C-Reactive Protein-to-Albumin Ratio Improves Prediction of 6-Month Major Adverse Limb Events in Patients with Diabetic Foot Ulcers
Summary: This retrospective study evaluated the prognostic value of the C-reactive protein-to-albumin ratio (CAR) in patients with diabetic foot ulcers (DFU). CAR, a readily available inflammatory biomarker, demonstrated strong independent predictive power for 6-month major adverse limb events (MALE), including major amputation and revascularization. Adding CAR to traditional risk models significantly improved discrimination and reclassification. The authors conclude that CAR is a simple, inexpensive tool that can help clinicians better stratify risk and guide intensified interventions in high-risk DFU patients.
Key Highlights:
- CAR independently predicts 6-month MALE in DFU patients
- Improves model performance when added to conventional risk factors
- Low-cost, routinely available biomarker from standard labs
- Useful for early risk stratification and personalized care
Keywords: CRP albumin ratio, DFU prognosis, major adverse limb events