From Glucose to Limb Salvage: New Therapeutic Frontiers to Redefine Outcomes in Diabetic Foot Disease
Summary: This forward-looking review in *Diabetes Care* emphasizes that while glycemic control remains foundational, new therapeutic frontiers are needed to address the persistent high amputation rates in diabetic foot disease. Highlighted areas include advanced wound biologics, stem cell and platelet-derived therapies, neuromodulation for perfusion and pain, smart offloading technologies, and personalized medicine approaches. The authors call for integrated multidisciplinary care models that combine metabolic optimization with these innovative tools to shift outcomes from amputation to durable limb salvage.
Key Highlights:
- Beyond glucose control: focus on perfusion, infection, and regenerative therapies
- Emerging role of biologics, neuromodulation, and sensor-based offloading
- Urgent need for better prevention and limb-preservation pathways
Keywords: limb salvage DFU, new therapies diabetic foot