Tag: Jinchen Fan & Xiansong Wang

MXenes-integrated microneedle combined with asiaticoside to penetrate the cuticle for treatment of diabetic foot ulcer

Pei Wang, Yun Wang, Yang Yi, Yan Gong, Haoran Ji, Yuci Gan, Fei Xie, Jinchen Fan & Xiansong Wang

 

Without an efficient and transdermal drug delivery system, patients who have skin disorders of various causes tend to experience incomplete or improper wound healing. Diabetic foot ulcer (DFU) resulting from decreased neurovascular response and multi-antibiotic-resistant bacterial infection [4] are an example of chronic wound healing. DFUs are accompanied by high morbidity and mortality and can lead to limb amputations [6] and hospitalization. Unfortunately, most treatments for diabetic skin disorders, including the application of acellular dermal matrix (ADM), electrospun nanofiber, are administered by smearing and are incapable of efficiently delivering drugs through the cuticle. Thus, to promote skin regeneration in patients with diabetes mellitus, it is necessary to develop a better drug delivery system … read more