Synthetic Electrospun Fiber Matrix Speeds Healing in Hidradenitis Suppurativa (HS) Excision Wounds
Summary: In a prospective pilot study, researchers evaluated a synthetic electrospun fiber matrix (SEFM) applied with negative pressure wound therapy (NPWT) to accelerate healing and prepare wound beds for skin grafting following surgical excision of moderate-to-severe HS lesions. The study found rapid granulation, low complication rates, and good graft take, suggesting SEFM may be a helpful adjunct in surgical wound management. (MDPI Polymers)
Key Highlights:
- Setting: Patients with HS Hurley Stage II & III undergoing excision of lesions, often in areas prone to bacterial colonization or contamination.
- Intervention: Use of SEFM, a biocompatible synthetic electrospun polymer scaffold designed to mimic extracellular matrix, with hydrolytic resorption over 1-3 weeks, plus NPWT and protective dressing (e.g. bismuth gauze).
- Outcomes: Granulation sufficient for split-thickness skin grafting achieved in approximately 2 weeks; on average, ~71% of wound bed ready for grafting; skin grafts incorporated successfully with minimal complications.
- Safety & complications: No surgical site infections reported; low rates of bleeding or hematoma; manageable in topographically challenging regions.
- Clinical relevance: SEFM may reduce time to grafting, lower risk of infection in challenging wounds, and support reconstructive efforts following HS excision.
Read the full article in MDPI Polymers
Keywords:
electrospun fiber matrix,
synthetic wound matrix,
HS excision wounds,
negative pressure wound therapy,
granulation tissue,
skin graft preparation