Development of a Novel Hydrogel Dressing Loaded with Curcumin and Aloe Vera for Diabetic Wound Healing
Summary: This 2026 study develops a novel hydrogel dressing incorporating curcumin and Aloe vera within a chitosan/gelatin matrix for diabetic wound healing. The formulation provides sustained release of bioactive compounds with antioxidant, anti-inflammatory, and antimicrobial properties. In STZ-induced diabetic rat models with full-thickness wounds, the hydrogel significantly accelerated wound closure, improved collagen deposition and organization, enhanced angiogenesis, and reduced oxidative stress and inflammation compared to controls. Demonstrates synergistic benefits of the natural compounds in a biocompatible delivery system. Supports further development as a promising, low-cost option for managing chronic diabetic foot ulcers.
Key Highlights:
- Curcumin + Aloe vera in chitosan/gelatin hydrogel
- Accelerated closure, better collagen, and angiogenesis in diabetic models
- Reduced oxidative stress and inflammation
- Relevance: Natural-functionalized hydrogel for hard-to-heal DFUs
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Keywords: curcumin hydrogel, Aloe vera, diabetic wound healing, natural hydrogel