Improved vascular response to a novel polymeric blend PLLA/PLGA coronary scaffold material: preclinical study
Summary: This preclinical study evaluated a new bioresorbable coronary scaffold composed of a PLLA/PLGA blend using a porcine restenosis model. Compared with traditional crystalline PLLA scaffolds, the new amorphous polymer blend demonstrated lower inflammation, better endothelialization, and positive vessel remodeling over a 90-day period, suggesting improved safety and healing potential for next-generation bioresorbable devices.
Key Highlights:
- Scaffold types tested: PLLA 120 µm, PLLA 150 µm, and PLLA/PLGA 200 µm devices were implanted under identical conditions.
- Inflammatory response: The PLLA/PLGA scaffold showed more struts free of inflammation and lower injury scores than PLLA counterparts.
- Endothelial coverage: By 90 days, all scaffolds achieved near-complete endothelialization, but the PLLA/PLGA devices exhibited superior vessel remodeling.
- Lumen remodeling: The PLLA/PLGA scaffold uniquely demonstrated lumen enlargement between 30 and 90 days, a benefit not observed in the PLLA scaffolds.
- Material implications: Findings suggest that amorphous PLLA/PLGA blends may overcome limitations of crystalline PLA, improving biocompatibility and clinical outcomes.
Read the full article in Scientific Reports
Keywords:
Piotr P. Buszman,
Mateusz Kachel,
Karolina Łukasik,
Jerzy Nożyński,
Rafał Skowronek,
Maksymilian Grajek,
Magdalena Michalak,
Michał Sobota,
Janusz Kasperczyk,
Jerzy Małachowski,
Kamil Sybilski,
Marta Mazur,
Paweł Kaźmierczak,
Krzysztof P. Milewski,
Paweł E. Buszman,
bioresorbable scaffold,
PLLA/PLGA,
vessel remodeling,
inflammation control