Application of Nanofiber Wound Dressings in Diabetic Wound Healing: A Review
Summary: This literature review examines the application of nanofiber wound dressings (typically produced via electrospinning) in diabetic wound healing. Nanofibers offer high surface area-to-volume ratio, excellent porosity, and biomimetic structure that supports cell adhesion, migration, and proliferation. They maintain optimal moisture balance, enable controlled release of antimicrobials/growth factors, and reduce inflammation while promoting angiogenesis and collagen deposition. Preclinical and early clinical data show faster closure rates, reduced infection, and improved tissue regeneration in diabetic models compared to conventional dressings. Discusses material choices (chitosan, PCL, PVA, collagen) and functionalization strategies. Positions nanofiber dressings as a promising advanced platform for managing hard-to-heal diabetic foot ulcers.
Key Highlights:
- High surface area and biomimetic architecture
- Controlled release and moisture management
- Enhanced angiogenesis and collagen formation in DFUs
- Relevance: Advanced dressing technology for chronic diabetic wounds
Keywords: nanofiber dressings, diabetic wound healing, electrospun scaffolds, advanced dressing