A multi therapy bioelectronic wound dressing
Summary: Researchers developed a flexible bioelectronic wound dressing integrating electric field (EF) therapy and on-demand iontophoretic drug delivery (fluoxetine) via integrated microfluidics. In a porcine excisional wound pilot, the dressing significantly improved closure rates, reduced inflammatory cytokines (IL-1β, IL-6, TNF), increased reparative factors (TGF-β1, IGF-1), decreased granulocytes, and produced more mature granulation tissue compared with standard care. The device allows sequential therapy—early EF to enhance galvanotaxis and later fluoxetine to modulate inflammation—offering a smart, localized approach with minimal off-target effects for chronic and acute wounds.
Key Highlights:
- Combines EF therapy (galvanotaxis) with programmable fluoxetine delivery
- Porcine study: faster closure (p=0.0145), reduced inflammation, improved tissue maturity
- Microfluidic switching enables stage-specific treatment
- Authors include Hsin-ya Yang, Jaime Tenedorio, Roslyn Rivkah Isseroff, Marco Rolandi et al.
Keywords: bioelectronic wound dressing, electric field therapy, chronic wound innovation, Hsin-ya Yang