Synergistic Innovative Therapies in Dermatology: Integrating Platelet Derivatives, Biomaterials, and Exogenous Bioactive Substances for Enhancing Skin Repair and Regeneration
Summary: This 2025 narrative review explores how platelet-derived products (such as PRP and PRGF), when combined with biomaterials and bioactive agents, enhance skin repair and regeneration. These biologically active substances are rich in growth factors and proteins that accelerate healing, reduce scarring, and improve skin rejuvenation. The review highlights their applications across chronic wounds, burns, scars, alopecia, and skin aging, while also emphasizing the need for standardized methodologies and long-term clinical validation.
Key Highlights:
- Mechanisms: Platelet-rich products release growth factors and cytokines that stimulate epithelial cells, promote angiogenesis, and modulate inflammation.
- Therapeutic synergy: Combining platelet-rich derivatives with hydrogels, scaffolds, or exogenous molecules improves healing efficacy and safety.
- Clinical applications: Evidence shows benefit in treating diabetic ulcers, pressure ulcers, scars, burns, skin aging, and hair loss.
- Challenges: Outcomes vary due to differences in preparation protocols; stronger randomized trials and reproducibility are needed.
- Future prospects: Multifunctional, hydrogel-based strategies that combine antimicrobial, antioxidant, and anti-inflammatory properties show particular promise.
Keywords:
Eduardo Anitua,
Roberto Tierno,
Gorka Orive,
Mohammad Hamdan Alkhraisat,
platelet-rich plasma,
PRGF,
wound healing,
skin regeneration,
biomaterials,
bioactive molecules