Recent Advances in Nanozymes Toward Diabetic Foot Ulcers
Summary: 2026 narrative review covers recent advances in nanozymes for diabetic foot ulcers (DFUs). Nanozymes: Nanomaterials (metal oxides, carbon-based) mimicking enzymes (catalase, superoxide dismutase, peroxidase, glucose oxidase) with high stability, low cost, tunable activity. In DFUs: Counter hyperglycemia-induced oxidative stress (ROS scavenging), reduce infection (antibacterial), modulate inflammation, promote angiogenesis/collagen via ROS regulation. Examples: MnO2, CeO2, Pt-based nanozymes; glucose oxidase-like for hyperglycemic control. Advantages: Overcome natural enzyme limitations (instability, immunogenicity); synergistic with dressings (hydrogels, films). Preclinical evidence: Accelerated closure, better granulation in diabetic models. Challenges: Biocompatibility, long-term safety, clinical translation. Future: Smart/multi-functional nanozymes for personalized DFU therapy.
Key Highlights:
- Activity: ROS scavenging, antimicrobial, anti-inflammatory.
- Benefits: Stability, cost-effectiveness vs. natural enzymes.
- Applications: Topical delivery in DFUs.
- Relevance: Nano-synthetic enzyme mimics for chronic diabetic wounds.
Keywords: nanozymes, diabetic foot ulcers, ROS scavenging, nano therapeutics