High Mortality & Amputation Rates After First Diabetic Foot Ulcer: CODIA Cohort Findings
Summary: A large cohort study from Greater Paris hospitals (August 2017-October 2023) examines the one-year outcomes in over 3,100 patients hospitalized with their first diabetic foot ulcer (DFU). The findings are alarming: ~21.6% died and ~24.2% underwent lower-limb amputation within 12 months. Key risk factors for death included older age, cardiac, hepatic or renal disease, cancer history, and systemic inflammation; amputation risk was linked to male sex, peripheral artery disease, admission through emergency, and markers of inflammation.
Key Highlights:
- Sample included 3,102 patients, median age ~70.7 years; 68% male.
- Cumulative incidence of death within 12 months: **21.64%**.
- Cumulative incidence of lower limb amputation within 12 months: **24.15%**.
- Strong predictors of mortality: chronic comorbidities (heart, liver, kidney), history of cancer, and elevated systemic inflammation.
- Key predictors of amputation: male gender, peripheral arterial disease, being admitted via the emergency department, and inflammation; interestingly, dementia was associated with *lower* risk of amputation.
Read the full article in Diabetes & Metabolism
Keywords:
first diabetic foot ulcer,
lower limb amputation,
one-year mortality,
peripheral artery disease,
systemic inflammation,
Julla Jean-Baptiste,
Théo Jolivet,
Candice Estellat,
Jean-François Gautier,
Florence Tubach