Biopolymer Hydrogel-Based Nanocomposites Functionalized with Natural Polyphenols for Diabetic Wound Healing
Summary: This review explores biopolymer hydrogel-based nanocomposites functionalized with natural polyphenols (e.g., curcumin, resveratrol, quercetin) as advanced dressings for diabetic wound healing. These systems combine the moist healing environment of hydrogels with the sustained release and bioactivity of polyphenols, addressing key DFU challenges: oxidative stress, chronic inflammation, infection, and impaired angiogenesis. Preclinical evidence shows enhanced fibroblast proliferation, collagen synthesis, reduced ROS and pro-inflammatory cytokines, and accelerated wound closure in diabetic animal models. Advantages: Biocompatible, biodegradable, multifunctional (antioxidant + antimicrobial). Highlights potential as a natural-derived, low-toxicity platform to improve outcomes in hard-to-heal diabetic foot ulcers.
Key Highlights:
- Polyphenols provide antioxidant, anti-inflammatory, and antimicrobial properties
- Hydrogel matrix enables sustained release and moist healing
- Accelerated closure, better collagen deposition, and angiogenesis in diabetic models
- Relevance: Promising natural-functionalized nanocomposites for chronic DFUs
Keywords: biopolymer hydrogel, natural polyphenols, diabetic wound healing, nanocomposites