Early Clinical Experience with a Topical Desiccating Agent for Wound Bed Preparation in Diabetic Foot Ulcers
Summary: This retrospective case series evaluated a novel topical desiccating agent (TDA) under compassionate use for wound bed preparation in 67 patients with chronic diabetic foot ulcers (DFUs) from 2020-2023. TDA facilitated debridement and granulation, achieving granulation in 88.1% (mean 44.3 days) and complete re-epithelialization in 85.1%, with no adverse events. The agent offers a safe, non-invasive option for high-risk cases, supporting further prospective validation for DFU protocols.
Key Highlights:
- Cohort: 67 adults with stalled DFUs; ethics-approved compassionate use.
- Granulation: 88.1% success; mean time 44.3 days to ready for grafting/closure.
- Healing: 85.1% full re-epithelialization; rapid progression post-TDA.
- Safety: No AEs; well-tolerated in diabetics.
- Implications: Chemical debridement adjunct; calls for RCTs.
Keywords: topical desiccating agent, diabetic foot ulcers, wound bed preparation, granulation, chemical debridement