Compression Bandages for Wound Healing: A Meta-Analysis of Randomized Controlled Trials
Summary: This meta-analysis of 21 RCTs (n=2,500) evaluates compression bandages for venous leg ulcers (VLUs), finding them superior to no compression for healing (RR 1.48, 95% CI 1.28-1.71) and recurrence prevention (RR 0.62, CI 0.50-0.77). Inelastic (short-stretch) bandages showed better outcomes (RR 1.62) than elastic, with high pressure (35-40 mmHg) optimal. No significant AEs; supports compression as first-line for VLUs.
Key Highlights:
- Healing: RR 1.48; 12-week rates 65% vs 45% without.
- Recurrence: RR 0.62 at 6 months; inelastic RR 1.62 for closure.
- Pressure: High (35-40 mmHg) superior; multilayer best.
- Safety: Minor skin irritation; no ulcers worsened.
- Authors: O’Brien J, Edwards H, Stewart S et al.
Keywords: compression bandages, venous ulcers, meta-analysis, inelastic, recurrence, O’Brien J, Edwards H, Stewart S