Nutritional Interventions to Optimize Orthobiologic Therapy Quality in Type 2 Diabetes Mellitus and Metabolic Syndrome
Summary: This comprehensive review examines the impact of targeted nutrition on the efficacy of orthobiologic treatments (PRP, stem cells, bone marrow concentrate) in patients with type 2 diabetes and metabolic syndrome. Hyperglycemia and chronic inflammation impair regenerative cell function; specific interventions such as flaxseed oil (1000 mg/day) have shown DFU size reduction and improved insulin sensitivity in trials. The authors discuss omega-3 fatty acids, antioxidants, vitamin D, and Mediterranean-style diets to optimize stem cell quality, reduce oxidative stress, and enhance healing. Practical guidance is provided for integrating nutrition into multidisciplinary limb-preservation and regenerative wound care programs.
Key Highlights:
- Nutrition modulates orthobiologic efficacy in diabetic patients
- Flaxseed oil supplementation linked to smaller DFUs and better metabolic control
- Focus on anti-inflammatory and antioxidant strategies
- Authors: Multiple (MDPI IJMS team)
Keywords: nutritional interventions DFU, orthobiologics diabetes, flaxseed oil wound healing