Important Terms to Know: Wound Biofilm
Summary: This educational blog defines and explains critical terms related to wound biofilm, a major barrier in chronic wounds (present in 60–90% of non-healing cases). Covers: Biofilm formation (bacterial attachment, EPS matrix), quorum sensing (communication), tolerance (reduced susceptibility to antimicrobials), and resistance. Discusses clinical impact: Persistent inflammation, delayed granulation, recurrent infection. Management: Aggressive debridement (sharp, mechanical, enzymatic), topical/systemic antimicrobials, anti-biofilm dressings (e.g., silver, DACC, honey), and prevention (wound hygiene). Emphasizes multimodal approaches and early intervention to disrupt biofilm and accelerate healing in hard-to-heal wounds (DFUs, VLUs, pressure injuries).
Keywords: wound biofilm, EPS matrix, quorum sensing, anti-biofilm dressing