Nanotechnology-Based Topical Insulin Delivery System: Promising Role in Diabetic Wound Healing
Summary: A narrative review published in Wound Repair & Regeneration (2025) by **Lalit Singh**, **Arpita Bhakuni**, **Monika**, **Rahul Pratap Singh**, and colleagues explores how nanotechnology-enhanced topical insulin delivery systems can revolutionize healing in diabetic wounds by enabling targeted, sustained insulin release at the wound site.
Key Highlights:
- Systemic insulin faces challenges like hypoglycemia and poor wound-site targeting, limiting its use in wound care.
- Nanotechnology-based platforms—such as nanoparticles, liposomes, and hydrogel carriers—improve localized insulin delivery, enhance bioavailability, and promote controlled release at the wound.
- Topical insulin delivered via nanosystems may boost angiogenesis, stimulate cell proliferation, reduce inflammation, and support the complex repair mechanisms needed in diabetic wound healing.
- The review argues that personalized topical insulin nanotherapies could transform DFU management, though clinical validation remains pending.
Read the full article in Wound Repair & Regeneration
Keywords:
topical insulin,
nanotechnology,
diabetic wound healing,
drug delivery systems,
Lalit Singh,
Arpita Bhakuni,
Monika,
Rahul Pratap Singh