would affect approximately 50% in those with over 10 years’ duration.1 DPN has been reported to lead to neuropathic pain, diabetic foot ulcers and lower-limb amputations, all of which contribute to a substantial effect on patient’s quality of life and a significant financial burden. However, other than improving glycemic control, there is no licensed pathogenetic treatment for DPN. Therefore, it would be of great importance if a simple, inexpensive, and reliable indicator is available for the early identification and management of individuals at high risk for DPN in clinical settings, and further effective strategies are formulated to prevent its development and progression … read more