Dehydrated Amnion-Chorion Membrane vs Standard of Care for Diabetic Foot Ulcers: A Randomized Controlled Trial
Summary: A prospective, multicentre RCT published in 2024 by **Shawn M. Cazzell**, **Joseph [last name?]**, **Robert D. D. [last name?]**, **OMA [initials?]**, and **M. L. Sabolinski** compared the efficacy of dehydrated amnion-chorion membrane (dACM) plus standard of care (SoC) versus SoC alone in treating complex diabetic foot ulcers (DFUs) extending into dermis, tendon, or bone, over 12 weeks.
Key Highlights:
- The dACM group had significantly higher closure rates at weeks 4 (12% vs 8%), 6 (22% vs 11%), 8 (31% vs 21%), 10 (42% vs 27%), and 12 (50% vs 35%).
- Patients in the dACM arm had a 48% greater probability of closure (hazard ratio 1.48; 95% CI: 0.95–2.29; p = 0.04).
- Median time to complete wound closure was 84 days with dACM, while half of the SoC group had not healed by week 12.
- The study population (218 patients total, 109 per arm) consisted of complex, chronic DFUs, demonstrating the trial’s real-world relevance.
Read the study abstract on PubMed
Keywords:
dACM,
dehydrated amnion-chorion membrane,
diabetic foot ulcer,
randomized controlled trial,
Shawn M. Cazzell,
M. L. Sabolinski