Treatment of Refractory Leg Ulcer in Patient with Lupus Undergoing Combination Therapy
Summary: Case report details management of refractory leg ulcer in a patient with systemic lupus erythematosus (SLE). Ulcer persistent despite standard care due to autoimmune inflammation, vasculitis, and impaired healing. Treatment: Multimodal combination—aggressive debridement (sharp/autolytic), advanced dressings (e.g., collagen/silver for infection/biofilm), topical agents, compression therapy, systemic lupus management (steroids, immunosuppressants, hydroxychloroquine). Outcomes: Progressive granulation, reduced inflammation, complete closure over months. Emphasizes challenges (recurrent flares, poor perfusion), need for rheumatology/wound collaboration, and tailored regimens. Demonstrates success in inflammatory/refractory ulcers with integrated therapy; relevant for autoimmune-associated chronic wounds.
Key Highlights:
- Challenges: Autoimmune vasculitis delays healing.
- Approach: Debridement + advanced dressings + systemic control.
- Outcome: Full healing; multidisciplinary key.
- Relevance: Insights for complex inflammatory chronic ulcers.
Keywords: lupus leg ulcer, refractory ulcer, combination therapy, autoimmune wound