Bioactive Platinum Nanozymes Accelerate Diabetic Wound Healing via Anti-Inflammation and Macrophage Polarization Modulation
Summary: Researchers developed sodium hyaluronate-assisted platinum nanozymes (SHA-PtNPs) with excellent catalase-like (3320 U/g) and superoxide dismutase-like (129,000 U/g) activities for efficient ROS scavenging. In streptozotocin-induced diabetic rat full-thickness wound models, topical SHA-PtNPs achieved 97.06% wound closure by day 15 and near-complete healing by day 28, with significantly smaller residual wound areas compared to controls. Mechanisms include suppression of pro-inflammatory cytokines (IL-1β), elevation of anti-inflammatory IL-4 and TGF-β1, promotion of M1-to-M2 macrophage polarization (increased CD206/CD86 ratio), and enhanced angiogenesis (upregulated CD31 and α-SMA). Histology showed reduced inflammation, increased collagen deposition, thicker re-epithelialization, and minimal scarring. The biocompatible nanozyme offers a promising multifunctional approach for chronic diabetic wounds by integrating antioxidant, immunomodulatory, and regenerative effects.
Key Highlights:
- 97% wound closure by day 15 in diabetic rat model
- Strong ROS scavenging via CAT- and SOD-mimicking activity
- Promotes M1-to-M2 macrophage shift and angiogenesis
- Authors: Liyong Shi, Jing Cheng, Lianshun Lin, Tanwei Liu, Linlin Chen
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Keywords: platinum nanozymes, diabetic wound healing, macrophage polarization, ROS scavenging, Liyong Shi