Huiyang Shengji Unguent Enhances Lymphangiogenesis & Healing in Diabetic Chronic Wounds
Summary: Investigators from Beijing Hospital of Traditional Chinese Medicine published new work in Journal of Inflammation Research showing that Huiyang Shengji (HYSJ) unguent accelerates healing of diabetic chronic wounds by boosting lymphangiogenesis, protecting lymphatic endothelial cells, and suppressing inflammatory cell death in high-glucose environments.
Key Highlights:
- Major constituents of the unguent (e.g. coclaurine, sinapine, ononin) identified via mass spectrometry; applied topically in diabetic mice with chronic wounds.
- Treated mice showed faster closure, improved lymphatic drainage in wound tissue; key lymphatic markers (LYVE-1, VEGF-C, PROX-1) increased.
- In vitro, high-glucose inflammatory conditions in human lymphatic endothelial cells responded favorably: function preserved, inflammatory cell death reduced, signaling via TLR2/Myd88/caspase-1 suppressed.
- Proteomics and bioinformatics analyses revealed upregulation of lymphatic repair pathways, downregulation of inflammasome-driven pyroptotic pathways.
Read the full article in Journal of Inflammation Research
Keywords:
Huiyang Shengji Unguent,
lymphangiogenesis,
diabetic chronic wounds,
TLR2 Myd88 caspase-1,
inflammatory cell death