Potential Application of Plant-Derived Extracellular Vesicles in Treatment of Burn Wounds
Summary: Review on plant-derived extracellular vesicles (pEVs) as nano-therapeutics for burn/chronic wounds. Sourced from plants (grapefruit, aloe vera, ginger, lemon, cabbage, etc.); deliver bioactives for anti-inflammatory (↓NF-κB/TNF-α), antioxidant (Nrf2/ROS reduction), pro-healing (proliferation/migration/collagen), pro-angiogenic (↑VEGF/CD31), antibacterial effects. Advantages: safe, non-immunogenic, scalable/cost-effective vs. mammalian exosomes. Evidence from in vitro/in vivo models; potential for diabetic/chronic wounds via similar mechanisms (inflammation control, regeneration).
Key Highlights:
- Sources: Grapefruit, aloe peel, lemon, wheat grass, strawberry, etc.
- Mechanisms: Inhibit cytokines/ROS; promote VEGF, collagen, macrophage reprogramming.
- Advantages: Biocompatible, abundant, eco-friendly production.
- Applications: Burn healing acceleration; extension to diabetic ulcers via oxidative/inflammatory modulation.
Keywords: plant-derived EVs, nanovesicles, burn wounds, chronic wound therapy