Association between controlling nutritional status (CONUT) score and amputation risk factors in T2DM patients with DFU
Summary: January 28, 2026 retrospective analysis (n=387 T2DM DFU inpatients, Jan 2024–Jun 2025) links CONUT score (albumin, cholesterol, lymphocytes) to amputation. 40.3% amputation rate (all minor); amputation group had worse nutrition (lower albumin/prealbumin/Hb/PNI), higher CONUT, larger ulcers, more osteomyelitis/PAD/smoking. Amputation rose with CONUT severity (15.1% normal → 68.3% moderate-severe). Logistic regression: CONUT (OR=1.655/unit), osteomyelitis (3.817), PAD (12.602) as independent risks. ROC: CONUT AUC=0.705 (cutoff 3.5). Subgroup: association strong except HbA1c <7%. Malnutrition exacerbates healing delays/infection/vascular issues; early CONUT assessment/nutrition improvement could lower amputation in DFU.
Key Highlights:
- Risks: CONUT, osteomyelitis, PAD independent predictors.
- Prediction: Good AUC; higher scores → poorer outcomes.
- Implications: Routine nutritional screening in DFU care.
- Relevance: Systemic factor in chronic diabetic wounds/amputation prevention.
Keywords: CONUT score, DFU amputation, nutritional status, T2DM DFU