Development and Validation of a Diagnostic Nomogram for Wagner Grade ≥2 Diabetic Foot Ulcers in Patients with Diabetic Kidney Disease
Summary: Researchers developed and validated a practical nomogram to predict the risk of moderate-to-severe (Wagner grade ≥2) diabetic foot ulcers in patients with diabetic kidney disease (DKD). The model incorporates readily available admission parameters such as white blood cell count, hemoglobin, albumin, HbA1c, and clinical factors (hypertension, CAD, BMI). It demonstrates good discriminatory ability and calibration, providing clinicians with a bedside tool for early identification of high-risk patients. Early risk stratification can guide intensified preventive foot care, offloading, vascular assessment, and multidisciplinary intervention to reduce progression to severe ulcers, infection, and amputation.
Key Highlights:
- Nomogram based on routine labs and comorbidities for Wagner ≥2 DFU prediction in DKD patients
- Supports early risk stratification and targeted prevention
- Addresses high amputation risk in combined diabetes + kidney disease population
Keywords: diabetic foot ulcer nomogram, Wagner grade DFU, diabetic kidney disease