Natural Bioactive-Based Advanced Wound Dressings for Diabetic Wound Healing: A Systematic Review of Emerging Biomaterial Platforms
Summary: This PRISMA-guided systematic review analyzed 14 studies on natural bioactive-incorporated advanced dressings for diabetic wounds. Hydrogels, hydrocolloids, nanofibers, and hybrid systems loaded with curcumin, propolis, berberine, and plant extracts demonstrated strong antimicrobial, anti-inflammatory, antioxidant, and pro-angiogenic effects via modulation of NF-κB, VEGF, and TGF-β pathways.
Key Highlights:
- 14 studies included after screening 5256 records
- Key bioactives: curcumin, propolis, bee venom, plant extracts
- Mechanisms: reduced inflammation/oxidative stress + enhanced angiogenesis
- Hydrogels and nanosystems showed highest translational potential
Keywords: natural bioactive wound dressings, diabetic wound hydrogel, curcumin wound, Fahrurroji A, Suhandi C