Negative Pressure Wound Therapy + Silver-Ion Dressing Dramatically Improves DFU Outcomes
Summary: Prospective study (n=78, Wagner grade 2–3 DFUs) compared NPWT + silver-ion dressing versus conventional dressings. Combination therapy reduced serum IL-6 and TNF-α by >50% at day 30 (p<0.01), achieved 88.5% complete healing at 12 weeks (vs 51.3% control), and shortened healing time by 38%. Lower infection rates and better granulation tissue formation observed. Authors conclude the dual approach synergistically controls infection and excessive inflammation — two core barriers in DFU healing.
Key Highlights:
- Patients: 78 (Feb 2023–Apr 2025).
- Healing Rate: 88.5% vs 51.3% at 12 weeks.
- Biomarkers: IL-6 ↓ 58%, TNF-α ↓ 54% at day 30.
- Healing Time: Reduced by 38%.
- Authors: Chinese multicenter team.
Keywords: NPWT, silver dressing, IL-6, TNF-α, diabetic foot ulcer, healing rate