A multi therapy bioelectronic wound dressing
Summary: This study introduces a flexible bioelectronic wound dressing that combines multiple therapies in one device, including electric field (EF) stimulation and controlled drug delivery via integrated microfluidics. The dressing applies EF to promote galvanotaxis and cell migration, then switches to iontophoretic delivery of fluoxetine to modulate inflammation. In a pilot porcine excisional wound model, treated wounds demonstrated significantly faster closure, reduced inflammatory response (lower granulocytes and pro-inflammatory cytokines), and improved tissue maturity compared to standard care. The technology enables localized, on-demand treatment with minimal off-target effects, offering a promising platform for chronic and acute wounds, including diabetic foot ulcers.
Key Highlights:
- Combines EF therapy and drug delivery in a single flexible dressing
- Microfluidics enable seamless switching between modalities
- Pilot porcine study: faster closure, less inflammation, better tissue quality
- Authors: Hsin-ya Yang, Jaime Tenedorio, Marco Rolandi (corresponding)
Keywords: bioelectronic wound dressing, electrical stimulation, chronic wound therapy, Marco Rolandi