Targeted Synergistic Therapy for Bone and Brain Disorders Using Hydrogel Microneedles Loaded with Exosomes
Summary: This study presents a novel hydrogel microneedle system engineered for controlled release of exosomes. The platform enables targeted, minimally invasive delivery with synergistic therapeutic effects. In diabetic wound models, the exosome-loaded microneedles reversed macrophage dysfunction and accelerated diabetic foot ulcer healing. The technology holds broad potential for regenerative applications in both hard and soft tissues.
Key Highlights:
- Hydrogel microneedles provide sustained, localized exosome delivery
- Reversed macrophage dysfunction and improved DFU healing
- Minimally invasive platform with strong translational potential
- Dual application for bone regeneration and neurological conditions
Keywords: hydrogel microneedles, exosome therapy, DFU regeneration