Silicon-Based Nanomaterials in Chronic Wound Healing: Mechanisms, Therapeutic Applications, and Clinical Prospects
Summary: This review, published in the International Journal of Nanomedicine, examines the role of silicon-based nanomaterials in addressing the challenges of chronic wound healing. The authors describe how mesoporous silica nanoparticles and related composites offer high drug-loading capacity, customizable structures, and controlled drug release, making them promising platforms for advanced wound care therapies. Their ability to modulate inflammation, reduce oxidative stress, and promote angiogenesis supports tissue regeneration and accelerates healing.
Key Highlights:
- Mechanisms of action: Nanomaterials enhance wound healing by controlling inflammation, reducing oxidative stress, stimulating angiogenesis, and supporting tissue remodeling.
- Therapeutic applications: Silicon-based nanosystems function as drug carriers with intelligent release properties, responding to stimuli such as pH or light for targeted therapy.
- Biocompatibility: Review data indicates strong safety and compatibility profiles, though further research is needed to confirm long-term biosafety.
- Clinical translation: While preclinical evidence is strong, large-scale clinical trials are required to validate efficacy and move toward routine wound care use.
- Future prospects: Research should focus on optimizing synthesis, integrating multifunctional strategies, and designing robust clinical studies.
Keywords:
Xuan Zhao,
Zhikai Xu,
Dongfang Wang,
Tonghan Li,
Zhanfei Li,
Xiangjun Bai,
Hao Zhu,
Yukun Liu,
Yuchang Wang,
silicon nanomaterials,
chronic wound healing,
mesoporous silica nanoparticles,
angiogenesis