Editorial: In vivo applications of nanozymes
Summary: This editorial discusses the expanding in vivo use of nanozymes—nanomaterials with enzyme-mimicking activities—for wound healing, with a strong focus on diabetic foot ulcer (DFU) therapy. Nanozymes address multiple barriers in chronic wounds: reactive oxygen species (ROS) scavenging (catalase/peroxidase-like activity), antibacterial effects, and promotion of angiogenesis and tissue regeneration. The piece reviews recent studies on nanozyme design for improved biocompatibility, targeted delivery, and multifunctionality. It emphasizes the need for robust preclinical models and translational strategies to overcome challenges such as long-term safety, scalability, and integration with existing wound care protocols. Nanozymes represent a promising “next-generation” approach for complex, multifactorial wounds like DFUs.
Key Highlights:
- Nanozymes combat oxidative stress, infection, and stalled healing in DFUs
- Multifunctional designs (ROS scavenging + antibacterial + pro-regenerative)
- Focus on clinical translation barriers and future design logic
- Strong potential as adjuncts or standalone advanced therapies
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Keywords: nanozymes, nanozymes DFU, oxidative stress wound healing