aFGF rescues high glucose-induced senescent fibroblasts and improves diabetic wound healing by regulating SIRT1/STAT3 pathway
Summary: February 9, 2026 study investigates acidic fibroblast growth factor (aFGF) in diabetic wound healing. In STZ-induced diabetic rats, local aFGF injection accelerates closure and ↓ SASP expression. In vitro (HG-induced L929 fibroblasts), aFGF reverses senescence, boosts antioxidant capacity. Mechanism: rescues SIRT1 expression, inhibits STAT3 phosphorylation in senescent tissue. Positions aFGF as candidate to ameliorate fibroblast dysfunction and promote healing in high-glucose environments.
Key Highlights:
- In vivo: Faster closure, reduced senescence markers.
- In vitro: Anti-senescence/antioxidant effects.
- Pathway: SIRT1/STAT3 modulation key.
- Relevance: Targets cellular aging in diabetic chronic wounds.
Keywords: aFGF, senescent fibroblasts, SIRT1/STAT3, diabetic wound