Green Synthesis of ZnO Nanoparticles: A Sustainable Approach for Wound Healing Applications
Summary: 2026 study develops ZnO nanoparticles via green synthesis (using plant extracts as reducing/capping agents) for wound healing. Advantages: Eco-friendly, low toxicity, cost-effective vs. chemical methods. Characterization: Uniform size/shape, stability, ROS scavenging. In vitro: Strong antibacterial (Gram-positive/negative, including resistant strains), antioxidant (DPPH assay), anti-inflammatory (↓ cytokines), promotes fibroblast migration/proliferation/collagen production. In vivo (rat models): Accelerated closure, granulation, re-epithelialization, angiogenesis in chronic/excisional wounds. Mechanisms: ZnO releases ions for antimicrobial action, modulates ROS signaling for repair. Positions green ZnO NPs as sustainable nanomaterial for topical dressings in chronic wounds (DFUs, burns); potential for composite gels/films. Calls for clinical trials.
Key Highlights:
- Synthesis: Plant-mediated, sustainable.
- Properties: Antimicrobial, antioxidant, pro-healing.
- Applications: Chronic wound dressings.
- Relevance: Green nano-approach for future synthetic therapies.
Keywords: green ZnO nanoparticles, wound healing, nano antimicrobial, sustainable synthesis