Association of Inflammation and Nutrition-Based Indicators With Diabetic Foot Ulcers
Summary: A new combined cross-sectional and retrospective study from China (Hua Chen, Yu Zhou, Jiezhi Dai) examines multiple inflammation and nutrition biomarkers and their association with prevalence of diabetic foot ulcers (DFUs). Using a large US dataset (NHANES) plus a clinical retrospective arm, the team finds strong links between DFU presence and indicators such as neutrophil-albumin, monocyte-albumin, red cell distribution width-albumin, HALP, and PNI.
Key Highlights:
- Data from ~31,126 participants in NHANES (1999–2004) and clinical data comparing DFU vs non-DFU patients.
- Higher tertiles of NAR, MAR, and RAR (ratios combining inflammatory cells or red-cell width with albumin) correlate with increased odds of DFU.
- Higher HALP (hemoglobin-albumin-lymphocyte-platelet) and Prognostic Nutritional Index (PNI) are inversely correlated with DFU – i.e. better nutrition/inflammation status associated with lower DFU risk.
- Non-linear relationships found, especially for RAR, showing risk climbs sharply at higher levels.
Read the full article in Frontiers in Endocrinology
Keywords:
inflammation biomarkers,
nutrition indices,
diabetic foot ulcer prevalence,
NHANES,
Hua Chen,
Yu Zhou,
Jiezhi Dai