Bioactive Platinum Nanozymes Accelerate Diabetic Wound Healing via Antioxidant and Antibacterial Effects
Summary: This study investigates platinum nanozymes (PtNZs) as a multifunctional nanotherapeutic for diabetic wound healing. PtNZs demonstrate potent antioxidant activity by scavenging reactive oxygen species (ROS) and exhibit broad-spectrum antibacterial effects. In streptozotocin-induced diabetic rat models with full-thickness wounds, topical PtNZs significantly accelerated wound closure, reduced inflammatory markers, promoted angiogenesis (↑ CD31), and enhanced collagen deposition/maturation compared to controls. The nanozymes mitigate oxidative stress and infection—two major barriers in diabetic ulcers—while supporting tissue regeneration. Biocompatible with low toxicity. Positions PtNZs as a promising bioactive agent for chronic diabetic foot ulcers, offering dual antioxidant and antimicrobial benefits in a single platform.
Key Highlights:
- Strong ROS scavenging and antibacterial properties
- Accelerated closure, reduced inflammation, better angiogenesis/collagen in diabetic models
- Biocompatible multifunctional nanozyme platform
- Relevance: Targeted nanotherapy for hard-to-heal DFUs
Keywords: platinum nanozymes, diabetic wound healing, ROS scavenging, antibacterial nano